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1. 发明专利

JP2017114898A ワクチン組成物审中-公开
公开(公告)号：JP2017114898A
公开(公告)日：2017-06-29
申请号：JP2017033269
申请日：2017-02-24
申请人：日東電工株式会社 , Nitto Denko Corp
发明人： FUKASAKA MASAHIRO , OKAZAKI ARIMICHI , ASARI DAISUKE , HORI MITSUHIKO , AKIRA SHIZUO , TAKEUCHI OSAMU
IPC分类号： A61K39/39 , A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/00034 , C12N2760/16034 , C12N2760/16134
摘要：【課題】感染症の予防又は治療剤として有用で、効果的に全身性免疫応答及び粘膜免疫応答を誘導させることのできる舌下投与可能なワクチン組成物を提供する。【解決手段】ヒト又は動物の口腔内に投与されるワクチン組成物であって、少なくとも一種類の感染症由来抗原と、トール様受容体2/6(TLR2/6)アゴニスト又はその塩とを含むことを特徴とするワクチン組成物。【選択図】なし

2. 发明专利

JP2014169275A Vaccine composition for mucosal administration 审中-公开
标题翻译：用于疫苗管理的疫苗组合物
公开(公告)号：JP2014169275A
公开(公告)日：2014-09-18
申请号：JP2014014795
申请日：2014-01-29
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： OKAZAKI ARIMICHI , MATSUSHITA KYOHEI , ASARI DAISUKE , SHISHIDO TAKUYA , MAEDA YOSHIMI , OKUBO KATSUYUKI , LI WENJING , HORI MITSUHIKO , SUGIYAMA HARUO
IPC分类号： A61K39/00 , A61K39/39 , C07K16/28 , C07K16/30
CPC分类号： A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55566 , A61K2039/55583 , A61K2039/572
摘要： PROBLEM TO BE SOLVED: To provide a vaccine composition which exerts a high cellular immunity inducing effect by mucosal administration.SOLUTION: The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.
摘要翻译：要解决的问题：提供通过粘膜给药发挥高细胞免疫诱导作用的疫苗组合物。解决方案：本发明提供一种用于粘膜给药以诱导细胞免疫的疫苗组合物，其包含：（i）抗原; 和（ii）选自TLR配体，环二核苷酸，辅助肽和免疫调节小分子药物的一种或多种细胞免疫诱导启动子。

3. 发明专利

JP2013231026A Vaccine composition 有权
标题翻译：疫苗组合物
公开(公告)号：JP2013231026A
公开(公告)日：2013-11-14
申请号：JP2013073406
申请日：2013-03-29
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： FUKASAKA MASAHIRO , OKAZAKI ARIMICHI , ASARI DAISUKE , HORI MITSUHIKO , AKIRA SHIZUO , TAKEUCHI OSAMU
IPC分类号： A61K39/39 , A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/00034 , C12N2760/16034 , C12N2760/16134
摘要： PROBLEM TO BE SOLVED: To provide a sublingually administrable vaccine composition, which is useful as a preventive or therapeutic agent for infectious diseases, and can effectively induce a systemic immune response and a mucosal immune response.SOLUTION: A vaccine composition for administration into the oral cavity of a human or an animal includes: at least one antigen derived from an infectious disease; and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic bis-dinucleotide, or a derivative or salt thereof.
摘要翻译：要解决的问题：提供一种舌下给药的疫苗组合物，其可用作感染性疾病的预防或治疗剂，并且可以有效诱导全身免疫应答和粘膜免疫应答。解决方案：用于口服给药的疫苗组合物人或动物的空腔包括：至少一种衍生自传染病的抗原; 和选自由toll样受体4（TLR4）激动剂，toll样受体2/6（TLR2 / 6）激动剂和环状双二核苷酸或其衍生物或盐组成的组中的至少一种。

4. 发明专利

JP2013006798A Method for manufacturing particulate preparation 有权
标题翻译：制备颗粒制剂的方法
公开(公告)号：JP2013006798A
公开(公告)日：2013-01-10
申请号：JP2011141058
申请日：2011-06-24
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： KONISHI TATSUYA , ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO
IPC分类号： A61K9/62 , A61K31/185 , A61K47/32 , A61K47/38 , A61P11/10
摘要： PROBLEM TO BE SOLVED: To providea method for manufacturing a highly drug elution-controlled particulate preparation, which can simply manufacture the particulate preparation by multilayer-coating drug particles through a spray-drying technique without using such a complicated method as simultaneous spraying of two different spray liquids from different nozzles.SOLUTION: The method for manufacturing the particulate preparation includes : a step of forming a first coating layer on drug particles through a spray-drying technique after dissolving and/or suspending the drug particles in a first coating solution containing a cellulose-based enteric polymer; and a step of forming a second coating layer on the drug particles through the splay-drying technique after suspending the drug particles in a second coating solution containing a water-insoluble polymer different from the cellulose-based enteric polymer.
摘要翻译：解决问题的方案：提供一种制备高药物洗脱控制的颗粒制剂的方法，其可以通过喷雾干燥技术多次涂覆药物颗粒来简单地制备颗粒制剂，而不使用如同时喷雾的这种复杂的方法来自不同喷嘴的两种不同喷雾液体。解决方案：制备颗粒制剂的方法包括：通过喷雾干燥技术在将药物颗粒溶解和/或悬浮在含有纤维素基的第一涂层溶液中之后在药物颗粒上形成第一涂层的步骤肠溶性聚合物以及在将药物颗粒悬浮在含有不同于纤维素类肠溶性聚合物的水不溶性聚合物的第二涂布溶液中之后，通过喷雾干燥技术在药物颗粒上形成第二涂层的步骤。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2011225525A Stabilized pharmaceutical composition, liquid preparation of stabilized pharmaceutical composition, and film-form preparation and method of producing the same 有权
标题翻译：稳定的药物组合物，稳定的药物组合物的液体制备和膜形式制备及其生产方法
公开(公告)号：JP2011225525A
公开(公告)日：2011-11-10
申请号：JP2011036311
申请日：2011-02-22
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , HORI MITSUHIKO , SHISHIDO TAKUYA
IPC分类号： A61K38/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/38
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/7007 , A61K39/35 , A61K39/36
摘要： PROBLEM TO BE SOLVED: To provide a stabilized pharmaceutical composition that enables the production of a preparation for desensitization therapy useful as an agent for the prevention or treatment of allergic diseases, such as pollen hypersensitivity, has outstanding allergen protein stability, and is useful for storage and transfer.SOLUTION: The stabilized pharmaceutical composition contains an allergen protein and at least one type of stabilizer selected from a group consisting of sugars, sugar alcohols, and sugar fatty acids.
摘要翻译：待解决的问题：提供能够生产用于预防或治疗过敏性疾病如花粉超敏反应的药剂的脱敏治疗制剂的稳定化药物组合物具有突出的变应原蛋白稳定性，并且是用于存储和传输。解决方案：稳定的药物组合物含有变应原蛋白和至少一种选自由糖，糖醇和糖脂肪酸组成的组的稳定剂。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2014169277A Wt1 peptide cancer vaccine composition for transdermal administration 有权
标题翻译： WT1胃癌用于远程管理的胃癌组合物
公开(公告)号：JP2014169277A
公开(公告)日：2014-09-18
申请号：JP2014014802
申请日：2014-01-29
申请人： Nitto Denko Corp , 日東電工株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： OKUBO KATSUYUKI , MAEDA YOSHIMI , OKAZAKI ARIMICHI , ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , SUGIYAMA HARUO
IPC分类号： A61K39/00 , A61K38/00 , A61K39/39 , A61P35/00 , A61P35/02 , C07K14/47
CPC分类号： A61K9/0014 , A61K38/10 , A61K39/0011 , A61K2039/54
摘要： PROBLEM TO BE SOLVED: To provide a composition for a cancer vaccine that has higher efficacy and is convenient for use.SOLUTION: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter.
摘要翻译：本发明提供一种用于细胞免疫诱导的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/ 或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。

7. 发明专利

JP2014169276A Wt1 peptide cancer vaccine composition for transdermal administration 有权
标题翻译： WT1胃癌用于远程管理的胃癌组合物
公开(公告)号：JP2014169276A
公开(公告)日：2014-09-18
申请号：JP2014014800
申请日：2014-01-29
申请人： Nitto Denko Corp , 日東電工株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： OKUBO KATSUYUKI , MAEDA YOSHIMI , OKAZAKI ARIMICHI , ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , SUGIYAMA HARUO
IPC分类号： A61K39/00 , A61K9/08 , A61K9/107 , A61K45/00 , A61K47/12 , A61K47/20 , A61P35/00
CPC分类号： A61K9/0014 , A61K31/045 , A61K31/437 , A61K31/451 , A61K31/513 , A61K31/708 , A61K31/716 , A61K31/728 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K2039/54
摘要： PROBLEM TO BE SOLVED: To provide a composition for a cancer vaccine that has higher efficacy and is convenient for use.SOLUTION: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a pharmacologically acceptable acid as a first cellular immunity induction promoter, or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供一种用于细胞免疫诱导的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/ 或修饰的WT1肽; 和（ii）药理学上可接受的酸作为第一细胞免疫诱导启动子或其药理学上可接受的盐。

8. 发明专利

JP2013006824A Edible jelly-form composition, jelly-form preparation and method for producing jelly-form preparation 审中-公开
标题翻译：可食用形状组合物，制备和制备果胶形式的制备方法
公开(公告)号：JP2013006824A
公开(公告)日：2013-01-10
申请号：JP2012098245
申请日：2012-04-23
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , MATSUSHITA KYOHEI
IPC分类号： A61K9/06 , A61K47/10 , A61K47/36 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide an edible jelly composition capable of favorably gelling and obtaining a jelly-form preparation by adding a drug-containing solution thereto afterward, and to provide a method for producing the jelly-form formulation.SOLUTION: The edible composition includes a gelling agent and is used for producing the jelly-form preparation by adding the drug-containing solution to be gelatinized.
摘要翻译：待解决的问题：提供一种能够通过向其中加入含药溶液而有利地胶凝和获得凝胶状制剂的食用胶冻组合物，并提供一种制备凝胶状制剂的方法。解决方案：可食用组合物包括胶凝剂，并通过加入待糊化的药物溶液来制备胶冻制剂。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012121873A Sheet-form preparation and method for producing the same 有权
标题翻译：表格制备及其制造方法
公开(公告)号：JP2012121873A
公开(公告)日：2012-06-28
申请号：JP2010276190
申请日：2010-12-10
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , OKAZAKI TOSHIHIKO
IPC分类号： A61K47/42 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38
CPC分类号： A61K38/014 , A61K9/0056 , A61K9/7007 , A61K31/00 , A61K47/26 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide a sheet-form preparation that can be easily dissolved intraorally, allows the dissolution time thereof to be easily controlled, and can stably contain a drug except an allergenic protein from cedar pollen.SOLUTION: The sheet-form preparation contains water, gelatin, and a drug except an allergenic protein from cedar pollen. Preferably, the preparation contains at least one selected from the group consisting of sugars, sugar alcohols and sugar fatty acids, and further polyethylene glycol or its derivative, crystalline cellulose and the like.

10. 发明专利

JP2011153113A Film-form preparation 有权
标题翻译：电影制作
公开(公告)号：JP2011153113A
公开(公告)日：2011-08-11
申请号：JP2010017321
申请日：2010-01-28
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , HORI MITSUHIKO , SHISHIDO TAKUYA
IPC分类号： A61K39/35 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61P37/08
CPC分类号： A61K9/006 , A61K9/1623 , A61K9/7007 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a film-form preparation which, in desensitization therapy, enables a patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers and additionally, enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little sticky sensation in the mouth and better feeling when touched by the fingers and to provide a method for producing the film-form preparation.
SOLUTION: The film-form preparation comprises an allergen, an edible polymer which is soluble in both water and a polar organic solvent, and one, two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 to 100 μm.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种薄膜形式的制剂，其在脱敏疗法中使得患者能够自我施用变应原并调节剂量，具有优异的携带性，没有残留感觉，提供极好的防止意外吞咽的保护作用护理人员很容易管理，可以大大提高患者和护理人员的生活质量，另外，可以任意控制口腔中溶出时间，特别是舌下，口感很小，触摸感更好并提供一种制备薄膜形成剂的方法。解决方案：膜形式制剂包含可溶于水和极性有机溶剂的变应原，可食用聚合物和选自单糖至六糖和糖的一种，两种或更多种颗粒醇的平均粒径为0.1〜100μm。版权所有（C）2011，JPO＆INPIT

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