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1. 发明专利

JP2008076093A Manufacturing method of analyzer, and coating composition 有权
标题翻译：分析仪的制造方法和涂料组合物
公开(公告)号：JP2008076093A
公开(公告)日：2008-04-03
申请号：JP2006252963
申请日：2006-09-19
申请人： Nissui Pharm Co Ltd , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 日水製薬株式会社
发明人： AKAHA SHUICHI , OKU YUICHI , ARAI SUSUMU
IPC分类号： G01N33/547 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a coating composition capable of avoiding the lowering phenomenon of the bonding capacity with a target physiologically active substance, without a capturing substance being coated with absorption-preventing agent, in the manufacture of an analyzer used in the detection and analysis of many kinds of physiologically active substances in a biosample that can prevent non-specific adsorption of proteins or labeled substance (labeled antibody, or the like) that are non-analyzing targets and simplifying a manufacturing process, and to provide a manufacturing method of the analyzer. SOLUTION: The coating composition contains a capturing-substance bonded polymer substance, obtained by bonding the capturing substance for capturing the physiologically active substance to a polymer substance, which contains a first functional group having phosphorylcholine and a second unit having a functional group, between the functional group contained in the capturing substance and the functional group of the second unit contained in the polymer substance. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种涂料组合物，其能够避免与目标生理活性物质的结合能力的降低现象，而没有捕获物质被吸收防止剂涂覆，在制造用于检测和分析生物样品中可以防止非特异性吸附作为非分析目标的蛋白质或标记物质（标记抗体等）并简化制造过程的生理活性物质，并提供一种分析仪的制造方法。解决方案：涂料组合物含有通过将捕获生理活性物质的捕获物质结合到含有具有磷酸胆碱的第一官能团的聚合物物质和具有官能团的第二单元获得的捕获物质结合的聚合物物质包含在捕获物质中的官能团与聚合物物质中所含的第二单元的官能团之间。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2005110664A Method for detecting presence of target dna by amplification of nucleic acid signal, and method for detecting or determining immunological ligand 审中-公开
标题翻译：通过放大核酸信号检测目标DNA存在的方法，以及检测或确定免疫配体的方法
公开(公告)号：JP2005110664A
公开(公告)日：2005-04-28
申请号：JP2004220747
申请日：2004-07-28
申请人： Nissui Pharm Co Ltd , 日水製薬株式会社
发明人： AKAHA SHUICHI
IPC分类号： G01N33/543 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting a target DNA without performing the amplification of the target DNA for performing the detection of the target DNA and without being limited by the base sequence of the target DNA. SOLUTION: This method for detecting the presence of the target DNA is provided by using a target DNA-detecting probe obtained by connecting a complemental base sequence to the target DNA and an optionally selectable base sequence which is not complemental, and amplifying a nucleic acid signal composed of oligo nucleotide containing a base sequence complemental to the base sequence which is not complemental to the target DNA in the probe. Although the base sequence of the target DNA is different, the amplified products can be detected by the probe having the same base sequence. The method for detecting the presence of the target DNA can be applied to the detection or determination of an immunological ligand. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种用于检测目标DNA而不进行靶DNA的扩增以进行目标DNA的检测的方法，而不受目标DNA的碱基序列的限制。解决方案：通过使用通过将补体碱基序列连接到靶DNA获得的靶DNA检测探针和任选的可选择的不互补的碱基序列来扩增靶向DNA的存在的方法，并扩增由寡核苷酸组成的核酸信号，所述寡核苷酸含有与所述探针中的靶DNA不互补的碱基序列互补的碱基序列。尽管目标DNA的碱基序列不同，但扩增产物可以通过具有相同碱基序列的探针来检测。用于检测靶DNA存在的方法可以应用于免疫配体的检测或测定。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2006337261A Method for manufacturing linear-shaped immobilizing substrate for biomolecule, chip and analysis method 审中-公开
标题翻译：用于生产分子，芯片和分析方法的线形固定基板的制造方法
公开(公告)号：JP2006337261A
公开(公告)日：2006-12-14
申请号：JP2005164303
申请日：2005-06-03
申请人： Nissui Pharm Co Ltd , 日水製薬株式会社
发明人： OKU YUICHI , AKAHA SHUICHI , HARA RYOTARO , UMEDA MAMORU
IPC分类号： G01N37/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method for precisely immobilizing a biomolecule in a linear fashion on a substrate, by using a discharge device having a syringe and a nozzle that communicates with the syringe.
SOLUTION: In the method, a liquid material including the biomolecule is contained in the syringe, and the inside of the syringe is pressurized, to continuously discharge a prescribed amount of the liquid material from the nozzle communicating with the syringe, and applying/drawing operations are carried out in a linear fashion on the substrate, while relatively moving the nozzle and the substrate which has at least a liquid-nonabsorbable surface, and then drying is carried out to immobilize the biomolecule.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过使用具有与注射器连通的注射器和喷嘴的排出装置将线性方式的生物分子精确地固定在基板上的方法。解决方案：在该方法中，包含生物分子的液体材料包含在注射器中，并且注射器的内部被加压，以从与注射器连通的喷嘴连续排出规定量的液体材料，并施加 /拉伸操作在基板上以直线方式进行，同时相对移动具有至少液体不可吸收表面的喷嘴和基板，然后进行干燥以固定生物分子。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007085779A Analysis method of biological substance using microchip and analyzing kit 审中-公开
标题翻译：使用微波和分析试剂盒分析生物物质的方法
公开(公告)号：JP2007085779A
公开(公告)日：2007-04-05
申请号：JP2005272289
申请日：2005-09-20
申请人： Nissui Pharm Co Ltd , 日水製薬株式会社
发明人： AKAHA SHUICHI , OKU YUICHI , HARA RYOTARO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/547 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an analysis method of a biological substance, using a microchip capable of sharply shortening a reaction time, without causing the detection sensitivity of the analysis of physiological polymers that uses a microfluid system to deteriorate, and to provide an analysis kit.
SOLUTION: In the measurement of a substance to be analyzed 3 by a premix reaction system using a microfluid system, either a ligand or a receptor, both of which are arranged in a flow channel, is set as biotin 6 to be bonded to a first bonding substance 1; and when the other of the ligand and the receptor is set as a polyvalent substance 2 selected from avidine and streptoavidine, the biological substance can be analyzed without lowering the detection sensitivity, as compared with stepwise reaction systems.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提供生物物质的分析方法，使用能够急剧缩短反应时间的微芯片，而不会引起使用微流体系统的生理性聚合物的分析的检测灵敏度劣化，并且提供分析工具包。解决方案：在通过使用微流体系统的预混合反应体系测定待分析物质3时，将其配置在流路中的配体或受体被设定为生物素6以进行键合到第一粘合物质1; 并且当另一个配体和受体被设定为选自阿维定和链脲霉素的多价物质2时，与步骤反应体系相比，可以分析生物物质而不降低检测灵敏度。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2003277398A Antibody against transferrin-including immune complex, method of producing the same, hybridoma and immunity measuring method 审中-公开
标题翻译：抗转铁蛋白抗体 - 包括免疫复合物，其生产方法，杂交和免疫测量方法
公开(公告)号：JP2003277398A
公开(公告)日：2003-10-02
申请号：JP2002083212
申请日：2002-03-25
申请人： Nissui Pharm Co Ltd , 日水製薬株式会社
发明人： AKAHA SHUICHI , HAMANO AKISHIGE
IPC分类号： G01N33/53 , C07K16/28 , C07K16/46 , C07K19/00 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/564 , G01N33/577
CPC分类号： G01N33/564 , C07K16/2881 , G01N2333/79
摘要： PROBLEM TO BE SOLVED: To provide an antibody that can identify a patient with alcoholism and a patient with hepatitis, a method of producing the antibody, a hybridoma for producing the antibody and a simple immunoassay using the antibody. SOLUTION: The antibody to be provided selectively reacts with an immune complex and the immune complex is composed of transferrin and immunoglobulin. The content of the immune complex in the body fluid is high in a patient with alcoholism but low in a patient with non-alcoholism and the difference can be measured with the antibody. Since the immune complex in the body fluid is determined with the antibody against the immune complex composed of transferring and immunoglobulin, the patients with alcoholism or hepatitis can be simply identified with high exactness. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供可以鉴定患有酒精中毒的患者和患有肝炎的患者的抗体，产生抗体的方法，用于产生抗体的杂交瘤和使用该抗体的简单免疫测定。提供的抗体选择性地与免疫复合物反应，免疫复合物由转铁蛋白和免疫球蛋白组成。在酒精中毒的患者体内的免疫复合物的含量较高，但在非酒精中毒的患者中，其含量较低，并且可以用抗体测量差异。由于身体流体中的免疫复合物是用针对由转移和免疫球蛋白组成的免疫复合物的抗体来确定的，所以可以用高精确度来简单地鉴定酒精中毒或肝炎患者。版权所有（C）2004，JPO

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