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1. 发明专利

JP2011246387A Composition for maintenance of muscle force and improvement of joint function 审中-公开
标题翻译：用于维持肌肉力量和改善关节功能的组合物
公开(公告)号：JP2011246387A
公开(公告)日：2011-12-08
申请号：JP2010120820
申请日：2010-05-26
申请人： Nisshin Pharma Inc , 日清ファルマ株式会社
发明人： ASADA KENICHI , NIIMURA YUKI , MINEMURA TAKESHI , YAMADA KAZUHIKO
IPC分类号： A61K38/00 , A23K1/16 , A23L1/305 , A61P19/02 , A61P21/00
摘要： PROBLEM TO BE SOLVED: To develop and provide a natural material which is safe and inexpensive and can be ingested easily, routinely and continuously, which has a remarkable action of maintaining muscle force and improving joint function, and which is effective for prevention and/or improvement of various muscle force maintenance and joint functional disorders, especially, subjective symptoms resulting from problems with muscles or joints, e.g., joint pain, gait disorder, and decrease in joint movement range.SOLUTION: The composition for maintenance of muscle force and improvement of joint function comprises a wheat protein hydrolyzate, preferably, a wheat gluten hydrolyzate, and especially preferably, a peptide having an L-glutamine content of 15-60 mass% and an average molar weight of 200-100,000 daltons.
摘要翻译：要解决的问题：开发和提供安全，便宜，可以容易，常规，持续地摄取的天然材料，具有维持肌肉力量和改善关节功能的显着作用，有效预防和/或各种肌肉力维持和关节功能障碍的改善，特别是由肌肉或关节问题引起的主观症状，例如关节疼痛，步态障碍和关节活动范围的减少。解决方案：用于维持肌肉力和改善关节功能的组合物包括小麦蛋白水解物，优选小麦谷蛋白水解物，特别优选L-谷氨酰胺含量为15-60质量％的肽和平均摩尔重量为200-100,000道尔顿。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2003286296A Method of preparation for amylase inhibitor 有权
标题翻译：制备AMYLASE抑制剂的方法
公开(公告)号：JP2003286296A
公开(公告)日：2003-10-10
申请号：JP2003016539
申请日：2003-01-24
申请人： Nagata Sangyo Kk , Nisshin Pharma Inc , 日清ファルマ株式会社 , 長田産業株式会社
发明人： MURANAKA RUMIKO , MURANAKA YASUTO , KANEFUJI GAKUO , MURAYAMA RYUJI , YAMADA KAZUHIKO , SATO KAZUO , SEKIKAWA AKIRA , IKEMOTO HIROYUKI , SUZUKI YOSHIO
IPC分类号： C07K1/30
摘要： PROBLEM TO BE SOLVED: To provide a method which effectively prepares an amylase inhibitor abundantly containing 0.19AI having high amylase inhibitory activity, in a simple step and a short time as compared to conventional process. SOLUTION: The method of preparation for the amylase inhibitor comprises: a step (A) obtaining a stock solution containing the amylase inhibitor; a step (B) collecting salting out insoluble substance by adding salt to the stock solution obtained in the step (A) to salt out the amylase inhibitor as the insoluble substance; and a step (C) collecting the amylase inhibitor from the insoluble substance collected in the step (B). The amylase inhibitor of the invention effectively suppresses secretion of insulin effective for prevention and/or remedy of hyperglycemia, diabetes, lipemia, arterial sclerosis or obesity because the amylase inhibitor has high amylase inhibitory activity on the other hand has no inhibitory activity to trypsin and has high amylase inhibitory activity especially to amylase contained in pancreatic juice. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种与常规方法相比，在简单的步骤和短时间内有效制备大量含有具有高淀粉酶抑制活性的0.19AI的淀粉酶抑制剂的方法。解决方案：制备淀粉酶抑制剂的方法包括：步骤（A）获得含有淀粉酶抑制剂的原液; （B）通过向步骤（A）中得到的储备溶液中加入盐来收集不溶物，将淀粉酶抑制剂盐析为不溶物; 和从步骤（B）中收集的不溶物中收集淀粉酶抑制剂的步骤（C）。由于淀粉酶抑制剂具有高淀粉酶抑制活性，所以本发明的淀粉酶抑制剂有效地抑制了对于预防和/或治疗高血糖症，糖尿病，血脂异常，动脉硬化症或肥胖症有效的胰岛素分泌，对胰蛋白酶没有抑制活性，高淀粉酶抑制活性，特别是胰液中所含的淀粉酶。版权所有（C）2004，JPO

3. 发明专利

JP2010195734A Phytic acid, carboxylic acid, and composition having fat absorption inhibitory action by synergistic effect of saccharides 审中-公开
标题翻译：植物酸，羧酸和具有脂肪吸收抑制作用的组合物通过食物的协同作用
公开(公告)号：JP2010195734A
公开(公告)日：2010-09-09
申请号：JP2009044601
申请日：2009-02-26
申请人： Nisshin Pharma Inc , 日清ファルマ株式会社
发明人： KATAYANAGI YUKI , HIRAMOTO SHIGERU , YAMADA KAZUHIKO
IPC分类号： A61K31/665 , A61K31/19 , A61K31/715 , A61P3/04 , A61P3/06 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition which shows good fat absorption inhibitory action, has no side effect, is safe, and can be taken simply and continuously, and as a result, can prevent and/or improve conditions related to excessive fat absorption, for example, obesity and hyperlipidemia.
SOLUTION: The present invention relates to a composition for inhibiting fat absorption that contains phytic acid, a carboxylic acid, and saccharides as active components.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供显示出良好的吸脂抑制作用的组合物，没有副作用，是安全的，并且可以简单且连续地进行，结果可以防止和/或改善与过量的脂肪吸收，例如肥胖和高脂血症。解决方案：本发明涉及含有植酸，羧酸和糖作为活性成分的抑制脂肪吸收的组合物。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2003055374A L-ASCORBIC ACID-2-O-MALEIC ACID-α-TOCOPHEROLDIESTER/1- PROPANOL ADDUCT AND METHOD FOR PRODUCING THE SAME 有权
标题翻译： L-抗坏血酸-2-氧杂 - 酸性-α-生物合成物/ 1-丙酰胺添加剂及其制备方法
公开(公告)号：JP2003055374A
公开(公告)日：2003-02-26
申请号：JP2002164600
申请日：2002-06-05
申请人： Nisshin Pharma Inc , Senju Pharmaceut Co Ltd , 千寿製薬株式会社 , 日清ファルマ株式会社
发明人： OGATA KAZUMI , SAITO NORIKO , YAMADA KAZUHIKO , MARUYAMA GENTA
IPC分类号： C07D407/12 , A61K8/02 , A61K8/49 , A61K31/353 , A61P1/00 , A61P1/02 , A61P11/02 , A61P13/08 , A61P13/10 , A61P17/16 , A61P19/02 , A61P27/02 , A61P27/16 , A61P29/00 , A61P39/06 , A61P43/00 , C07H19/23 , A61K7/00
CPC分类号： C07H19/23 , C07D407/12
摘要： PROBLEM TO BE SOLVED: To provide a new L-ascorbic acid-2-O-maleic acid-α-tocopheroldiester/1- propanol adduct, to provide a method for producing the adduct, and to provide its applications.
SOLUTION: There are provided the L-ascorbic acid-2-O-maleic acid-α- tocopheroldiester/1-propanol adduct and its pharmacologically permissible salt; and a cosmetic component, an antioxidant, a radical scavenger, an anti- inflammatory agent and an elastase inhibitor each containing the adduct or the salt as the effective component. The method for producing the adduct is characterized by treating a solution containing L-ascorbic acid-2-O-maleic acid-α- tocopheroldiester with extraction using an extracting solvent, removing the extracting solvent to obtain the residue, adding 1-propanol or a mixture liquid of 1-propanol with an organic solvent to the residue and crystallizing the adduct.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供新的L-抗坏血酸-2-O-马来酸-α-生育酚/ 1-丙醇加合物，以提供生产加合物的方法，并提供其应用。解决方案：提供L-抗坏血酸-2-O-马来酸-α-生育酚/ 1-丙醇加合物及其药理学允许的盐; 以及各自含有加合物或盐作为有效成分的化妆品成分，抗氧化剂，自由基清除剂，抗炎剂和弹性蛋白酶抑制剂。加合物的制造方法的特征在于，使用萃取溶剂进行萃取处理含有L-抗坏血酸-2-O-马来酸-α-生育酚的溶液，除去萃取溶剂得到残渣，加入1-丙醇或将1-丙醇与有机溶剂的混合液体加入到残余物中并结晶加合物。

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