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1. 发明专利

JP2011137769A Measuring instrument comprising biosensor 审中-公开
标题翻译：包含生物传感器的测量仪器
公开(公告)号：JP2011137769A
公开(公告)日：2011-07-14
申请号：JP2009299075
申请日：2009-12-29
申请人： Nipro Corp , ニプロ株式会社
发明人： SEKINE SHIGERU , SHIRASAKI KATSUYA , MORITA MITSUHIRO
IPC分类号： G01N27/26 , G01N27/28 , G01N27/327 , G01N27/416
CPC分类号： G01N27/3272 , C12Q1/006
摘要： PROBLEM TO BE SOLVED: To provide a means for accurately and rapidly measuring the temperature of a biosensor. SOLUTION: This measuring instrument includes a biosensor attachable to and detachable from an instrument body. The biosensor includes a first electrode, a second electrode, and a third electrode for detecting temperatures. The instrument body is equipped with: a quantity determination means for determining the quantity of a substance to be detected in a specimen based on an electric current flowing through the first and second electrodes owing to a reaction between an enzyme and the substance; a pair of connection terminals electrically contacting with the third electrode; a temperature calculation means for calculating the temperature of the third electrode based on a resistance value of the third electrode acquired between the connection terminals; a correction means for correcting quantitative values of the substance with the quantity thereof determined by the determination means based on the temperature calculated by the calculation means; a mounting detection means for detecting the mounting of the biosensor; and a control means causing the calculation means to calculate the temperature of the third electrode on condition that the mounting of the biosensor has been detected by the detection means. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于准确和快速地测量生物传感器的温度的手段。
解决方案：该测量仪器包括可附接到仪器主体和从仪器主体拆卸的生物传感器。生物传感器包括第一电极，第二电极和用于检测温度的第三电极。仪器主体配备有：数量确定装置，用于基于由于酶和物质之间的反应而流过第一和第二电极的电流来确定样品中待检测物质的量; 一对与第三电极电接触的连接端子; 温度计算装置，用于基于在连接端子之间获取的第三电极的电阻值来计算第三电极的温度; 校正装置，用于根据由计算装置计算出的温度来校正由确定装置确定的数量的物质的定量值; 用于检测生物传感器的安装的安装检测装置; 以及控制装置，其使得所述计算装置在由所述检测装置检测到所述生物传感器的安装的条件下计算所述第三电极的温度。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011117911A Blood glucose concentration measuring device 有权
标题翻译：血液葡萄糖浓度测量装置
公开(公告)号：JP2011117911A
公开(公告)日：2011-06-16
申请号：JP2009277967
申请日：2009-12-07
申请人： Nipro Corp , ニプロ株式会社
发明人： YOSHIDA HIROSHI , SATO SHINPEI , SHIRASAKI KATSUYA
IPC分类号： G01N27/28 , G01N27/26 , G01N27/327 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide a blood glucose concentration measuring device which includes a means capable of ex-post facto determining a relation between the food and drink ingested by a subject, and the concentration of blood sugar in the subject.
SOLUTION: A portable blood glucose concentration measuring device 10 includes a measuring section 21, that generates and outputs a signal indicative of a concentration of blood glucose; a camera section 15, that generates and outputs a signal indicative of an image taken of a subject; a storage section 24, in which the signal indicative of the concentration of blood glucose and the image signal are stored, and a display 12 that displays the concentration of glucose and the image, according to the signal indicative of the concentration of glucose and the image signal stored in the storage section 24.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种血糖浓度测定装置，其包括能够事后决定受试者摄取的食物与饮料之间的关系以及受试者的血糖浓度的手段。解决方案：便携式血糖浓度测量装置10包括测量部分21，其产生并输出指示血糖浓度的信号; 相机部分15，其产生并输出指示被摄体拍摄的图像的信号; 存储表示血糖浓度和图像信号的信号的存储部24，以及根据表示葡萄糖浓度和图像的信号的显示葡萄糖和图像的浓度的显示器12 信号存储在存储部分24中。版权所有：（C）2011，JPO＆INPIT

3. 发明专利

JP2011089781A Biological sample detector 有权
标题翻译：生物样本检测器
公开(公告)号：JP2011089781A
公开(公告)日：2011-05-06
申请号：JP2009241260
申请日：2009-10-20
申请人： Nipro Corp , ニプロ株式会社
发明人： BABA TOSHIAKI , MORITA MITSUHIRO , SHIRASAKI KATSUYA
IPC分类号： G01N27/327 , G01N27/416
CPC分类号： G01N27/3272
摘要： PROBLEM TO BE SOLVED: To provide a means capable of judging the mounting posture of the sensor mountable on either one of the surface and rear of a detector body and capable of accurately detecting the substance to be detected in a biological sample. SOLUTION: In a blood sugar measuring instrument 10, a biosensor 11 formed into a sheet shape having first and second surfaces 21 and 22 as the surface and the back and having a space 40 into which blood is introduced is provided to the connection part 13 of an instrument body 12 in either one of a first posture wherein the first surface 21 is a surface side and a second posture wherein the second surface 22 is a surface side in a detachable manner. A control part 55 judges whether the connection terminal 39 of a third electrode 27 electrically comes into contact with either one of a first terminal 61 and a second terminal 62 on the basis of the electrical state of the first terminal 61 or second terminal 62 to set either one of a first electrode 24 and a second electrode 26 to a positive electrode while setting the other one of them to a negative electrode to thereby measure a blood sugar level. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够判断可安装在检测器主体的表面和后面的传感器的安装姿势并且能够精确地检测生物样品中待检测物质的装置。解决方案：在血糖测量仪器10中，形成为具有作为表面和背面的第一表面21和第二表面21和具有引入血液的空间40的片状的生物传感器11设置在连接仪器主体12的第一姿势中的任何一个，其中第一表面21是表面侧，第二姿势中的第二表面22是可拆卸的第二表面22。控制部55基于第一端子61或第二端子62的电气状态来判断第三电极27的连接端子39是否与第一端子61和第二端子62中的任一个电接触以设定将第一电极24和第二电极26中的任一个连接到正极，同时将另一个电极设置为负极，从而测量血糖水平。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2005140590A Biological sample measuring apparatus system by surface plasmon resonance 审中-公开
标题翻译：通过表面等离子体共振的生物样品测量装置系统
公开(公告)号：JP2005140590A
公开(公告)日：2005-06-02
申请号：JP2003375949
申请日：2003-11-05
申请人： Nipro Corp , ニプロ株式会社
发明人： SUETAKE TOSHINORI , WADA MASAAKI , SHIRASAKI KATSUYA , KOBAYASHI SUSUMU , HARUHARA TAKASHI
IPC分类号： G01N33/543 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide an apparatus system for introducing a practical function into a biological sample measuring apparatus utilizing a SPR phenomenon and surely measuring an actual biological sample.
SOLUTION: The biological sample measuring apparatus system based on SPR employs a sensor comprising a material having a capability for specifically bonding to a measured object and fixed to a metal thin film carrier, and has four functions. A function (1) supplies a plurality of reagents used for a measuring system under conditions of adjustment. A function (2) supplies a buffer liquid used for the measuring system under the conditions of adjustment. A function (3) supplies a cleaning liquid for cleaning a sample port and a sensor under the conditions of adjustment. A function (4) installs a liquid reservoir of the liquids (the cleaning liquid and the measured sample) flowing through the measuring system.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于将实用功能引入到利用SPR现象并可靠地测量实际生物样品的生物样品测量装置中的装置系统。解决方案：基于SPR的生物样品测量装置系统采用传感器，该传感器包括具有特异性地结合到测量对象并固定到金属薄膜载体的能力的材料，并且具有四种功能。功能（1）在调节条件下提供用于测量系统的多种试剂。功能（2）在调整条件下提供用于测量系统的缓冲液。功能（3）在调节条件下提供清洗样品口和传感器的清洗液。功能（4）安装流经测量系统的液体（清洗液和被测样品）的液体储存器。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2011203032A Measuring device and method 有权
标题翻译：测量装置和方法
公开(公告)号：JP2011203032A
公开(公告)日：2011-10-13
申请号：JP2010069165
申请日：2010-03-25
申请人： Nipro Corp , ニプロ株式会社
发明人： INOUE HIROKO , AKASAKA YUKI , SHIRASAKI KATSUYA
IPC分类号： G01N27/416 , G01N27/327
CPC分类号： G01N27/3272 , G01N27/3273
摘要： PROBLEM TO BE SOLVED: To provide a blood glucose measuring device that suppresses PAM from affecting measured values, and that suppresses dissolved oxygen and other sugars such as maltose from affecting measured values using a measurement system of a reagent containing FAD-GDH and potassium ferricyanide.SOLUTION: A biosensor 11 includes a first electrode 24, a second electrode 26, a space 40, and a reagent. The reagent contains at least potassium ferricyanide and glucose dehydrogenase with a flavin compound as a coenzyme. Each component of the reagent is applied to at least one of the first electrode 24 and the second electrode 26. A blood glucose measurement device 10 measures the amperage arising between the first electrode 24 and the second electrode 26 when a voltage of no more than 200 mV is applied for a certain period of time between the first electrode 24 and the second electrode 26.
摘要翻译：要解决的问题：提供一种抑制PAM影响测量值的血糖测量装置，并且使用含有FAD-GDH和铁氰化钾的试剂的测量系统来抑制溶解氧和其它糖如麦芽糖影响测量值。解决方案：生物传感器11包括第一电极24，第二电极26，空间40和试剂。该试剂至少含有铁氰化钾和葡萄糖脱氢酶与黄素化合物作为辅酶。试剂的每个成分被施加到第一电极24和第二电极26中的至少一个。血糖测量装置10测量当不大于200的电压时在第一电极24和第二电极26之间产生的电流强度在第一电极24和第二电极26之间施加一定时间的mV。

6. 发明专利

JP2011133294A Biosensor 有权
标题翻译：生物传感器
公开(公告)号：JP2011133294A
公开(公告)日：2011-07-07
申请号：JP2009291813
申请日：2009-12-24
申请人： Nipro Corp , ニプロ株式会社
发明人： MORITA MITSUHIRO , SHIRASAKI KATSUYA , AKASAKA YUKI
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： PROBLEM TO BE SOLVED: To provide a means for rapidly filling a sample space with a sample in a biosensor wherein first and second electrodes are arranged in counter relationship through a sample space. SOLUTION: One of regions 38 and 42 is coated with one component selected from a group consisting of a water-soluble polymer, a hemolytic agent and a surfactant among the respective components of a reagent containing enzyme, a mediator, the water-soluble polymer, the hemolytic agent, the surfactant and a buffer solution and the other components are applied to the other one of the regions 38 and 42. By this constitution, a space 40 is rapidly filled with the sample. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在生物传感器中用样品快速填充样品空间的装置，其中第一和第二电极通过样品空间以对置的关系布置。解决方案：区域38和42中的一个涂覆有选自含有试剂的试剂，介体，水溶性聚合物，水溶性聚合物，可溶性聚合物，溶血剂，表面活性剂和缓冲溶液，其它组分被施加到区域38和42中的另一个。通过这种结构，空间40被快速填充样品。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2011013193A Reagent for measuring copper concentration in blood 有权
标题翻译：用于测量血液中铜浓度的试剂
公开(公告)号：JP2011013193A
公开(公告)日：2011-01-20
申请号：JP2009160086
申请日：2009-07-06
申请人： Nipro Corp , ニプロ株式会社
发明人： SHIRASAKI KATSUYA , NISHIMURA EMI , INOUE HIROKO
IPC分类号： G01N33/84 , G01N21/78 , G01N31/00 , G01N31/22 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a reagent measuring accurately, safely and simply a copper concentration in blood.SOLUTION: This reagent includes a citrate buffer solution, a nonionic surfactant and a reducing agent, and liberates copper ion bonded to proteins in a specimen, when measuring the copper concentration in blood. Further, a kit for measuring the copper concentration in blood, including the reagent, and a measuring method of the copper concentration in blood using the reagent are also provided.
摘要翻译：要解决的问题：提供一种精确，安全，简单地测量血液中铜浓度的试剂。溶液：该试剂包括柠檬酸盐缓冲溶液，非离子表面活性剂和还原剂，释放与样品中蛋白质结合的铜离子，当测量血液中的铜浓度时。此外，还提供了用于测量包括试剂在内的血液中的铜浓度的试剂盒，以及使用试剂测定血液中铜浓度的测定方法。

8. 发明专利

JP2011137767A Biosensor and measuring instrument comprising the biosensor 审中-公开
标题翻译：生物传感器和测量仪器包括生物传感器
公开(公告)号：JP2011137767A
公开(公告)日：2011-07-14
申请号：JP2009299042
申请日：2009-12-29
申请人： Nipro Corp , ニプロ株式会社
发明人： SEKINE SHIGERU , SHIRASAKI KATSUYA , MORITA MITSUHIRO
IPC分类号： G01N27/26 , G01N27/28 , G01N27/327 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide a means for accurately and rapidly measuring the temperature of a specimen as to a biosensor. SOLUTION: This biosensor 11 includes first and second electrodes 24 and 26 that form a pair, an enzyme fixed in a domain 38 of the second electrode 26 to react with a substance to be detected in the specimen, and a thermocouple 42 comprising a contact 45 in the vicinity of the domain 38 of the second electrode 26. Since the thermocouple 42 comprising the contact 45 is provided in the vicinity of a domain of the first electrode 24 or the second electrode 26 with the specimen put into contact therewith, the temperature of the specimen can be measured accurately and rapidly. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于准确且快速地测量生物传感器的样本的温度的装置。解决方案：该生物传感器11包括形成一对的第一和第二电极24和26，固定在第二电极26的畴38中以与待检测物质反应的酶和热电偶42，热电偶42包括在第二电极26的畴38附近的接触45.由于包含触点45的热电偶42设置在与第一电极24或第二电极26的区域接触的区域附近，可以准确快速地测量样品的温度。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2011095158A Case for blood sugar measuring device 审中-公开
标题翻译：用于血糖测量装置的情况
公开(公告)号：JP2011095158A
公开(公告)日：2011-05-12
申请号：JP2009250686
申请日：2009-10-30
申请人： Nipro Corp , ニプロ株式会社
发明人： INOUE HIROKO , AKASAKA YUKI , SHIRASAKI KATSUYA
IPC分类号： G01N27/28
摘要： PROBLEM TO BE SOLVED: To provide a case facilitating measurement work, at a location where blood sugar is measured.
SOLUTION: A case 10 includes: a magnet 21 that is provided on an outer surface of the case 10 and repeatedly fixes and separate the case 10 in which a blood sugar measuring device 11 has been housed to and from a wall 30; and a member of a fixing band 23 that is provided on the inner surface of the case 10, makes visible a display 17 in the blood sugar measuring device 11, and operably fixes an operation key 18, while the case 10 is open.
COPYRIGHT: (C)2011,JPO&INPIT

10. 发明专利

JP2010051555A Patient's health condition evaluating method 有权
标题翻译：患者健康状况评估方法
公开(公告)号：JP2010051555A
公开(公告)日：2010-03-11
申请号：JP2008219868
申请日：2008-08-28
申请人： Nipro Corp , Hirokazu Shibahara , ニプロ株式会社 , 裕和芝原
发明人： SHIBAHARA HIROKAZU , KINOSHITA RYOJI , SHIRASAKI KATSUYA
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/1468
摘要： PROBLEM TO BE SOLVED: To provide an estimating method by which the health condition of a patient can highly precisely be evaluated from nutrition evaluation items (biochemical examination values) of the patient.
SOLUTION: In this method for evaluating the health condition of the patient, (A) at the starting of a nutrition management, the hematocrit which is the biochemical examination value of the patient, the urea nitrogen concentration in blood, the albumin concentration in blood, and the zinc concentration in blood are measured. Also, (B) an SPI (simple prognosis index) value is calculated by respectively substituting each biochemical examination value having been measured in the following formula (1) SPI=a
0 +a
1 ×Hct+a
2 ×BUN+a
3 ×ALB+a
4 ×Zn (in formula (1), a
0 , a
1 , a
2 , a
3 and a
4 are partial regression coefficients which are obtained by performing a linear multiple regression analysis). Then, (C) when the obtained SPI value is at a preset reference value or higher, the health condition is judged to be preferable, and when the obtained SPI value is less than the reference value, the health condition is judged to be poor by the patient's health condition evaluating method.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种估计方法，通过该估计方法能够从患者的营养评价项目（生化检查值）高精度地评价患者的健康状况。
解决方案：在评估患者健康状况的方法中，（A）营养管理开始时，作为患者的生化检查值的血细胞比容，血液中的尿素氮浓度，白蛋白浓度在血液中测量血液中的锌浓度。另外，（B）SPI（简单预后指数）值是通过分别用下式（1）中测量的每个生化检查值代替SPI = a 0 / SB>×Hct + a 2 ×BUN + a 3 ×ALB + a 4 ×Zn（式（1） SB> 0 ， 1 ， 2 ， 3 和 4 是部分回归通过进行线性多元回归分析获得的系数）。然后，（C）当所获得的SPI值为预先设定的基准值以上时，判断为健康状态是优选的，当得到的SPI值小于基准值时，健康状况判断为差病人的健康状况评估方法。版权所有（C）2010，JPO＆INPIT

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