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1. 发明专利

JP2009084161A Protease inhibitor and antibacterial agent 有权
标题翻译： PROTEASE抑制剂和抗菌剂
公开(公告)号：JP2009084161A
公开(公告)日：2009-04-23
申请号：JP2007251996
申请日：2007-09-27
申请人： Niigata Prefecture , Niigata Univ , 国立大学法人新潟大学 , 新潟県
发明人： TAYOJI MAYUMI , OOTSUBO SADAMI , TANIGUCHI MASAYUKI
IPC分类号： A61K38/55 , A23L1/305 , A61K8/64 , A61K8/97 , A61K36/899 , A61P43/00 , A61Q11/00 , C07K14/415 , C12N9/99 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a protease inhibitor and antibacterial agent which is effective for the prevention and treatment of periodontal diseases, excellent in safety and used for medical uses and as a foodstuff component. SOLUTION: The protease inhibitor contains a protein having 5.0 to 6.5 isoelectric point or its partial peptide contained in rice (Oryza sativa) as an active ingredient. The protein or its partial peptide as the active ingredient has a specific amino acid sequence, and inhibitory activity and antibacterial activity against the protease of periodontal disease bacteria, Porphyromonas gingivalis. The oral composition or foodstuff are obtained by adding the above protease inhibitor or antibacterial agent. The nucleic acid has the specific base sequence and encodes the protein having the protease inhibitory activity or antibacterial activity. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效预防和治疗牙周疾病，安全性和医疗用途以及用作食品成分的蛋白酶抑制剂和抗菌剂。解决方案：蛋白酶抑制剂含有作为活性成分的水稻（Oryza sativa）中含有5.0〜6.5等电点或其部分肽的蛋白质。蛋白质或其部分肽作为活性成分具有特定的氨基酸序列，并且对牙周病细菌，牙龈卟啉单胞菌的蛋白酶具有抑制活性和抗菌活性。口服组合物或食品通过加入上述蛋白酶抑制剂或抗菌剂而获得。核酸具有特异性碱基序列，并编码具有蛋白酶抑制活性或抗菌活性的蛋白质。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2003061615A Telomerase inhibitor and food composition 审中-公开
标题翻译： TELOMERASE抑制剂和食品组合物
公开(公告)号：JP2003061615A
公开(公告)日：2003-03-04
申请号：JP2001256589
申请日：2001-08-27
申请人： Niigata Prefecture , 新潟県
发明人： OOTSUBO SADAMI , NAKAJIMA MASAHARU , KUSUNOKI MASATOSHI
IPC分类号： A23L1/30 , A61K36/18 , A61K36/28 , A61K36/42 , A61K36/60 , A61K36/73 , A61K36/896 , A61P35/00 , A61P43/00 , C12N9/99 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a telomerase inhibitor or the like which has been eaten as a food hitherto and is safely usable as a medicine for treatment and prevention of tumors, a quasi-drug and a food from plants such as farm products which have no problem from the aspect of safety. SOLUTION: This telomerase inhibitor inhibits telomerase activity and comprises one or more kinds of plants selected from mulberry, watermelon, Actinidia polygama, chrysanthemum, onion, jujube, and peach or an extract of these plants as an active ingredient.
摘要翻译：要解决的问题：提供作为迄今为止食用的端粒酶抑制剂等，并可安全地用作治疗和预防肿瘤的药物，准药物和来自诸如农产品的植物的食物，其具有从安全方面没有问题。解决方案：该端粒酶抑制剂抑制端粒酶活性，并含有一种或多种选自桑，西瓜，猕猴桃，菊花，洋葱，枣和桃的植物或这些植物的提取物作为活性成分。

3. 发明专利

JP2004196672A Antimicrobial agent and anti-periodontal disease agent 有权
公开(公告)号：JP2004196672A
公开(公告)日：2004-07-15
申请号：JP2002364053
申请日：2002-12-16
申请人： Niigata Prefecture , 新潟県
发明人： SATO KAZUTO , OOTSUBO SADAMI , KUSUNOKI MASATOSHI , TANIGUCHI MASAYUKI , SAITO HIDEKAZU
IPC分类号： A23L1/30 , A61K8/96 , A61K8/97 , A61K36/899 , A61P1/02 , A61P31/04 , A61Q11/00 , A61K35/78 , A61K7/26
摘要： PROBLEM TO BE SOLVED: To provide an extremely safe natural antimicrobial agent and anti-periodontal disease agent having excellent antimicrobial effects by effectively utilizing rice bran produced as a by-product during rice milling of rice processing and to provide a composition for the oral cavity and a food composition having antimicrobial actions or anti-periodontal disease actions. SOLUTION: The anti-periodontal disease agent is obtained by heat-treating rice bran or brown rice or rice embryo containing the rice bran or an extract therefrom and including the resultant heat-treated material as an active ingredient. The anti-periodontal disease agent has growth inhibitory actions on the causative microorganisms of periodontal disease and widely applicable as the anti-periodontal disease agent effective for prophylaxis and treatment of the periodontal disease. The composition for the oral cavity and food composition having prophylactic effects on periodontal disease can be provided by formulating the anti-periodontal disease agent in a dentifrice, a mouthwash or a food and drink. COPYRIGHT: (C)2004,JPO&NCIPI

4. 发明专利

JP2001275694A METHOD FOR PRODUCING ANTHOCYANIN BY USING CULTURED CELL OF STRAWBERRY 失效
公开(公告)号：JP2001275694A
公开(公告)日：2001-10-09
申请号：JP2000099688
申请日：2000-03-31
申请人： NIIGATA PREFECTURE
发明人： ASANO SATOSHI , NAKAJIMA MASAHARU , OOTSUBO SADAMI , ISHIKAWA ATSUSHI , SATO KAZUTO , MATSUMOTO ISAO
IPC分类号： C12P19/44 , C12N5/04 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To provide a method for excellently producing anthocyanin by using a strain of strawberry culture cells of extremely high practicality in no need of auxins and cytokinins. SOLUTION: The tissue from strawberry is subjected to repeated successive subculture to establish a strain of anthocyanin-producing cells that proliferate in a culture medium containing no auxin and cytokinin. Then, the resultant cells are proliferated in the auxin and cytokinin-free culture medium and the objective anthocyanin is extracted from the proliferated cells.

5. 发明专利

JP2000201651A PRODUCTION OF GAMMA-AMINOBUTYRIC ACID AND FOOD CONTAINING GAMMA-AMINOBUTYRIC ACID 失效
公开(公告)号：JP2000201651A
公开(公告)日：2000-07-25
申请号：JP736699
申请日：1999-01-14
申请人： NIIGATA PREFECTURE
发明人： OOTSUBO SADAMI , ASANO SATOSHI , SATO KAZUTO , MATSUMOTO ISAO , EGAWA KAZUNORI
IPC分类号： A23L1/305 , A23L7/10 , A23L7/152 , A61K31/00 , A61K31/195 , A61K31/197 , A61P9/00 , A61P9/12
摘要： PROBLEM TO BE SOLVED: To provide a practically excellent technique enabling the safe and simple production of γ-aminobutyric acid in a large amount in a high concentration and at a low cost in order to apply the antihypertensive action of the γ-aminobutyric acid to a wide range of foods. SOLUTION: This method for producing γ-aminobutyric acid comprises adding a solution containing glutamic acid or its salt to at least one of rice embryo buds, rice bran containing the embryo buds, and milled rice with embryo. Thus, the glutamic acid contained in the added solution and glutamic acid contained in at least one of the rice embryo buds, the rice bran containing the embryo buds, and the milled rice with embryo are converted into the γ-aminobutyric acid by the enzymatic action of a glutamic acid-decarbonating enzyme contained in at least one of the rice embryo buds, the rice bran containing the embryo buds, and the milled rice with embryo.

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