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1. 发明专利

JP2003320017A Calcium phosphate porous body and method of manufacturing the same 审中-公开
标题翻译：磷酸钙多孔体及其制造方法
公开(公告)号：JP2003320017A
公开(公告)日：2003-11-11
申请号：JP2002131979
申请日：2002-05-07
申请人： Ngk Spark Plug Co Ltd , 日本特殊陶業株式会社
发明人： MIZUTANI YOICHIRO , SAWAMURA TAKENORI , KASAHARA SHINJIRO , IWAMOTO KOICHI , HATTORI MASAAKI , NAKAMURA KOZO , ODA HIROMI
IPC分类号： A61L27/00 , C01B25/32 , C04B14/36 , C04B28/34 , C04B111/40
摘要： PROBLEM TO BE SOLVED: To provide a calcium phosphate porous body into which an living tissue can easily infiltrate when buried in an organism, and a method of manufacturing the same.
SOLUTION: The calcium phosphate porous body is made of calcium phosphate granules and a calcium phosphate hydrate hardened material for conjugating parts of adjacent calcium phosphate granules. The calcium phosphate porous body is obtained by hardening a calcium phosphate paste comprising calcium phosphate granules whose diameter is 20 μm-5 mm (for example, granules made of unhardened calcium phosphate, granules made of calcium phosphate hydrate hardened material, and granules made of a calcium phosphate sintered body), a hydration hardenable calcium phosphate powder (such as calcium hydrogen phosphate and tetracalcium phosphate) and a hardening solution.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种生物体组织在埋藏于生物体中时容易渗透的磷酸钙多孔体及其制造方法。解决方案：磷酸钙多孔体由磷酸钙颗粒和磷酸钙水合物硬化材料制成，用于接合相邻的磷酸钙颗粒的部分。磷酸钙多孔体通过硬化含有直径为20μm〜5mm的磷酸钙颗粒的磷酸钙糊料（例如，由未硬化的磷酸钙制成的颗粒，由磷酸钙水合物硬化材料制成的颗粒，以及由磷酸钙烧结体），水合可硬化磷酸钙粉末（如磷酸氢钙和磷酸四钙）和硬化溶液。版权所有（C）2004，JPO

2. 发明专利

JP2003321281A Porous calcium phosphate body 审中-公开
标题翻译：多孔磷酸钙体
公开(公告)号：JP2003321281A
公开(公告)日：2003-11-11
申请号：JP2002131978
申请日：2002-05-07
申请人： Ngk Spark Plug Co Ltd , 日本特殊陶業株式会社
发明人： SAWAMURA TAKENORI , MIZUTANI YOICHIRO , KASAHARA SHINJIRO , IWAMOTO KOICHI , HATTORI MASAAKI , NAKAMURA KOZO , ODA HIROMI
IPC分类号： A61C8/00 , A61L27/00 , C04B28/34 , C04B35/447 , C04B38/00 , C04B111/40
摘要： PROBLEM TO BE SOLVED: To provide a porous calcium phosphate body which, when implanted in the living body, is amenable to the penetration of the living tissue thereinto a can be easily absorbed by the living body.
SOLUTION: The porous calcium phosphate body comprises a cured product obtained by hydrating and curing a calcium phosphate paste prepared by kneading a calcium phosphate powder (for example, calcium hydrogenphosphate powder or tetracalcium phosphate powder) with a water-containing curing agent (for example, aqueous sodium dextransulfate solution), wherein the porosity of the porous calcium phosphate body is 30-90% (desirably, 35-85%), and 30-70% (desirably 35-65%) of the entire pores are interconnected ones having a diametric size of 10-1,000 μm (desirably 20-800 μm) and being open to the surface.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种多孔磷酸钙体，其能够容易地被活体吸收，该多孔磷酸钙体在植入生物体时易于使生物体组织侵入其中。解决方案：多孔磷酸钙体包括通过将磷酸钙粉末（例如磷酸氢钙粉末或磷酸四钙粉末）与含水固化剂（例如，例如，十二烷基硫酸钠水溶液），其中多孔磷酸钙体的孔隙率为30〜90％（优选为35〜85％），全孔的30〜70％（优选为35〜65％）互相连接那些具有10-1,000μm（优选为20-800μm）的直径，并且对表面开口。版权所有（C）2004，JPO

3. 发明专利

JP2003320015A Calcium phosphate porous body and method of manufacturing the same 审中-公开
标题翻译：磷酸钙多孔体及其制造方法
公开(公告)号：JP2003320015A
公开(公告)日：2003-11-11
申请号：JP2002131977
申请日：2002-05-07
申请人： Ngk Spark Plug Co Ltd , 日本特殊陶業株式会社
发明人： MIZUTANI YOICHIRO , SAWAMURA TAKENORI , KASAHARA SHINJIRO , IWAMOTO KOICHI , HATTORI MASAAKI , NAKAMURA KOZO , ODA HIROMI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a calcium phosphate porous body with an excellent affinity and an excellent biological absorbency when buried inside an organism. SOLUTION: A mixture of a calcium phosphate powder (such as tetracalcium phosphate powder and calcium hydrogenphosphate powder) and a hardening solution (such as dextran sulfate sodium solution) is formed to make a fibered body. The fibered body is jointed at a number of arbitrary positions to form a three-dimensional frame structure. After that, the fibered structure is hardened to make the calcium phosphate porous body. In another case, the mixture of the calcium phosphate powder and the hardening solution is formed to make the fibered body, and a plurality of fibered bodies are arranged in rows to form one tier. Next, a plurality of fibered bodies are further arranged in rows and layered for forming other tiers to form the three-dimensional frame structure. After that, the three-dimensional frame structure is hardened to make the calcium phosphate porous body. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种当埋入生物体内时具有优异的亲和力和优异的生物吸收性的磷酸钙多孔体。解决方案：形成磷酸钙粉末（例如磷酸四钙粉末和磷酸氢钙粉末）和硬化溶液（例如硫酸葡聚糖钠溶液）的混合物以制成纤维体。纤维体连接在多个任意位置以形成三维框架结构。之后，将纤维结构硬化以制造磷酸钙多孔体。在另一种情况下，形成磷酸钙粉末和硬化溶液的混合物以制成纤维体，并且将多个纤维体排成行以形成一层。接下来，多个纤维体进一步排列成一层并形成其他层以形成三维框架结构。之后，三维框架结构被硬化以制成磷酸钙多孔体。版权所有（C）2004，JPO

4. 发明专利

JP2003320515A Method and device for manufacturing porous calcium phosphate body 有权
标题翻译：用于制造多孔磷酸钙体的方法和装置
公开(公告)号：JP2003320515A
公开(公告)日：2003-11-11
申请号：JP2002131976
申请日：2002-05-07
申请人： Ngk Spark Plug Co Ltd , 日本特殊陶業株式会社
发明人： MIZUTANI YOICHIRO , SAWAMURA TAKENORI , KASAHARA SHINJIRO , IWAMOTO KOICHI , HATTORI MASAAKI , NAKAMURA KOZO , ODA HIROMI
IPC分类号： A61L27/00 , B28B3/20 , B28B3/24 , C04B28/34
摘要： PROBLEM TO BE SOLVED: To provide a method for making a porous calcium phosphate body which permits the easy penetration of tissue of a living body and is easily absorbed by the living body when embedded in the living body and a device for making the porous calcium phosphate body. SOLUTION: The porous calcium phosphate body having open cells is formed by passing a calcium phosphate paste obtained by mixing calcium phosphate powder with a curing liquid containing water through a pore forming porous plate having a large number of through-holes from its one end side to the other end side. The device for making the porous body has a cylinder having a paste extrusion opening on one end side thereof, a plunger sliding in the cylinder, and the pore forming porous plate arranged to the paste extrusion opening. The device for making the porous calcium phosphate body further has a function of kneading the calcium phosphate powder and the curing liquid. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种制造多孔磷酸钙体的方法，其允许容易地穿透生物体的组织并且当嵌入生物体中时容易被生物体吸收，并且制造多孔磷酸钙体。解决方案：具有开孔的多孔磷酸钙体通过将磷酸钙粉末与含有固化液的磷酸钙糊料从其一次通过具有大量通孔的孔形成多孔板而形成端侧到另一端。用于制造多孔体的装置具有在其一端侧具有糊状挤出开口的圆筒，在圆筒中滑动的柱塞，以及布置到糊料挤出口的孔形成多孔板。用于制造多孔磷酸钙体的装置还具有捏合磷酸钙粉末和固化液体的功能。版权所有（C）2004，JPO

5. 发明专利

JP2003325653A Calcium phosphate porous body 审中-公开
标题翻译：磷酸氢钙多孔体
公开(公告)号：JP2003325653A
公开(公告)日：2003-11-18
申请号：JP2002134457
申请日：2002-05-09
申请人： Ngk Spark Plug Co Ltd , 日本特殊陶業株式会社
发明人： MIZUTANI YOICHIRO , SAWAMURA TAKENORI , KASAHARA SHINJIRO , IWAMOTO KOICHI , HATTORI MASAAKI , NAKAMURA KOZO , ODA HIROMI
IPC分类号： A61L27/00 , A61K6/033
摘要： PROBLEM TO BE SOLVED: To provide a calcium phosphate porous body having an excellent bioabsorbability by a hole suitable for advancing a living body structure formed before the porous body is buried in a living body. SOLUTION: This calcium phosphate porous body is provided by filling the mixture of calcium phosphate powder and water in a mold having bar-like projections 21 formed in the inner wall surface 20 thereof, hardening the mixture, and releasing the porous body from the mold. The maximum dimension of the cross section thereof is desirably be 10 to 1000 μm. The cross section of the projections is desirably be generally circular. Thus, the calcium phosphate porous body having the hole suitable for advancing the living structure formed therein can be provided. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种通过适于使在多孔体埋藏在生物体中形成的活体结构前进的孔的生物吸收性优异的磷酸钙多孔体。解决方案：该磷酸钙多孔体通过将磷酸钙粉末和水的混合物填充在其内壁表面20中形成有棒状突起21的模具中，使混合物硬化，并将多孔体从模具。其截面的最大尺寸优选为10〜1000μm。突起的横截面优选为大致圆形。因此，可以提供具有适于前进其中形成的活体结构的孔的磷酸钙多孔体。版权所有（C）2004，JPO

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