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1. 发明专利

JP2010006708A External preparation for skin, bleaching agent, anti-aging agent and anti-oxidizing agent 审中-公开
标题翻译：皮肤，漂白剂，抗老化剂和抗氧化剂的外用制剂
公开(公告)号：JP2010006708A
公开(公告)日：2010-01-14
申请号：JP2008164053
申请日：2008-06-24
申请人： National Science & Technology Development Agency , Shiseido Co Ltd , ナショナルサイエンスアンドテクノロジーディベロープメントエイジェンシー , 株式会社資生堂
发明人： KUSAKARI TAKESHI , MAEDA KAZUHISA , OCHIAI NOBUHIKO , TAGUCHI ERIKO , TAKADA KEIKO , KANEKO MAKI , IIDA TOSHIMOCHI , YAGI EIICHIRO , KANYAWIM KIRTIKARA , NUNTAVAN BUNYAPRAPHATSARA
IPC分类号： A61K8/97 , A61K36/18 , A61K36/48 , A61P17/16 , A61P39/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/97 , A61K2800/522 , A61Q1/02 , A61Q1/12 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide an external preparation for skin, bleaching agent, anti-aging agent, and anti-oxidizing agent which are high in safety, and have an excellent melamine production-inhibiting action, anti-aging action or anti-oxidizing action. SOLUTION: One or more plant extracts selected from among Cinnamomum ilicioides in Lauraceae, Cinnamomum, Fagraea fragrans in Loganiaceae, Fagraea, Lepisanthes fruticosa in Sapindaceae, Lepisanthes, Boesenbergia regalis in Zingiberaceae, Boesenbergia, Aquilaria crassna in Thymelaeaceae, Aquillaria, and Pterocarpus indicus in Leguminosae, Pterocarpus are compounded. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供安全性高的皮肤，漂白剂，抗老化剂和抗氧化剂的外用剂，具有优异的三聚氰胺抑制作用，抗老化作用或抗氧化作用。解决方案：一种或多种植物提取物，其选自樟科，樟树，樟树中的樟树，椴树中的Fagraea fragran，椴树科，Lepisanthes，椴树科，Boesenbergia regace，Boesenbergia，Thymelaeaceae中的Aquilaria crassna，Aquillaria和Pterocarpus 豆科植物，蕨类植物的复合。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009242345A Scca-1 production inhibitor having 1-piperidinepropionic acid and/or its salt as active ingredient 有权
标题翻译：具有1-哌啶酸和/或其盐作为活性成分的SCCA-1生产抑制剂
公开(公告)号：JP2009242345A
公开(公告)日：2009-10-22
申请号：JP2008093571
申请日：2008-03-31
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KATAGIRI CHIKA , IIDA TOSHIMOCHI , KANEKO MAKI , KAMINUMA MIKIKO , SUETSUGU MASARU , HIBINO TOSHIHIKO
IPC分类号： A61K31/4453 , A61P17/00 , A61P17/02 , A61P17/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07D295/18 , C07K14/82
摘要： PROBLEM TO BE SOLVED: To provide a novel drug for preventing and/or treating a disease caused by cell abnormal multiplication and a disease caused by SCCA-1 (squamous cell carcinoma antigen 1) production acceleration based on the SCCA-1 production inhibition. SOLUTION: The SCCA-1 production inhibitor comprises 1-piperidinepropionic acid of formula (I) and/or its salt as an active ingredient. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于预防和/或治疗由细胞异常增殖引起的疾病和由基于SCCA-1生产的SCCA-1（鳞状细胞癌抗原1）产生加速引起的疾病的新型药物抑制。解决方案：SCCA-1生产抑制剂包含式（I）的1-哌啶丙酸和/或其盐作为活性成分。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009242249A Parakeratosis inhibitor and pore shrinking agent 审中-公开
标题翻译： PARAKERATOSIS抑制剂和孔收缩剂
公开(公告)号：JP2009242249A
公开(公告)日：2009-10-22
申请号：JP2008087497
申请日：2008-03-28
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： IIDA TOSHIMOCHI , KANEKO MAKI , KAMINUMA MIKIKO , SUETSUGU MASARU
IPC分类号： A61K8/44 , A61K8/43 , A61K31/198 , A61P17/00 , A61P17/02 , A61P17/16 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a parakeratosis inhibitor and a pore shrinking agent having high safety which has an excellent effect on the parakeratosis inhibition and pore shrinkage and has no problem of safety such as sensory irritation.
SOLUTION: The parakeratosis inhibitor or the pore shrinking agent has at least one compound selected from the group consisting of N-amidinoglutamic acid of structural formula (1) and its salt as an active ingredient. Further, a skin external preparation includes the parakeratosis inhibitor or the pore shrinking agent.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供具有高度安全性的角化不全抑制剂和孔收缩剂，其对角化不良抑制和孔收缩具有优异的效果，并且没有诸如感觉刺激的安全性问题。解决方案：角化不全抑制剂或孔收缩剂具有至少一种选自结构式（1）的N-脒基谷氨酸及其盐作为活性成分的化合物。此外，皮肤外用制剂包括角化不全抑制剂或孔收缩剂。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009215267A External composition for skin 有权
标题翻译：皮肤外用组合物
公开(公告)号：JP2009215267A
公开(公告)日：2009-09-24
申请号：JP2008063354
申请日：2008-03-12
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KAMINUMA MIKIKO , SUETSUGU MASARU , KANEKO MAKI , IIDA TOSHIMOCHI
IPC分类号： A61K8/49 , A61K8/44 , A61Q1/12 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a highly safe parakeratosis inhibitor, a pore-contracting agent, an agent for preventing and ameliorating skin roughness and an external composition for the skin, which are excellent in functions such as suppression of parakeratosis, contraction of pores and prevention, amelioration, etc., of skin roughness and causes no safety problems such as sensory irritation.
SOLUTION: The external composition for the skin comprises at least one compound chosen from the group consisting of a pyroglutamic acid derivative of formula (1) (wherein X is H, a 1-3C alkyl group, an aryl group, a benzyl group, a benzyloxycarbonyl group or a benzenesulfonyl group; and Y is OH, a 1-3C alkoxy group or a group of the formula: NR
1 R
2 (wherein R
1 and R
2 are each H or a 1-3C hydrocarbon group, or NR
1 R
2 forms a heterocyclic ring), provided that when X is H, Y is not OH) and a salt thereof.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供高度安全的角化不全抑制剂，孔收缩剂，用于预防和改善皮肤粗糙度的试剂和外用组合物，其功能如抑制角化不全，收缩的毛孔和预防，改善等皮肤粗糙度，并且不会引起诸如感觉刺激的安全问题。皮肤的外用组合物包含至少一种选自下组的化合物：式（1）的焦谷氨酸衍生物（其中X为H，1-3C烷基，芳基，苄基基团，苄氧基羰基或苯磺酰基; Y是OH，1-3C烷氧基或下式的基团：其中R < SB> 1 和R 2 各自为H或1-3C烃基，或NR R SB 2形成杂环环），条件是当X为H时，Y不为OH）及其盐。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2010254656A Scca-1 production inhibitor including carboxamide derivative and/or its salt as active ingredient 有权
标题翻译：包括碳酰胺衍生物和/或其作为活性成分的盐的SCCA-1生产抑制剂
公开(公告)号：JP2010254656A
公开(公告)日：2010-11-11
申请号：JP2009110112
申请日：2009-04-28
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KANEKO MAKI , HIRUMA TAKUYA , SUETSUGU MASARU , KATAGIRI CHIKA , IIDA TOSHIMOCHI , ONODERA TOMOKO
IPC分类号： A61K31/17 , A61K31/4015 , A61K31/4166 , A61P17/00 , A61P17/06 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D207/26 , C07D207/27 , C07D233/34 , C07D233/40
CPC分类号： A61K31/17 , A61K31/4015 , A61K31/4166 , C07D207/27 , C07D233/34 , C07D233/40
摘要： PROBLEM TO BE SOLVED: To provide a new medicine for prophylaxis or treatment of diseases caused by abnormal cell proliferation based on SCCA-1 production inhibiting behavior, and by SCCA-1 production acceleration. SOLUTION: The SCCA-1 production inhibitor contains, as active ingredients, at least one kind carboxamide derivative selected from a compound expressed by general formula (I), allantoin and salts thereof. In the formula (I), X is CR 5 or N; R 1 , R 4 , R 5 are each independently a hydrogen atom, an alkyl group, or the like; R 2 and R 3 are each independently a hydrogen atom, an alkyl group or may form a five-membered or six-membered ring. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种基于SCCA-1生产抑制行为，通过SCCA-1生产加速来预防或治疗由异常细胞增殖引起的疾病的新药。解决方案：SCCA-1生产抑制剂含有选自通式（I）表示的化合物，尿囊素及其盐中的至少一种羧酰胺衍生物作为活性成分。在式（I）中，X是CR 3或N; R SB 1，R SB 4，R SB 5，各自独立地为氢原子，烷基等; R SB 2和R SB 3各自独立地为氢原子，烷基或可以形成五元或六元环。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2007204417A Parakeratosis-suppressing agent and pore shrinking agent 有权
标题翻译： PARAKERATOSIS-SUPPRESSING AGENT和PORE SHRINKING AGENT
公开(公告)号：JP2007204417A
公开(公告)日：2007-08-16
申请号：JP2006024804
申请日：2006-02-01
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： IIDA TOSHIMOCHI , KANEKO MAKI , KAMINUMA MIKIKO , SUETSUGU MASARU
IPC分类号： A61K8/44 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a new parakeratosis-suppressing agent having excellent parakeratosis-suppressing effect and a pore shrinking agent having pore shrinking effect.
SOLUTION: The problem has been solved by the finding that L-theanine and its salt have excellent parakeratosis-suppressing effect or pore shrinking effect. The parakeratosis-suppressing agent or pore shrinking agent is composed of one or more compounds selected from L-theanine and its salt. The L-theanine salt is preferably selected from sodium salt, potassium salt, calcium salt, zinc salt, magnesium salt, ammonium salt, hydrochloride, sulfate, phosphate, hydrobromide, methylamine salt, pyridine salt, trimethylamine salt, triethanolamine salt, methylsulfate, p-toluenesulfonate, acetate, lactate, maleate, fumarate, oxalate, succinate, tartrate, citrate, betaine salt, glycine salt, serine salt and taurine salt.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有优异的角化不全抑制作用的新型角化不全症抑制剂和具有孔收缩效果的孔收缩剂。解决方案：通过发现L-茶氨酸及其盐具有优异的角化不全抑制效果或孔收缩效果已经解决了问题。角化不全抑制剂或孔收缩剂由一种或多种选自L-茶氨酸及其盐的化合物组成。 L-茶氨酸盐优选选自钠盐，钾盐，钙盐，锌盐，镁盐，铵盐，盐酸盐，硫酸盐，磷酸盐，氢溴酸盐，甲胺盐，吡啶盐，三甲胺盐，三乙醇胺盐，甲基硫酸盐， - 甲苯磺酸盐，乙酸盐，乳酸盐，马来酸盐，富马酸盐，草酸盐，琥珀酸盐，酒石酸盐，柠檬酸盐，甜菜碱盐，甘氨酸盐，丝氨酸盐和牛磺酸盐。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006327971A Inhibitor for parakeratosis, pore reducing agent or skin roughening preventing or ameliorating agent and composition for skin care preparation 有权
标题翻译：防腐剂抑制剂，减水剂或皮肤粗化预防或调理剂及皮肤护理产品的组合物
公开(公告)号：JP2006327971A
公开(公告)日：2006-12-07
申请号：JP2005151983
申请日：2005-05-25
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KAMINUMA MIKIKO , SUETSUGU MASARU , KANEKO MAKI , IIDA TOSHIMOCHI , INOMATA SHINJI
IPC分类号： A61K8/00 , A61K8/30 , A61Q19/00
CPC分类号： A61K8/0212 , A61K8/44 , A61K8/46 , A61Q1/02 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an inhibitor for parakeratosis, a pore reducing agent, a skin roughening preventing agent or ameliorating agent having functions such as inhibition of parakeratosis, pore reducing, skin roughening prevention or ameliorating, free from safety problems such as feeling irritation or the like, and to provide a composition for skin care preparation formulated with a compound having above-mentioned functions. SOLUTION: The invention relates to the inhibitor for parakeratosis, pore reducing agent or skin roughening preventing or ameliorating agent comprising one or two or more kind of compounds selected from a group comprising derivatives of α-amino acids and salts thereof. The invention also relates to the composition for skin care preparation comprising one or two or more kind of derivatives of the α-amino acids and salts thereof which are the inhibitor for parakeratosis, pore reducing agent or skin roughening preventing or ameliorating agent. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供角化不全的抑制剂，减少孔剂，皮肤粗糙化防止剂或具有抑制角化不全，减少孔隙，防止皮肤粗糙化或改善功能的改善剂，没有安全问题，例如作为感觉刺激等，并提供用具有上述功能的化合物配制的护肤制剂组合物。解决方案：本发明涉及用于角化不全，减孔剂或皮肤粗糙化防止或改善剂的抑制剂，其包含一种或两种以上选自α-氨基酸衍生物及其盐的化合物。本发明还涉及包含一种或两种以上的α-氨基酸衍生物及其盐的皮肤护理制剂用组合物，其为角化不全，减孔剂或皮肤粗糙化防止剂或改善剂的抑制剂。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2006298796A External preparation for improving fine wrinkle 审中-公开
标题翻译：用于改善微细皱纹的外用制剂
公开(公告)号：JP2006298796A
公开(公告)日：2006-11-02
申请号：JP2005120160
申请日：2005-04-18
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： MATSUNAGA YUKIKO , OGURA ARINORI , AMANO SATOSHI , INOMATA SHINJI , TSUNENAGA MAKOTO , IWAKI HARUHI , KANEKO MAKI , KUNISAWA NAOMI , YAMASHITA TOYONOBU , OGURI MOTOKI
IPC分类号： A61K8/00 , A61K8/30 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an external preparation for improving fine wrinkles that include a medicine that is compatible with the mechanism of fine wrinkle formation and has an excellent remedial effect more than the moisturizing action.
SOLUTION: This invention provide an external preparation for improving fine wrinkles by including glycylglycine as an active component.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于改善细小皱纹的外用制剂，其包括与微皱纹形成机理相容的药物，并且具有比保湿作用更好的补救效果。解决方案：本发明提供了通过包括甘氨酰甘氨酸作为活性成分来改善细小皱纹的外用制剂。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2011053609A Skin care effect model 审中-公开
标题翻译：护肤效果模型
公开(公告)号：JP2011053609A
公开(公告)日：2011-03-17
申请号：JP2009204747
申请日：2009-09-04
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KANEKO MAKI , KAJIKAWA TOMOKO , NAKAYA MASASHI , HIROMESHI TAEKO , MATSUMOTO CHIKAKO , MATSUO REI
IPC分类号： G09F5/00
摘要： PROBLEM TO BE SOLVED: To provide a skin care effect model that shows an effect of a skin care product by feel.
SOLUTION: The skin care effect model 1 is configured by combining a before-artificial skin model 2 having a feel imitating a skin feel before a skin care product is applied with an after-artificial skin model 3 having a feel imitating a skin feel after the skin care product is applied.
COPYRIGHT: (C)2011,JPO&INPIT

10. 发明专利

JP2009242341A SCCA-1 PRODUCTION INHIBITOR HAVING N-BENZENSULFONYL-γ-AMINOBUTYRIC ACID AND/OR ITS SALT AS ACTIVE INGREDIENT 有权
标题翻译：具有N-苄基呋喃-γ-氨基丁酸和/或其作为活性成分的盐的SCCA-1生产抑制剂
公开(公告)号：JP2009242341A
公开(公告)日：2009-10-22
申请号：JP2008093430
申请日：2008-03-31
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KATAGIRI CHIKA , IIDA TOSHIMOCHI , KANEKO MAKI , KAMINUMA MIKIKO , SUETSUGU MASARU , HIBINO TOSHIHIKO
IPC分类号： A61K31/197 , A61P17/00 , A61P17/06 , A61P35/00 , A61P37/06 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a novel drug for preventing and/or treating a disease caused by cell abnormal multiplication and a disease caused by SCCA-1 (squamous cell carcinoma antigen-1) production acceleration based on the SCCA-1 production inhibition. SOLUTION: The SCCA-1 production inhibitor comprises N-benzenesulfonyl-γ-aminobutyric acid of formula (I) and/or its salt as an active ingredient. COPYRIGHT: (C)2010,JPO&INPIT

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