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    • 2. 发明专利
    • ULTRAVIOLET MICROSCOPE AND CONTROL METHOD THEREFOR
    • JP2002023063A
    • 2002-01-23
    • JP2000206230
    • 2000-07-07
    • NIKON CORP
    • TSURUMUNE TOKUJITAKENAKA HIDEKAZU
    • G01J1/42G02B5/22G02B21/16
    • PROBLEM TO BE SOLVED: To provide a ultraviolet microscope, with which damage to occur on an observation object because of the irradiation with ultraviolet rays can be reduced when inaging the observation object by using the ultraviolet microscope and to provide a control method therefor. SOLUTION: In the search stage of an observation position, an ND(neutral density) filter 12 is inserted on the optical path of DUV(deep ultraviolet) laser beam, the quantity of that light is reduced to the prescribed quantity of light within an allowable value, and damage on the irradiated surface of a sample caused by the Koehler illumination of DUV laser light is reduced. At such a time, the frame rate of a CCD(charge coupled device) camera 16 is decelerated by a frame rate control part 21, the analog image signal of an image picked up by the CCD camera 16 is amplified by an amplifier circuit 19, and the luminance gradation of the image made into digital signal is shifted to the side of lighter gradation by a gradation shift processing circuit 20. Thus, the brightness and contrast of the picture displayed on a monitor 26 are increased and the reduction of picture quality with the reduction of the quantity of DUV laser beam is complemented.
    • 3. 发明专利
    • LASER SCANNING MICROSCOPE AND SCANNING MIRROR DRIVING METHOD FOR LASER SCANNING MICROSCOPE
    • JP2000121947A
    • 2000-04-28
    • JP29632198
    • 1998-10-19
    • NIKON CORP
    • TAKENAKA HIDEKAZU
    • G02B21/06
    • PROBLEM TO BE SOLVED: To eliminate positional deviation caused between the first observed image and the second and succeeding observed images by repeatedly moving the angle position of a scanning mirror from a scanning start position to a scanning finish position at the time of laser scanning and stopping the angle position of the scanning mirror at the scanning finish position after finishing the laser scanning. SOLUTION: A computer (scanning control system) controls the driving of a galvano scanner driver (driving device). Then, the galvano scanner mirror is always stopped at the scanning finish position 42 when a scanning control signal is not inputted. When a scanning start instruction is inputted, operation (4) is started. In the operation (4), the galvano scanner mirror at the position 42 is moved to the scanning start position 41 at a stretch. An XY plane to be observed is scanned in operation (5). Thereafter, the scanning control signals for the operation (4) and (5) are repeated till finishing the scanning of the XY plane. When the finish of the scanning is instructed, the galvano scanner mirror is stopped at the position 42 after the operation (5).
    • 5. 发明专利
    • MICROSCOPE
    • JPH1020206A
    • 1998-01-23
    • JP18879996
    • 1996-06-28
    • NIKON CORP
    • TAKENAKA HIDEKAZU
    • G01N21/64G01N33/483G02B21/06G02B21/16G02B26/04
    • PROBLEM TO BE SOLVED: To obtain an inexpensive microscopic device capable of consecutively performing the stable opening/closing operation of a shutter device for a long time by arranging a disk where light transmission parts are formed at regular intervals on an illuminating light path and rotating the disk by a pulse motor. SOLUTION: Plural holes (light transmission parts) 31 through which illuminating light from a lamp house 2 is transmitted and whose diameter is (r) are formed at regular intervals R along a peripheral direction on the disk 30, and the rotary shaft 15 of the pulse motor 11 is attached to the center of the disk 30. By selecting properly the pulse frequency and the number of steps of the motor 11, the disk 30 is rotated and the intercepted state and the transmitted state of the illuminating light are switched at the interval of several ten milliseconds, for instance. The disk 30 where the holes 31 are formed at the regular intervals is arranged on the illuminating light path and rotated by the motor 11, so that the opening/closing operation of the shutter device 10 is stably consecutively performed for a long term without imposing a heavy burden on an electromagnetic shutter driving circuit.
    • 7. 发明专利
    • IMAGE SIGNAL CONTROL DEVICE
    • JP2000337826A
    • 2000-12-08
    • JP15229099
    • 1999-05-31
    • NIKON CORP
    • TAKENAKA HIDEKAZU
    • G01B11/24G01B11/245G02B21/00
    • PROBLEM TO BE SOLVED: To provide an image signal control device capable of obtaining images of a high S/N ratio without being affected by the non-uniformity of the oscillation speed of a resonant scanner. SOLUTION: This device is provided with a photodetector 10 to detect reflected light or fluorescence from a sample scanned through the use of a resonant scanner, an analogue processing part 20 to process a signal outputted from the photodetector, an A/D converter 50 to convert the analogue-processed signal into a digital signal, memory 60 to store and hold the digital signal, and an image processing part 70 to create an image on the basis of the signal stored and held at the memory. In this case, an analogue signal obtained by the photodetector 10 is stored in a signal storage part 30 on the basis of switching instructing signals A and B synchronized with a clock signal generated in synchronization with the oscillation of the resonant scanner, the signal storage part is discharged, and an output signal of the signal storage part is sampled and held according to timing signals C and D created from the clock signal at a signal holding part 40 and is outputted to the A/D converter 50 on the basis of the switching instructing signals A and B.
    • 9. 发明专利
    • FLUORESCENT MICROSCOPE
    • JPH1152252A
    • 1999-02-26
    • JP22432297
    • 1997-08-06
    • NIKON CORP
    • TAKENAKA HIDEKAZUHAKOZAKI HIROYUKI
    • G01N21/64G02B21/16G02B21/36
    • PROBLEM TO BE SOLVED: To obtain a bright multiple fluorescent image without the positional deviation of a sample being multiply dyed by changing over dichroic mirrors. SOLUTION: In a fluorescent microscope provided with a light source 1 emitting an excited laser beam, plural dichroic mirrors 13 reflecting the excited laser beam, transmitting a fluorescent beam through and changeably provided in an optical path, an XY scanner 14 for scanning the excited laser beam on a sample in a two-dimensional manner, an objective lens 18 arranged between the XY scanner 14 and the sample and a monitor for observing the fluorescent light beam, a controller 50 for inputting the information as to the kinds of the dichroic mirrors arranged in the optical path at the time of accquiring an image, a memory 33 for storing the information on an image deviation in the dichroic mirrors at the time of accquiring the image and a computer 30 for reading out the information on the image deviation stored in the memory 33 based on the information from the controller 50 and controlling the XY scanner 14 so that the images obtained by the different kinds of the dichronic mirrors are superimposed, are provided.
    • 10. 发明专利
    • FLOW CYTOMETERY SYSTEM
    • JPH09145593A
    • 1997-06-06
    • JP32404695
    • 1995-11-17
    • NIKON CORP
    • TAKENAKA HIDEKAZU
    • G01N21/64G01N15/14G01N21/47G01N21/59G01N33/483
    • PROBLEM TO BE SOLVED: To extract only a sample substance having arbitrary physical quantity out of sample substances contained in a sample liquid by an arrangement wherein a control means produces a control signal when a detector detects a mass of sample having a physical quantity being set by a physical quantity setting means. SOLUTION: When a mass of sample having an arbitrary physical quantity is extracted from a sample solution containing sample substances, a physical quantity setting section 8 sets the physical quantity of a mass of sample to be extracted. When a detector 7 detects a mass of sample having an arbitrary physical quantity being set at the setting section 8, a control section 9 produces a control signal. Based on the control signal, a solution feeding member 14 in an extraction unit 11 is moved to the position of a specific container, e.g. a container 10-1, among a plurality of containers 10-1,..., 10-n. Consequently, a sample solution containing a mass of sample having a set physical quantity being fed from the member 14 is extracted into a specific container.