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1. 发明专利

JP2006127248A Apparatus, program and method for predicting activated g protein 有权
标题翻译：装置，方案和预测激活的G蛋白的方法
公开(公告)号：JP2006127248A
公开(公告)日：2006-05-18
申请号：JP2004316279
申请日：2004-10-29
申请人： Mitsubishi Chemicals Corp , National Institute Of Advanced Industrial & Technology , 三菱化学株式会社 , 独立行政法人産業技術総合研究所
发明人： SUWA MAKIKO , HIROKAWA TAKATSUGU , MUKAI HIDEHITO
IPC分类号： G01N33/53 , G06F19/00 , G06F19/18 , G06F19/24
摘要： PROBLEM TO BE SOLVED: To provide technology for predicting a G protein type to be activated in inputting GPCR and ligand information. SOLUTION: A feature parameter extraction part 14 extracts a feature parameter which is a prescribed physical-chemical parameter related to G protein selectivity from the input information of the GPCR and ligand to be predicted. A feature vector data generation part 16 generates feature vector data to be predicted which includes the extracted feature parameter. A classification information storage part 20 stores known data classification information to classify the feature vector obtained from the GPCR and ligand information of which activated G protein is known in accordance with the activated G protein type. A prediction processing part 18 predicts the activated G protein based on the feature vector to be predicted by referring to the known data classification information. The known data classification information is super-plane information obtained by a support vector machine. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于预测在输入GPCR和配体信息中被激活的G蛋白类型的技术。解决方案：特征参数提取部分14从GPCR的输入信息和要预测的配体提取与G蛋白选择性相关的规定的物理化学参数的特征参数。特征矢量数据生成部16生成包含提取的特征参数的要预测的特征矢量数据。分类信息存储部分20存储已知的数据分类信息，以根据激活的G蛋白类型从GPCR获得的特征向量和其活化的G蛋白是已知的配体信息。预测处理部18通过参照已知的数据分类信息来预测基于要预测的特征向量的激活的G蛋白。已知的数据分类信息是由支持向量机获得的超平面信息。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2007215459A Peptide activating bombesin-like peptide receptor and utilization thereof 有权
标题翻译：肽激活类似贝贝氏素的受体及其利用
公开(公告)号：JP2007215459A
公开(公告)日：2007-08-30
申请号：JP2006038503
申请日：2006-02-15
申请人： Mitsubishi Chemicals Corp , National Institute Of Advanced Industrial & Technology , 三菱化学株式会社 , 独立行政法人産業技術総合研究所
发明人： SUWA MAKIKO , HIROKAWA TAKATSUGU , MUKAI HIDEHITO
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P3/04 , A61P43/00 , C07K7/06 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K7/086
摘要： PROBLEM TO BE SOLVED: To provide a peptide activating a BRS-3 (bombesin-like peptide receptor sub-type 3), to provide a prophylactic method or a therapeutic method for obesity comprising a step of administering the peptide to the object and to provide a prophylactic agent or a therapeutic agent for the obesity comprising the peptide as an active ingredient. SOLUTION: A plurality of peptidic ligands containing the minimum activity units considered to activate the BRS-3 are chemically synthesized to study the ability to activate the BRS-3. As a result, the peptide having an amino acid sequence of Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met is found out. The peptide selectively activates the BRS-3. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供活化BRS-3（铃蟾肽样肽受体亚型3）的肽，以提供肥胖症的预防方法或治疗方法，包括向所述物体施用所述肽的步骤并提供包含该肽作为活性成分的肥胖症的预防剂或治疗剂。解决方案：化学合成含有被认为激活BRS-3的最小活性单位的多个肽配体，以研究激活BRS-3的能力。结果发现具有Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met的氨基酸序列的肽。该肽选择性地激活BRS-3。版权所有（C）2007，JPO＆INPIT

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