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1. 发明专利

JP2012177710A Method for evaluating skin-lightening agent 有权
标题翻译：评估皮肤发光剂的方法
公开(公告)号：JP2012177710A
公开(公告)日：2012-09-13
申请号：JP2012125775
申请日：2012-06-01
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , ONISHI KAZUSADA , KURIYAMA KENICHI , TSUJINO YOSHIO , FUJIWARA NOBUNORI
IPC分类号： G01N33/50 , A61Q19/02 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating a skin-lightening agent, which is capable of achieving at least one of easily selecting a skin-lightening agent capable of at least one of suppression or prevention of the occurrence of cutaneous inflammation or akin problems due to ultraviolet rays and skin-lightening, easily evaluating the quality and the like of a skin-lightening agent, etc.SOLUTION: The method for evaluating a skin-lightening agent evaluates whether or not the expression of ELAM-1 or a nucleic acid encoding the same is suppressed due to the existence of a material to be inspected.
摘要翻译：要解决的问题：提供一种评价皮肤亮白剂的方法，其能够实现至少一种容易选择能够至少抑制或防止皮肤发生的皮肤发光剂由于紫外线和皮肤亮白引起的炎症或皮肤问题，容易评估皮肤亮白剂的质量等。解决方案：用于评估皮肤亮白剂的方法评估是否表达由于存在要检查的材料，ELAM-1或其编码的核酸被抑制。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011207811A Dna repair accelerator and dna damage suppressant 有权
标题翻译： DNA修复加速器和DNA损伤抑制剂
公开(公告)号：JP2011207811A
公开(公告)日：2011-10-20
申请号：JP2010077256
申请日：2010-03-30
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , FUJITA IKUNAO , ONISHI KAZUSADA , KURIYAMA KENICHI
IPC分类号： A61K36/18 , A61K36/00 , A61K36/02 , A61K36/23 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/71 , A61K36/73 , A61P17/00 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA repair accelerator excellent in action of accelerating repair of damaged DNA, and a DNA damage suppressant excellent in action of suppressing production of damaged DNA.SOLUTION: The DNA repair accelerator contains a cinchona extract. The DNA damage suppressant contains at least one chosen from a cinchona extract, a comfrey extract, an arabian coffee extract, a Pueraria root extract, a burdock extract, a Coptis japonica extract, a Sophora angustifolia extract, a chlorella extract, a lavender extract, an Oenothera biennis extract, a rose extract, a Gynostemma pentaphyllum extract, a Rabdosia japonica extract, a Lamium album extract, a carrot extract, a Tilia japonica extract, a great burnet extract, a lotus extract, a tea extract and an Abelmoschus esculentus extract.
摘要翻译：要解决的问题：提供一种加速损伤DNA修复作用的DNA修复促进剂，抑制DNA损伤作用优异的DNA损伤抑制剂。解决方案：DNA修复促进剂含有金丝桃提取物。 DNA损伤抑制剂含有至少一种选自香草提取物，芒果提取物，阿拉伯咖啡提取物，葛根提取物，牛蒡提取物，黄连提取物，苦参提取物，小球藻提取物，薰衣草提取物，日本植物提取物，玫瑰提取物，绞股蓝提取物，R ica提取物，苎麻提取物，胡萝卜提取物，椴树提取物，大灼烧提取物，莲花提取物，茶提取物和阿维莫斯提取物。

3. 发明专利

JP2007246410A Sun burn cell formation inhibitor and dna damage repair promoter 有权
标题翻译： SUN BURN细胞形成抑制剂和DNA损伤修复促进剂
公开(公告)号：JP2007246410A
公开(公告)日：2007-09-27
申请号：JP2006069433
申请日：2006-03-14
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , ONISHI KAZUSADA , KURIYAMA KENICHI , TSUJINO YOSHIO
IPC分类号： A61K8/97 , A61K36/71 , A61P17/16 , A61P43/00 , A61Q17/04
摘要： PROBLEM TO BE SOLVED: To provide a sun burn cell formation inhibitor or DNA damage repair promoter capable of improving the resistance of skin cell itself against the skin trouble caused by ultraviolet light and consisting of a substance having high safety as an active ingredient. SOLUTION: This sun burn cell formation inhibitor or DNA damage repair promoter contains an extract of peony root as an active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供能够提高皮肤细胞本身抵抗由紫外线引起的皮肤问题的抗性并由具有高安全性的物质组成的阳光燃烧细胞形成抑制剂或DNA损伤修复促进剂作为活性成分。
解决方案：这种阳光燃烧细胞形成抑制剂或DNA损伤修复促进剂含有牡丹根提取物作为活性成分。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2012017290A Skin care preparation 审中-公开
标题翻译：皮肤护理准备
公开(公告)号：JP2012017290A
公开(公告)日：2012-01-26
申请号：JP2010155588
申请日：2010-07-08
申请人： Kwansei Gakuin , Mandom Corp , 学校法人関西学院 , 株式会社マンダム
发明人： HIRAI YOHEI , OKUKAWA YOJI , KURATA RYUICHIRO , ONISHI KAZUSADA , FUJITA IKUNAO , KURIYAMA KENICHI
IPC分类号： A61K8/64 , A61K38/00 , A61Q19/00 , C07K7/06
摘要： PROBLEM TO BE SOLVED: To provide a skin care preparation for preventing or improving the skin condition due to parakeratosis.SOLUTION: The skin care preparation contains cyclopeptide compounds shown in formula (1) [wherein Xaaand Xaaare each ceril, threonyl or thiosynyl; Xaais isoleucyl, valyl or leucyl; Xaaand Xaaare each asparaginyl, glutaminyl, aspartyl or glutamyl; Cys is cysteinyl; and Ris shown either in formula (II) or in formula (III) wherein n is an integer of 1 through 10 or in formula (III)].
摘要翻译：要解决的问题：提供用于预防或改善由角化不全引起的皮肤状况的皮肤护理制剂。解决方案：皮肤护理制剂含有式（1）所示的环肽化合物[其中Xaa 1 和Xaa 5 每个铈，苏氨酰或硫代炔基; Xaa 2 是异亮氨酰基，缬氨酰基或亮氨酰; Xaa 3 和Xaa 4 分别为天冬酰胺酰基，谷氨酰胺基，天冬氨酰基或谷氨酰; Cys是半胱氨酰; 在式（II）或式（III）中，其中n为1〜10的整数或式（III）中的R 1表示。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2010273736A Method of evaluating obviousness of surface reflection of skin 有权
标题翻译：评价皮肤表面反射的有效性的方法
公开(公告)号：JP2010273736A
公开(公告)日：2010-12-09
申请号：JP2009127001
申请日：2009-05-26
申请人： Mandom Corp , 株式会社マンダム
发明人： YAMAGUCHI AYUMI , ONISHI KAZUSADA , KURIYAMA KENICHI
IPC分类号： A61B5/107 , G01J3/50 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a method of evaluating obviousness of the surface reflection of skin, capable of quantitatively evaluating whether the surface reflection of the skin is apparently obvious or not based on characteristic factors of the skin such as texture and color of the skin.
SOLUTION: In the method of evaluating the obviousness of the surface reflection of the skin, the degree of smoothness of texture of the skin in a target region is obtained, and the color of the skin of the target region is measured to obtain the brightness of the skin, and then the obviousness of the surface reflection is evaluated based on the obtained degree of smoothness of texture and the brightness of the skin.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种评估皮肤表面反射的显着性的方法，其能够基于皮肤的特征因素（例如质地和颜色）定量评估皮肤的表面反射是否明显明显的皮肤。解决方案：在评估皮肤表面反射的明显性的方法中，获得目标区域中皮肤的质地平滑度，并测量目标区域的皮肤的颜色以获得基于获得的纹理平滑度和皮肤亮度来评价皮肤的亮度，然后评价表面反射的明显性。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2008290970A Sunburn cell development inhibitor, and composition for sun care formulation containing the same 审中-公开
标题翻译： SUNBELL细胞发育抑制剂及其相关化合物的组合物
公开(公告)号：JP2008290970A
公开(公告)日：2008-12-04
申请号：JP2007138151
申请日：2007-05-24
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , ONISHI KAZUSADA , KURIYAMA KENICHI
IPC分类号： A61K8/97 , A61K36/00 , A61K36/18 , A61K36/48 , A61K36/53 , A61K36/73 , A61P17/16 , A61Q17/04
摘要： PROBLEM TO BE SOLVED: To provide a sun burn cell formation inhibitor for improving the resisting power of a skin cell itself against skin damage caused by ultraviolet light, and a composition for a sun care formulation containing the inhibitor. SOLUTION: This sun burn cell formation inhibitor is characterized by containing at least ≥1 kind of an extract of a plant selected from the group consisting of Ampelopsis grossedentata, Aspalathus linearis, Hypericum erectum, Perilla frutescens, Ginkgo biloba, black tea, oolong tea, green tea, Potentilla tormentilla vulgaris, Hamamelis vernalis and Scutellaria baicalensis as an active ingredient. Also, the composition for the sun care formulation containing such the inhibitor is provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决的问题：提供一种用于提高皮肤细胞本身抵抗由紫外光引起的皮肤损伤的抗力的太阳燃烧细胞形成抑制剂和含有抑制剂的防晒制剂组合物。解决方案：该阳光燃烧细胞形成抑制剂的特征在于，含有至少≥1种选自以下的植物提取物：大of ata，芦苇，金丝桃，紫苏，银杏，红茶，乌龙茶，绿茶，万寿菊，马蹄莲和黄芩作为活性成分。此外，提供了含有这种抑制剂的防晒制剂的组合物。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2011246416A Agent for imparting high molecular weight to hyaluronic acid and skin wound healing promoter 审中-公开
标题翻译：将高分子量重量转化成羟丙酸和皮肤愈合促进剂的药剂
公开(公告)号：JP2011246416A
公开(公告)日：2011-12-08
申请号：JP2010123184
申请日：2010-05-28
申请人： Mandom Corp , 株式会社マンダム
发明人： IWASHITA SHIZUKA , KURATA RYUICHIRO , ONISHI KAZUSADA , FUJITA IKUNAO , MISAKI JIN
IPC分类号： A61K31/728 , A61K8/73 , A61P17/02 , A61P17/16 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an agent for imparting high molecular weight to hyaluronic acid which has excellent permeability to the living body and also can impart high molecular weight to hyaluronic acid in the living body, and a skin wound healing promoter containing the compound.SOLUTION: The agent for imparting high molecular weight to hyaluronic acid contains a compound having a repeated unit expressed by formula (I) (wherein, Rto Rdenote a hydrogen atom, a 1 to 4C alkyl group or the like), and having the viscosity average molecular weight of 500 to 20,000. The skin wound healing promoter contains the compound.
摘要翻译：待解决的问题：提供一种赋予生物体的渗透性优异的透明质酸赋予高分子量的药剂，并且能够赋予生物体中的透明质酸高分子量，以及含有化合物。对于透明质酸赋予高分子量的试剂含有具有由式（I）表示的重复单元的化合物（其中，R 1 至R 5 表示氢原子，1〜4个碳原子等），粘均分子量为500〜20000。皮肤伤口愈合促进剂含有该化合物。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2011208964A Melanin production inducer, and evaluation method of test material 有权
标题翻译：梅拉宁生产电感器和测试材料的评估方法
公开(公告)号：JP2011208964A
公开(公告)日：2011-10-20
申请号：JP2010074286
申请日：2010-03-29
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , FUJITA IKUNAO , ONISHI KAZUSADA , KURIYAMA KENICHI
IPC分类号： G01N33/50 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a melanin production inducer capable of inducing melanin production in a pigment cell by a simple operation, and to provide an evaluation method of a test material capable of evaluating a whitening effect of the test material by a quick and simple operation.SOLUTION: The melanin production inducer includes at least one kind of factor selected from a group composed of IL-8, CTGF and IL-IF9. In the evaluation method of the test material, the test material is brought into contact with a cell group in which melanin production is induced by bringing the factor into contact with the pigment cell-including cell group, and the amount of melanin is measured, and the whitening effect of the test material is evaluated based on the measured melanin amount.
摘要翻译：要解决的问题：提供能够通过简单的操作在颜料细胞中诱导黑色素生成的黑色素生成诱导剂，并且提供能够通过快速和简单地评价测试材料的美白效果的测试材料的评估方法操作。解决方案：黑色素生产诱导剂包括从由IL-8，CTGF和IL-IF9组成的组中选择的至少一种因子。在试验材料的评价方法中，使试验材料与通过使该因子与含有颜料细胞的细胞组接触而诱导黑色素生成的细胞群接触，测定黑色素的量，基于测定的黑色素量来评价试验材料的美白效果。

9. 发明专利

JP2012016311A Method for evaluating substance to be tested 有权
标题翻译：评估待测物质的方法
公开(公告)号：JP2012016311A
公开(公告)日：2012-01-26
申请号：JP2010155603
申请日：2010-07-08
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , ONISHI KAZUSADA , FUJITA IKUNAO , KURIYAMA KENICHI
IPC分类号： C12Q1/02 , C12N5/10 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating a substance to be tested which evaluates a substance for suppressing an abnormality of a skin condition caused by sebum by a simple operation.SOLUTION: The method for evaluating a substance to be tested includes culturing a keratinocyte for expressing epimorphin or its differentiating cell structure under a differentiation condition while keeping contact with the substance to be tested or culturing a wild-type keratinocyte or its differentiating cell structure under a differentiation condition while keeping a contact with an unsaturated fatty acid and the substance to be tested, observing the morphology of the obtained cell structure and evaluating whether or not the substance to be tested is a substance for suppressing occurrence of an abnormality of a skin condition caused by sebum on the basis of the morphology of the cell structure.
摘要翻译：要解决的问题：提供一种用于评估通过简单操作来评估由皮脂引起的皮肤状况异常的物质的待测试物质的评价方法。评价待测物质的方法包括在保持接触待测物质或培养野生型角质形成细胞或其分化细胞的同时，在分化条件下培养表达异丙肾上腺素或其分化细胞结构的角化细胞在与不饱和脂肪酸和待测物质保持接触的同时，在分化条件下进行结构观察，观察所获得的细胞结构的形态，评价待测物质是否为抑制异常的发生的物质基于细胞结构形态的皮脂引起的皮肤状况。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011042614A Sunburn cell-formation inhibitor 有权
标题翻译： SUNBURN细胞形成抑制剂
公开(公告)号：JP2011042614A
公开(公告)日：2011-03-03
申请号：JP2009191327
申请日：2009-08-20
申请人： Mandom Corp , 株式会社マンダム
发明人： KURATA RYUICHIRO , ONISHI KAZUSADA , KURIYAMA KENICHI
IPC分类号： C07H17/04 , A61K8/60 , A61K31/7048 , A61P17/16 , A61Q17/04
摘要： PROBLEM TO BE SOLVED: To provide a sunburn cell-formation inhibitor which exhibits an excellent cell-formation inhibition effect, a skin external preparation and a cosmetic which contain the sunburn cell-formation inhibition. SOLUTION: The sunburn cell-formation inhibitor contains at least one galloyl group-containing compound selected from the group consisting of a galloyl group-containing albiflorin and a galloyl group-containing peoniflorin as an active ingredient. The skin external preparation and the cosmetic contain the sunburn cell-formation inhibitor. COPYRIGHT: (C)2011,JPO&INPIT

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