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1. 发明专利

JP2011251932A Ophthalmic solution and eye wash 审中-公开
标题翻译：眼科解决方案和眼睛洗发
公开(公告)号：JP2011251932A
公开(公告)日：2011-12-15
申请号：JP2010126212
申请日：2010-06-01
申请人： Mandom Corp , 株式会社マンダム
发明人： SAKAKIBARA SEI , NAGAMATSU TAKEAKI , OKADA FUMIHIRO
IPC分类号： A61K9/08 , A61K47/02 , A61K47/10 , A61P27/02 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To provide a composition for an ophthalmic solution or eye wash exhibiting excellent antiseptic stability without containing an antiseptic agent with no irritation to eye mucosa that can be used while contact lenses are fitted to a wearer.SOLUTION: The composition is used for ocular instillation or eye washing and contains 1,2-octanediol, desirably contains a boric acid and/or borax. There are also provided an ophthalmic solution and eye wash composed of the composition.
摘要翻译：待解决的问题：提供一种具有优异的消毒稳定性的眼用溶液或眼洗液的组合物，而不含有在将隐形眼镜装配到穿着者时可以使用的眼睛粘膜无刺激性的防腐剂。该组合物用于滴眼或眼睛洗涤，并含有1,2-辛二醇，理想地含有硼酸和/或硼砂。还提供了由该组合物组成的眼用溶液和洗眼剂。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2008019186A Antiseptic/bactericide and cosmetic, medicament or food formulated therewith 有权
标题翻译：抗菌/杀菌剂和化妆品，药物或食品配方
公开(公告)号：JP2008019186A
公开(公告)日：2008-01-31
申请号：JP2006190675
申请日：2006-07-11
申请人： Mandom Corp , 株式会社マンダム
发明人： OKAMOTO HIRONARI , OKADA FUMIHIRO , ENDO YUKO
IPC分类号： A61K8/34 , A23L3/3472 , A23L3/349 , A61K8/97 , A61K47/10 , A61K47/46 , A61Q19/00
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an antiseptic/bactericide which enhances the inherent antibacterial power of a 1,2-alkanediol, to provide a cosmetic, a medicament, or a food formulated therewith, and to provide a cosmetic, a medicament, or a food. SOLUTION: The antiseptic/bactericide comprises a 5-10C 1,2-alkanediol, desirably a 1,2-octanediol, and a grape fruit extract, desirably a grape fruit seed extract. The cosmetic, medicament, or food is formulated therewith. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种增强1,2-链烷二醇固有的抗菌力的防腐/杀菌剂，以提供化妆品，药物或与其配制的食品，并提供化妆品，药物，或食物。解决方案：防腐/杀菌剂包括5-10C 1,2-链烷二醇，优选1,2-辛二醇和葡萄果提取物，理想地是葡萄果实种子提取物。化妆品，药物或食物与其配制。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2006083119A Germicidal disinfectant composition 审中-公开
标题翻译：灭菌剂组合物
公开(公告)号：JP2006083119A
公开(公告)日：2006-03-30
申请号：JP2004270937
申请日：2004-09-17
申请人： Mandom Corp , Maruishi Pharmaceutical Co Ltd , 丸石製薬株式会社 , 株式会社マンダム
发明人： OKADA FUMIHIRO , OKAMOTO HIRONARI , KANEHISA SHUSUKE , FUJIWARA NOBUNORI , IKEDA MASAHIRO , SOGA MANABU
IPC分类号： A61K8/00 , A61K8/19 , A61K8/30 , A61K8/49 , A61K8/72 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a gel-like germicidal disinfectant composition free of sags from hand or the like in use, getting nongreasy both in use and after use, free of feeling of being left after use, and affording dry feeling in use.
SOLUTION: The germicidal disinfectant composition comprises an acrylic acid-methacrylic acid alkyl ester copolymer, a germicidal disinfectant, a cyclic silicone and a lower alcohol.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种在使用中不含手感等的凝胶状杀菌消毒剂组合物，在使用中和使用后均不会留下使用后的残留感，并且具有干燥感正在使用。解决方案：杀菌消毒剂组合物包含丙烯酸 - 甲基丙烯酸烷基酯共聚物，杀菌消毒剂，环状硅氧烷和低级醇。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005232012A Antiseptic sterilizer, and cosmetic, medicine and food compounded with the antiseptic sterilizer 有权
标题翻译：抗菌杀菌剂，化学杀菌剂，抗菌杀菌剂，化妆品，医药和食品
公开(公告)号：JP2005232012A
公开(公告)日：2005-09-02
申请号：JP2004039214
申请日：2004-02-17
申请人： Mandom Corp , 株式会社マンダム
发明人： OKAMOTO HIRONARI , OKADA FUMIHIRO
IPC分类号： A23L3/349 , A01N31/02 , A01N43/40 , A23L3/3526 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/49 , A61K47/10 , A61K47/22 , A61L2/00 , A61Q17/00 , A61Q19/00 , A61K7/00
CPC分类号： A61Q17/005 , A61K8/345 , A61K8/4926 , A61L2/0088
摘要： PROBLEM TO BE SOLVED: To obtain an antiseptic sterilizer together using a 1,2-alkanediol and octopirox and synergistically reinforcing the original anti-microbial forces of the 1,2-alkanediol and the octopirox against wide kinds of microbes, and to prepare a cosmetic, a medicine and a food each compounded with the antiseptic sterilizer.
SOLUTION: The antiseptic sterilizer is characterized by containing the 1,2-alkanediol represented by the formula (1): R-CH(OH)-CH
2 -OH (1) (R is a 3 to 8C alkyl) and the octopirox, and the cosmetic, the medicine and the food are each compounded with the antiseptic sterilizer. The 1,2-alkanediol is preferably 1,2-hexanediol or 1,2-octanediol, more preferably 1,2-octanediol.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了使用1,2-链烷二醇和八倍体一起获得消毒灭菌器，并且协同地增强了1,2-链烷二醇和八面体对各种微生物的原始抗微生物力，并且准备与防腐消毒剂配合的化妆品，药物和食物。解决方案：消毒灭菌器的特征在于含有由式（1）表示的1,2-链烷二醇：R-CH（OH）-CH 2 -OH（1）（R是 3至8C烷基）和八制辛，化妆品，药物和食品均与防腐消毒剂混合。 1,2-链烷二醇优选为1,2-己二醇或1,2-辛二醇，更优选为1,2-辛二醇。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2005029535A Antiseptic bactericide, and cosmetic, medicine and food compounded therewith 有权
标题翻译：抗菌杀菌剂，化妆品，药物和食品
公开(公告)号：JP2005029535A
公开(公告)日：2005-02-03
申请号：JP2003272667
申请日：2003-07-10
申请人： Mandom Corp , 株式会社マンダム
发明人： OKAMOTO HIRONARI , OKADA FUMIHIRO
IPC分类号： A23L3/349 , A01N31/02 , A01N65/00 , A01N65/28 , A01P3/00 , A23L3/3517 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/96 , A61K8/97 , A61K9/00 , A61K9/06 , A61K31/045 , A61K36/18 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/30 , A61K47/44 , A61P17/16 , A61K7/00 , A61K35/78
CPC分类号： A61K8/922 , A01N31/02 , A01N65/00 , A61K8/345 , A61Q17/005 , A01N2300/00 , A01N65/28
摘要： PROBLEM TO BE SOLVED: To obtain an antiseptic bactericide improved in the antibacterial power of 1,2-octanediol by compounding 1,2-octanediol with tea tree oil, and provide cosmetics, medicines and foods compounded with the antiseptic bactericide. SOLUTION: The antiseptic bactericide contains a 5-10C alkanediol and the tea tree oil as active components. The cosmetics, medicines and foods are compounded with the antiseptic bactericide. The 1,2-alkanediol is preferably 1,2-hexanediol or 1,2-octanediol, especially preferably 1,2-octanediol. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：通过将1,2-辛二醇与茶树油混合，获得提高1,2-辛二醇的抗菌能力的杀菌剂，并提供与防腐杀菌剂复合的化妆品，药物和食品。
解决方案：消毒杀菌剂含有5-10C链烷二醇和茶树油作为活性成分。化妆品，药品和食品与防腐杀菌剂复合。 1,2-链烷二醇优选为1,2-己二醇或1,2-辛二醇，特别优选1,2-辛二醇。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2004307484A Antiseptic bactericide, and cosmetic, pharmaceutical and foodstuff blended with the same 有权
公开(公告)号：JP2004307484A
公开(公告)日：2004-11-04
申请号：JP2004082232
申请日：2004-03-22
申请人： Mandom Corp , 株式会社マンダム
发明人： OKAMOTO HIRONARI , OKADA FUMIHIRO
IPC分类号： A23L3/349 , A01N31/02 , A23L3/358 , A61K8/19 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/41 , A61K47/04 , A61K47/10 , A61K47/12 , A61Q1/00 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q3/02 , A61Q5/02 , A61Q5/04 , A61Q11/00 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an antiseptic bactericide in which a 5-10C 1,2-alkane diol and a chelating agent are contained for enhancing the bactericidal activity intrinsic to 1,2-alkane diol, and to provide cosmetics, pharmaceuticals and foodstuffs blended with the bactericide. SOLUTION: This antiseptic bactericide contains the 5-10C 1,2-alkane diol and chelating agent. The cosmetics, pharmaceuticals and foodstuffs are blended with the bactericide. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JP2003081761A Emulsified composition 审中-公开
标题翻译：乳化组合物
公开(公告)号：JP2003081761A
公开(公告)日：2003-03-19
申请号：JP2001300068
申请日：2001-09-28
申请人： Mandom Corp , 株式会社マンダム
发明人： KOBAYASHI AKI , OKAMOTO HIRONARI , OKADA FUMIHIRO , KANEHISA SHUSUKE
IPC分类号： A61K47/10 , A61K8/06 , A61K8/30 , A61K8/34 , A61K47/44 , A61Q1/00 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/00 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01F17/38 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/34 , A61K8/345 , A61K2800/52 , A61K2800/70 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q5/12 , A61Q17/04 , A61Q19/10
摘要： PROBLEM TO BE SOLVED: To provide an emulsified composition having excellent emulsion stability with time and feeling to the skin, free from an antiseptic agent such as paraben (p-hydroxybenzoate) or if any, capable of keeping the antiseptic stability of the composition at a low compounding ratio of the antiseptic agent.
SOLUTION: The emulsified composition contains a 1,2-alkanediol, a surfactant, an oily substance and water. The emulsion composition may further contain ≤0.2 wt.% antiseptic agent. An emulsified composition essentially free from an antiseptic agent is also disclosed in the invention.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种乳化组合物，其具有优异的乳化稳定性和时间和对皮肤的感觉，不含能够使组合物的防腐性稳定性保持在一定程度上的防腐剂如对羟基苯甲酸酯（对羟基苯甲酸酯）或如果有的话防菌剂配伍比低。溶液：乳化组合物含有1,2-链烷二醇，表面活性剂，油状物和水。乳液组合物还可含有<= 0.2重量％的防腐剂。本发明还公开了一种基本上不含防腐剂的乳化组合物。

8. 发明专利

JP2012168316A Ophthalmic composition 有权
标题翻译：眼科组合物
公开(公告)号：JP2012168316A
公开(公告)日：2012-09-06
申请号：JP2011028422
申请日：2011-02-14
申请人： Mandom Corp , 株式会社マンダム
发明人： SAKAKIBARA SEI , NAGAMATSU TAKEAKI , OKADA FUMIHIRO
IPC分类号： G02C7/04 , G02C13/00
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic composition which causes no stimulus to eye mucosa and can improve the wettability of a contact lens.SOLUTION: Provided is an ophthalmic composition containing two kinds or more of 1,2-alkanediol of 4-10C, preferably, 1,2-pentanediol and 1,2-hexanediol, 1,2-pentanediol and 1,2-octanediol, or 1,2-hexanediol and 1,2-octanediol, and there is also provided a method of improving the wettability of a contact lens using the composition.
摘要翻译：要解决的问题：提供一种对眼粘膜没有刺激作用并可以提高隐形眼镜的润湿性的眼用组合物。本发明提供一种含有4-10℃的1,2-链烷二醇，优选1,2-戊二醇和1,2-己二醇，1,2-戊二醇，1,2-戊二醇，辛二醇或1,2-己二醇和1,2-辛二醇，并且还提供了使用该组合物改善隐形眼镜的润湿性的方法。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2010180213A Antiseptic microbicide, and composition for applying to human body 有权
标题翻译：抗微生物剂，以及适用于人体的组合物
公开(公告)号：JP2010180213A
公开(公告)日：2010-08-19
申请号：JP2010038006
申请日：2010-02-23
申请人： Kankosha:Kk , Mandom Corp , 株式会社マンダム , 株式会社感光社
发明人： KOBAYASHI AKI , MORI NORIKO , MATSUURA YUKA , YASUI SHIGEO , OKADA FUMIHIRO , SHIMIZU HIDEO , NAGAI AKIHIKO
IPC分类号： A61K31/047 , A01N31/02 , A01N31/08 , A01N31/14 , A01N37/10 , A01P3/00 , A61K8/34 , A61K8/368 , A61K31/05 , A61K31/085 , A61K31/192 , A61P17/00 , A61P31/02 , A61P43/00 , A61Q17/00
摘要： PROBLEM TO BE SOLVED: To provide an antiseptic microbicide which can exclude or reduce the dose of antiseptic microbicides used so far such as paraben and benzoic acid, and has an excellent antimicrobial potency, and a highly safe composition for applying to a human body to which a small amount of a conventional antiseptic microbicide or no microbicide is added.
SOLUTION: The antiseptic microbicide contains a combination of 1,2-pentanediol or 1,2-hexanediol with benzoic acid and a salt thereof.
COPYRIGHT: (C)2010,JPO&INPIT

10. 发明专利

JP2009225733A Method for evaluation of trpa1 activator 有权
标题翻译：用于评估TRPA1激活剂的方法
公开(公告)号：JP2009225733A
公开(公告)日：2009-10-08
申请号：JP2008076109
申请日：2008-03-24
申请人： Mandom Corp , National Institutes Of Natural Sciences , 大学共同利用機関法人自然科学研究機構 , 株式会社マンダム
发明人： FUJITA IKUNAO , SAKUYAMA HIDE , OKADA FUMIHIRO , TSUJINO YOSHIO , TOMINAGA MAKOTO
IPC分类号： C12Q1/02 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluation of a TRPA1 activator which is capable of evaluating a substance activating the physiological function of TRPA1 in high evaluation sensitivity, and a method for evaluating a substance inducing sensory stimulation which is capable of evaluating the sensory stimulation inducing substance in high evaluation accuracy and sensitivity.
SOLUTION: Provided are a method for evaluating a TRPA1 activator by contacting a tested substance with an alkaline solution and a TRPA1 expression cell and examining the activation of the physiological function of TRPA1 by the tested substance, and a method for evaluating a sensory stimulation inducing substance by contacting the tested substance with an alkaline solution and a TRPA1 expression cell and examining the activation of the physiological function of TRPA1 by the tested substance.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够以高评价灵敏度评价激活TRPA1的生理功能的物质的TRPA1活化剂的评价方法，以及评价能够诱导感觉刺激的物质的方法以高评价精度和灵敏度评估感觉刺激诱导物质。解决方案：提供一种通过使被测物质与碱性溶液和TRPA1表达细胞接触并检测被检物质对TRPA1的生理功能的活化来评估TRPA1活化剂的方法，以及评估感觉的方法通过使测试物质与碱性溶液和TRPA1表达细胞接触并检测被检物质对TRPA1的生理功能的活化来刺激诱导物质。版权所有（C）2010，JPO＆INPIT

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