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1. 发明专利

JP2007254458A Cancer vaccine 有权
标题翻译：癌症疫苗
公开(公告)号：JP2007254458A
公开(公告)日：2007-10-04
申请号：JP2007025080
申请日：2007-02-05
申请人： Malaysian Palm Oil Board , マレーシアン・パーム・オイル・ボード
发明人： KALANITHI NESARETNAM , SITTI RAHMA ABDUL HAFID , KANGA RANI SELVADURAY , BASIRON YUSOF
IPC分类号： A61K39/00 , A61K35/12 , A61K39/39 , A61P35/00 , C12N5/0784
CPC分类号： A61K39/0011 , A61K31/353 , A61K31/355 , A61K2039/5158 , C12N5/0639 , C12N2501/22 , C12N2501/23
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a composition used as a treating or preventing vaccine of cancer.
SOLUTION: This method for producing the composition used as the treating or preventing medicine comprises a step of culturing dendritic cells isolated from a patient in a medium containing a nutrient and under a condition suitable for the survival and growth of a mammalian animal cells, a step of pulse-treating the dendritic cells with a lysate from a cancer cell system or specie-regulating antigen and tocotrienol, and a step of incorporating the pulse-treated dendritic cells in a solid or liquid form suitable for the administration to cancer patients, and a method for using the same as a cancer vaccine is also provided.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种制备用作治疗或预防癌症疫苗的组合物的方法。解决方案：用于制备用作治疗或预防药物的组合物的方法包括在含有营养物的培养基中和在适合于哺乳动物细胞的存活和生长的条件下培养从患者分离的树突细胞的步骤用来自癌细胞系统或特异性调节抗原和生育三烯酚的裂解液脉冲处理树突状细胞的步骤，以及将脉冲处理的树突状细胞以适合给予癌症患者的固体或液体形式引入的步骤，还提供了将其用作癌症疫苗的方法。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2009102313A Vitamin e supplementation to tetanus toxoid 有权
标题翻译：维生素E补充剂给牙龈炎
公开(公告)号：JP2009102313A
公开(公告)日：2009-05-14
申请号：JP2008257171
申请日：2008-10-02
申请人： Malaysian Palm Oil Board , マレーシアン・パーム・オイル・ボード
发明人： KALANITHI NESARETNAM
IPC分类号： A61K39/39 , A61K31/355 , A61K39/08 , A61P31/04 , A61P43/00
CPC分类号： A61K31/355
摘要： PROBLEM TO BE SOLVED: To overcome problems in the technical field by developing a supplementation on immune response to tetanus by using vitamin E, that is, to disclose effects of the vitamin E supplementation on immune modulation in a mammal, whereby the mammal is vaccinated with tetanus toxoid, and, in addition, to disclose effects of different types of vitamin E such as TRF (tocotrienol rich fraction), δ-tocotrienol and α-tocopherol supplementation on the immune response to tetanus toxoid vaccination. SOLUTION: A formulation for supplementation on the immune response to a biological substance is provided. More specifically, the formulation consists of one or a plurality of forms of vitamin E which provide the supplementation on the immune response to the tetanus toxoid. In addition, there are the effects of the different types of vitamin E such as the TRF, the δ-tocotrienol and the α-tocopherol supplementation on the immune response to the tetanus toxoid vaccination. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过使用维生素E开发对破伤风免疫反应的补充来克服技术领域的问题，即，公开补充维生素E对哺乳动物免疫调节的作用，由此哺乳动物接种了破伤风类毒素，此外，还揭示了不同类型维生素E（如富含生育三烯酚的富含生育三烯酚），δ-生育三烯酚和α-生育酚补充剂对破伤风类毒素疫苗接种的免疫反应的影响。解决方案：提供了用于补充生物物质的免疫应答的制剂。更具体地，该制剂由一种或多种形式的维生素E组成，其提供对破伤风类毒素的免疫应答的补充。此外，还有不同类型的维生素E如TRF，δ-生育三烯酚和α-生育酚补充对破伤风类毒素疫苗接种的免疫应答的影响。版权所有（C）2009，JPO＆INPIT

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