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1. 发明专利

JPH05322898A REAGENT FOR DETECTING ANTIBODY AGAINST NUCLEOPROTEIN OF RINDERPEST VIRUS AND ITS MANUFACTURE 失效
公开(公告)号：JPH05322898A
公开(公告)日：1993-12-07
申请号：JP7259692
申请日：1992-02-20
申请人： MORINAGA MILK INDUSTRY CO LTD
发明人： YAMAUCHI KAZUYA , YOSHIKAWA YASUHIRO , MATSUURA ZENJI , KAMATA HIROSHI , INUI KENJIRO , OKUBO SHIGETOSHI , ISHIMOTO TETSUYA , SAKURAOKA MUTSUMI
IPC分类号： C12N7/00 , C12N7/01 , C12N15/09 , C12N15/45 , C12N15/62 , C12P21/02 , C12R1/92 , G01N33/53 , G01N33/531 , G01N33/569
摘要： PURPOSE:To obtain a diagnostic reagent by sensitizing recombined RPV-NP on a carrier for diagnosing cattle whether or not the cattle is infected with a rinderpest virus or for confirming the effect of a rinderpest vaccine and its manufacturing method. CONSTITUTION:The title reagent is manufactured in such a way that a recombined virus is generated by recombining part of the gene of the nucleopolyhedrosis virus of a night moth having a polyhedral protein structure on a DNA piece obtained by cutting off the 35th base pairing in the 5'-side non-translated area from the DND-sequence coding the nucleoprotein of rinderpest virus and collecting nucleopretein-like protein generated in an insect cell after making the insect cell (Sf cell) to be infected with the generated recombined virus, and then, sensitizing a protein having an antigenic property against an RPV-NP antibody on a carrier as an antigen. Therefore, the protein having a strong antigenic property against the antibody of the nucleoprotein of rinderpest virus and a reagent manufactured by sensitizing the protein to a carrier can be mass-produced. When the reagent is used, in addition, the diagnosis on cattle whether or not the cattle is infected with the RPV virus and discrimination of the effect of an RPV vaccine can be easily and quickly performed at a sample (serum) collecting site without requiring any special equipment and skilled technician.

2. 发明专利

JPH08220099A SUBSTANCE DETECTING REAGENT AND DETECTING METHDO FOR CHRONIC ARTICULAR RHEUMATISM 失效
公开(公告)号：JPH08220099A
公开(公告)日：1996-08-30
申请号：JP2309195
申请日：1995-02-10
申请人： MORINAGA MILK INDUSTRY CO LTD , EISAI CO LTD
发明人： SAKURAOKA MUTSUMI , AONUMA IKUE , HARADA YOSHITSUGU , YAMADA YUJI
IPC分类号： G01N33/53 , G01N33/543 , G01N33/564 , G01N33/66
摘要： PURPOSE: To accurately, simply and rapidly diagnose chronic articular rheumatism. CONSTITUTION: A chronic articular rheumatism is detected by the steps of reacting a film solidified from one of galactose defect IgG (human immunity globulin G) and Ricinus comunis agglutinin I, colored fine particles solidified with the other with biological sample collected from a person to be detected, and detecting the fine particles trapped on the film via the bond of the anti- galactose defect IgG antibody included in the sample to the galactose defect IgG and the bond of Ricinus communis agglutinin I to galactose included in the anti-galactose defect IgG antibody.

3. 发明专利

JPH06118000A CLINICALLY INSPECTING METHOD 失效
公开(公告)号：JPH06118000A
公开(公告)日：1994-04-28
申请号：JP29194792
申请日：1992-10-07
申请人： MORINAGA MILK INDUSTRY CO LTD
发明人： SAKURAOKA MUTSUMI , ISHIMOTO TETSUYA , HARADA YOSHITSUGU
IPC分类号： G01N21/78 , G01N33/52 , G01N33/533
摘要： PURPOSE:To convert measured data obtained by measuring a color difference into a numeric value and to impart objectivity to an inspecting decision by measuring one of colorimetric data selected from a group consisting of X, Y, X colorimetric systems, CIELAB colorimetric system and CIFLUV colorimetric system by a colorimeter, and quantitatively analyzing substance to be inspected. CONSTITUTION:Substance to be inspected is quantitatively analyzed by measuring at least one colorimetric data selected from a group consisting of X, Y, Z, x and y of X, Y, X colorimetric systems, L*, a*, B* and aEQAb* and L*, u*, v* and AFuv* of CIELUV colorimetric system by a colorimeter in the case of coloring of the substance to be inspected. An inspecting method includes a carrier agglomeration method, a sedimentation method, and an oxygen immunity measuring method, etc., and colorimetric data is desirably set with an allowable limit value for removing influence of coloring due to specimen. A color difference between two objects obtained by a predetermined formula satisfactorily coincides with a magnitude of a color difference between the two sensitive objects, and if the difference is a predetermined value or less, the two objects can be decided to be the same color.

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