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1. 发明专利

JPH1033190A PRODUCTION OF SECONDARY METABOLITE OF PLANT 失效
公开(公告)号：JPH1033190A
公开(公告)日：1998-02-10
申请号：JP19676296
申请日：1996-07-25
申请人： MITSUI PETROCHEMICAL IND
发明人： YUKIMUNE TAKAHITO , HARA YASUHIRO
IPC分类号： A01H4/00 , A23L1/275 , A61K36/00 , C12N5/00 , C12N5/04 , C12P1/00 , C12P7/40 , C12P13/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To efficiently obtain the subject product useful as a raw material for medicines, cosmetics, as a pigment for foods, etc., by culturing the tissues or cells of a specific plant belonging to the order Polemoniales, etc., in a culture medium containing a coronatine compound, its producing microorganism, etc., and subsequently recovering the metabolite. SOLUTION: This method for producing the secondary metabolite of a plant comprises culturing the tissues or cells of a plant belonging to the order Polemoniales, Rubiales, Boraginales, Ranunculales, Ranunculales, Cucurbitales, Cornales, Cornales, Chenopodiales, Amaryllidales, Euphorbiales or Liliales in a culture medium containing a coronatine compound of the formula [R is OH, OR (R is a 1-6C alkyl, a hydrocarbon residue), OM (M is an alkali metal, an alkaline earth metal, NH4 ), NR R R , R are each H, a 1-6C acyl, a 1-6C alkyl, an amino acid residue, etc.,), etc.; R , R , R , R , R , R , R , R , R , R , R , R , R are each H, OH, a 1-6C alkyl, a 1-6C alkoxy], etc., its producing microorganism, a microorganism culture solution therefor or a culture solution extract therefrom, etc., and subsequently recovering the metabolite from the culture product.

2. 发明专利

JPH0956387A PRODUCTION OF TAXANE TYPE DITERPENE 失效
公开(公告)号：JPH0956387A
公开(公告)日：1997-03-04
申请号：JP21312195
申请日：1995-08-22
申请人： MITSUI PETROCHEMICAL IND
发明人： HARA YASUHIRO , YUKIMUNE TAKAHITO
IPC分类号： C12P17/02 , A61K36/18 , A61P35/00 , C12N5/04
摘要： PROBLEM TO BE SOLVED: To profitably obtain a taxane type diterpene useful for medicines for treating overian cancer, breast cancer, lung cancer, etc., by culturing the cells and tissues of a plant producing the taxane type diterpene in the presence of a specific compound and subsequently collecting the product from the obtained culture product. SOLUTION: A method for producing a taxane type diterpene comprises culturing the cells and/or tissues of a plant (e.g. Taxus media) producing the taxane type diterpene in the presence of a compound of the formula R to R , R to R are each H, OH, a 1-12C alkyl, a 2-12C alkenyl, a 1-12C alkoxy, a 6-12C aryloxy, a is OH, OM [M is an alkali (alkaline earth) metal, NH4 ), NR , R (R , R are each H, a 1-12C acyl, a 1-12C alkyl, etc.,), OR (R is a 1-12C alkyl, a (R is a 1-12C alkyl, a

3. 发明专利

JPH0928392A PRODUCTION OF TAXANE-TYPE DITERPENE 失效
公开(公告)号：JPH0928392A
公开(公告)日：1997-02-04
申请号：JP18020695
申请日：1995-07-17
申请人： MITSUI PETROCHEMICAL IND
发明人： TABATA HOMARE , HARA YASUHIRO
IPC分类号： C12P17/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a diterpene useful for curing, etc., of ovarium cancer, breast cancer, lung cancer, etc., in high productivity by culturing tissue or cell of a plant producing taxane-type diterpene in the presence of a compound increasable of Ca concentration in the cell and recovering the product. SOLUTION: The objective taxane-type diterpene (e.g. taxol) is obtained by culturing a tissue and/or cell of a plant producing taxane-type diterpene (e.g. Taxus baccata LINN) in the presence of a compound increasable of calcium concentration in the cell (e.g. calcium ionophore) or in the presence of a compound of the formula ]R -R are each H, OH, a 1-6C alkyl or a 1-6C alkoxy; R -R are each H or a 1-6C alkyl; a side chain may contain more than one double bond; R is OH, an OM (M is an alkali metal, an alkaline earth metal or NH4 ), an OR (R0 is a 1-8C alkyl or a hydrocarbon residue) or a 1-6C alkyl, etc.; (n) is 1-7[ (e.g. tuberonic acid) and recovering a product from the resultant cultured substance and/or the medium.

4. 发明专利

JPH04262788A PRODUCTION OF INDOLE ALKALOID 失效
公开(公告)号：JPH04262788A
公开(公告)日：1992-09-18
申请号：JP2351591
申请日：1991-02-18
申请人： MITSUI PETROCHEMICAL IND
发明人： ENMI AKIKO , HARA YASUHIRO
IPC分类号： C12N5/04 , C12P17/00 , C12R1/91
摘要： PURPOSE:To obtain the subject compound useful as a raw material for antitumor agent, etc., on an industrial scale at a low cost by carrying out the tissue culture of a tissue or cell of an indole alkaloid-producing plant in a medium containing amines, and collecting the objective product from the cultured tissue or cell. CONSTITUTION:Tissue or cell of an indole alkaloid-producing plant (e.g. Madagascar perwinkle) is cultured by standing culture in dark place at 25 deg.C and the obtained callus is subjected to tissue culture in a medium containing amines (e.g. ethylenediamine), naphthaleneacetic acid and kinetin. After the cultivation, the callus is collected by filtration and dried in air for a night at 40 deg.C. Indole alkaloid such as catharanthine and aziallicin is extracted from the dried callus and purified by high performance liquid chromatography to obtain the objective indole alkaloid in a mass.

5. 发明专利

JPH02291288A PRODUCTION OF INDOLE ALKALOID 失效
公开(公告)号：JPH02291288A
公开(公告)日：1990-12-03
申请号：JP8813389
申请日：1989-04-10
申请人： MITSUI PETROCHEMICAL IND
发明人： ITO FUMI , HARA YASUHIRO
IPC分类号： C12P17/10 , C12R1/91
摘要： PURPOSE:To enable efficient obtaining of an indole alkaloid in a large amount by carrying out tissue culture of tissues from a plant capable of producing the indole alkaloid in a culture medium containing fructose as a saccharide source. CONSTITUTION:A cultivar Cathranthus roseus var. Little.Bright.Eye, etc., of a plant of the genus Lochnera is bedded on a solid Murashige.Skoog culture medium containing agar and cultured at 10 to 35 deg.C for 7 to 30 days to provide calli. On the other hand, 2 to 5wt.% fructose is blended with 0.1muM to 100mM inorganic ingredient, such a s Ca, 0.01 to 10muM phytohormone, such as indoleacetic acids, 0.1 to 100mg/l each of vitamins, such as biotin or glycine, and amino acids and added to the Murashige.Skoog culture medium to afford a liquid culture medium for tissue culture. The aforementioned calli are then inoculated into the abovementioned culture medium and cultured at 10 to 35 deg.C. After completing the culturing. calli are separated by a decantation method or filtration, etc., to afford calli, which are subsequently extracted and purified with methanol, etc., to produce an indole alkaloid, such as catharanthine.

6. 发明专利

JPS60987B2 失效
公开(公告)号：JPS60987B2
公开(公告)日：1985-01-11
申请号：JP12476881
申请日：1981-08-11
申请人： MITSUI PETROCHEMICAL IND
发明人： HARA YASUHIRO , SUGA CHUZO
IPC分类号： C12N5/02 , C12P7/66 , C12R1/91

7. 发明专利

JPS6034B2 失效
公开(公告)号：JPS6034B2
公开(公告)日：1985-01-05
申请号：JP11590180
申请日：1980-08-25
申请人： MITSUI PETROCHEMICAL IND
发明人： HARA YASUHIRO , OGINO TAKAO
IPC分类号： C12N5/04 , A61K36/18 , C12N5/02 , C12P7/66 , C12R1/91

8. 发明专利

JPH0833490A PRODUCTION OF TAXANE-TYPE DITERPENE 失效
公开(公告)号：JPH0833490A
公开(公告)日：1996-02-06
申请号：JP4758095
申请日：1995-03-07
申请人： MITSUI PETROCHEMICAL IND
发明人： YUKIMUNE TAKAHITO , HARA YASUHIRO , TABATA HOMARE
IPC分类号： C12P7/40 , C12P17/02 , C12R1/91
摘要： PURPOSE:To produce a taxane-type diterpene useful e.g. as a treating agent for ovarian cancer, mammary cancer, pulmonary cancer, etc., by culturing cells or tissues of a plant capable of producing a taxane-type diterpene in the presence of a specific jasmonic acid and recovering the compound from the cultured product. CONSTITUTION:This taxane-type diterpene (e.g. taxol) is produced in high productivity by culturing the cells or tissues of a plant capable of producing a taxane- type diterpene (e.g. Taxus brevifolia) in the presence of a jasmonic acid compound of, formula [R , R , R , R and R are each H, OH, a l-6C alkyl or a l-6C alkoxy; R to R are each H or a 1-6C alkyl; the side chain bonded to C may contain one or more double bonds; R is OH, OM (M is an alkali metal, an alkaline earth metal or NH4), NR R (R and R are each H, a 1-6C acyl, a 1-6C alkyl or an amino acid residue), OR (R is a 1-6C alkyl or a carbohydrate residue) or a l-6C alkyl; (n) is 1-7] (e.g. methyl jasmonate) and recovering the compound from the cultivation product.

9. 发明专利

JPH07308197A PRODUCTION OF TAXANE TYPE DITERPENE 失效
公开(公告)号：JPH07308197A
公开(公告)日：1995-11-28
申请号：JP10421294
申请日：1994-05-18
申请人： MITSUI PETROCHEMICAL IND
发明人： YUKIMUNE TAKAHITO , HARA YASUHIRO
IPC分类号： C12P17/02 , C12R1/91
摘要： PURPOSE:To industrially and advantageously obtain the subject compound useful as a therapeutic agent for ovarian carcinoma, mastocarcinoma, lung cancer, etc., by culturing a cell or a tissue of a plant capable of producing a taxane type terpene in the presence of a specific jasmonic acid and recovering a formed product from the culture mixture. CONSTITUTION:A cell or a tissue of a plant (e.g. Taxus baccata) capable of producing taxane type terpene is cultured in the presence of a jasmonic acid of formula I {R is a 1-4C alkyl, a group of formula II [R is OH, an OM (M is an alkali metal, an alkaline earth metal or NH4), an NHR (R is a 1-4C acyl, a 1-4C alkyl or amino acid) or an OR (R is a 1-4C alkyl or a hydrocarbon residue; (n) is an integer of 1-7]; R to R are each H or R and R , R and R or R and R may form a double bond together; the five-membered ring may be further substituted with a hydroxyl group and may form a double bond between adjoining carbon atoms} and a formed product is recovered to give the abjective taxane type terpene (e.g. taxol).

10. 发明专利

JPH06296443A METHOD FOR OBTAINING SEEDLING HIGHLY PRODUCING SECONDARY METABOLITE BY CULTURE OF PLANT TISSUE 失效
公开(公告)号：JPH06296443A
公开(公告)日：1994-10-25
申请号：JP8727193
申请日：1993-04-14
申请人： MITSUI PETROCHEMICAL IND
发明人： AZUMA YASUSUKE , HARA YASUHIRO
IPC分类号： A01H1/00
摘要： PURPOSE:To efficiently and simply obtain the subject seedling useful for medicines, etc., by forming lateral buds on a specific seedling, selecting lateral buds having a high ability to produce a secondary metabolite from the lateral buds, culturing the buds to again produce the seedlings, and further repeating the processes. CONSTITUTION:This method for obtaining a seedling highly producing a secondary metabolite comprises forming lateral buds on the seedling of a Vinca rosea L. plant such as Catharant husoseus var. Little Bright Eye having a high ability to produce the secondary metabolite such as ajmalicine, selecting lateral buds having a high secondary metabolite-producing ability from the lateral buds, culturing the selected lateral buds to again produce the seedlings, and subsequently repeating the operations.

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