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1. 发明专利

JP2002080472A METHOD OF PRODUCING ALKYLOXYAMINOFURANONE DERIVATIVE 失效
公开(公告)号：JP2002080472A
公开(公告)日：2002-03-19
申请号：JP2000347835
申请日：2000-11-15
申请人： MITSUBISHI CHEM CORP
发明人： TAKUMA YUUKI , KATSURADA MANABU , KASUGA YUUZOU , WATANABE NAOYUKI , MURAKAMI TAKESHI , SUDO TOMOKO , MATSUMOTO YOICHI
IPC分类号： C07D307/33 , C07C227/06 , C07C229/22 , C07C229/30
摘要： PROBLEM TO BE SOLVED: To provide a method of inexpensively and simply producing an alkyloxyaminofaranone derivative in a practically industrial scale. SOLUTION: The objective industrial method for producing an alkyloxyaminofuranon derivative starts with the reduction step of a compound represented by general formula (A) followed by the step of cyclization of the reduced product to a compound represented by general formula (D) [wherein R1 and R3 are each same defined as in the general formula (A)].

2. 发明专利

JP2000169423A PRODUCTION OF FUMARIC ACID 失效
公开(公告)号：JP2000169423A
公开(公告)日：2000-06-20
申请号：JP34519998
申请日：1998-12-04
申请人： MITSUBISHI CHEM CORP
发明人： WATANABE NAOYUKI , UBUKAWA YOSHIZO , KATO NAOKI
IPC分类号： C07C51/353 , C07C57/15
摘要： PROBLEM TO BE SOLVED: To provide a process capable of extremely increasing the conversion of maleic acid and remarkably reduce the particle diameter of produced fumaric acid in the production of fumaric acid by the isomerization of maleic acid using a catalyst comprising a combination of a bromine-donative compound with an oxidizing agent. SOLUTION: Fumaric acid is produced by the isomerization of maleic acid in the presence of a compound having a standard electrode potential of >=1 V and, as necessary, a water-soluble bromine-donative compound. The production process is carried out by (1) keeping the sum of the concentration of maleic acid and fumaric acid in the reactor to 15-60 wt.% and (2) continuously feeding maleic acid, a compound having a standard electrode potential of >=1 V and, as necessary, a water-soluble bromine-donative compound and continuously extracting produced fumaric acid slurry from the reactor.

3. 发明专利

JPH09322790A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09322790A
公开(公告)日：1997-12-16
申请号：JP14418996
申请日：1996-06-06
申请人： MITSUBISHI CHEM CORP
发明人： MIURA MIYUKI , KATO NAOKI , MORI YOSHIAKI , WATANABE NAOYUKI
IPC分类号： C12P13/20 , C07C229/24 , C12R1/13
摘要： PROBLEM TO BE SOLVED: To provide a profitable and balanced process for continuously producing L-aspartic acid from fumaric acid as a raw material. SOLUTION: This method for producing L-aspartic acid comprises (1) a process for obtaining an aqueous solution containing L-aspartic acid ammonium salt from fumaric acid and ammonia as starting raw materials by an enzymatic reaction, (2) a process for adding fumaric acid to the solution obtained in the process (1) to deposit the L-aspartic acid, and (3) a process for recovering the L-aspartic acid crystals obtained in the process (2) and recycling the mother liquor into the process (1). Therein, the fumaric acid as the raw material is supplied to the reaction system in the process (2) and to the reaction system at least in the process (1) or the process (3), and the fumaric acid added to the reaction system in the process (2) is added in a molar ratio of 0.1-0.85 to the L-aspartic ammonium salt existing in the process (2).

4. 发明专利

JPH09322789A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09322789A
公开(公告)日：1997-12-16
申请号：JP14284196
申请日：1996-06-05
申请人： MITSUBISHI CHEM CORP
发明人： KATO NAOKI , MORI YOSHIAKI , WATANABE NAOYUKI , MIURA MIYUKI
IPC分类号： C12P13/20 , C12R1/13
摘要： PROBLEM TO BE SOLVED: To profitably obtain L-aspartic acid useful as a medicine, a food additive, etc., by subjecting maleic acid, maleic anhydride, etc., to an enzymatic isomerization reaction in an aqueous solution having a specific dissolved oxygen concentration and subsequently reacting the isomerization product with ammonia in the presence of an enzyme. SOLUTION: This method for producing L-aspartic acid comprises isomerizing maleic acid and/or maleic anhydride in the presence of isomerase or an isomerase-producing microorganism (e.g. Alcaligenes faecalis IFO 12669), subsequently or simultaneously reacting at least a part of the isomerization reaction product with ammonia in the presence of aspartase or an aspartase-producing microorganism [e.g. Brevibacterium flavum MT-233 (FERM BP-1497)] in an aqueous solution, and subsequently treating the produced L-aspartic acid ammonium salt with an acid. Therein, the concentration of oxygen dissolved in the aqueous solution on the isomerization reaction is maintained to at least

5. 发明专利

JPH09163993A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH09163993A
公开(公告)日：1997-06-24
申请号：JP32707195
申请日：1995-12-15
申请人： MITSUBISHI CHEM CORP
发明人： MORI YOSHIAKI , KATO NAOKI , WATANABE NAOYUKI , FUJII SEIJI
IPC分类号： C12P13/20 , C07C227/40 , C07C229/24 , C12R1/05 , C12R1/13
摘要： PROBLEM TO BE SOLVED: To efficiently obtain L-aspartic acid useful as e.g. a food additive, medicine, by converting ammonium maleate into ammonium L-aspartate with an enzyme followed by distillation to effect removal of NH3 and then acid deposition with maleic acid and neutralization of NH3 with maleic acid, and by circulating the resultant mother liquor. SOLUTION: An aqueous solution of ammonium maleate as feedstock is first subjected to isomerization reaction through enzymatic treatment with aspartase or aspartase-productive microorganisms in the presence of ammonia to yield an aqueous solution of ammonium L-aspartate. Secondly, the aqueous solution of ammonium L-aspartate is distilled to effect NH3 removal to produce monoammonium L-aspartate, whose aqueous solution is then subjected to acid deposition by use of maleic acid and/or maleic anhydride to effect deposition of L-aspartic acid crystal. Thirdly, the resultant mother liquor containing monoammonium maleate after acid deposition is used as a feedstock, an ammonia-contg. gas discharged via the column top during the distillation is absorbed into an aqueous solution prepared by use of part of the acid deposition agent, and the resultant aqueous solution is also used as a feedstock together with the mother liquor after acid deposition, thus efficiently obtaining the objective L-aspartic acid.

6. 发明专利

JPH08205880A PRODUCTION OF L-ASPARTIC ACID 失效
公开(公告)号：JPH08205880A
公开(公告)日：1996-08-13
申请号：JP31083195
申请日：1995-11-29
申请人： MITSUBISHI CHEM CORP
发明人： KATO NAOKI , MORI YOSHIAKI , MITSUNE NORIOKI , WATANABE NAOYUKI
IPC分类号： C12P13/20
摘要： PURPOSE: To provide a well-balanced and industrially advantageous continuous production process for L-aspartic acid using maleic acid and/or maleic anhydride as raw material(s). CONSTITUTION: The objective L-aspartic acid is obtained through the following consecutive processes: process 1: an ammonium L-aspartate-contg. aqueous solution is obtained by enzymatic treatment of monoammonium maleate as starting material; process 2: the ammonia is removed by distillation (including stripping) from the above-mentioned aqueous solution; process 3: maleic acid and/or maleic anhydride is added to the aqueous sol-ution produced in the process 2 to crystallize L-aspartic acid to form a slurry; process 4: a solid-liquid separation is conducted to separate the above slurry into the L-aspartic acid crystal and a mother liquor; and process 5: the mother liquor is recycled to the process 1.

7. 发明专利

JPH08143505A PRODUCTION OF FUMARIC ACID 失效
公开(公告)号：JPH08143505A
公开(公告)日：1996-06-04
申请号：JP28091194
申请日：1994-11-15
申请人： MITSUBISHI CHEM CORP
发明人： MITSUNE NORIOKI , WATANABE NAOYUKI
IPC分类号： B01J31/26 , B01J31/30 , C07B61/00 , C07C51/353 , C07C57/15
摘要： PURPOSE: To profitably obtain fumaric acid in a good yield in a short time by isomerizing maleic acid in the presence of an alkaline compound in an aqueous solvent by using a thiourea compound and a Lewis acid as a main catalyst and an auxiliary catalyst, respectively. CONSTITUTION: The maleic acid is isomerized in an aqueous solvent to obtain the maleic acid. Therein, a thiourea compound and a Lewis acid are used as a main catalyst and an auxiliary catalyst, respectively. The thiourea compound is especially preferably a compound of the formula (R to R are H, acyl, alkyl, phenyl), e.g. thiourea, N-methylthiourea, and suitably used in an amount of 0.1-0.5 equivalent per equivalent of the maleic acid. The Lewis acid is a metal salt of formula: MXn (M is metal atom; X is halide, nitrate, sulfate, perchlorate, acetate, etc.; n is 1-4), e.g. ScCl3 , YCl3 , LaCl3 . The Lewis acid is used in an amount of 0.04-0.25 equivalent (converted into metal ions) per equivalent of the maleic acid. The alkali compound is sodium hydroxide, calcium hydroxide, etc.

8. 发明专利

JP2001064265A ALKYL HYDANTOINS 失效
公开(公告)号：JP2001064265A
公开(公告)日：2001-03-13
申请号：JP24089299
申请日：1999-08-27
申请人： MITSUBISHI CHEM CORP
发明人： TAKUMA YUUKI , WATANABE NAOYUKI , HARA MARI
IPC分类号： C07D233/74 , C07D233/96
摘要： PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an intermediate for effectively producing (L)-Boc-N-methyl-leucine and analogous compounds thereof and useful as a producing material for medical and agrochemical compounds. SOLUTION: This compound is represented by the formula (R1 is a 1-6C alkyl; R2 and R3 are each H or a 1-6C alkyl) e.g. 5-alkylidene-1-alkylhydantoin. The compound is obtained e.g. by reacting 1-substituted hydantoin with 0.8-1.5 molar times compound containing bromine (e.g. bromine or N- bromosuccinimide) in the presence of a solvent such as acetic acid at 70-120 deg.C to brominate 5-position of the hydantoin, then reacting the brominated product with 1-2 molar times phosphite based on the applied 1-substituted hydantoin and then reacting the resultant product with 1-5 molar times compound containing a carbonyl group (e.g. isobutly aldehyde) in a solvent e.g. ethanol in the presence of a base (e.g. triethylamine) at room temperature.

9. 发明专利

JP2000344754A PRODUCTION OF 5-(SUBSTITUTED BENZYL)HYDANTOIN 失效
公开(公告)号：JP2000344754A
公开(公告)日：2000-12-12
申请号：JP15609599
申请日：1999-06-03
申请人： MITSUBISHI CHEM CORP
发明人： TAKUMA YUUKI , WATANABE NAOYUKI
IPC分类号： C07D233/74 , B01J23/42 , B01J23/44 , B01J23/46 , C07B61/00 , C07D233/76 , C07D233/78
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic raw material of a medicine, an agrochemical, etc., in an efficient method excellent in selectivity by hydrogenating a substituted bezalhydantoin in the presence of a metal catalyst. SOLUTION: This 5-(substituted benzyl)hydantoin of formula II is obtained by hydrogenating a 5-(substituted benzal)hydantoin of formula I [R1, R2 are each H or an alkyl; X is a halogen, an alkyl or an alkoxy; (n) is 1-5], [e.g.; 5-(o-fluorobenzal)-1-methylhydantoin] in the presence of a catalyst consisting of at least one metal selected from platinum, rhodium, ruthenium, iridium or rhenium (e.g.; a loaded material obtained by loading the above mentioned metal on a carrier such as a carbon and alumina, such as a platinum on carbon, etc.). The reaction is preferably carried out by using 1-50 mole % catalyst based on the metal per 1 mole of the compound of the formula I in hydrogen atmosphere at around room temperature at atmospheric pressure to 2 Mpa.

10. 发明专利

JP2000159723A PRODUCTION OF FUMARIC ACID 失效
公开(公告)号：JP2000159723A
公开(公告)日：2000-06-13
申请号：JP27086599
申请日：1999-09-24
申请人： MITSUBISHI CHEM CORP
发明人： WATANABE NAOYUKI , KATO NAOKI
IPC分类号： B01J27/055 , B01J27/122 , B01J27/128 , B01J27/138 , C07B61/00 , C07C51/353 , C07C57/15
摘要： PROBLEM TO BE SOLVED: To obtain a fumaric acid in a high yield by isomerizing maleic acid in the presence of a catalyst system comprising the combination of a bromine- donating compound with a specific oxidizing agent and further in the coexistence of a specific auxiliary catalyst. SOLUTION: This method for producing fumaric acid comprises isomerizing maleic acid in the presence of (A) a water-soluble bromine-donating compound (for example, lithium bromide or N-bromosuccinic acid imide), (B) a compound (oxidizing agent) having a standard electrode potential of >=1 V [for example, ammonium cerium (IV) nitrate] and (C) an auxiliary catalyst comprising a metal salt containing a heavy metal, for example, a metal salt containing iron, copper or zinc, (e.g. CuCl2), preferably at 40-100 deg.C at a pressure of 0.2-1 kg/cm2. By the method, the conversion and the reaction rate are improved, and, even when the mother solution is reused, the lowering in the conversion of the maleic acid can be stopped.

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