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1. 发明专利

JPH0959247A ETHYLENIC COMPOUND CONTAINING ARGININE DERIVATIVE BONDED THERETO AND ITS PRODUCTION 失效
公开(公告)号：JPH0959247A
公开(公告)日：1997-03-04
申请号：JP21741295
申请日：1995-08-25
申请人： MITSUBISHI CHEM CORP
发明人： NOGUCHI HIROSHI , ISODA NAOMI
IPC分类号： A61L33/00 , C07C211/01 , C07C311/19 , C07C311/29 , C07C311/42
摘要： PROBLEM TO BE SOLVED: To produce the subject compound useful as a raw material for antithrombotic polymeric materials. SOLUTION: This ethylenic compound of formula I [A is NH or O; R is H or a 1-5C alkyl; R is a group of formula II (R is a 1-6C alkyl, a 2-7C alkoxyalkyl, etc.; R is a 1-3C alkylene), etc.; R is formula III [R and R are each independently H, a 1-4C alkoxy, a 1-4C alkylamino or a 1-4C dialkylamino; R is H or a 1-4C alkyl; (m) is an integer of 0-18; (n) is 3 or 4] containing an arginine derivative bonded thereto, e.g. a compound of formula IV. The compound of formula I is obtained by reacting, e.g. the arginine derivative having one carboxyl group and antithrombin activities with an ethylenic compound having amino or hydroxyl group.

2. 发明专利

JPH083432A POLYLACTIC ACID RESIN COMPOSITION 失效
公开(公告)号：JPH083432A
公开(公告)日：1996-01-09
申请号：JP13902394
申请日：1994-06-21
申请人： MITSUBISHI CHEM CORP
发明人： NOGUCHI HIROSHI , KASAI ATSUSHI , OTA TAKAYUKI , MIYAZAKI KEIKO , ISHII YUKIKO
IPC分类号： C08K3/34 , C08K3/38 , C08L67/00 , C08L67/04 , C08L101/16
摘要： PURPOSE:To obtain a polylactic acid resin composition which is biodegradable and excellent in moldability with a high rate of crystallization and has satisfac tory mechanical properties. CONSTITUTION:This composition has a number-average molecular weight of 10,000 to 100,000 and contains 0.5-5wt.% inorganic particles comprising talc having a mean particle diameter of 5mum or smaller and/or boron nitride having a mean particle diameter of 30mum or smaller.

3. 发明专利

JP2003206338A FILM COMPRISING ALIPHATIC POLYESTER COPOLYMER 审中-公开
公开(公告)号：JP2003206338A
公开(公告)日：2003-07-22
申请号：JP2002374758
申请日：2002-12-25
申请人： MITSUBISHI CHEM CORP
发明人： MIYAZAKI KEIKO , NOGUCHI HIROSHI , KASAI ATSUSHI , OTA TAKAYUKI , YAMAOKA HIROAKI
IPC分类号： C08J5/18 , C08G63/60 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a film comprising an aliphatic polyester which has biodegradability, and is excellent in a heat stability, tensile strengths, and the like. SOLUTION: The film comprises an aliphatic polyester copolymer comprising 0.02-30 mol% of an aliphatic oxycarboxylic acid unit represented by the formula (I): -O-R 1 -CO- (wherein R 1 is a divalent aliphatic hydrocarbon group), 35-49.99 mol% of an aliphatic or an alicyclic diol unit represented by the formula (II): -O-R 2 -O (wherein R 2 is a divalent aliphatic hydrocarbon group or a divalent alicyclic hydrocarbon group), and 35-49.99 mol% of an aliphatic dicarboxylic and unit represented by the formula (III): -OC-R 3 -CO- (wherein R 3 is a direct bond or a divalent aliphatic hydrocarbon group), the copolymer has a number- average molecular weight of 10,000-200,000. COPYRIGHT: (C)2003,JPO

4. 发明专利

JPH08259679A PRODUCTION OF ALIPHATIC POLYESTER COPOLYMER 失效
公开(公告)号：JPH08259679A
公开(公告)日：1996-10-08
申请号：JP6987595
申请日：1995-03-28
申请人： MITSUBISHI CHEM CORP
发明人： MIYAZAKI KEIKO , KASAI ATSUSHI , YAMAOKA HIROAKI , NOGUCHI HIROSHI
IPC分类号： C08G63/60 , C08G63/86
摘要： PURPOSE: To readily obtain an aliphatic polyester copolymer of a high molecular weight in high polymerization rate, having both of excellent physical properties and optimal melt viscosity by allowing a specific acid component to react with a diol component together with a difunctional hydroxy-carboxylic acid. CONSTITUTION: In the presence of (A) a difunctional hydroxy-carboxylic acid of the formula (n

5. 发明专利

JPH083296A ALIPHATIC POLYESTER COPOLYMER AND ITS PRODUCTION 失效
公开(公告)号：JPH083296A
公开(公告)日：1996-01-09
申请号：JP14024194
申请日：1994-06-22
申请人： MITSUBISHI CHEM CORP
发明人： NOGUCHI HIROSHI , KASAI ATSUSHI , OTA TAKAYUKI , MIYAZAKI KEIKO , ISHII YUKIKO
IPC分类号： C08G63/06 , C08G63/02 , C08G63/60 , C08G63/78 , C08G63/82 , C08L67/00 , C08L101/16
摘要： PURPOSE:To obtain a high-molecular-weight biodegradable aliphatic polyester copolymer having excellent mechanical strengths by polycondensing an aliphatic hydroxy acid with an aliphatic diol and an aliphatic dicarboxylic acid in a specified ratio. CONSTITUTION:This copolymer mainly consists of 98-70mol% aliphatic hydroxycarboxylic acid units (O-R -CO (wherein R is a bivalent aliphatic hydrocarbon group)), 1-15mol% aliphatic diol units [O-R -O (wherein R is a bivalent aliphatic hydrocarbon group] and 1-15mol% aliphatic dicarboxylic acid units [OC-R -CO](wherein R is a direct bond or a bivalent aliphatic hydrocarbon group)] and has a number-average molecular weight of 10000-150000. It is desirable that this copolymer is produced by directly polycondensing lactic acid with an aliphatic diol and an aliphatic dicarboxylic acid in the presence of a germanium compound or titanium compound as the catalyst.

6. 发明专利

JPH083262A COPOLYMER OF POLYURETHANE WITH ALIPHATIC POLYESTER AND ITS PREPARATION 失效
公开(公告)号：JPH083262A
公开(公告)日：1996-01-09
申请号：JP14446994
申请日：1994-06-27
申请人： MITSUBISHI CHEM CORP
发明人： KASAI ATSUSHI , OTA TAKAYUKI , NOGUCHI HIROSHI , MIYAZAKI KEIKO , ISHII YUKIKO
IPC分类号： C08G63/685 , C08G18/42 , C08G63/91
摘要： PURPOSE:To prepare the subject copolymer which has a high m.p. and possesses excellent heat resistance, high modulus of elasticity, breaking strength and breaking extension and excellent mechanical properties by copolymerizing a polyurethane, comprising a polyester polyol and an aliph. polyisocyanate, with an aliph. polyester. CONSTITUTION:A copolymer comprising two constituent units, i.e., (A) 4 to 90wt.% polyurethane unit comprising a polyester polyol having a no. average mol.wt. of 500 to 4000 and an aliph. polyisocyanate and (B) 96 to 10wt.% aliph. polyester unit having a no. average mol.wt. of 1000 to 300000. This copolymer is a polyurethane/aliph. polyester copolymer having a no. average mol.wt. of 3000 to 1000000. The reaction is carried out under a dry nitrogen atmosphere at room temp. to 120 deg.C for 1 to 20hr. If necessary, a catalyst, such as an amine compd. or a tin compd., may be added thereto in order to promote the reaction. After the completion of the reaction, the copolymer soln. is poured into a poor solvent, such as methanol, ethanol, or acetone, to re-precipitate the resultant copolymer.

7. 发明专利

JPH07238067A ETHYLENIC COMPOUND CONTAINING ARGININE DERIVATIVE BOUND THERETO AND ITS PRODUCTION 失效
公开(公告)号：JPH07238067A
公开(公告)日：1995-09-12
申请号：JP2980794
申请日：1994-02-28
申请人： MITSUBISHI CHEM CORP
发明人： NOGUCHI HIROSHI , OTA TAKAYUKI , KASAI ATSUSHI , ISHII YUKIKO
IPC分类号： C07D307/14 , C07C303/40 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D401/12 , C08F16/14 , C08F18/02 , C08F20/38 , C08F20/52 , C08F20/60
摘要： PURPOSE:To obtain a new ethylenic compound, excellent in heat resistance and useful as a raw material, etc., for antithrombotic polymeric materials and bound to an arginine derivative. CONSTITUTION:This compound is expressed by formula I {A is an optional bond; R is H or a 1-5C alkyl; R is expressed by formula II [R is a (substituted)1-6C alkyl, a 2-7C alkoxyalkyl, etc.; R is a 1-3C alkylenel, etc.; R is expressed by formula III (R and R each is H, a 1-4C alkoxy, a 1-4C alkylamino, etc.), etc.; (n) is 0 or 1; (m) is 1-10; (l) is 3 or 4), e.g. a compound expressed by formula IV. Furthermore, the compound expressed by formula I is obtained by reacting an arginine derivative expressed by formula V with a compound expressed by formula VI.

8. 发明专利

JPH10265448A PURIFICATION OF 2CYANOACRYLATE 失效
公开(公告)号：JPH10265448A
公开(公告)日：1998-10-06
申请号：JP7121297
申请日：1997-03-25
申请人： MITSUBISHI CHEM CORP
发明人： OTA TAKAYUKI , NOGUCHI HIROSHI
IPC分类号： C07C253/34 , C07C255/23 , C09J4/04
摘要： PROBLEM TO BE SOLVED: To efficiently obtain the subject compound useful for medical adhesives, etc., by treating impurities such as reaction materials used in a synthetic process and the resultant by-products by separation, etc., using a specific organic solvent. SOLUTION: A saturated hydrocarbon organic solvent having 6.5-8.5 solubility parameter, e.g. C5 H12 or C6 H14 , using usually in an amount of 1-20 pts.wt., preferably 2-5 pts.wt. based on 1 pt.wt. crude compound of a compound represented by the formula CH2 = C(CN)COOR (R is an 8-20C hydrocarbon group) is added to the crude compound and both components are sufficiently stirred and as necessary, the mixture is allowed to stand for about 10-200 min under ice-chilled conditions to sufficiently subject the reaction product to phase separation. The separated undissolved material is preparedly distilled under reduced pressure at a low temperature to provide 2-cyanoacrylate in high purity. The compound of the formula is obtained by reacting isobutly cyanoacrylate with anthracene, hydrolyzing the reaction product under basic conditions, acidifying the reaction solution to afford 2-cyanoacrylic acid, then, changing the 2- cyanoacrylic acid to corresponding acid chloride, reacting the acid chloride with an alcohol and reacting the reaction product with a stroingly acidic dienophile.

9. 发明专利

JPH09302039A SUSTAINED-RELEASE ANTITHROMBOTIC COPOLYMER 失效
公开(公告)号：JPH09302039A
公开(公告)日：1997-11-25
申请号：JP11472996
申请日：1996-05-09
申请人： MITSUBISHI CHEM CORP
发明人： IKADA YOSHITO , IWATA HIROO , NOGUCHI HIROSHI
IPC分类号： A61L33/00 , C08F16/14 , C08F20/52 , C08F216/12 , C08F220/00 , C08F220/56 , C08F220/60
摘要： PROBLEM TO BE SOLVED: To obtain an antithrombotic material or antithrombotic agent having a longer duration of antithrombotic effect by copolymerizing a specified ethylenic compound with a water-soluble compound. SOLUTION: An ethylenic compound represented by formula I [wherein A is an arbitrary bond; R is H or a 1-5C alkyl; R is formula II (wherein R is a 1-6C alkyl, a 2-7C alkoxyalkyl or tetrahydrofurfuryl; and R is a 1-3C alkylene), formula III (wherein R is H or a 1-4C alkyl); R is formula IV (wherein R and R are each H, a 1-4C alkoxyl, a 1-4C alkylanino or a 1-4C dialkylamino; formula V (wherein R is H or a 1-4C alkyl; m is 0-18; n is 0 or 1; and p is 3 or 4) is copolymerized with a water-soluble compound represented by formula VI (wherein R to R are each H or a 1-4C alkyl) to obtain a sustained-release antithrombotic copolymer which sustainedly releases formula VII (wherein R and R and p are as defined in formula I) upon hydrolysis. When this compound is stored in the form of an aqueous solution, arginine derivatives resulting from the hydrolysis of ester bonds are sustainedly released from the copolymer.

10. 发明专利

JPH0959319A POLYMER COMPRISING ETHYLENIC COMPOUND AND ANTITHROMBOTIC MATERIAL HAVING THE SAME POLYMER 失效
公开(公告)号：JPH0959319A
公开(公告)日：1997-03-04
申请号：JP21741695
申请日：1995-08-25
申请人： MITSUBISHI CHEM CORP
发明人： NOGUCHI HIROSHI , ISODA NAOMI
IPC分类号： A61L33/00 , C08F10/02 , C08F210/00
摘要： PROBLEM TO BE SOLVED: To obtain a polymer, having a prescribed number average molecular weight, excellent in antithrombotic properties and suitable as an antithrombotic material such as an artificial vessel or an artificial heart by polymerizing a specific ethylenic compound. SOLUTION: This polymer is obtained by polymerizing an ethylenic compound of formula I [A is an optional bond; B is NH or O; R is H or a 1-5C alkyl; R is formula II (R is a 1-6C alkyl, a 2-7C alkoxyalkyl, etc.; R is a 1-3C alkylene) etc.; R is formula III (R and R are each H, a 1-4C alkoxy or a 1-4C alkylamino, etc.), etc.] such as a compound of formula IV and has 2000-1000000 number-average molecular weight. Furthermore, a surface is coated with the polymer to afford the antithrombotic material.

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