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1. 发明专利

JP2012077032A Oral composition 审中-公开
标题翻译：口腔组成
公开(公告)号：JP2012077032A
公开(公告)日：2012-04-19
申请号：JP2010223967
申请日：2010-10-01
申请人： Lion Corp , ライオン株式会社
发明人： ISHIGURO KEIJI
IPC分类号： A61K8/41 , A61K8/33 , A61K8/34 , A61K8/49 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide an oral composition exhibiting high antiseptic effect on oral bacteria, having no bitter taste but good refreshing taste, hardly irritating a tongue, and giving excellent sense of use.SOLUTION: The oral composition includes: (A) a cationic antiseptic; (B) l-menthol; (C) chlorobutanol; and (D) anethole.
摘要翻译：要解决的问题：为了提供对口腔细菌具有高消毒作用的口服组合物，没有苦味，但是具有良好的清爽口感，几乎不刺激舌头，并且具有优异的使用感。口服组合物包括：（A）阳离子防腐剂; （B）l-薄荷醇; （C）氯丁醇; 和（D）anethole。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011051955A Dentifrice composition 有权
标题翻译： DENTIFRICE组成
公开(公告)号：JP2011051955A
公开(公告)日：2011-03-17
申请号：JP2009204362
申请日：2009-09-04
申请人： Lion Corp , ライオン株式会社
发明人： ISHIGURO KEIJI
IPC分类号： A61K8/365 , A61K8/73 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a dentifrice composition that has a convergence feeling derived from an organic acid or its salt and good moldability and is free from liquid separation after storage of a long period, less sticky and excellent in usability.
SOLUTION: The dentifrice composition is characterized by including (A) an organic acid selected from gluconic acid, malic acid, tartaric acid and phytic acid and/or its salt, (B) xanthan gum, and (C) carboxymethylcellulose sodium, wherein the mass ratio of (B)/(A) is 0.3-2.0; the mass ratio of (C)/(B) is 0.2-5.0; and the pH at 25°C is 5.5-6.5. The dentifrice composition has a convergence feeling derived from an organic acid or its salt and good moldability, and is almost free from liquid separation after storage of a long period and less sticky. The dentifrice composition has a moderate convergence feeling suitable from the standpoints of matching with a flavor added to the dentifrice composition and giving a functional feeling and can be converted to a preparation making the best use of the convergence feeling.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有从有机酸或其盐衍生的收敛感和良好的成型性的洁牙剂组合物，并且在长时间保存后不会发生液体分离，粘度低，使用性优异。（A）选自葡萄糖酸，苹果酸，酒石酸和植酸和/或其盐的有机酸，（B）黄原胶和（C）羧甲基纤维素钠，（B）/（A）的质量比为0.3〜2.0; （C）/（B）的质量比为0.2-5.0; 25℃下的pH为5.5-6.5。洁齿剂组合物具有从有机酸或其盐衍生的收敛感和良好的成型性，并且在长时间储存和较少粘稠之后几乎没有液体分离。洁齿剂组合物具有适度的融合感，从与添加到洁齿剂组合物中的风味匹配的观点来看，具有功能感，并且可以转化为最佳利用收敛感的制剂。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2010150155A Composition for oral cavity 有权
标题翻译：口腔组成
公开(公告)号：JP2010150155A
公开(公告)日：2010-07-08
申请号：JP2008327815
申请日：2008-12-24
申请人： Lion Corp , ライオン株式会社
发明人： ARAI MASAHITO , HIRASAWA AYAKA , UNO DAISUKE , ISHIGURO KEIJI
IPC分类号： A61K8/35 , A61K8/34 , A61K8/44 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a hinokitiol-containing composition for oral cavity, which is excellent in stability of hinokitiol in a preparation, exerts high antibacterial activity and suppresses discoloration or phase separation during long-term storage and is thus excellent in shelf stability. SOLUTION: The composition for oral cavity comprises: (a) hinokitiol; (b) at least one edetate chosen from disodium edetate, trisodium edetate, dipotassium edetate dihydrate and tetrasodium edetate dihydrate; (c) ethanol; and (d) water, provided that the contents of component (b) and component (c) are 0.02-1 mass% and 0.2-10 mass%, respectively, and the mass ratio of (d)/(c) is 3-200. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供在制剂中桧醇的稳定性优异的用于口腔的含桧醇的组合物，在长期保存中具有高抗菌活性和抑制变色或相分离，因此优异货架稳定。解决方案：口腔用组合物包含：（a）桧醇; （b）至少一种选自乙二胺四乙酸二钠，依地酸三钠，依地酸二钾二水合物和依地酸四钠二水合物的乙二胺四乙酸盐; （c）乙醇; 和（d）水，条件是组分（b）和组分（c）的含量分别为0.02-1质量％和0.2-10质量％，质量比（d）/（c）为3- 200。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2007001954A TOOTHPASTE COMPOSITION 审中-公开
公开(公告)号：JP2007001954A
公开(公告)日：2007-01-11
申请号：JP2005186263
申请日：2005-06-27
申请人： LION CORP
发明人： SHIMIZU HIROYUKI , ISHIGURO KEIJI
IPC分类号： A61K8/00 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a toothpaste composition which is excellent in anti-dryness at the mouth part of a filled tube, has no sticky feeling in use, and further, can realize good shelf life stability (causing no liquid separation). SOLUTION: The tooth paste composition contains the following components; water (A), a wetting agent (B), a caking agent (C), and a trimethylglicine (D); wherein the mass ratio of the component (A)/component (B) is 1.2-4. COPYRIGHT: (C)2007,JPO&INPIT

5. 发明专利

JP2000290200A MEDICINAL COMPOSITION 失效
公开(公告)号：JP2000290200A
公开(公告)日：2000-10-17
申请号：JP9695499
申请日：1999-04-02
申请人： LION CORP
发明人： ISHIGURO KEIJI , ONIKI TAKAYUKI
IPC分类号： A61K9/08 , A61K8/00 , A61K8/72 , A61K31/00 , A61K47/32 , A61P1/00 , A61P1/02 , A61Q11/00 , A61K7/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To obtain an aqueous medicinal composition which possesses a specific range of gel transition temperature T, shows a liquid state at a temperature lower than T and a gel state at a temperature of T or above and exerts improved medicine retentivity in the diseased part by including a gel formable substance. SOLUTION: By including a gel formable substance (e.g. a polyvinylacetal diethylaminoacetate or the like), the aqueous medicinal composition which possesses gel transition temperature T (G) in a range of 5-40 deg.C and shows a liquid state at a temperature lower than the above T (G) and a gel state at a temperature of T (G) or above is obtained. The above gel formable substance is included in an amount capable of controlling the temperature T (G) in the above temperature range, preferably at 10-37 deg.C. For example, in the case of a polyvinyl acetal diethylamino-acetate, it is included in a proportion of 0.1-15 wt.%, preferably 0.1-15 wt.%, based on the composition. As the medicinal composition, the composition for oral cavity (particularly a peridontal disease therapeutic agent, a hyperesthesia therapeutic agent or a dental calculus suppressive agent) is preferably illustrated.

6. 发明专利

JP2000226398A CLEAVAGE OF NUCLEIC ACID AND CONTROLLING AGENT FOR VIRUS OR BACTERIUM 失效
公开(公告)号：JP2000226398A
公开(公告)日：2000-08-15
申请号：JP2635799
申请日：1999-02-03
申请人： LION CORP
发明人： ISHIGURO KEIJI , FUKUDA ICHIRO , ONIKI TAKAYUKI , SHIMOTSUURA ISAO
IPC分类号： C07H21/00 , A01N25/00 , A01N59/20 , A61K31/00 , A61K31/047 , A61K31/05 , A61K31/375 , A61K45/00 , A61P31/00
摘要： PROBLEM TO BE SOLVED: To provide a method for cleaving a nucleic acid extremely effective in controlling viruses or bacteria, capable of manifesting powerfully inhibiting actions on infection with viruses even in a small dose and having a strong germicidal power even for the bacteria by which the nucleic acid which is an object of cleavage can moderately and surely be cleaved, and to obtain a controlling agent for the viruses or bacteria capable of imparting cleaving effects. SOLUTION: This method is to cleave a nucleic acid by actions of radicals chemically generated from a radical former and the radicals have a smaller peak area obtained when measuring the radicals by an electron spin resonance method (ESR) than that obtained when measuring a mixture of a 0.1 mM hydrogen peroxide with 0.05 mM copper chloride by the ESR. The nucleic acid of especially infected viruses or bacteria can moderately and surely be cleaved without adversely affecting biological cells of an animal or a plant which is a host by a cleaving power of feeble radicals chemically generated from the radical former for the nucleic acid.

7. 发明专利

JP2000189060A STAIN-REMOVING GUM COMPOSITION 失效
公开(公告)号：JP2000189060A
公开(公告)日：2000-07-11
申请号：JP37128398
申请日：1998-12-25
申请人： LION CORP
发明人： ONIKI TAKAYUKI , ISHIGURO KEIJI
IPC分类号： A23G4/00 , A61K8/00 , A61K8/18 , A61K8/33 , A61K8/65 , A61Q11/00 , A23G3/30 , A61K7/20
摘要： PROBLEM TO BE SOLVED: To obtain a stain-removing gum composition having excellent cleaning power against stain in the oral cavity, especially stain such as tea-incrustations and capable of conveniently performing cleaning at any place by adding the main base material consisting of a complex of a gelatin and a polyphenol with an abrasive. SOLUTION: This composition is composed of (A) the main base material consisting of a complex of a gelatin obtained by decomposing collagen followed by purification and a polyphenol such as gallic acid (ester) and (B) an abrasive (an average particle size is preferably 0.1-100 μm) such as precipitated silica. Further, it is preferable that the amount of the polyphenol compound to be added is 1/5 to 1/1 the net weight of the gelatin, and the amount of the abrasive is 1/10 to 1/1 the net weight of the gelatin.

8. 发明专利

JP2000178153A COMPOSITION FOR ORAL CAVITY 失效
公开(公告)号：JP2000178153A
公开(公告)日：2000-06-27
申请号：JP35350298
申请日：1998-12-11
申请人： LION CORP
发明人： ISHIGURO KEIJI , ONIKI TAKAYUKI
IPC分类号： A61K8/18 , A61K8/00 , A61K8/37 , A61K8/60 , A61K8/72 , A61K8/73 , A61K8/86 , A61K8/90 , A61Q11/00 , A61K7/16 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a composition containing methyl cellulose, used for oral cavities, and scarcely changing the viscosity with the passage of time. SOLUTION: This composition for oral cavities contains methyl cellulose. Therein, (i) polyoxyethylene-cured caster oil and/or (ii) polyoxyethylene/ polyoxypropylene copolymer are added. The polyoxyethylene/polyoxypropylene copolymer used therein is a block copolymer comprising a polyoxyethylene portion A and a polyoxypropylene portion B. The polyoxyethylene portion A is contained in the 60-90 wt.%, preferably 70-85 wt.%, in the molecule, and the polyoxypropylene portion B has a mol.wt. of 2,000-4,500, preferably 2,500-4,000.

9. 发明专利

JP2000178151A COMPOSITION FOR ORAL CAVITY 失效
公开(公告)号：JP2000178151A
公开(公告)日：2000-06-27
申请号：JP35343398
申请日：1998-12-11
申请人： LION CORP
发明人： ISHIGURO KEIJI , ONIKI TAKAYUKI
IPC分类号： A61K8/00 , A61K8/20 , A61K8/23 , A61K8/73 , A61Q11/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To provide a composition containing a salt, used for oral cavities, and improving a bad aftertaste on its use. SOLUTION: This composition for oral cavities contains one or more salts selected from sodium sulfate, magnesium chloride, sodium chloride, and potassium chloride. Therein, at least one cellulosic polymer selected from hydroxyethylmethylcellulose, hydroxypropylmethylcellulose and ethylhydroxyethylcellulose is added to the composition.

10. 发明专利

JP2000169351A COMPOSITION FOR ORAL CAVITY 失效
公开(公告)号：JP2000169351A
公开(公告)日：2000-06-20
申请号：JP36853098
申请日：1998-12-09
申请人： LION CORP
发明人： ISHIGURO KEIJI , ONIKI TAKAYUKI
IPC分类号： A61K8/00 , A61K8/34 , A61K8/86 , A61Q11/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To obtain an oral cavity composition having a reduced bitter taste by adding a polyoxyethylenepolyoxypropylene copolymer to a pentylene glycol or an octylene glycol. SOLUTION: This composition for oral cavities contains (A) a pentylene glycol (for example, 1,2-pentylene glycol) or (B) an octylene glycol (for example, 1,2-octylene glycol). Therein, (C) a polyoxyethylenepolyoxypropylene copolymer, preferably the copolymer wherein the ethylene oxide units are contained in an amount of >=50% based on the total polymer and wherein the mol.wt. of the polypropylene glycol unit is >=1,400 [for example, Pluronic (trade name)] is added to the composition. The component A or B and the component C are preferably added in amounts of 0.01-40 wt. and 0.01-50 wt., respectively. The composition may further be mixed with usually used amounts of conventional components, such as an abrasive, a binder, a thickener and a surfactant.

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