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1. 发明专利

JP2009294078A Microinspection chip, dividing and quantifying liquid sending method thereof and inspection device 审中-公开
标题翻译：微型检验芯片，分流和定量液体发送方法及检测装置
公开(公告)号：JP2009294078A
公开(公告)日：2009-12-17
申请号：JP2008147834
申请日：2008-06-05
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , MORI TAKAHIRO , AOKI YOICHI , NAKAJIMA AKIHISA
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microinspection chip for accurately dividing and quantifying a liquid such as a specimen or a reagent at each flow channel, for further individually and independently sending the respective divided and quantified liquids and also having the degree of freedom of the arrangement of the flow channel, a dividing and quantifying liquid sending method of the microinspection chip and an inspection device.
SOLUTION: The liquid stored in a liquid storage part is sent to a plurality of liquid quantifying parts through a branch part and a plurality of branched flow channels to fill a plurality of the liquid quantifying parts and held to be divided and quantified. Thereafter, a high flow channel resistor high in viscosity is injected in the branch part to increase the flow channel resistance value between the liquid storage part and a plurality of the branched flow channels, so that the liquid held to a plurality of the liquid quantifying parts is sent in a downstream direction. By this constitution, the liquid such as the specimen or the reagent is accurately divided and quantified and the respective divided and quantified liquids are further individually and independently sent. The degree of freedom of the arrangement of the flow channels is also enhanced. The dividing and quantifying liquid sending method of the microinspection chip and the inspection device is provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在每个流动通道处准确地分离和定量诸如样品或试剂之类的液体的微检测芯片，用于进一步单独和独立地发送相应的分开和定量的液体，并且还具有流路布置的自由度，微检测芯片的分流定量送液方法和检查装置。解决方案：储存在液体储存部分中的液体通过分支部分和多个分支流动通道被输送到多个液体定量部件，以填充多个液体量化部件并保持分割和量化。此后，在分支部分注入高粘度的高流动通道电阻，以增加液体储存部分和多个分支流动通道之间的流动通道电阻值，使得保持在多个液体量化部件沿下游方向发送。通过这种结构，准确地划分和定量诸如试样或试剂的液体，并且进一步单独和独立地发送各个分开和定量的液体。流量通道的排列自由度也得到提高。提供了微检测芯片和检测装置的分流定量送液方法。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009229262A Microchip 审中-公开
标题翻译： MICROCHIP
公开(公告)号：JP2009229262A
公开(公告)日：2009-10-08
申请号：JP2008075503
申请日：2008-03-24
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , SANTO YASUHIRO , AOKI YOICHI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip for searching the characteristics of a specimen while preventing a gas from getting mixed in a mixing part, with the gas used for separating a reagent from the specimen so as to prevent them from getting mixed with each other in the middle of a flow path.
SOLUTION: Assuming that V1 is the volume of the gas used for separating the reagent from the specimen, S1 a cross section of the mixing part for mixing the reagent with the specimen, with the cross section viewed from a flow-path direction of the mixing part, W1 the width of the flow path, and V2 the total volume of the reagent and the specimen, if the following relations hold, (2/π)×S1×W1 >V1 and (2/π)×S1×W1 >V2, then the gas is trapped on a wall surface of the flow path in the mixing part. Accordingly, the reagent and the specimen can be forwarded to a next process while outrunning a gas bubble, allowing the characteristics of the specimen to be investigated.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在防止气体混合在混合部分中的试样的特性的微芯片中，与用于从试样分离试剂的气体，以防止它们混合彼此在流路的中间。
解决方案：假设V1是用于从试样中分离试剂的气体的体积，S1是用于将试剂与样品混合的混合部分的横截面，从流路方向看截面（2 /π）×S1×W1> V1和（2 /π）×S1的混合部分的宽度，W1是流路的宽度，V2是试剂和试样的总体积 ×W1> V2，则气体被捕获在混合部中的流路的壁面上。因此，试剂和样品可以在超出气泡的同时转到下一个过程，从而允许研究试样的特性。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009168761A Analyte pretreatment apparatus 审中-公开
标题翻译：分析预处理设备
公开(公告)号：JP2009168761A
公开(公告)日：2009-07-30
申请号：JP2008009932
申请日：2008-01-19
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/02 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an analyte pretreatment apparatus capable of securing the safety of an operator and reducing the risk of contamination by easily, surely and inexpensively sealing an injection port of a micro inspection chip after injecting a pretreated analyte.
SOLUTION: The analyte pretreatment apparatus includes a sealing mechanism for sealing the injection port of the micro inspection chip into which the pretreated analyte is injected, with a sealing member. The injection port of the micro inspection chip after injecting the pretreated analyte can thereby be easily, surely and inexpensively sealed to secure the safety of the operator and to reduce the risk of contamination.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种分析物预处理装置，其能够在注入预处理的分析物之后容易地，可靠和廉价地密封微检查芯片的注入口，从而确保操作者的安全性并降低污染的风险。解决方案：分析物预处理装置包括密封机构，用于密封经预处理的分析物注入到其中的微检查芯片的注射口与密封构件。因此，在注入预处理的分析物之后，微检查芯片的注入口因此可以容易且可靠且廉价地密封以确保操作者的安全性并降低污染的风险。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009145256A Microchip and microchip analyzing system 审中-公开
标题翻译： MICROCHIP和MICROCHIP分析系统
公开(公告)号：JP2009145256A
公开(公告)日：2009-07-02
申请号：JP2007324468
申请日：2007-12-17
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , SANTO YASUHIRO , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/02 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To realize a microchip capable of bringing a plurality of kinds of liquids to flow into each other and then branching them at a prescribed mixture ratio, even if the length of its mixing channel is short. SOLUTION: The microchip includes: a first inflow channel 101 for bringing first liquid to flow into a confluence section JC; a second inflow channel 102 and a third inflow channel 103 for bringing second liquid different from the first liquid to flow into the confluence section from an area being in the same plane as and on both the sides of the first inflow channel; an intermediate channel 110 for feeding the first liquid and the second liquid from the confluence section JC to a branch section SP, in the state of a laminar flow; a first outflow channel 111 for branching the confluent liquid of the first liquid and the second liquid fed from the second inflow channel 102 from the branch section SP, while keeping the laminar flow state from the confluence section JC; and a second outflow channel 112 for branching the confluent liquid of the first liquid and the second liquid fed from the third inflow channel 103 from the branch section SP, while keeping the laminar flow state. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了实现能够使多种液体彼此流动然后以规定的混合比分支的微芯片，即使其混合通道的长度短。解决方案：微芯片包括：用于使第一液体流入汇合部分JC的第一流入通道101; 第二流入通道102和第三流入通道103，用于使与第一液体不同的第二液体从与第一流入通道的两侧位于同一平面的区域流入汇合部; 中间通道110，用于以层流的状态将第一液体和第二液体从汇流部分JC供给到分支部分SP; 第一流出通道111，用于分支第一液体的汇合液体和从分支部分SP从第二流入通道102供给的第二液体，同时保持来自汇合部分JC的层流状态; 以及第二流出通道112，用于在保持层流状态的同时从分支部分SP分支第一液体和从第三流入通道103供给的第二液体的汇合液体。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009115732A Micro-inspection chip, method for micro-inspection chip to determine quantity of a liquid, and inspection method 审中-公开
标题翻译：微检查芯片，用于微检查芯片的方法来确定液体的数量和检查方法
公开(公告)号：JP2009115732A
公开(公告)日：2009-05-28
申请号：JP2007291649
申请日：2007-11-09
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , SANTO YASUHIRO , AOKI YOICHI
IPC分类号： G01N35/08 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a micro-inspection chip capable of accurately determining the quantity of an analyte, a reagent, or the like by simple operation with a minimum of waste of the analyte, the reagent, or the like, a method for a micro-inspection chip to determine the quantity of a liquid, and an inspection method. SOLUTION: Into a liquid storage unit communicating with a liquid inlet communicating with an air outlet via a branch pipe, a liquid is poured via the liquid inlet, and the liquid is transported after the liquid storage unit has been filled completely with the liquid and the branch pipe has been filled half-full with the liquid. This makes it possible to provide a micro-inspection chip capable of accurately determining the quantity of an analyte, a reagent, or the like by simple action with a minimum of waste of the analyte, the reagent, or the like. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供能够通过简单的操作以最少的分析物，试剂等的浪费精确地确定分析物，试剂等的量的微检查芯片，用于确定液体量的微检查芯片的方法和检查方法。解决方案：通过支管与与出气口连通的液体入口连通的液体存储单元，通过液体入口注入液体，并且在液体储存单元已经被完全填充之后输送液体液体和分支管已用液体填满半满。这使得可以提供能够通过简单的动作精确地确定分析物，试剂等的量的微检查芯片，同时以最少的分析物，试剂等的浪费。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009063474A Microchip 审中-公开
标题翻译： MICROCHIP
公开(公告)号：JP2009063474A
公开(公告)日：2009-03-26
申请号：JP2007232430
申请日：2007-09-07
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI , SANTO YASUHIRO
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip for injecting and mixing a reagent with an analyte into reaction and capable of injecting reagents without leaks.
SOLUTION: The microchip includes both a reservoir part for storing an injected reagent and having an opening part in its upper surface and a fine channel for transferring a reagent from the reservoir part, mixes the reagent transferred through the fine channel with an analyte into reaction in a reaction part, detects the state of reaction, and analyzes target substances in the analyte. The reservoir part 16 for the injection of analytes is higher and wider than the fine channel 15b communicating with it.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于将试剂与分析物一起注入和混合成反应并能够注射试剂而不泄漏的微芯片。解决方案：微芯片包括用于存储注入的试剂并在其上表面具有开口部分的储存部分和用于从储存部分转移试剂的精细通道，将通过精细通道转移的试剂与分析物混合在反应部分进行反应，检测反应状态，并分析分析物中的目标物质。用于注入分析物的储存器部分16比与其通信的细通道15b更高和更宽。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2009019890A Micro inspection chip and inspection device 审中-公开
标题翻译：微检查芯片和检查设备
公开(公告)号：JP2009019890A
公开(公告)日：2009-01-29
申请号：JP2007180743
申请日：2007-07-10
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： SANTO YASUHIRO , HIGASHINO KUSUNOKI , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01N35/08 , B81B1/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a micro inspection chip and an inspection device capable of preventing channel air bleeding from becoming disabled, caused by blocking an air bleeding high-resistance channel by leakage liquid of a reagent, preventing bubbles from being interposed between driving liquid and the reagent, and stably sending the reagent.
SOLUTION: By having an upstream-side interface of the reagent stored in a reagent storage part come into contact with an upstream-side water-repellent valve, and a downstream-side interface into contact with the air inside the reagent storage part, since the reagent will not leak to the upstream side, the micro inspection chip and the inspection device can be provided, capable of preventing channel air bleeding from becoming disabled caused by blocking the air bleeding high-resistance channel by leakage liquid of the reagent, preventing bubbles from being interposed between the driving liquid and the reagent, and stably sending the reagent.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种微检查芯片和能够防止通道空气渗出变得无效的检查装置，其通过试剂的泄漏液阻塞排气高阻通道而引起，防止气泡被插入驱动液和试剂之间，稳定地送出试剂。解决方案：通过将存储在试剂储存部件中的试剂的上游侧界面与上游侧防水阀接触，并且将下游侧界面与试剂储存部内的空气接触由于试剂不会向上游侧泄漏，所以可以提供微检查芯片和检查装置，能够防止通过试剂的泄漏液堵塞排气高阻流路导致的通道空气流出不能变为禁止，防止气泡插入驱动液和试剂之间，稳定地送出试剂。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2007322284A Microchip and filling method of reagent in microchip 审中-公开
标题翻译： MICROCHIP中微生物和试剂的填充方法
公开(公告)号：JP2007322284A
公开(公告)日：2007-12-13
申请号：JP2006153903
申请日：2006-06-01
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： NAKAJIMA AKIHISA , SANTO YASUHIRO , HIGASHINO KUSUNOKI , AOKI YOICHI
IPC分类号： G01N35/08 , B81B1/00 , G01N35/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip and a filling method of a reagent in the microchip capable of filling quickly and accurately the required trace amount of reagent to each of a plurality of reagent storage parts simultaneously, and moreover, preventing the reagent from leaking out from the reagent storage part into a fine channel communicating therewith, when filling the reagent.
SOLUTION: The microchip, having the reagent storage parts for storing an aqueous reagent equipped respectively with a reagent supply part, a liquid sending control part or the like, has characteristics wherein the pressure of the reagent passing through the reagent supply part is higher than the liquid holding pressure, which is the pressure with which the reagent starts to pass the liquid sending control part. The filling method of the reagent has characteristics where the pressure necessary for starting, to pass the reagent supply part is applied to the reagent by a micropump provided in a micropump unit, and after start of inflow of the reagent, a pressure lower than the liquid-holding pressure of the liquid-sending control part is applied to the reagent.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供微芯片的微芯片和填充方法，其能够同时快速准确地填充所需的痕量的试剂至多个试剂储存部件中的每一个，并且还防止当试剂填充时，试剂从试剂储存部分泄漏到与其连通的细小通道中。解决方案：具有用于储存配备有试剂供给部，送液控制部等的水性试剂的试剂储存部的微芯片具有以下特征：通过试剂供给部的试剂的压力为高于液体保持压力，其为试剂开始通过送液控制部分的压力。试剂的填充方法的特征在于，通过设置在微型泵单元中的微型泵将试剂供给部开始通过所需的压力施加到试剂，并且在试剂开始流入后，具有低于液体的压力将送液控制部的保压压力施加到试剂上。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2007309845A Detection chip 审中-公开
标题翻译：检测芯片
公开(公告)号：JP2007309845A
公开(公告)日：2007-11-29
申请号：JP2006140672
申请日：2006-05-19
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： AOKI YOICHI , SANTO YASUHIRO , NAKAJIMA AKIHISA , HIGASHINO KUSUNOKI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a detection chip capable of preventing the occurrence of connections between a plurality of connecting parts due to a leakage of a driving liquid from connecting parts of a detection chip and a micropump unit.
SOLUTION: A detection chip which has protrusion parts in surfaces in the peripheries of openings is provided as a first mode of the present invention. A detection chip which has grooves in surfaces in the peripheries of openings is provided as a second mode of the present invention. A detection chip which keeps at least part of the openings of pump connecting parts arranged at specific intervals (a) on two parallel straight lines, and the distance (b) between any opening on one straight line and the closest opening on the other straight line arranged in such a way as to satisfy the relation a/2
摘要翻译：要解决的问题：提供一种能够防止由于检测芯片和微型泵单元的连接部分的驱动液体的泄漏而导致多个连接部件之间的连接发生的检测芯片。解决方案：作为本发明的第一模式，提供了在开口周边的表面中具有突起部的检测芯片。作为本发明的第二模式，提供了在开口周边的表面具有凹槽的检测芯片。一种检测芯片，其保持泵连接部件的开口的至少一部分以特定间隔（a）布置在两条平行的直线上，并且将一条直线上的任何开口与另一条直线上最近的开口之间的距离（b）以满足作为本发明的第三模式的关系a / 2

10. 发明专利

JP2007240413A Micro fluid chip 审中-公开
标题翻译： MICRO FLUID CHIP
公开(公告)号：JP2007240413A
公开(公告)日：2007-09-20
申请号：JP2006065449
申请日：2006-03-10
申请人： Konica Minolta Medical & Graphic Inc , コニカミノルタエムジー株式会社
发明人： HIGASHINO KUSUNOKI , SANTO YASUHIRO , NAKAJIMA AKIHISA , AOKI YOICHI
IPC分类号： G01N35/08 , G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To restrain a temperature of a reagent storage part from being elevated by heating a reaction part in analysis, and to restrain a reagent from being deteriorated or like in accompaniment thereto, in a micro fluid chip provided with micro flow passages having the reagent storage part. SOLUTION: A distance between an area on a chip surface abutting on a heating member and the reagent storage part is three times or more in a thickness of the chip, in this micro fluid chip of the present invention. Heat conduction due to the heating of the reaction part in the analysis is restrained by providing a prescribed space by this manner, so as to prevent the temperature elevation of the reagent storage part, the reagent deterioration accompanied thereto and the like. The micro fluid chip is compactified and gets suitable, without widening unnecessarily a space interval for the micro flow passages provided in the chip, since a space between the reaction part and the reagent storage part is enough to restrain the heat conduction, by the prescribed distance. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了通过分析加热反应部分来抑制试剂储存部分的温度升高并且抑制试剂劣化或类似伴随的微细流体芯片中。具有试剂储存部的流路。解决方案：在本发明的这种微流体芯片中，与加热部件邻接的芯片表面上的区域与试剂储存部之间的距离为芯片厚度的三倍以上。通过以这种方式提供规定的空间来抑制由于分析中的反应部分的加热引起的热传导，从而防止试剂储存部件的温度升高，伴随的试剂劣化等。由于反应部和试剂收容部之间的空间足以将热传导限制在规定的距离，所以微流体芯片被压实并且变得适合，而不会不必要地增加设置在芯片中的微流路的空间间隔。版权所有（C）2007，JPO＆INPIT

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