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1. 发明专利

JP2014136696A Autoinducer-2 inhibitor 审中-公开
标题翻译： AUTOINDUCER-2抑制剂
公开(公告)号：JP2014136696A
公开(公告)日：2014-07-28
申请号：JP2013006720
申请日：2013-01-17
申请人： Kao Corp , 花王株式会社
发明人： FUJINAKA EIGO , WATANABE MANABU
IPC分类号： A61K31/122 , A61P1/02 , A61P31/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an AI-2 inhibitor that has activity of inhibiting AI-2 and is effective in preventing and treating dental caries or periodontal disease.SOLUTION: An AI-2 inhibitor includes pulegone as an active ingredient.
摘要翻译：要解决的问题：提供具有抑制AI-2的活性并且有效预防和治疗龋齿或牙周病的AI-2抑制剂。解决方案：AI-2抑制剂包括胡椒粉作为活性成分。

2. 发明专利

JP2012246235A Autoinducer-2 inhibitor 审中-公开
标题翻译： AUTOINDUCER-2抑制剂
公开(公告)号：JP2012246235A
公开(公告)日：2012-12-13
申请号：JP2011118072
申请日：2011-05-26
申请人： Kao Corp , 花王株式会社
发明人： SONO HATSUMI , FUJINAKA EIGO , WATANABE MANABU , ARAI NAOMI
IPC分类号： A61K31/335 , A23L1/30 , A61K8/49 , A61K31/351 , A61P31/00 , A61P43/00 , A61Q19/00 , C07D309/30 , C07D313/04
摘要： PROBLEM TO BE SOLVED: To provide an autoinducer-2 inhibitor, which has activity to inhibit autoinducer-2 and is effective for prevention and treatment of infectious diseases.SOLUTION: The autoinducer-2 inhibitor contains as an active ingredient, at least one kind selected from the group consisting of δ-lactones having 9 to 12 carbon atoms and ε-lactones having 9 to 12 carbon atoms.
摘要翻译：要解决的问题：提供具有抑制自身诱导剂-2的活性的自动诱导剂-2抑制剂，并且有效预防和治疗感染性疾病。解决方案：自动诱导剂-2抑制剂含有选自具有9至12个碳原子的δ-内酯和具有9至12个碳原子的ε-内酯中的至少一种作为活性成分。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2012116791A Autoinducer-2 inhibitor 审中-公开
标题翻译： AUTOINDUCER-2抑制剂
公开(公告)号：JP2012116791A
公开(公告)日：2012-06-21
申请号：JP2010268201
申请日：2010-12-01
申请人： Kao Corp , 花王株式会社
发明人： HASHIZUME KOJIRO , FUJINAKA EIGO , ARAI NAOMI
IPC分类号： A61K31/7024 , A23L1/30 , A61K8/60 , A61P1/00 , A61P1/02 , A61P27/16 , A61P31/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an autoinducer-2 inhibitor which has excellent autoinducer-2 inhibitory activity.SOLUTION: The autoinducer-2 inhibitor contains at least one kind of hydrolyzable tannin as an active ingredient. Preferably, the hydrolyzable tannin is ellagitannin.
摘要翻译：要解决的问题：提供一种具有优异的自体诱导剂-2抑制活性的自动诱导剂-2抑制剂。解决方案：自动诱导剂-2抑制剂含有至少一种可水解的单宁作为活性成分。优选地，可水解单宁是鞣花素。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2010159219A Ai-2 inhibitor 审中-公开
标题翻译： AI-2抑制剂
公开(公告)号：JP2010159219A
公开(公告)日：2010-07-22
申请号：JP2009001608
申请日：2009-01-07
申请人： Kao Corp , 花王株式会社
发明人： KAWASAKI KEIKO , FUJINAKA EIGO , NAKAMURA JUNJI
IPC分类号： A61K31/353 , A61P31/04 , A61P43/00
CPC分类号： Y02A50/406 , Y02A50/471
摘要： PROBLEM TO BE SOLVED: To provide an AI-2 (autoinducer-2) inhibitor inhibiting the activities of AI-2, and useful as a medicine, an unregulated drug or a food and drink for preventing, treating or ameliorating infectious disease.
SOLUTION: The AI-2 inhibitor contains catechins in a concentration of 0.001-0.1 mM. The catechins are preferably one or more kinds selected from catechin, catechin gallate, gallocatechin, gallocatechin gallate, epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate in the AI-2 inhibitor.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供抑制AI-2活性的AI-2（自动诱导剂-2）抑制剂，可用作药物，不受管制的药物或用于预防，治疗或改善感染性疾病的食物和饮料。解决方案：AI-2抑制剂含有浓度为0.001-0.1mM的儿茶素类。儿茶素类优选为AI-2抑制剂中的儿茶素，儿茶素没食子酸酯，儿茶素，没食子儿茶素，表儿茶素，表没食子儿茶素，表儿茶素没食子酸酯和表没食子儿茶素没食子酸酯中的一种以上。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2005002091A Intestinal mineral absorption capacity improver 有权
标题翻译： INTESTINAL矿物吸收能力改善
公开(公告)号：JP2005002091A
公开(公告)日：2005-01-06
申请号：JP2003380653
申请日：2003-11-11
申请人： Kao Corp , 花王株式会社
发明人： FUJINAKA EIGO , NAKAMURA JUNJI , MURASE DAIKI , SOUNO HATSUMI , KOBAYASHI HISATAKA
IPC分类号： A23L2/38 , A21D2/18 , A23C9/152 , A23F3/14 , A23F5/40 , A23G3/00 , A23G3/34 , A23G3/36 , A23G3/42 , A23G9/32 , A23G9/34 , A23L1/068 , A23L1/09 , A23L1/238 , A23L1/30 , A23L1/302 , A23L1/304 , A23L2/39 , A23L2/52 , A61K9/08 , A61K31/70 , A61P1/00 , C07H11/04
CPC分类号： A23G3/36 , A21D2/18 , A23C9/1522 , A23F3/14 , A23F5/40 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23G2200/00 , A23G2200/04 , A23L2/39 , A23L2/52 , A23L21/15 , A23L27/50 , A23L29/30 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K31/70 , A23V2250/7042 , A23V2250/7044 , A23V2250/7052 , A23V2250/708 , A23V2250/712 , A23V2250/628 , A23V2250/5036 , A23V2250/507 , A23V2250/032 , A23V2250/156 , A23V2250/61 , A23V2250/54246 , A23V2250/0632 , A23V2250/70 , A23V2250/5108 , A23V2250/5118
摘要： PROBLEM TO BE SOLVED: To obtain an intestinal mineral absorption capacity improver that has high safety. SOLUTION: This intestinal mineral absorption capacity improver contains sodium glucose-1-phosphate as an active ingredient. In a preferred embodiment, the intestinal mineral absorption capacity improver is an oral agent. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得具有高安全性的肠道矿物质吸收能力改进剂。
解决方案：该肠道矿物质吸收能力改进剂含有葡萄糖-1-磷酸钠作为活性成分。在优选的实施方案中，肠内矿物质吸收能力改进剂是口服剂。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2003079337A Mineral taste improver 有权
标题翻译：矿物质改良剂
公开(公告)号：JP2003079337A
公开(公告)日：2003-03-18
申请号：JP2001271805
申请日：2001-09-07
申请人： Kao Corp , 花王株式会社
发明人： FUJINAKA EIGO , KOBAYASHI HISATAKA
IPC分类号： A23C9/152 , A21D2/02 , A21D2/30 , A21D13/08 , A23L1/015 , A23L1/226 , A23L1/304
摘要： PROBLEM TO BE SOLVED: To obtain a mineral taste improver which excellently reduces taste such as bitterness, astringency, harsh taste, astringent taste, etc., caused by minerals such as calcium, magnesium, etc., rough palatability and powdery palatability, a food containing the mineral taste improver, especially a mineral enriched food having improved and extremely excellent mineral taste and palatability and high preference. SOLUTION: This mineral taste improver comprises sugar phosphate or its ester.
摘要翻译：要解决的问题：为了获得由诸如钙，镁等矿物质引起的苦味，涩味，涩味，涩味等优异地降低口味的矿物味道改良剂，具有粗糙的适口性和粉末适口性，食物含有矿物质改进剂，特别是矿物质丰富的食品，其具有改善的极好的矿物味和适口性以及高度的偏好。解决方案：该矿物味改进剂包括糖磷酸酯或其酯。

7. 发明专利

JP2012097035A Autoinducer-2 inhibitor, and preventing and/or therapeutic agent of periodontal disease 审中-公开
标题翻译： AUTOINDUCER-2抑制剂，预防和/或治疗周期性疾病
公开(公告)号：JP2012097035A
公开(公告)日：2012-05-24
申请号：JP2010246113
申请日：2010-11-02
申请人： Kao Corp , 花王株式会社
发明人： FUJINAKA EIGO , SHIMIZU ERI
IPC分类号： A61K31/661 , A23L1/30 , A61K8/55 , A61P1/02 , A61P31/00 , A61P31/04 , A61P43/00 , A61Q11/00
CPC分类号： Y02A50/481
摘要： PROBLEM TO BE SOLVED: To provide an autoinducer-2 inhibitor which has activity for inhibiting autoinducer-2, and which is effective to prevention and treatment or the like of an infectious disease.SOLUTION: This autoinducer-2 inhibitor contains glycerophosphoric acid or its salt as an active ingredient. The salt is a sodium salt.
摘要翻译：待解决的问题：提供一种具有抑制自身诱导剂-2的活性的自体诱导剂-2抑制剂，其对预防和治疗等有益于感染性疾病。解决方案：该自动诱导剂-2抑制剂含有甘油磷酸或其盐作为活性成分。盐是一种钠盐。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2012097033A Autoinducer-2 inhibitor 审中-公开
标题翻译： AUTOINDUCER-2抑制剂
公开(公告)号：JP2012097033A
公开(公告)日：2012-05-24
申请号：JP2010246111
申请日：2010-11-02
申请人： Kao Corp , 花王株式会社
发明人： FUJINAKA EIGO , SHIMIZU ERI
IPC分类号： A61K31/194 , A23L1/30 , A23L1/305 , A61K8/362 , A61K8/44 , A61K31/198 , A61P1/02 , A61P1/04 , A61P31/04 , A61Q11/00 , A61Q19/00
CPC分类号： Y02A50/481
摘要： PROBLEM TO BE SOLVED: To provide an autoinducer-2 inhibitor which has activity for inhibiting autoinducer-2, and which is effective to prevention and treatment or the like of an infectious disease.SOLUTION: This autoinducer-2 inhibitor contains as an active ingredient, at least one kind selected from a group comprising azelaic acid, tyrosine, histidine, phenylalanine, tryptophan, glycine, and salts thereof.
摘要翻译：待解决的问题：提供一种具有抑制自身诱导剂-2的活性的自体诱导剂-2抑制剂，其对预防和治疗等有益于感染性疾病。解决方案：该自动诱导剂-2抑制剂含有选自包括壬二酸，酪氨酸，组氨酸，苯丙氨酸，色氨酸，甘氨酸及其盐的组中的至少一种作为活性成分。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2009269912A Ai-2 inhibitor 有权
标题翻译： AI-2抑制剂
公开(公告)号：JP2009269912A
公开(公告)日：2009-11-19
申请号：JP2009091211
申请日：2009-04-03
申请人： Kao Corp , 花王株式会社
发明人： KAWASAKI KEIKO , SAKAMOTO KOJI , FUJINAKA EIGO
IPC分类号： A61K36/18 , A61K36/48 , A61K36/53 , A61K36/73 , A61P31/04 , A61P43/00
CPC分类号： Y02A50/406 , Y02A50/471
摘要： PROBLEM TO BE SOLVED: To provide an AI-2 inhibitor inhibiting activity of AI-2 and useful as a medicine or a food for preventing, treating or improving infectious diseases. SOLUTION: The AI-2 inhibitor comprises a plant selected from tamarind, pennyroyal, rosaceous plants, clove and cranberry or an extract thereof as an active ingredient. COPYRIGHT: (C)2010,JPO&INPIT

10. 发明专利

JP2009114120A Autoinducer-2 inhibitor and agent for preventing and/or treating infectious disease 有权
标题翻译： AUTOINDUCER-2抑制剂和用于预防和/或治疗感染性疾病的药剂
公开(公告)号：JP2009114120A
公开(公告)日：2009-05-28
申请号：JP2007288556
申请日：2007-11-06
申请人： Kao Corp , 花王株式会社
发明人： SAKAMOTO KOJI , FUJINAKA EIGO , NAKAMURA JUNJI
IPC分类号： A61K31/341 , A61P1/02 , A61P31/04 , C07D307/58 , C07D307/60
摘要： PROBLEM TO BE SOLVED: To provide a material for inhibiting autoinducer-2, and to provide a material effective for prevention and/or treatment of an infectious disease.
SOLUTION: The autoinducer-2 inhibitor includes a compound represented by formula I (wherein, R
1 and R
2 are each independently hydrogen, a hydroxy group, an aryl group or an alkoxy group, or form an oxo group by bonding to each other; R
3 is a halogen; and R
4 is hydrogen, an amino group or a halogen) or a salt thereof as an active ingredient. The agent for preventing and/or treating the infectious disease includes the compound or the salt thereof as an active ingredient.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供抑制自体诱导剂-2的材料，并提供有效预防和/或治疗感染性疾病的材料。解决方案：自动诱导剂-2抑制剂包括由式I表示的化合物（其中R 1和R 2彼此独立地是氢，羟基，芳基基团或烷氧基，或通过彼此键合形成氧代基团; R 3是卤素;且R 4是氢，氨基或卤素）或其盐作为活性成分。用于预防和/或治疗感染性疾病的药物包括作为活性成分的化合物或其盐。版权所有（C）2009，JPO＆INPIT

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