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1. 发明专利

JPH1121250A PHARMACEUTICAL PREPARATION 失效
公开(公告)号：JPH1121250A
公开(公告)日：1999-01-26
申请号：JP17702297
申请日：1997-07-02
申请人： KYOWA HAKKO KOGYO KK
发明人： KATOU YASUKI , KUSANO HIROKO , KAWAGUCHI YUJI , ITO KUNIO
IPC分类号： A61K9/127 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/44 , A61K38/46 , A61K45/00 , A61K47/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a pharmaceutical preparation capable of dissociating various compounds having free amino acid groups corresponding to a pH value by including a compound obtained by reacting the compound having the free amino acid group with saccharides having reducibility. SOLUTION: The objective preparation is obtained by including a compound obtained by reacting 1 pts.wt. of a compound having a free amino acid group (e.g. enkephalin) or a compound having the free amino acid group modified by a medicine carrier (e.g. liposome) with 10-1000 pts.wt. of saccharides having reducibility (e.g. glucose) in an aqueous solution having pH 7.5-10 at 20-50 deg.C for 1-96 hr. The various compounds having the free amino acid groups are specifically dissociated only at the target portion with lowered pH value such as an inflammatory portion and a tumor portion to manifest the activities, and the effect such as reduction of side effect is expected. When the preparation is administered in a body, pharmacokinetics is changed compared to an unmodified medicine, and the effect such as improvement of sustainability in the blood is expected.

2. 发明专利

JPH10114655A SLID PHARMACEUTICAL PREPARATION 失效
公开(公告)号：JPH10114655A
公开(公告)日：1998-05-06
申请号：JP26876196
申请日：1996-10-09
申请人： KYOWA HAKKO KOGYO KK
发明人： MIYABE JUNICHI , SHIMAGUCHI NAOTAKE , HAYAKAWA EIJI , ITO KUNIO
IPC分类号： A61K9/20 , A61K31/445 , A61K47/02 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain the subject pharmaceutical preparation, comprising a medicine, an additive and disintegrating agent and rapidly disintegrable with a 1st fluid according to the Japanese Pharmacopoeia without using a surfactant. SOLUTION: This solid pharmaceutical preparation comprises (A) a therapeutically effective amount of at least one medicine, (B) at least one neutral or basic additive and (C) a disintegrating agent. The ingredient A is preferably the medicine capable of forming a gel-like film in a solution at an acidic pH, a piperidinoalkanol, especially a terfenadie and is contained in an amount of preferably 60-120mg based on one preparation. The ingredient B is a salt of silicic acids, preferably magnesium metasilicate aluminate or special calcium silicate and is contained in an amount of preferably 1-30wt.%. The ingredicent C is preferably crospovidone, a low-substitution degree hydroxypropyl cellulose, etc., and is contained in an amount of preferably 1-30wt.%.

3. 发明专利

JPH04367662A VIAL VESSEL 失效
公开(公告)号：JPH04367662A
公开(公告)日：1992-12-18
申请号：JP16917891
申请日：1991-06-14
申请人： KYOWA HAKKO KOGYO KK
发明人： ITO KUNIO , NAKAKURA MASASHI , HOSOKAWA TOSHIHITO , MIWA SEIJI , HAYAKAWA EIJI
IPC分类号： A61J1/05
摘要： PURPOSE:To allow the suction of a medicine without making an operation having the danger of using an injection needle by directly connecting an injection cylinder to the above vessel. CONSTITUTION:The injection cylinder 20 has an injection needle mounting port 20a. Its suction part B consists of a suction pipe 6 which is provided on the outside surface 3a of a rubber plug 3 and is inserted with the injection needle mounting port 20a, a suction tube 7 which arrives at the medicine M in a vessel body 2 from the suction pipe 6 and an air vent port A which vents air when the port is provided from the outside surface 3a of the rubber plug 3 into the inside surface 3b.

4. 发明专利

JPH04244018A LIPOSOME PREPARATION TRANSITIONAL TO LIVER 失效
公开(公告)号：JPH04244018A
公开(公告)日：1992-09-01
申请号：JP1115691
申请日：1991-01-31
申请人： KYOWA HAKKO KOGYO KK
发明人： HAYAKAWA EIJI , KATOU YASUKI , WATANABE KYOKO , ITO KUNIO
IPC分类号： A61K9/127 , B01J13/02
摘要： PURPOSE:To obtain a liposome preparation having high transition to liver by using a raw material having established safety as injection. CONSTITUTION:A liposome preparation containing phospholipid and >=150wt.% based on phospholipid of a nonionic surfactant, preferably polyoxyethylene group-containing nonionic surfactant such as polyoxyethylene hardened castor oil or polyoxyethylene sorbitan monooleate as an essential component, having increased transition to liver.

5. 发明专利

JPH11169437A MANUFACTURE OF TABLET 失效
公开(公告)号：JPH11169437A
公开(公告)日：1999-06-29
申请号：JP33281297
申请日：1997-12-03
申请人： KYOWA HAKKO KOGYO KK
发明人： HAYAKAWA EIJI , OTA MOTOHIRO , MORIMOTO HIROYUKI , MORIMOTO KIYOSHI , WATANABE YASUSHI , ITO KUNIO , TOKUNO SANJI
IPC分类号： A61J3/10 , B30B11/00 , B30B11/08 , B30B15/00
摘要： PROBLEM TO BE SOLVED: To provide a manufacture of tablets capable of stably and continuously punching tablets for a long time without sticking a molding material to the pounder and mortar of a tablet punching machine or the like and being executed as the industrial manufacture of the tablets without changing the collapse time of the punched tablets or changing hardness. SOLUTION: This manufacture comprises a process for preparing a molding material (m) containing an effective component, excipient and a part of lubricant K, a process for housing the pounders 3 and 4 and mortar 2 of the tablet punching machine A inside a scattering chamber 10, a process for atomizing the residual amount of the lubricant K inside the scattering chamber 10, generating air pulse waves inside the scattering chamber 10 and applying the lubricant K to the surfaces of the pounders 3 and 4 and the surface of the mortar 2, and a process for punching the molding material (m) into the tablets by using the pounders 3 and 4 applied with the lubricant K on the surface and the mortar 2 applied with the lubricant K on the surface.

6. 发明专利

JPH1171266A LIPOSOME PREPARATION OF XANTHIN DERIVATIVE 失效
公开(公告)号：JPH1171266A
公开(公告)日：1999-03-16
申请号：JP23404297
申请日：1997-08-29
申请人： KYOWA HAKKO KOGYO KK
发明人： YAMAUCHI MASAHIRO , YAMAMOTO YOSHIHIKO , KATOU YASUKI , ITO KUNIO
IPC分类号： A61K9/127 , A61K31/52
摘要： PROBLEM TO BE SOLVED: To obtain a liposome preparation useful for a hypotensive, a diuretic and a renal protective agents on by including a xanthin derivative as an active ingredient therein. SOLUTION: This liposome preparation useful as a therapeutic agent for acute renal insufficiency is obtained by including a xanthin derivative represented by the formula [R and R are each a (substituted)lower alkyl; Q is H or OH] [preferably 8-(3-noradamantyl)-1,3-dipropylxanthin] as an active ingredient. A phospholipid (preferably phosphatidylcholine or the like) is preferred as a lipid constituting the liposome and the particle diameter of the liposome preparation is preferably 0.005-1 μm. The method for administration is preferably parenteral administration such as intravenous, intramuscular or subcutaneous administration and the liposome preparation preferably used as a parenteral injection.

7. 发明专利

JPH10192370A PRODUCTION OF CAPSULE AGENT AND APPARATUS FOR PRODUCTION OF THE CAPSULE AGENT 失效
公开(公告)号：JPH10192370A
公开(公告)日：1998-07-28
申请号：JP438197
申请日：1997-01-14
申请人： KYOWA HAKKO KOGYO KK
发明人： HAYAKAWA EIJI , MORIMOTO HIROYUKI , ITO KUNIO , MORIMOTO KIYOSHI , WATANABE YASUSHI , TOKUNO SANJI
IPC分类号： A61J3/07 , A61K9/48
摘要： PROBLEM TO BE SOLVED: To provide a process for producing capsule agents which is capable of packing these capsule agent into capsules without the occurrence of sticking. SOLUTION: A prescribed amt. of powder and granular materials are taken out and the prescribed amt. of the taken out powder and granular Materials are packed into the bodies Ca of the capsules by using a capsule packing device 2 which is coated with lubricants in contact parts S2a, S2b by applying the lubricant on the contact parts S2a, S2b where the powder and granular materials of the capsule packing device 2 come into contact under the state in which the lubricants are diffused by air pulsation waves.

8. 发明专利

JPH05223724A INJECTION-FLUID EVALUATING SYSTEM 失效
公开(公告)号：JPH05223724A
公开(公告)日：1993-08-31
申请号：JP5712492
申请日：1992-02-07
申请人： KYOWA HAKKO KOGYO KK
发明人： KATOU YASUKI , NAGANUMA KOKI , OKUBO YUICHI , HAYAKAWA EIJI , ITO KUNIO
IPC分类号： G01N15/00
摘要： PURPOSE:To quantitatively and economically predict the occurrence of insoluble fine particles by constituting the system with a pump and circulating path and measuring means composed of a fine particle detecting sensor and number- of-fine-particles analyzer. CONSTITUTION:An injection-fluid injected from an injection-fluid injecting port 8 is circulated in a circulating path 6 by means of a returned fluid circulating pump 5 and buffered and carried by means of a returned liquid 4. When insoluble fine particles are generated when the injection-fluid is carried, a fine particle detecting sensor 12 detects the particles and a number-of-fine-particles analyzer 3 determines the number of the particles. In addition, since this system is constituted of a circulating system 3, the system 3 not only evaluates the presence/absence of insoluble fine particles by one time after the injection-fluid is injected, but can also dynamically evaluate the variation of the fluid with time in the system 3. Therefore, the presence of insoluble fine particles can be quantitatively measured with lapse of time.

9. 发明专利

JPH04235923A PHARMACEUTICAL PREPARATION FOR NASAL ADMINISTRATION 失效
公开(公告)号：JPH04235923A
公开(公告)日：1992-08-25
申请号：JP345691
申请日：1991-01-16
申请人： KYOWA HAKKO KOGYO KK
发明人： HAYAKAWA EIJI , TERAJIMA MITSURU , NAKAKURA MASASHI , UENO YASUHIKO , SHIMAGUCHI NAOTAKE , SHODA TOMOAKI , ITO KUNIO
IPC分类号： A61K9/08 , A61K38/22 , A61K47/12 , A61K47/28 , A61P1/00
摘要： PURPOSE:To provide a pharmaceutical preparation enabling the administration of motilins to a patient using a simple method without inflicting pain on the patient. CONSTITUTION:A pharmaceutical preparation for nasal administration containing motilins as active component. The active component can easily be absorbed in the body by the nasal administration and keeps effective blood concentration over a long period. The effect can be promoted by the addition of a membrane- permeation promoting agent and a protease-inhibiting agent.

10. 发明专利

JPH04235914A SUSTAINED RELEASE PREPARATION 失效
公开(公告)号：JPH04235914A
公开(公告)日：1992-08-25
申请号：JP429091
申请日：1991-01-18
申请人： KYOWA HAKKO KOGYO KK
发明人： ITO KUNIO , MIYAMOTO NORIBUMI , ABE TOSHIKAZU , SHODA TOMOAKI
IPC分类号： A61K9/36 , A61K31/20 , A61K47/02 , A61P25/08
摘要： PURPOSE:To obtain a suspended release preparation of sodium valproate. CONSTITUTION:Raw tablets comprising 100 pts.wt. sodium valproate as an active ingredient and 20-25 pts.wt magnesium metasilicic acid aluminate are coated with a coating agent consisting of 100 pts.wt. ethyl cellulose and 45-55 pts.wt. hydroxypropylmethyl cellulose in 70-120mu thickness to give a suspended release preparation. The preparation can release a medicine without depending upon pH in the digestive tubes and increase treating effects.

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