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    • 8. 发明专利
    • DENTIFRICE COMPOSITION
    • JPS6335516A
    • 1988-02-16
    • JP17963486
    • 1986-07-30
    • KUSANO KEIGO
    • KUSANO KEIGO
    • A61K8/66A61K8/26A61K8/34A61K8/44A61K8/73A61Q11/00
    • PURPOSE:To obtain a dentifrice composition capable of keeping the activity of an anti-inflammatory enzyme papain over a long period and exhibiting remarkable effect against periodontosis, by using an aqueous solution of sodium bicarbonate as a substrate solvent and adding the above enzyme and a specific foaming agent to the solvent. CONSTITUTION:A substrate solvent produced by dissolving 10-40(wt)%, preferably 15-30% sodium bicarbonate based on the whole water content of the dentifrice composition is compounded with 0.1-0.25% papain of 500-100,000 unit/g as an anti-inflammatory enzyme and 0.2-10% each of sodium N- laurylsarcosine and sucrose lauric acid ester as a foaming agent. The mixture is further compounded with sorbitan (preferably at an amount of 30-40%) which is a wetting agent necessary for the stable compounding and effective in improving the survival ratio of the enzymatic activity and aluminum hydroxide acting as an abrasion material. The composition has anti-inflammation and tartar-deposition preventive effects relating to gingivitis and pyorrhea, cleans and keeps the teeth and oral cavity in clean state and prevents periodontosis.