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1. 发明专利

JPH08337531A NEW ANTIBIOTIC KP-3052 AND ITS PREPARATION 失效
公开(公告)号：JPH08337531A
公开(公告)日：1996-12-24
申请号：JP14588095
申请日：1995-06-13
申请人： KITASATO INST , CHUGOKU IGAKU KAGAKUIN IYAKU S
发明人： OMURA SATOSHI , SHIOMI KAZURO , TAKAHASHI YOKO , RIYUU JIN RON
IPC分类号： C12P1/06 , A61K35/74 , A61P31/04 , C07G11/00 , C12R1/01
摘要： PURPOSE: To produce a new antibiotic useful as a therapeutic agent or a prophylatic agent for bacterial or fungal infectious diseases. CONSTITUTION: This antibiotic KP-3052 has the following physicochemical properties: Property: white powder; molecular weight: 344.1573; molecular formula: C13 H21 N5 O6 ; melting point: 260 deg.C (decomposition); specific rotatory power [α]D =-9 deg. (c=0.65, H2 O); solubility: soluble in water and sparingly soluble in methanol, acetone and chloroform; color reaction: positive to the ninhydrin reaction. The antibiotic is obtained by culturing a microorganism, belonging to actinomyces and having the ability to produce the antibiotic KP-3052 [a strain KP-3052 which is a new microorganism (FERM P14875)] in a culture medium and then collecting the substance from the cultured product. The culture temperature is preferably 27 deg.C. The culture time is usually 2-7 days; however, the culture is preferably completed when the amount of the accumulated antibiotic KP-3052 attains the maximum. Liquid culture is preferred for the mass culture of the antibiotic KP-3052.

2. 发明专利

JPH11158194A NEW K96-0188 ANTIBIOTIC AND ITS PRODUCTION 失效
公开(公告)号：JPH11158194A
公开(公告)日：1999-06-15
申请号：JP32612497
申请日：1997-11-27
申请人： KITASATO INST
发明人： OMURA SATOSHI , SHIOMI KAZURO , TAKAHASHI YOKO , IWAI YUZURU
IPC分类号： C12P1/06 , A01N59/16 , A01N63/02 , A61K35/74 , C07F15/02 , C12N1/20 , C12P13/00 , C12R1/465
摘要： PROBLEM TO BE SOLVED: To obtain the subject new antibiotic comprising a substance prepared by culturing a bacterium belonging to the actinumycetes, capable of producing K96-0188 substance, having inhibitory activity against microorganisms, nematodes and arthropods, useful as an antimicrobial agent, an anti-helminth agent, an insecticide, etc. SOLUTION: This new K-96 antibiotic is a compound of the formula, has inhibitory activity against microorganisms, nematodes and arthropods, useful as an antimicrobial agent, an anti-helminth agent, an insecticide, etc., in the field of medicines, animal medicines, agrochemicals, etc. The new antibiotic is obtained by culturing a bacterium [e.g. Streptomyces sp. K96-0188 (FERM P-16,398) or the like] belonging to an actiomycetes, capable of producing K96-0188 substance in a medium, accumulating K96-0188 substance in the culture product and collecting K96-0188 substance from the culture product.

3. 发明专利

JPH0310692A ANTIBIOTIC SUBSTANCE OM-5714 AND PRODUCTION THEREOF 失效
公开(公告)号：JPH0310692A
公开(公告)日：1991-01-18
申请号：JP14509989
申请日：1989-06-09
申请人： KITASATO INST
发明人： OMURA SATOSHI , TANAKA YOSHITAKE , TAKAHASHI YOKO
IPC分类号： C12P17/14 , A01N43/76 , C07D263/32 , C12R1/465
摘要： NEW MATERIAL:A compound, expressed by the formula and having the following physico-chemical properties. Melting point; 58-62 deg.C. Elementary analysis (%); C, 66.2+ or -1.0; H, 7.6+ or -0.3; N, 9.7+ or -0.3. Molecular weight; 290.16. Molecular formula; C16H22N2O3. Specific rotation; [alpha] =+23.0 deg. (c=1.0, chloroform). Solubility; soluble in methanol, ethanol, ethyl acetate and chloroform and insoluble in water and n-hexane. Color reaction; positive to sulfuric acid, iodine, phosphorus-molybdenic acid reagent and negative to ninhydrin, the Elson-Morgan reagent. Neutral substance. Color; white to light yellow, etc. USE:Useful as an agricultural chemical, capable of exhibiting activity against plant pathogenic fungi and having also herbicidal activity. PREPARATION:A strain, such sa Streptomyces.sp. OM-5714 (FERM P-10775), belonging to the genus Streptomyces is cultures at 20-40 deg.C and about pH7 for 1-7 days.

4. 发明专利

JPH01228484A ANTIBIOTIC SUBSTANCE WK-1875 AND PRODUCTION THEREOF 失效
公开(公告)号：JPH01228484A
公开(公告)日：1989-09-12
申请号：JP5555888
申请日：1988-03-09
申请人： KITASATO INST
发明人： OMURA SATOSHI , TANAKA YOSHITAKE , NAKAGAWA AKIRA , TAKAHASHI YOKO
IPC分类号： C12P1/06 , A61K35/74 , A61P31/04 , C07G11/00 , C12R1/465
摘要： PURPOSE:To obtain an antibiotic substance WK-1875 active against phytopathogenic fungi and useful as an agricultural chemical by culturing a microbial strain belonging to genus Streptomyces and capable of producing antibiotic substance WK-1875 and treating the culture product. CONSTITUTION:A microbial strain belonging to genus Streptmyces and capable of producing antibiotic substance WK-1875 (FERM P-9859) is cultured in a proper medium under aerobic condition e.g., by shaking culture or submerged culture under aeration and agitation, at 20-40 deg.C and pH4-9 for 1-7days to accumulate the antibiotic substance WK-1875 inside and outside of the cell. The culture product is separated by centrifugal separation, the filtrate is adsorbed to a porous polymer resin, etc., and eluted, and the eluate is concentrated, dried and purified to obtain the objective antibiotic substance WK-1875 having the following properties. Elemental analysis (measured value, %), C 64.7+ or -1.0, H 9.1+ or -0.3; specific rotation, -12.1 deg. (c=0.5, methanol); melting point, 116-119 deg.C; ultraviolet absorption, infrared absorption and proton nuclear magnetic resonance spectra, exhibiting specific respective patterns; solubility, soluble in methanol, ethanol, ethyl acetate and CHCl3 and insoluble in water and n- hexane; molecular formula C40H68O12.

5. 发明专利

JP2001122875A NEW WK-6326 MATERIAL AND METHOD FOR PREPARING THE SAME 失效
公开(公告)号：JP2001122875A
公开(公告)日：2001-05-08
申请号：JP30495299
申请日：1999-10-27
申请人： KITASATO INST
发明人： OMURA SATOSHI , KODA HIROSHI , ARAI MASAKICHI , TAKAHASHI YOKO
IPC分类号： C12P17/06 , A61K31/366 , A61P11/06 , A61P17/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07D311/78 , C07D407/04 , C12N1/20 , C12R1/465
摘要： PROBLEM TO BE SOLVED: To obtain a new WK-6326 material having activities for inhibiting the activity of interleukin 4, and further having antibacterial activities against Gram positive and Gram negative bacteria, and further to provide a method for preparing the material. SOLUTION: This WK-6326 material is obtained by culturing a microorganism belonging to actinomyces, and having abilities for producing the WK-6326 material represented by formula [I] in a medium to accumulate the WK-6326 material in the cultured material, and collecting the WK-6326 material from the cultured material. The material is useful for the therapy of allergic disease such as asthma, atopic dermatitis and pollinosis, and many infectious diseases because the material has an extreme inhibiting activities against the activities of the interleukin 4.

6. 发明专利

JPH0539265A NEW SUBSTANCE, WK-2,955, AND ITS PRODUCTION 失效
公开(公告)号：JPH0539265A
公开(公告)日：1993-02-19
申请号：JP21626691
申请日：1991-08-02
申请人： KITASATO INST
发明人： OMURA SATOSHI , KODA HIROSHI , IWAI YUZURU , TAKAHASHI YOKO , SUNATSUKA TOSHIAKI
IPC分类号： A61K31/40 , A61K31/00 , A61K31/403 , A61K31/404 , A61P33/00 , A61P33/02 , C07D209/10 , C12P7/02 , C12P17/10 , C12R1/465
摘要： PURPOSE:To obtain a new compound useful as a coccidiostat, having growth inhibiting activity against coccidium protozoan resistant to polyether-based antibiotic monensin. CONSTITUTION:New substance, WK-2,955, shown by the formula. Streptomyces sp. WK-2,955 strain (FERM P-12,318) belonging to the genus Streptomyces is cultured in a medium under an aerobic condition and the culture mixture is extracted with an organic solvent, etc., to give the objective compound. Or, 3-indoleacetaldehyde and p-hydroxyphenylacetaldehyde are subjected to alodol addition reaction to give the compound shown by the formula. Properties of the compound shown by the formula. White solid substance. Molecular formula: C18H19NO3 (measured value: 297.1363). Soluble in methanol, ethanol, acetonitrile, dimethyl sulfoxide, etc., and insoluble in chloroform, hexance, etc.

7. 发明专利

JP2573018B2 失效
公开(公告)号：JP2573018B2
公开(公告)日：1997-01-16
申请号：JP5555888
申请日：1988-03-09
申请人： KITASATO INST
发明人： OOMURA SATOSHI , TANAKA YOSHITAKE , NAKAGAWA AKIRA , TAKAHASHI YOKO
IPC分类号： C12P1/06 , A61K35/74 , A61P31/04 , C07G11/00 , C12R1/465

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