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1. 发明专利

JP2004059469A Hair tonic 有权
公开(公告)号：JP2004059469A
公开(公告)日：2004-02-26
申请号：JP2002217678
申请日：2002-07-26
申请人： Kanebo Ltd , カネボウ株式会社
发明人： SUGIMOTO KENICHI , HAMADA KAZUTO , MATSUI JUNICHI
IPC分类号： A61K8/00 , A61K8/60 , A61K8/73 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To provide a hair tonic which has excellent hair-restoring, hair-growing and hair falling-preventing effects, has excellent solubility in ethanol, water-containing ethanol, and the like, and gives an excellent sense of use.
SOLUTION: This hair tonic is characterized by containing a sugar farnesylacetate. The hair tonic exhibits a remarkably hair growth-promoting effect, an excellent hair-restoring effect, an excellent hair falling-preventing effect, excellent solubility, and an excellent touch of use.
COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2004043318A Hair tonic 审中-公开
公开(公告)号：JP2004043318A
公开(公告)日：2004-02-12
申请号：JP2002199581
申请日：2002-07-09
申请人： Kanebo Ltd , カネボウ株式会社
发明人： SUGIMOTO KENICHI , HAMADA KAZUTO , MATSUI JUNICHI
IPC分类号： A61K8/00 , A61K8/30 , A61K8/37 , A61Q5/00 , A61Q7/00 , A61K7/06 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a hair tonic having excellent hair growth, hair tonic and prophylactic effects on alopecia, excellent solubility in aqueous solvents such as ethanol or hydrous ethanol and an excellent feeling of use.
SOLUTION: The hair tonic comprises at least one or more kinds of farnesylacetic acid esters represented by formula (1) (wherein, R denotes a 1-9C straight-chain or branched chain saturated or unsaturated hydrocarbon group).
COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2000178140A HAIR TONIC PREPARATION 失效
公开(公告)号：JP2000178140A
公开(公告)日：2000-06-27
申请号：JP36062998
申请日：1998-12-18
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , NAKAGAWA NORIAKI , IKEMOTO TAKESHI , NAKATSUGAWA HIROKO
IPC分类号： A61K8/00 , A61K31/00 , A61K31/70 , A61K36/18 , A61P17/00 , A61P17/14 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair tonic preparation having good bloodstream promoting actions and excellent in hair growth effects and alopecia and dandruff preventing effects and having low skin irritation properties by formulating a zingerone glycoside. SOLUTION: This hair tonic preparation is obtained by including a zingerone glycoside. The zingerone glycoside is preferably a glucose glycoside (e.g. a zingerone α-D-glucoside or a zingerone 73-D-glucoside). The amount of the formulated zingerone glycoside is preferably 0.1-8.0 wt.% based on the total weight of the composition of the hair tonic preparation. The hair tonic preparation can be formed into various kinds of dosage forms directly applied to the scalp, e.g. an ointment, a cream, a milky lotion, a hair tonic, a hair lotion, a hair mousse, a hair mist or a hair spray. A coloring matter, a perfume, a germicide, a preservative, a keratolytic agent, an antiandrogen agent, a hair tonic, an antioxidant, etc., can be formulated in the hair tonic preparation.

4. 发明专利

JPH02221215A HAIR TONIC COSMETIC 失效
公开(公告)号：JPH02221215A
公开(公告)日：1990-09-04
申请号：JP4363389
申请日：1989-02-23
申请人： KANEBO LTD
发明人： HAMADA KAZUTO
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a hair tonic cosmetic which has action to inhibit 5alpha-reductase and manifests excellent hair-growing effect and hair-falling and dandruff prevention with reduced skin irritation by using Carthami Flos essence. CONSTITUTION:An essence of Carthami Flos, a red pigment of a safflower, BENIBANA (Carthamus tinctorius L. in Compositae) is added, in an amount of 0.004 to 0.4wt.%, preferably 0.004 to 3.2wt.% (on the dry basis) of the total weight of the composition, to a base for hair tonic, hair lotion, hair cream or the like and the subject cosmetic is obtained according to the usual manner. The hair tonic cosmetic can appropriately contain pigments, perfumes, antiseptics, disifectants, keratin-dissolving agent, anti-androgen, hair tonics, antioxidants and so on.

5. 发明专利

JP2001089326A HAIR-GROWING COSMETIC 失效
公开(公告)号：JP2001089326A
公开(公告)日：2001-04-03
申请号：JP26341299
申请日：1999-09-17
申请人： KANEBO LTD
发明人： MORITA KAZUYOSHI , HAMADA KAZUTO , FUKUDA YASUKO
IPC分类号： A61K8/00 , A61K8/49 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a cosmetic having excellent hair-growing effect and hair loss preventive effect. SOLUTION: This hair-growing cosmetic is obtained by formulating a purified fraction consisting mainly of sesaminol of the general structural formula (the 2-position and 6-position each indicates α-or β-stereoisomer) or sesaminol such as 2β,6β-sesaminol, 2α,6β-(+)sesaminol[i.e., 6-epi-(+)sesaminol] or 2β,6α-(+) sesaminol[i.e. 2-epi-(+)sesaminol]; by the way, the above sesaminol is obtained, for example, by the following procedure: deodorized and decolored sesame oil (e.g. white sesame oil on the market) or a methanol-soluble fraction obtained by dissolving deodorized and decolored sesame oil in methanol followed by chilling the resultant methanol solution and then removing the resultant precipitate, is used as starting material and subjected to such a means as organic solvent two-phase partition column chromatography, high-performance liquid chromatography, molecular sieve membrane or supercritical extraction.

6. 发明专利

JP2001048756A HAIR GROWER 失效
公开(公告)号：JP2001048756A
公开(公告)日：2001-02-20
申请号：JP22498299
申请日：1999-08-09
申请人： KANEBO LTD
发明人： MORITA KAZUYOSHI , HAMADA KAZUTO
IPC分类号： A61K8/00 , A61K8/35 , A61K31/12 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair grower having a promoting action on peripheral blood circulation of scalp and an activating action on a hair-mother cell, excellent hair growing effect and a preventing effect on depilation by making the hair growing cosmetic include a bis(hydroxyphenyl)pentadienone compound. SOLUTION: This hair growing composition contains preferably 0.0001-10.0 wt.% more preferably 0.005-5.0 wt.% of a bis(hydroxyphenyl)pentadienone compound of the formula (R1 is H, CH3 or C2H5; OR1 shows 1-3 substituents on each aromatic ring) [e.g. 1,5-bis(p-hydroxy-m-methoxyphenyl)-1,4-pentadien-3-one]. The compound of the formula can be produced, for example, by a method for protecting the hydroxyl group of 3-methoxy-4-hydroxybenzaldehyde, 4- hydroxybenzaldehyde, etc., with 3,4-dihydropyran, methoxymethyl chloride, etc., then, condensing the protected substance with acetone and finally deprotecting the condensed substance with an acid, etc.

7. 发明专利

JPH10236924A HAIR-RESTORING COSMETIC 失效
公开(公告)号：JPH10236924A
公开(公告)日：1998-09-08
申请号：JP5391997
申请日：1997-02-21
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , IKEMOTO TAKESHI , KUWABARA YASUSHI
IPC分类号： A61K8/00 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair-restoring cosmetic safe for skins and having sufficient effects for restoring hair, preventing the falling of hair, etc., by formulating a specific capsaicin analogue, vanillyl amide derivative, in the form of its glycoside with a saccharide such as glucose, galactose, xylose or maltose. SOLUTION: This hair-restoring cosmetic contains at least one kind of glycoside expressed by the formula (G is a saccharide residue obtained from a monosaccharide or an oligosaccharide; R is a 8-11C saturate/unsaturated hydrocarbon). A vanillyl amide derivative for forming the glycoside is capsaicin, etc. The saccharide to be combined with the vanillyl amide derivative includes all of saccharides forming the glycosides, but preferably is a monosaccharide such as glucose or an oligosaccharide such as maltose from the aspects of easy availability, solubility in aqueous solvents, and endermic absorbability. The obtained glycoside is especially preferably a glucose glycoside, concretely capsaicin β-D-glucoside, etc. The glycoside is formulated in an amount of 0.1-10.0wt.% based on the cosmetic.

8. 发明专利

JPH1077216A HAIR-RESTORING COSMETIC MATERIAL 失效
公开(公告)号：JPH1077216A
公开(公告)日：1998-03-24
申请号：JP25551096
申请日：1996-09-04
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , SUZUKI KEIKO , NAKAGAWA NORIAKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/97 , A61Q5/00 , A61Q7/00 , A61K7/06 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a hair-restoring cosmetic material excellent in hair-growing effect and prevention effect against loss of hair. SOLUTION: This hair-restoring cosmetic material contains substances of more than at least one selected form a group consisting of nicotinic alcohol tartrate, extracts of Swertia japonica, extracts of Panax Schinseng, extracts of duke, Capsicum annum tincture, diisopropylamine dichloroacetate, γ- aminobutyric acid derivatives, hinokitiol, vitamine E derivatives, pantothenic acid derivatives, nicotinic acid derivatives, glycyrrhizin derivatives and glycyrrhetinic acid derivatives.

9. 发明专利

JPH0940531A HAIR TONIC 失效
公开(公告)号：JPH0940531A
公开(公告)日：1997-02-10
申请号：JP21260295
申请日：1995-07-27
申请人： KANEBO LTD
发明人： HAMADA KAZUTO , IKEMOTO TAKESHI , NISHIO HIROYUKI
IPC分类号： A61K8/00 , A61K8/33 , A61K31/085 , A61K31/70 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair tonic that has sustained-release hair tonic effects, such as hair growing, depilation-preventive and dandruff-preventive effects, by using eugenol in a specific form as a 5α-reductase activity inhibitor. SOLUTION: This hair tonic is obtained by blending an eugenol glycoside. The blending ratio is preferably 0.1-10.0wt.% to the whole quantity of the hair tonic. The eugenol glycoside can be easily synthesized by a well known method. Among eugenol glycosides, glucose glycosides, specifically eugenyl α-D-glucoside and/or eugenyl β-D-glucosicle, are preferable because of degree of manifestation of their effects. In this case, although β-glucosides are more preferable, α- glucosides may be contained without affecting the effects. This hair tonic can be formulated in such a form as hair tonic, hair lotion and hair mousse which are directly applied to the scalp.

10. 发明专利

JPH07215824A HAIR GROWTH STIMULANT 失效
公开(公告)号：JPH07215824A
公开(公告)日：1995-08-15
申请号：JP2893694
申请日：1994-01-31
申请人： KANEBO LTD
发明人： MIYAMOTO TATSU , SEKO NORIHIKO , HAMADA KAZUTO , NAKAGAWA NORIAKI
IPC分类号： A61K8/00 , A61K8/43 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PURPOSE:To obtain a hair growth stimulant containing a specific cyanoguanidine derivative, effective for improving the peripheral blood flow of scalp and activating the hair matrix cell and exhibiting excellent hair-growing effect, hair-falling prevention effect and safety. CONSTITUTION:This hair growth stimulant contains a cyanoguanidine derivative of the formula (R and R are each a halogen, cyano or nitro; R is a 4-7C alkyl having a branched chain at 1-site). The compound the formula is known as a substance having potassium channel opening action. The cyanoguanidine derivative of the formula is e.g. N-t-butyl-N'-cyano-N''-(3,5dichlorophenyl)- guanidine and N-cyano-N'-(3,5-dichlorophenyl)N''-(1,1,2-trimethylpropyl)guanidine. The compounding amount of the compound of the formula is preferably about 0.01-3.0wt.%. The hair growth stimulant is used e.g. in the form of hair tonic, hair lotion, hair cream, hair conditioner, shampoo, rinse, hair gel, hair mist, hair foam, etc.

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