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1. 发明专利

JP2014144953A Pai-1 inhibitor 有权
标题翻译： PAI-1抑制剂
公开(公告)号：JP2014144953A
公开(公告)日：2014-08-14
申请号：JP2014004588
申请日：2014-01-14
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： YAMAGUCHI YOICHI , YANASE TAKASHI , MUTO SUSUMU , ITAI AKIKO
IPC分类号： C07C59/64 , A61K31/11 , A61K31/167 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/402 , A61K31/4453 , A61K31/45 , A61K31/495 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P7/02 , A61P43/00 , C07C59/66 , C07C59/68 , C07C59/90 , C07C65/24 , C07C205/34 , C07C205/35 , C07C205/56 , C07C217/80 , C07C217/92 , C07C229/18 , C07C229/42 , C07C229/44 , C07C233/25 , C07C233/48 , C07C233/56 , C07C235/56 , C07C255/54 , C07C255/60 , C07C311/29 , C07C317/22 , C07C323/12 , C07C323/41 , C07C323/62 , C07D211/40 , C07D295/04 , C07D295/12
CPC分类号： C07D211/42 , C07C59/66 , C07C59/68 , C07C59/70 , C07C65/24 , C07C69/712 , C07C69/736 , C07C69/76 , C07C205/37 , C07C217/80 , C07C217/84 , C07C233/15 , C07C233/29 , C07C233/51 , C07C233/56 , C07C235/38 , C07C235/40 , C07C235/68 , C07C235/80 , C07C255/54 , C07C311/08 , C07C311/29 , C07C317/22 , C07C323/12 , C07C323/22 , C07C323/41 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D257/04 , C07D295/12 , C07D317/54
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as plasminogen activator inhibitor-1 (PAI-1) inhibitor and use thereof.SOLUTION: There is provided a compound represented by the formula (I), where Ris Caryl group which may be substituted and the like, T is a single bond, 1,4-piperazinine and the like, m is 0 or 1, G is -N-C(=O)-COH when m is 0, G is O when m is 1, Ris H, Caryl group which may be substituted, E is the formula (II), where one of Rto Ris the formula R-T-, remaining three are each independently a hydrogen atom and the like, Ris the formula -X-Y', H and the like, X is -CH- and the like, Y' is a carboxyl group and the like, and M is a single bond and the like.
摘要翻译：要解决的问题：提供可用作纤溶酶原激活物抑制剂-1（PAI-1）抑制剂的化合物及其用途。溶液：提供由式（I）表示的化合物，其中Ris可以被取代的卡瑞基和 T为单键，1,4-哌嗪基等，m为0或1，当m为0时，G为-NC（= O）-COH，当m为1时，G为O，R为H，可以被取代的卡瑞基，E是式（II），其中Rto R中的一个为式RT-，其余三个各自独立地为氢原子等，R为式-X-Y'，H等，X为-CH-等，Y'为羧基等，M为单键等。

2. 发明专利

JP2013010692A Halogenated alkylsulfonamide derivative 审中-公开
标题翻译：氢化烷基磺酰胺衍生物
公开(公告)号：JP2013010692A
公开(公告)日：2013-01-17
申请号：JP2009235006
申请日：2009-10-09
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： YAMAGUCHI YOICHI , YANASE KENJI , ICHIGE TATSURO , MUTO SUSUMU , ITAI AKIKO
IPC分类号： C07C311/08 , A61K31/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/08 , A61P17/02 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P31/04 , A61P35/00 , A61P37/06 , A61P43/00 , C07C317/36
CPC分类号： C07C323/49 , A61K31/18 , C07C311/09 , C07C317/40
摘要： PROBLEM TO BE SOLVED: To provide a compound having a plasminogen activator inhibitor-1(PAI-1) inhibitory effect, and a utilization method thereof.SOLUTION: A compound represented by formula (I) or the like has a PAI-1 inhibitory effect. [In the formula, Rrepresents an optionally substituted Caryl group or the like; Rrepresents an optionally substituted Caryl group or the like; E represents a benzene ring; Z represents a halogenated Calkyl group; T represents a single bond or the like; G represents an oxygen atom or the like; and m represents 0 or 1].
摘要翻译：待解决的问题：提供具有纤溶酶原激活物抑制剂-1（PAI-1）抑制作用的化合物及其使用方法。解决方案：由式（I）等表示的化合物具有PAI-1抑制作用。 [式中，R 1 表示任选取代的C 6 -C 12芳基; R 2 表示任选取代的C 6 -C 12芳基; E表示苯环; Z表示卤代C 1-6烷基; T表示单键等; G表示氧原子等; m表示0或1]。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2009215300A Derivative having ppar(peroxisome proliferator-activated receptor) agonistic activity 审中-公开
标题翻译：具有PPAR（过氧化物促进激活受体）的激活活性衍生物
公开(公告)号：JP2009215300A
公开(公告)日：2009-09-24
申请号：JP2009100563
申请日：2009-04-17
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , Shionogi & Co Ltd , 塩野義製薬株式会社 , 株式会社医薬分子設計研究所
发明人： ITAI AKIKO , MUTO SUSUMU , TOKUYAMA TATSUMITSU , FUKAZAWA HIROSHI , OHARA TAKAFUMI , KATO TERUKAZU
IPC分类号： C07D211/34 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07D215/38 , C07D241/04 , C07D241/44 , C07D277/20 , C07D277/42 , C07D277/82 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D487/08 , C07D513/04
CPC分类号： C07D211/22 , C07D211/58 , C07D241/04 , C07D241/44 , C07D277/82 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as a PPAR agonist. SOLUTION: The compound is represented by formula (I) (wherein, the ring Q is a monocyclic aryl group that may be substituted or the like; Y 1 is a single bond, -NR 6 - or the like; the ring A is a nonaromatic heterocyclic diyl or the like; formulae: -Y 2 and Z 1 -are each a group represented by formula (II) or the like; in formula (II), R 7 , R 8 and R 9 are each a lower alkyl group or the like, n is an integer of 0 to 3, and Z 1 is a single bond, O, S or NR 9 ; the ring B is an aromatic carbocyclic diyl or the like; Y 3 is a lower alkenylene group or the like; and Z 2 is COOR 3 or the like). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供可用作PPAR激动剂的化合物。解决方案：该化合物由式（I）表示（其中，环Q是可被取代的单环芳基等; Y 1是单键，-NR' SP> 6等;环A是非芳族杂环二基等;式：-Y 2 和Z 1 - 各a 式（II）表示的基团等;在式（II）中，R“SP”7 ，R“SP”8“和”SP“9 分别为较低烷基等，n为0〜3的整数，Z 1为单键，O，S或NR 9;环B为芳香族碳环二基等; Y 3是低级亚烯基或类似物; Z 2 是COOR 3等。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2007200315A Method for predicting medical molecule side effect and method for predicting drug discovery target 有权
标题翻译：用于预测药物分子侧效应的方法和用于预测药物发现目标的方法
公开(公告)号：JP2007200315A
公开(公告)日：2007-08-09
申请号：JP2007002958
申请日：2007-01-11
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： ITAI AKIKO
IPC分类号： G06F17/30 , G06F19/00 , G06F19/12 , G06F19/18
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting a medical molecule side effect or drug discovery target by use of a database capable of connecting biomolecule information with bio-events. SOLUTION: The method for predicting a medical molecule side effect comprises steps of: (a) storing information on a biomolecule pair in a biomolecule-linkage database including information on the bio-events; (b) selecting one or more biomolecules and/or bio-events as an end point of search; (c) performing a connection search for automatically searching a linkage of functionally or biosynthetically relevant molecules, thereby generating a molecule-function network that is a linkage of functionally or biosynthetically relevant molecules including the end point; and (d) displaying the molecule-function network as a graph having the biomolecules and/or bio-events as nodes. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过使用能够将生物分子信息与生物事件连接的数据库来预测医学分子副作用或药物发现靶标的方法。解决方案：用于预测医学分子副作用的方法包括以下步骤：（a）在生物分子连锁数据库中存储生物分子对上的信息，包括关于生物事件的信息; （b）选择一种或多种生物分子和/或生物事件作为搜索的终点; （c）执行连接搜索以自动搜索功能或生物合成相关分子的连接，由此产生分子功能网络，其是包括终点的功能或生物合成相关分子的连接; 和（d）将分子功能网络显示为具有生物分子和/或生物事件作为节点的图。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2012121889A Hdl enhancer 有权
标题翻译： HDL增强器
公开(公告)号：JP2012121889A
公开(公告)日：2012-06-28
申请号：JP2012007712
申请日：2012-01-18
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , Shionogi & Co Ltd , 塩野義製薬株式会社 , 株式会社医薬分子設計研究所
发明人： ITAI AKIKO , MUTO SUSUMU , TOKUYAMA TATSUMITSU , FUKAZAWA HIROSHI , OHARA TAKAFUMI , KATO TERUKAZU
IPC分类号： A61K31/428 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/5377 , A61K31/55 , A61K31/551 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an HDL (high density lipoprotein) enhancer for producing a medicine for treating and/or preventing arteriosclerosis, in particular, coronary artery disease such as myocardial infarction and angina pectoris, hyperlipemia, diabetes, obesity, atherosclerosis, hyperglycemia and/or syndrome X.SOLUTION: The compound is exemplified by formula. The HDL enhancer is completed by selecting a compound which can be made into a PPAR agonist, synthesizing many derivatives based on the structure of the selected compound, selecting a compound having high activity and desired pharmacological activity, and further performing the derivative synthesis thereof.
摘要翻译：待解决的问题：提供一种用于制备用于治疗和/或预防动脉硬化的药物的HDL（高密度脂蛋白）增强剂，特别是冠状动脉疾病如心肌梗塞和心绞痛，高脂血症，糖尿病，肥胖症，动脉粥样硬化，高血糖症和/或症状综合症。解决方案：该化合物以式表示。通过选择可以制成PPAR激动剂的化合物，基于所选化合物的结构合成许多衍生物，选择具有高活性和所需药理活性的化合物，并进一步进行其衍生合成来完成HDL增强子。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2010215644A Antiallergic agent 审中-公开
标题翻译：抗真菌剂
公开(公告)号：JP2010215644A
公开(公告)日：2010-09-30
申请号：JP2010117814
申请日：2010-05-21
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： MUTO SUSUMU , ITAI AKIKO
IPC分类号： A61K31/12 , A61K31/055 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/277 , A61K31/335 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/455 , A61K31/47 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/505 , A61K31/5375 , A61K31/5377 , A61K31/606 , A61K31/609 , A61K31/616 , A61K31/63 , A61K31/695 , A61P11/06 , A61P15/00 , A61P17/00 , A61P17/04 , A61P27/16 , A61P37/08 , C07D207/48 , C07D209/34 , C07D209/88 , C07D211/26 , C07D213/76 , C07D213/81 , C07D215/12 , C07D231/12 , C07D231/38 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/44 , C07D261/14 , C07D277/20 , C07D277/28 , C07D277/34 , C07D277/42 , C07D277/44 , C07D277/56 , C07D285/135 , C07D295/12 , C07D295/18 , C07D295/192 , C07D317/66 , C07D319/20 , C07D321/10 , C07D323/00 , C07D333/38 , C07D333/68 , C07D471/04
CPC分类号： C07D295/192 , A61K31/055 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/445 , A61K31/4453 , A61K31/455 , A61K31/47 , A61K31/498 , A61K31/5375 , A61K31/606 , A61K31/609 , A61K31/616 , A61K31/63 , C07C235/64
摘要： PROBLEM TO BE SOLVED: To provide medicaments which enable radical preventive and/or therapeutic treatment of allergy by an inhibition of allergic reactions.
SOLUTION: There is provided the medicament for the preventive and/or therapeutic treatment of allergic diseases which comprises as an active ingredient, a substance selected from the group consisting of compounds represented by general formula (I) (wherein X is a connecting group whose main chain has the number of atoms of 2 to 5, or the like; A is hydrogen or the like; E is an aryl group which may be substituted, or the like; and ring Z is an arene which may have further substituents in addition to the group represented by formula -O-A or -X-E, or the like), pharmacologically acceptable salt thereof, hydrate thereof and solvate thereof.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供能够通过抑制过敏反应进行过敏的基础性预防和/或治疗性治疗的药物。解决方案：提供了用于预防和/或治疗过敏性疾病的药物，其包含作为活性成分的选自由通式（I）表示的化合物的物质（其中X为连接其主链的原子数为2〜5个的基团等; A为氢等; E为可被取代的芳基等;环Z为可具有其他取代基的芳烃除了由式-OA或-XE表示的基团等），其药学上可接受的盐，其水合物和其溶剂化物。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009221204A Derivative having ppar agonistic activity 审中-公开
标题翻译：具有PPAR激活活性的衍生物
公开(公告)号：JP2009221204A
公开(公告)日：2009-10-01
申请号：JP2009100585
申请日：2009-04-17
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , Shionogi & Co Ltd , 塩野義製薬株式会社 , 株式会社医薬分子設計研究所
发明人： ITAI AKIKO , MUTO SUSUMU , TOKUYAMA TATSUMITSU , FUKAZAWA HIROSHI , OHARA TAKAFUMI , KATO TERUKAZU
IPC分类号： C07D211/34 , A61K31/454 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/551 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P9/10 , A61P9/12 , A61P15/08 , A61P19/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D215/38 , C07D241/44 , C07D277/82 , C07D401/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
CPC分类号： C07D211/22 , C07D211/58 , C07D241/04 , C07D241/44 , C07D277/82 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as a PPAR agonist. SOLUTION: A compound expressed by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the compound or salt are provided. In the formula, the ring Q represents a monocyclic aryl which may be substituted, a monocyclic heteroaryl which may be substituted, a fused aryl which may be substituted, a fused heteroaryl which may be substituted, or the like; Y 1 represents a single bond, -NR 6 - or the like; the ring A represents a non-aromatic heterocyclic diyl which may be substituted; the formula: -Y 2 -represents a group comprising an amide, an acyl, a sulfonyl or the like; Z 1 represents a single bond, O, S or NR 9 ; the ring B represents an aromatic carbocyclic diyl which may be substituted or an aromatic heterocyclic diyl which may be substituted; Y 3 represents a single bond, a lower alkylene which may be substituted and may have -O- inserted therein, a lower alkylene which may be substituted, or the like; and Z 2 represents COOR 3 or the like. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供可用作PPAR激动剂的化合物。解决方案：提供由式（I）表示的化合物，其药学上可接受的盐或该化合物或其盐的溶剂合物。在该式中，环Q表示可被取代的单环芳基，可被取代的单环杂芳基，可被取代的稠合芳基，可被取代的稠合杂芳基等; Y 1 表示单键，-NR 6 SP 6等。环A表示可以被取代的非芳族杂环二基; 式：-Y 2 - 表示包含酰胺，酰基，磺酰基等的基团; Z 1 表示单键，O，S或NR 9 ; 环B表示可被取代的芳族碳环二基或可被取代的芳族杂环二基; Y 2 表示COOR 3 等。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2008208129A Derivative having ppar agonistic activity 有权
标题翻译：具有PPAR激活活性的衍生物
公开(公告)号：JP2008208129A
公开(公告)日：2008-09-11
申请号：JP2008061970
申请日：2008-03-12
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , Shionogi & Co Ltd , 塩野義製薬株式会社 , 株式会社医薬分子設計研究所
发明人： ITAI AKIKO , MUTO SUSUMU , TOKUYAMA TATSUMITSU , FUKAZAWA HIROSHI , OHARA TAKAFUMI , KATO TERUKAZU
IPC分类号： C07D211/16 , A61K31/439 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P5/50 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/08 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D215/38 , C07D241/04 , C07D241/44 , C07D277/20 , C07D277/42 , C07D277/82 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/08 , C07D513/04
CPC分类号： C07D211/22 , C07D211/58 , C07D241/04 , C07D241/44 , C07D277/82 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as a PPAR (peroxisome proliferator-activated receptor) agonist. SOLUTION: There is provided a compound represented by formula (I), a pharmaceutically acceptable salt or solvate thereof (wherein ring Q is an optionally substituted monocyclic or fused aryl or heteroaryl; Y 1 is a single bond, -NR 6 - or the like; ring A is an optionally substituted nonaromatic heterocyclic-diyl; the formula, -Y 2 Z 1 - is a specific binding group having N, S and O atoms; Z 1 is a single bond, O, S or NR 9 ; ring B is an optionally substituted aromatic carbocyclic- or heterocyclic-diyl; Y 3 is a single bond, an optionally substituted lower alkylene optionally interposed by -O-, an optionally substituted lower alkenylene or the like; and Z 2 is COOR 3 or the like). COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供可用作PPAR（过氧化物酶体增殖物激活受体）激动剂的化合物。提供由式（I）表示的化合物，其药学上可接受的盐或溶剂合物（其中环Q是任选取代的单环或稠合的芳基或杂芳基; Y 1是单键，-NR 6 SP 6等;环A是任选取代的非芳族杂环二基;式-Y SP SP 2 >是具有N，S和O原子的特异性结合基团; Z 1是单键，O，S或NR 9;环B是任选取代的芳族碳环或杂环二基; Y 3是单键，任选被取代的低级亚烷基，任选被-O-插入，任选取代的低级亚烯基等; Z 2， SP>是COOR 3 等）。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2012027939A Method for generating molecular function network 审中-公开
标题翻译：生成分子功能网络的方法
公开(公告)号：JP2012027939A
公开(公告)日：2012-02-09
申请号：JP2011211321
申请日：2011-09-27
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： TOMIOKA NOBUO , ITAI AKIKO
IPC分类号： G06F17/30 , A61P43/00 , C07K1/00 , G01N33/15 , G01N33/50 , G06F19/00 , G06F19/12 , G06F19/18
CPC分类号： G06F19/12 , C07K1/00 , G06F19/702
摘要： PROBLEM TO BE SOLVED: To provide a mechanism and method for understanding various biological responses and phenomena in aspects of functions of biological molecules and inter-molecule relations.SOLUTION: Information of biological molecule pairs for generating information representing a continuous connection of a set number of molecules with a biological molecule designated by a user among biological molecules included in a first molecular network comprising information representing a connection between two or more biological molecules, as the origin, is searched using a database including the information of the biological molecule pairs, and a second molecular network including the information representing the continuous connection of the molecules with the user-designated biological molecule as the origin and the first molecular network is generated and displayed on the basis of the search result, and clinical state event information associated with the information comprising two or more connected biological molecule pairs, which is included in the second molecular network, is searched and displayed by using clinical state event information associating a clinical state event and the information triggering the clinical state event and comprising two or more connected biological molecule pairs.
摘要翻译：要解决的问题：提供一种理解生物分子和分子间关系功能方面的各种生物反应和现象的机制和方法。生物分子对的信息，用于产生表示一组数量的分子与用户指定的生物分子的生物分子的连续连接的信息，包括在第一分子网络中的生物分子，包括表示两个或更多个生物使用包括生物分子对的信息的数据库来搜索作为起点的分子，以及包括表示分子与用户指定的生物分子作为起点和第一分子网络的连续连接的信息的第二分子网络基于搜索结果生成和显示，并且通过使用临床状态事件信息相关联来搜索和显示与包括在第二分子网络中的包括两个或更多个连接的生物分子对的信息相关联的临床状态事件信息临床状态并且触发临床状态事件的信息并且包括两个或多个连接的生物分子对。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2010092492A Method for forming molecular function network 审中-公开
标题翻译：形成分子功能网络的方法
公开(公告)号：JP2010092492A
公开(公告)日：2010-04-22
申请号：JP2009259881
申请日：2009-11-13
申请人： Iyaku Bunshi Sekkei Kenkyusho:Kk , 株式会社医薬分子設計研究所
发明人： TOMIOKA NOBUO , ITAI AKIKO
IPC分类号： G06F19/00 , A61P43/00 , C07K1/00 , G01N33/15 , G01N33/50 , G06F17/30 , G06F19/12 , G06F19/18
CPC分类号： G06F19/12 , C07K1/00 , G06F19/702
摘要： PROBLEM TO BE SOLVED: To provide a mechanism and a method for understanding various biological responses and phenomena in the relationship among functions of biomolecules and the molecules. SOLUTION: In this method, information about pairs of biomolecules for generating the information indicating bond of the set number of continuous molecules is retrieved by using a database including the information about pairs of biomolecules beginning from the biomolecule specified by a user from among the biomolecules included in a first molecular network constituted by the information indicating the bond among two biomolecules or more. A second molecular network including the information indicating the bond of continuous molecules beginning from the biomolecule specified by the user and the first molecular network is generated based on the information about pairs of biomolecules obtained by the retrieval of the information about pairs of biomolecules and is displayed. The information about the biological event related to the biomolecules or the like included in the second molecular network is retrieved by using the biological event and the information about the biological event relating the biomolecules or the like being primers for the biological event and is displayed. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于理解生物分子和分子的功能之间的关系中的各种生物反应和现象的机制和方法。解决方案：在该方法中，通过使用包括从用户指定的生物分子开始的生物分子对的信息的数据库从数据库中获取关于生成指示连续分子数目的连接的信息的生物分子对的信息，包含在由表示两个生物分子之间的键的信息构成的第一分子网络中的生物分子或更多。基于通过检索关于生物分子对的信息获得的关于生物分子对的信息，生成第二分子网络，其包括从用户和第一分子网络指定的生物分子开始的表示连续分子的键的信息，并显示。通过使用生物事件和关于生物分子等与生物事件的引物相关联的生物事件的信息来显示关于生物分子等与生物分子相关的生物学事件的信息，并且被显示。版权所有（C）2010，JPO＆INPIT

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