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JP2013199457A Chaperonin complex and method of producing the same 有权
标题翻译： CHAPERONIN复合物及其生产方法
公开(公告)号：JP2013199457A
公开(公告)日：2013-10-03
申请号：JP2012070329
申请日：2012-03-26
申请人： Ikutoku Gakuen , 学校法人幾徳学園
发明人： KOIKE AYUMI , YODA HIROMI , YAMAMOTO OSAMU
IPC分类号： C07K14/245 , A61K8/19 , A61K8/64 , A61Q1/00 , C07K1/02 , C07K17/02 , C07K17/14 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a chaperonin complex capable of encapsulating metal nano particles with excellent efficiency.SOLUTION: A chaperonin complex comprises: a chaperonin variant; and metal nano particles. The chaperonin variant comprises a plurality of GroEL subunits containing at least one GroEL subunit variant selected from the group comprising: a first GroEL subunit variant that consists of a specific amino acid sequence; and a second GroEL subunit variant that consists of an amino acid sequence in which one or more amino acid residues other than an alanine residue lying at a specific position are substituted, deleted, or added, among the amino acid sequences, and that has molecular chaperone activity. The metal nano particles are surrounded with the plurality of GroEL subunits.
摘要翻译：要解决的问题：提供能够以优异的效率包封金属纳米颗粒的伴侣伴侣配合物。解决方案：伴侣伴侣配合物包括：伴侣伴侣变体; 和金属纳米颗粒。伴侣伴侣变体包含多个含有至少一个选自下组的GroEL亚基变体的GroEL亚基，所述GroEL亚基变体包含：由特定氨基酸序列组成的第一GroEL亚基变体; 以及由氨基酸序列组成的第二个GroEL亚基变体，其氨基酸序列中氨基酸序列中被替换，缺失或添加了除位于特定位置的丙氨酸残基之外的一个或多个氨基酸残基，并且具有分子伴侣活动。金属纳米颗粒被多个GroEL子单元包围。

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