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1. 发明专利

JP2014210742A 持続性磁性抗がん剤审中-公开
标题翻译：永久磁性反应剂代理
公开(公告)号：JP2014210742A
公开(公告)日：2014-11-13
申请号：JP2013088559
申请日：2013-04-19
申请人：株式会社Ihi , Ihi Corp , 株式会社Ihi , 石川義弘 , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： A61K45/00 , A61K31/337 , A61K41/00 , A61K47/48 , A61P35/00 , C07F15/02
CPC分类号： A61K31/33 , A61K41/00 , A61K45/00 , A61K47/48 , C07F15/02
摘要：【課題】金属サレン錯体を利用した有益な抗ガン剤を提供する。【解決手段】本発明は、(N,N,O,O)を4座配位子として金属を配位させた金属サレン錯体に、タキサン系抗がん性分子を結合した複合体を有効成分として含有し、細胞周期の複数のフェーズで作用する、持続性磁性抗がん剤である。【選択図】なし
摘要翻译：要解决的问题：提供使用金属salen复合物的有用的抗癌剂。解决方案：持久性磁性抗癌剂含有作为活性成分的配合物，其中紫杉烷抗癌分子与金属配位的金属salen复合物结合为4- 配位配体与（N，N，O，O）配位，并在细胞周期的多个阶段起作用。

2. 发明专利

JP2013170133A Inorganic compound, medicament containing inorganic compound, delivering system of medicament, magnetism-detecting apparatus and apparatus for cancer hyperthermic potentiation method 审中-公开
标题翻译：无机化合物，含有无机化合物的药物，药物递送系统，检测装置和用于癌症高血压潜伏方法的装置
公开(公告)号：JP2013170133A
公开(公告)日：2013-09-02
申请号：JP2012033960
申请日：2012-02-20
申请人： Ihi Corp , 株式会社Ihi , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： C07F7/08 , A61K31/713 , A61K47/02 , A61K47/48 , A61K48/00 , A61K49/00 , A61P35/00 , C07F7/10 , C07F7/21 , C07F19/00
摘要： PROBLEM TO BE SOLVED: To provide an easily practicable drug delivery system by solving a conventional technical problem by imparting magnetism to a short-chain RNA (siRNA), an anticancer agent and an in-vivo marker.SOLUTION: There is provided a compound represented by the formula, and obtained by binding a nucleic acid or a medicament through a silane coupling agent to an inorganic compound such as iron oxide and cobalt oxide. [In the formula, M is an inorganic compound such as iron oxide, chromium oxide, manganese oxide, cobalt oxide and nickel oxide; R1 is hydrocarbon; and X is a nucleic acid or a medicament such as ibuprofen and an amino acid].
摘要翻译：要解决的问题：通过向短链RNA（siRNA），抗癌剂和体内标记物赋予磁性来解决常规技术问题，提供了一种易于实用的药物递送系统。溶液：提供了一种代表性的化合物并通过将核酸或药物通过硅烷偶联剂与无机化合物如氧化铁和氧化钴结合而得到。 [式中，M为氧化铁，氧化铬，氧化锰，氧化钴，氧化镍等无机化合物， R1是烃; X是核酸或药物如布洛芬和氨基酸]。

3. 发明专利

JP2009196912A Medicine having magnetism, guiding system for medicine and magnetism-detecting system 有权
标题翻译：具有磁性药物，药物和检测系统指导系统
公开(公告)号：JP2009196912A
公开(公告)日：2009-09-03
申请号：JP2008038458
申请日：2008-02-20
申请人： Ihi Corp , Yoshihiro Ishikawa , 株式会社Ihi , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： A61K41/00 , A61K31/19 , A61K47/48 , A61K49/00 , A61P25/00
摘要： PROBLEM TO BE SOLVED: To realize a drug delivery system that solves conventional technical problems and can be readily put into practice. SOLUTION: The medicine having magnetism is obtained by converting an -NH 2 group in a compound bearing the -NH 2 group in its side chain into a stable radical comprising NO* (NO radical). As the medicine itself has magnetism, it can be guided to an affected part in the body utilizing the magnetism of the medicine itself without using a carrier composed of a magnetic substance as before. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：实现解决传统技术问题并可以很容易实施的药物输送系统。解决方案：具有磁性的药物通过在其侧链中具有-NHS SB 2基团的化合物中的-NHS SB 2基团转化成稳定的基团而获得，所述基团包含 NO *（NO基）。由于药物本身具有磁性，因此可以利用药物本身的磁性将其引导到身体的受影响部位，而不使用如前所述的由磁性物质组成的载体。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2014152121A Magnetic material 有权
标题翻译：磁性材料
公开(公告)号：JP2014152121A
公开(公告)日：2014-08-25
申请号：JP2013020939
申请日：2013-02-05
申请人： Ihi Corp , 株式会社Ihi , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： C07F15/02
CPC分类号： C07F15/025 , C07F15/02 , H01F1/42 , Y10T428/2982
摘要： PROBLEM TO BE SOLVED: To clarify the structure of a metal complex having ferromagnetism and provide a magnetic material which has such a structure and can exert ferromagnetism surely.SOLUTION: A magnetic material contains a metal complex compound consisting of a plurality of metal complex molecules in which a heterocycle is bonded to a metal and each of the metals of the metal complex molecules is bonded to another metal of the metal complex molecules through an electron donor, with a metal-(electron donor)-metal bond angle of 130° to 160°.
摘要翻译：要解决的问题：为了阐明具有铁磁性的金属络合物的结构，并提供具有这种结构并且可以发挥铁磁性的磁性材料。解决方案：磁性材料包含由多个金属络合物分子组成的金属络合物，其中杂环与金属键合，并且金属络合物分子的每种金属通过电子给体与金属络合物分子的另一金属键合，金属（电子给体） - 金属键合角为130°至160° °。

5. 发明专利

JP2013159598A Ultraviolet absorber and cosmetic using the same 审中-公开
标题翻译：超声波吸收器和使用它的化妆品
公开(公告)号：JP2013159598A
公开(公告)日：2013-08-19
申请号：JP2012025318
申请日：2012-02-08
申请人： Ihi Corp , 株式会社Ihi , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： A61K8/58 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide an ultraviolet absorber that has a sufficient blocking effect on ultraviolet light, can naturally color the skin in harmony with a skin color of a race having a dark skin color when applied to the skin, induce pigment by a magnet since the ultraviolet absorber itself is a magnetic substance and can put on makeup to exhibit three-dimensional effects so that an applied face, body, etc., look three-dimensional, and a cosmetic using the same.SOLUTION: An ultraviolet absorber includes pigment having an ultraviolet absorption function and magnetism. A cosmetic contains the ultraviolet absorber.
摘要翻译：要解决的问题：为了提供对紫外线具有足够的阻挡作用的紫外线吸收剂，当施加到皮肤上时，可以自然地将皮肤与具有深色肤色的种族的皮肤颜色一致地变色，通过磁体诱导颜料由于紫外线吸收剂本身是磁性物质，并且可以化妆以展现立体效果，使得所涂敷的面部，身体等看起来立体，并且使用它们的化妆品。解决方案：紫外线吸收剂包括颜料具有紫外线吸收功能和磁性。化妆品含有紫外线吸收剂。

6. 发明专利

JP2010000202A Medical tube or medicine guide system 有权
标题翻译：医疗管道或医疗指导系统
公开(公告)号：JP2010000202A
公开(公告)日：2010-01-07
申请号：JP2008160794
申请日：2008-06-19
申请人： Ihi Corp , Yoshihiro Ishikawa , 株式会社Ihi , 義弘石川
发明人： ISHIKAWA YOSHIHIRO , EGUCHI HARUKI
IPC分类号： A61M25/00 , A61K31/555 , A61M31/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To guide a medicine by a magnetic field to an affected part in the deep part of a body. SOLUTION: A medical tube is provided, which includes a ferromagnetic part at the distal end or at least in a part of the tube. It is preferable that the ferromagnetic part consists of an electromagnet or a permanent magnet. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：将药物通过磁场引导到身体深部的受影响部位。解决方案：提供医疗管，其包括在远端或至少部分管的铁磁部分。铁磁部件优选由电磁体或永磁体构成。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009274962A Iron salen complex, medicine having magnetism, guiding system of medicine and device for detecting magnetism 审中-公开
标题翻译：铁矿复合物，具有磁性的药物，用于检测磁铁的医学指导系统和装置
公开(公告)号：JP2009274962A
公开(公告)日：2009-11-26
申请号：JP2008125202
申请日：2008-05-12
申请人： Ihi Corp , Yoshihiro Ishikawa , 株式会社Ihi , 義弘石川
发明人： ISHIKAWA YOSHIHIRO , EGUCHI HARUKI
IPC分类号： C07C251/24 , A61K31/136 , A61K31/409 , A61K31/519 , A61K31/704 , A61P13/08 , A61P35/00 , C07D475/08 , C07D487/22 , C07F15/02 , C07H15/24
摘要： PROBLEM TO BE SOLVED: To achieve a drug delivery system, capable of solving conventional technical problems and easily made as practically useful.
SOLUTION: An iron salen complex is expressed by formula (1) [wherein, R is a substituent having a hydroxy group]. Since it is possible to give magnetism to the iron salen complex itself, by using it as a medicine, it is possible to guide the medicine to an affected part in a body by utilizing the magnetism which the medicine itself has, without using a conventional carrier consisting of a magnetic substance.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：实现药物递送系统，能够解决常规的技术问题，并且容易地实现为实用的。解决方案：铁盐配合物由式（1）表示[其中，R是具有羟基的取代基]。由于可以对铁盐络合物本身赋予磁性，因此通过使用它作为药物，可以通过利用药物本身具有的磁性将药物引导到身体的受影响部位，而不使用常规的载体由磁性物质组成。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009256232A Medicine having magnetism, guiding system of medicine and device for detecting magnetism 审中-公开
标题翻译：具有磁性的药物，用于检测磁性的药物和装置的指导系统
公开(公告)号：JP2009256232A
公开(公告)日：2009-11-05
申请号：JP2008105912
申请日：2008-04-15
申请人： Ihi Corp , Yoshihiro Ishikawa , 株式会社Ihi , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： A61K47/48 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/198 , A61K31/337 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K31/496 , A61K31/565 , A61K41/00 , A61K47/18 , A61K49/00 , A61P15/10 , A61P35/00 , C07C251/24 , C07C279/14 , C07C323/57 , C07F15/02
摘要： PROBLEM TO BE SOLVED: To provide a drug delivery system, capable of solving conventional technological problems and easily utilized.
SOLUTION: This medicine having magnetism is provided by containing an acid salen complex expressed by formula (I) [wherein, R is a substituting group obtained by leaving hydrogen from a compound having a hydroxy group]. Since it is possible to make an iron salen complex itself have the magnetism, by using the same as the medicine, it is possible to induce the medicine to an affected part in a body by utilizing the magnetism which the medicine itself has, without using a carrier consisting of a magnetic material, as performed conventionally.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够解决常规技术问题并易于使用的药物递送系统。解决方案：具有磁性的药物通过含有由式（I）表示的酸性盐配合物[其中，R是通过从具有羟基的化合物中留下氢而获得的取代基]而提供。由于可以通过使用与药物相同的方式使铁盐络合物本身具有磁性，因此可以通过利用药物本身具有的磁性将药物诱导到身体的受影响部位，而不使用由磁性材料构成的载体，如常规执行的那样。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2014193860A Iron-salen complex, magnetic pharmaceutical, pharmaceutical guidance system, and magnetic detection device 有权
标题翻译：铁酸盐复合物，磁性药物，药物指导系统和磁性检测装置
公开(公告)号：JP2014193860A
公开(公告)日：2014-10-09
申请号：JP2014046808
申请日：2014-03-10
申请人： Ihi Corp , 株式会社Ihi , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： C07D475/08 , A61K31/519 , A61K31/555 , A61K41/00 , A61N2/00 , A61P35/00 , C07F15/02
摘要： PROBLEM TO BE SOLVED: To realize, by solving technical problems of the prior art, a drug delivery system which can be easily implemented practically.SOLUTION: The provided iron-salen complex is expressed by the following formula (1). Since the iron-salen complex per se can potentially be magnetic, it becomes possible, in a case where the same is used as a pharmaceutical, to guide the pharmaceutical to an affected site inside a patient's body by taking advantage of the magnetic property borne by the pharmaceutical per se without using carriers consisting of magnets, as in the prior art.
摘要翻译：要解决的问题：通过解决现有技术的技术问题来实现可以实际容易实施的药物递送系统。解决方案：提供的铁 - salen复合物由下式（1）表示。由于铁盐复合体本身可能是磁性的，所以在将其用作药物的情况下，可以通过利用由药物本身不使用由磁体组成的载体，如现有技术。

10. 发明专利

JP2013063926A Carrier compound for drug delivery, drug bound to lipid membrane including the drug in the carrier compound, and drug delivery system using the drug 有权
标题翻译：用于药物递送的载体化合物，包含载体化合物中的药物的脂质膜的药物和使用药物的药物递送系统
公开(公告)号：JP2013063926A
公开(公告)日：2013-04-11
申请号：JP2011203497
申请日：2011-09-16
申请人： Ihi Corp , 株式会社Ihi , Yoshihiro Ishikawa , 義弘石川
发明人： EGUCHI HARUKI , ISHIKAWA YOSHIHIRO
IPC分类号： A61K9/127 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/34 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide a carrier compound which substantially improves availability of liposome in a drug delivery system.SOLUTION: The carrier compound for a drug delivery includes: a first region having affinity to a lipid membrane having a drug at the inside; and a second region including self-magnetic organic molecules.

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