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1. 发明专利

JP2009100747A TRANSFORMING GROWTH FACTOR αHII 审中-公开
标题翻译：转化生长因子αHII
公开(公告)号：JP2009100747A
公开(公告)日：2009-05-14
申请号：JP2008298834
申请日：2008-11-21
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： IN FEI UEI , MEISSNER PAUL S , NI JIAN
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/16 , A61P9/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P17/14 , A61P25/00 , A61P27/02 , A61P35/00 , C07K14/495 , C07K16/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a transforming growth factor αHII polypeptide, a polynucleotide encoding the polypeptide, a method for producing the polypeptide by a recombinant technique and a method for using the same. SOLUTION: A new matured polypeptide, its analogues, and biologically active fragments thereof useful for diagnosis and treatment are provided. The transforming growth factor αHII polypeptide is useful for stimulating healing of wounds, curing neurological disorders, eye disorders, renal disorders and hepatic disorders, stimulating embryogenesis and angiopoiesis, and so forth. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供转化生长因子αHII多肽，编码多肽的多核苷酸，通过重组技术产生多肽的方法及其使用方法。提供了用于诊断和治疗的新的成熟多肽，其类似物和生物活性片段。转化生长因子αHII多肽可用于刺激伤口愈合，治愈神经障碍，眼睛疾病，肾脏疾病和肝脏疾病，刺激胚胎发生和血管生成等。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2006094863A Chemokine alpha-5 审中-公开
标题翻译： CHEMOKINE ALPHA-5
公开(公告)号：JP2006094863A
公开(公告)日：2006-04-13
申请号：JP2005334620
申请日：2005-11-18
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： WEI IN-FEI , NI JIAN , RI I , ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61P37/00 , A61P43/00 , C07K14/47 , C07K14/52 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y10T436/143333
摘要： PROBLEM TO BE SOLVED: To provide a new CK alpha-5 protein which is a member of the alpha chemokine family, CK alpha-5 polypeptide, particularly an isolated nucleic acid encoding a human CK alpha-5 protein; a vector, host cell and recombinant method for producing the CK alpha-5 polypeptide; a screening method for identifying agonists and antagonists of CK alpha-5 activity; a diagnostic method for detecting immune system-related disorders and a therapeutic method for treating the immune system-related disorders. SOLUTION: Provided is an isolated nucleic acid molecule comprising a polynucleotide encoding at least one part of a CK alpha-5 polypeptide having a full-length amino acid sequence having a specific amino acid sequence or a full-length amino acid sequence encoded by a cDNA contained as a plasmid DNA in ATCC Deposit No. 209231. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供作为α趋化因子家族成员的CKα-5蛋白质，特别是编码人CKα-5蛋白质的分离的核酸的CKα-5多肽; 用于产生CKα-5多肽的载体，宿主细胞和重组方法; 用于鉴定CKα-5活性的激动剂和拮抗剂的筛选方法; 用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。解决方案：提供了分离的核酸分子，其包含编码CKα-5多肽的至少一部分的多核苷酸，其具有全长氨基酸序列，其具有特定氨基酸序列或编码的全长氨基酸序列通过在ATCC保藏号209231中作为质粒DNA包含的cDNA。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2006087443A Transforming growth factor αHII 审中-公开
标题翻译：转化生长因子αHII
公开(公告)号：JP2006087443A
公开(公告)日：2006-04-06
申请号：JP2005348542
申请日：2005-12-01
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： IN FEI UEI , MEISSNER PAUL S , NI JIAN
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/14 , A61P25/00 , A61P25/28 , A61P27/02 , A61P35/00 , C07K14/495 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a transforming growth factor αHII polypeptide, a polynucleotide encoding the polypeptide, a method for producing the polypeptide by a recombinant technique and a method for applying the same. SOLUTION: According to one aspect of the present invention, a novel matured polypeptide and its analogues as well as biologically active fragments useful for diagnosis and treatment are provided. The transforming growth factor αHII polypeptide is useful for stimulating healing of wounds, curing neurological disorders, eye disorders, renal disorders and hepatic disorders, stimulating embryogenesis and angiogenesis, and so forth. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供转化生长因子αHII多肽，编码多肽的多核苷酸，通过重组技术制备多肽的方法及其应用方法。解决方案：根据本发明的一个方面，提供了一种新的成熟多肽及其类似物以及可用于诊断和治疗的生物活性片段。转化生长因子αHII多肽可用于刺激伤口愈合，治愈神经障碍，眼睛疾病，肾脏疾病和肝脏疾病，刺激胚胎发生和血管生成等。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2007277249A Neutrokine-alpha and neutrokine-alpha splice variant 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：JP2007277249A
公开(公告)日：2007-10-25
申请号：JP2007111070
申请日：2007-04-19
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： ROSEN CRAIG A , NI JIAN , EBNER REINHARD , YU GUO-LIANG
IPC分类号： C07K14/52 , C12N15/09 , A61K38/00 , A61K38/19 , A61P31/00 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/06 , C07K14/715 , C07K16/24 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19 , C12P21/02
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/24 , C07K2317/34
摘要： PROBLEM TO BE SOLVED: To provide a cytokine similar to TNF involved in a pathological state. SOLUTION: The above protein is an isolated protein containing a Neutrokine-α protein fused to a toxin protein, wherein the Neutrokine-alpha protein contains an amino acid sequence chosen from the group consisting of (a) the amino acid sequence of particular amino acid residues, (b) an amino acid sequence that is at least 90% identical to the particular amino acid residues and (c) the amino acid sequence of a portion of the particular polypeptide, wherein the portion is at least 30 amino acids in length and is capable of stimulating B cell proliferation. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供与参与病理状态的TNF相似的细胞因子。解决方案：上述蛋白质是含有与毒素蛋白质融合的中和蛋白α蛋白质的分离蛋白质，其中中性粒细胞-β蛋白质含有选自（a）特定氨基酸序列的氨基酸序列氨基酸残基，（b）与特定氨基酸残基至少90％相同的氨基酸序列和（c）特定多肽的一部分的氨基酸序列，其中该部分至少具有30个氨基酸，长度，能够刺激B细胞增殖。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2004041212A T1 receptor-like ligand i 审中-公开
标题翻译： T1受体样配对
公开(公告)号：JP2004041212A
公开(公告)日：2004-02-12
申请号：JP2003280479
申请日：2003-07-25
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： NI JIAN , GENTZ REINER L , ROSEN CRAIG A
IPC分类号： C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an isolated nucleic acid molecule containing a polynucleotide which has a specified amino acid sequence or encodes a human T1 receptor-like (T1R-like) ligand I polypeptide. SOLUTION: This isolated nucleic acid molecule contains a polynucleotide having a nucleotide sequence of which at least 95% is identical to any one of sequences selected from a group comprising: a nucleotide sequence which has the specified amino acid sequence or encodes a full-length T1R-like ligand I polypeptide encoded by a cDNA clone contained in ATCC accession No.97656; another nucleotide sequence which encodes a mature T1R-like ligand I polypeptide encoded by the cDNA clone; a third nucleotide sequence which encodes a T1R-like ligand extracellular domain encoded by the cDNA clone; a fourth nucleotide sequence which encodes a T1R-like ligand membrane-penetrating domain encoded by the cDNA clone; a fifth nucleotide sequence which encodes a T1R-like ligand intracellular domain encoded by the cDNA clone; and the other nucleotide sequence which is complementary to any one of the above nucleotide sequences. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供含有具有特定氨基酸序列或编码人T1受体样（T1R样）配体I多肽的多核苷酸的分离的核酸分子。解决方案：该分离的核酸分子含有多核苷酸，其核苷酸序列至少95％与选自以下的序列中的任何一个相同：包含特定氨基酸序列或编码完整的核苷酸序列由ATCC登录号97656中包含的cDNA克隆编码的长度T1R样配体I多肽; 编码由cDNA克隆编码的成熟T1R样配体I多肽的另一核苷酸序列; 编码由cDNA克隆编码的T1R样配体胞外结构域的第三核苷酸序列; 编码由cDNA克隆编码的T1R样配体膜穿透结构域的第四核苷酸序列; 编码由cDNA克隆编码的T1R样配体胞内结构域的第五核苷酸序列; 和与上述核苷酸序列中的任一个互补的另一核苷酸序列。版权所有（C）2004，JPO

6. 发明专利

JP2012044999A NEUTROKINE α 审中-公开
标题翻译： NEUTROKINEα
公开(公告)号：JP2012044999A
公开(公告)日：2012-03-08
申请号：JP2011242255
申请日：2011-11-04
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-RIAN , EBNER REINHARD , NI JIAN
IPC分类号： C12N15/09 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a TNF-like cytokine involved in a pathological state.SOLUTION: An isolated nucleic acid molecule containing polynucleotide with a sequence at least 95% homology with the following sequences is provided: (a) a sequence encoding neutrokine α polypeptide having a complete amino acid sequence in Fig.1; (b) a sequence encoding neutrokine α having a complete amino acid sequence encoded by cDNA clone included in deposition to ATCC on October 22nd 1996; (c) a sequence encoding neutrokine α polypeptide extracellular domain; (d) a sequence encoding neutrokine α polypeptide transmembrane domain; (e) a sequence encoding neutrokine α polypeptide intracellular domain; (f) a sequence encoding soluble neutrokine α polypeptide deleted of transmembrane domain; and (g) a sequence complementary to optional sequence of (a), (b), (c), (d), (e) or (f).
摘要翻译：待解决的问题：提供涉及病理状态的TNF样细胞因子。提供了一种分离的核酸分子，其含有与以下序列具有至少95％同源性的序列的多核苷酸：（a）编码具有图1中完整氨基酸序列的中性粒细胞α多肽的序列; （b）1996年10月22日向ATCC提供的具有由cDNA克隆编码的完整氨基酸序列的中性粒细胞α的序列; （c）编码中性粒细胞α多肽细胞外结构域的序列; （d）编码中性粒细胞α多肽跨膜结构域的序列; （e）编码中性粒细胞α多肽细胞内结构域的序列; （f）编码跨膜结构域缺失的可溶性中性粒细胞α多肽的序列; 和（g）与（a），（b），（c），（d），（e）或（f）的任选序列互补的序列。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2010279364A 207 human secreted proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：JP2010279364A
公开(公告)日：2010-12-16
申请号：JP2010152548
申请日：2010-07-02
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： PAUL YOUNG , JOHN M GREEN , FERRIE ANN M , RUBEN STEVEN M , ROSEN CRAIG A , HU JING-SHAN , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , SHI YANGGU , FLORENCE CHARLES , FLORENCE KIMBERLY , LAFLEUR DAVID W , NI JIAN , FAN PIN , WEI IN-FEI , FISCHER CARRIE L , DANIEL R SOPETTO , LI YI , ZENG ZHIZHEN , KYAW HLA , YU GUO-LIANG , FENG PING , DILLON PATRICK J , ENDRESS GREGORY A , CARTER KENNETH C
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12P21/08 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide secreted proteins or genes encoding such proteins, and methods for detecting, treating and preventing medical disorders using the proteins or genes. SOLUTION: There are disclosed 207 human secreted proteins and isolated nucleic acids comprising the coding regions of the genes encoding such proteins. There are also disclosed vectors, host cells, antibodies, and recombinant methods for producing the human secreted proteins. There are further disclosed diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these human secreted proteins. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供编码这种蛋白质的分泌蛋白质或基因，以及使用蛋白质或基因检测，治疗和预防医学病症的方法。解决方案：公开了207种人分泌蛋白质和分离的核酸，其包含编码这种蛋白质的基因的编码区。还公开了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。进一步公开了用于诊断和治疗与这些人分泌蛋白相关的疾病的诊断和治疗方法。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2008194038A HUMAN TUMOR NECROSIS FACTOR δ and ε 审中-公开
标题翻译：人肿瘤坏死因子三角洲和epsilon
公开(公告)号：JP2008194038A
公开(公告)日：2008-08-28
申请号：JP2008015655
申请日：2008-01-25
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： NI JIAN , YU GUO-LIANG , GENTZ REINER L , DILLON PATRICK J
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/24 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/577
CPC分类号： Y02A50/411 , Y02A50/58
摘要： PROBLEM TO BE SOLVED: To provide a human TNF δ and TNF ε polypeptides and a polynucleotide encoding the polypeptide and to provide a method for producing the polynucleotide. SOLUTION: The isolated polynucleotide includes a polynucleotide having at least 70% homology to a member selected from the following group of (a) a polynucleotide encoding a polypeptide including a specific amino acid sequence, (b) a polynucleotide encoding a polypeptide including a specific amino acid sequence, (c) a polynucleotide encoding a polypeptide including amino acid 39 to amino acid 233 of a specific sequence, (d) a polynucleotide complementary to the polynucleotide of (a), (b) or (c) and (e) a polynucleotide including at least 15 bases of the polynucleotide of (a), (b), (c) or (d). COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供人TNFδ和TNFε多肽和编码多肽的多核苷酸，并提供生产多核苷酸的方法。解决方案：分离的多核苷酸包括与选自以下组的成员具有至少70％同源性的多核苷酸，（a）编码包含特定氨基酸序列的多肽的多核苷酸，（b）编码多肽的多核苷酸，包括特定氨基酸序列，（c）编码包含特定序列的氨基酸39至氨基酸233的多肽的多核苷酸，（d）与（a），（b）或（c）和（ e）包含（a），（b），（c）或（d）的多核苷酸的至少15个碱基的多核苷酸。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2009165466A Vegi(vascular endothelial cell growth inhibitor) as inhibitor of neovascularization and tumor growth 审中-公开
标题翻译： VEGI（血管内皮细胞生长抑制剂）作为新生血管和肿瘤生长的抑制剂
公开(公告)号：JP2009165466A
公开(公告)日：2009-07-30
申请号：JP2008300188
申请日：2008-11-25
申请人： Georgetown Univ Medical Center , Human Genome Sciences Inc , ジョージタウンユニバーシティーメディカルセンター , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： LI LU-YUAN , ZHAI YIFAN , YU GUO-LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K48/00 , A61P1/00 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/00 , A61P17/02 , A61P17/06 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/525 , C07K14/705 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026
摘要： PROBLEM TO BE SOLVED: To provide a VEGI inhibiting neovascularization in cellular models and tumorigenesis in animal models, and to provide a method for using the same. SOLUTION: An isolated nucleic acid molecule is provided, comprising a polynucleotide selected from the group consisting of (a) a polypeptide comprising amino acids 1 to 174 of a specific amino acid sequence, (b) a polypeptide comprising amino acids 23-174 of a specific amino acid sequence, (c) a polypeptide comprising amino acids 39-174 of a specific amino acid sequence, (d) a polynucleotide encoding fragments having neovascularization-inhibitory activity of the polynucleotide (a), respectively, (e) a polynucleotide hybridizable with the complement of a polypeptide having neovascularization-inhibitory activity, (f) a polynucleotide encoding the allelic form of the polynucleotide (a), and (g) the complementary strand of (a), (b), (c), (d), (e) or (f). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：在动物模型中提供VEGI抑制新生血管形成细胞模型和肿瘤发生，并提供使用该方法。解决方案：提供分离的核酸分子，其包含选自（a）包含特定氨基酸序列的氨基酸1至174的多肽的多核苷酸，（b）包含氨基酸23- （c）包含特定氨基酸序列的氨基酸39-174的多肽，（d）编码分别具有多核苷酸（a）的新血管形成抑制活性的片段的多核苷酸，（e）（f）编码多核苷酸（a）的等位基因形式的多核苷酸，和（g）（a），（b），（c）的互补链，可以与具有新血管形成抑制活性的多肽的补体杂交的多核苷酸，，（d），（e）或（f）。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2007326879A Death domain-containing receptor 4 (dr4: death receptor 4), member of tnf-receptor superfamily and binding to trail 审中-公开
标题翻译：死亡含域受体4（DR4：死亡受体4），TNF受体超家族成员和TRAIL结合
公开(公告)号：JP2007326879A
公开(公告)日：2007-12-20
申请号：JP2007230847
申请日：2007-09-05
申请人： Human Genome Sciences Inc , Regents Of The Univ Of Michigan , ザリージェンツオブザユニバーシティオブミシガンThe Regents of the University of Michigan , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： GENTZ REINER L , NI JIAN , ROSEN CRAIG A , DIXIT VISHVA M , PAN JAMES G
IPC分类号： C07K14/705 , C12N15/09 , C07H21/04 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/70578
摘要： PROBLEM TO BE SOLVED: To identify and characterize a receptor and a ligand having influence on the bioactivity in both normal and diseased states, especially to isolate and characterize a receptor on a newly found TRAIL ligand. SOLUTION: The invention provides a new death domain containing receptor 4 (DR4) protein which is a member of tumor necrosis factor (TNF) receptor family, especially provide an isolated nucleic acid molecule encoding human DR4 protein, and a DR4 polypeptide. COPYRIGHT: (C)2008,JPO&INPIT

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