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1. 发明专利

JP2007169148A Carbon structure production method, carbon structure, and aggregate and dispersion of carbon structure 审中-公开
标题翻译：碳结构生产方法，碳结构，碳结构聚集和分散
公开(公告)号：JP2007169148A
公开(公告)日：2007-07-05
申请号：JP2006317609
申请日：2006-11-24
申请人： Hokkaido Univ , Mitsubishi Chemicals Corp , 三菱化学株式会社 , 国立大学法人北海道大学
发明人： SHIRATANI TOSHIFUMI , AIKYO HIROYUKI , YAMAMOTO MASAKI , TODA ATSUSHI , SHIMOMURA MASATSUGU , YAMAMOTO SADAAKI , ISHIRO KUNIHARU , HIJIKATA KENJI , YABU HIROSHI , MATSUO YASUTAKA , TANAKA MASARU
IPC分类号： C04B35/52 , C01B31/02
摘要： PROBLEM TO BE SOLVED: To provide a carbon structure production method capable of inexpensively and efficiently producing variously shaped carbon nanostructures. SOLUTION: The carbon structure production method comprises molding a carbon-containing material into a pattern, covering the obtained pattern with a template, and carbonizing the pattern by firing. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：提供能够廉价高效地生产各种形状的碳纳米结构的碳结构制造方法。解决方案：碳结构生产方法包括将含碳材料模制成图案，用模板覆盖所获得的图案，并通过烧制碳化图案。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2007307300A Material for vascular prosthesis 审中-公开
标题翻译：血管造影材料
公开(公告)号：JP2007307300A
公开(公告)日：2007-11-29
申请号：JP2006141838
申请日：2006-05-22
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： CHEN YONGMEI , TANAKA MASARU , GUN CHENPIN , YASUDA KAZUNORI , YAMAMOTO SADAAKI , SHIMOMURA MASATSUGU , OSADA YOSHIHITO
IPC分类号： A61L27/00 , A61F2/06
摘要： PROBLEM TO BE SOLVED: To provide a material for a vascular prosthesis to manufacture the vascular prosthesis excellent in antithrombogenic property. SOLUTION: The material for the vascular prosthesis is hydrogel having negative electric charges coated with human vascular endothelial cells. The hydrogel is poly (p-styrene sulfonic acid sodium) or poly (2-acrylamido-2-methyl-1-propane sulfonic acid sodium). The biocompatible material of the present invention is excellent in the antithrombogenic property being an important characteristic as blood compatibility and is preferably used for manufacturing the vascular prosthesis, especially, an artificial capillary vessel with the inner diameter of not more than 6 mm. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于血管假体的材料以制造具有优异的抗血栓形成性质的血管假体。解决方案：用于血管假体的材料是具有涂覆人血管内皮细胞的负电荷的水凝胶。水凝胶是聚（对苯乙烯磺酸钠）或聚（2-丙烯酰胺基-2-甲基-1-丙磺酸钠）。本发明的生物相容性材料抗血栓形成性质优异，作为血液相容性的重要特征，优选用于制造血管假体，特别是内径不大于6mm的人造毛细血管。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007061559A New complex and its manufacturing method 审中-公开
标题翻译：新型复合材料及其制造方法
公开(公告)号：JP2007061559A
公开(公告)日：2007-03-15
申请号：JP2005266439
申请日：2005-09-14
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： TANAKA MASARU , OSATO DAISUKE , HIGUCHI TSUYOSHI , YABU HIROSHI , YAMAMOTO SADAAKI , SHIMOMURA MASATSUGU
IPC分类号： A61M37/00 , A61L31/00
摘要： PROBLEM TO BE SOLVED: To provide a honeycomb porous body with a drug, metallic nanoparticulates and/or a coloring matter, which can also be used as a carrier for drug delivery. SOLUTION: The honeycomb porous body with the drug, the metallic nanoparticulates and/or the coloring matter, which is composed of a water-insoluble polymer, is useful as the carrier for the sustained release of the drug and a drug delivery system, particularly, because the honeycomb porous body retains particulates composed of a polymer supporting the drug, the metallic nanoparticulates and/or the coloring matter. Particularly, since the drug is released by making the porous body retain the drug-supporting particulates, a release pattern can be more finely and freely controlled. Additionally, a scaffold for cell expansion can be provided. Since the drug required for the expansion or differentiation induction of cells is released from the scaffold, the honeycomb porous body is extremely useful for a field of regenerative medicine. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有药物，金属纳米颗粒和/或着色剂的蜂窝状多孔体，其也可以用作药物递送的载体。解决方案：具有药物的蜂窝多孔体，由水不溶性聚合物组成的金属纳米颗粒和/或着色剂可用作药物的持续释放的载体和药物递送系统特别是因为蜂窝状多孔体保持由支撑药物的聚合物，金属纳米颗粒和/或着色物质构成的微粒。特别地，由于通过使多孔体保持药物支持性微粒来释放药物，因此可以更加精细和自由地控制释放模式。另外，可以提供用于细胞扩增的支架。由于细胞的扩增或分化诱导所需的药物从支架中释放出来，所以蜂窝状多孔体对于再生医学领域是非常有用的。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2008296502A Method for manufacturing resin film having periodic structure 有权
标题翻译：制造具有周期性结构的树脂薄膜的方法
公开(公告)号：JP2008296502A
公开(公告)日：2008-12-11
申请号：JP2007146849
申请日：2007-06-01
申请人： Hokkaido Univ , Mitsui Chemicals Inc , 三井化学株式会社 , 国立大学法人北海道大学
发明人： NISHINO FUMIAKI , TAKAGI TOSHIHIKO , KUWABARA MASAHIRO , SHIMOMURA MASATSUGU , ISHIRO KUNIHARU , YAMAMOTO SADAAKI , MATSUO YASUTAKA , YABU HIROSHI
IPC分类号： B29C61/02 , B29C59/00 , B29D7/01 , B29L7/00 , B29L31/60 , C08J7/00 , C08J7/04 , G02B5/18 , G02B5/30 , G03F7/20
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive simple method for forming a resin film having periodic minute unevenness and to provide a manufacturing method in which a material of the resin film and a material forming the periodic structure in the resin film can be selected from among various materials in a method for forming the resin film having the periodic minute unevenness.
SOLUTION: The method for manufacturing the resin film with the periodic structure formed comprises a step of contracting a resin film having a periodic dot pattern. A honeycombed porous film is used as a casting mold, and its honeycombed pattern is transferred to the resin film having the periodic dot pattern.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种用于形成具有周期性微小凹凸的树脂膜的便宜的简单方法，并且提供一种制造方法，其中树脂膜的材料和在树脂膜中形成周期性结构的材料可以是在用于形成具有周期性微小凹凸的树脂膜的方法中的各种材料中选择。解决方案：制造具有周期性结构的树脂膜的方法包括使具有周期性点图案的树脂膜收缩的步骤。使用蜂窝状多孔膜作为铸模，将其蜂窝状图案转印到具有周期性点图案的树脂膜。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008278769A Method for producing three-dimensional aggregate comprising pancreatic islet cells in vitro 审中-公开
标题翻译：生产包含胰岛素分离细胞的三维聚集体的方法
公开(公告)号：JP2008278769A
公开(公告)日：2008-11-20
申请号：JP2007123708
申请日：2007-05-08
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： TSUKIYAMA SHUSAKU , TANAKA MASARU , YAMAMOTO SADAAKI , SHIMOMURA MASATSUGU , MATSUSHITA MICHIAKI , TODO SHO
IPC分类号： A61L27/00 , C12N5/07 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide a method for culturing pancreatic islet cells in vitro for a long period without losing the specific functions. SOLUTION: This method for producing the three-dimensional aggregate comprising the pancreatic islet cells in vitro comprises a process (a) for preparing a honeycomb-like porous body comprising a water-insoluble polymer coated with an extracellular substrate, and a process (b) for culturing the isolated pancreatic islet cells on the honeycomb-like porous body. According to this production method, the three-dimensional aggregate can be formed without forming a single layer, even when the pancreatic islet cells are cultured in vitro. Therefore, the pancreatic islet cell aggregate can be produced and collected without using a protein digestion enzyme such as trypsin, while maintaining the functions of pancreatic islet cells, such as an insulin-secreting ability. Such the pancreatic islet cells are useful for pancreatic islet transplantation treatments. The honeycomb-like porous body holding the three-dimensional aggregate comprising the pancreatic islet cells can be used as bio-artificial pancreas, cell chips or a carrier for transplanting pancreatic islet cells. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种长期培养胰岛细胞的方法，而不失去特定功能。解决方案：用于生产包含胰岛细胞的三维骨料的方法在体外包括制备蜂窝状多孔体的方法（a），该蜂窝状多孔体包含涂覆有细胞外基质的水不溶性聚合物，以及方法（b）在蜂窝状多孔体上培养分离的胰岛细胞。根据该制造方法，即使在体外培养胰岛细胞的情况下，也可以形成三维聚集体而不形成单层。因此，可以在不使用蛋白质消化酶如胰蛋白酶的情况下生产和收集胰岛细胞聚集体，同时保持胰岛细胞的功能，例如胰岛素分泌能力。这种胰岛细胞可用于胰岛移植治疗。保持包含胰岛细胞的三维聚集体的蜂窝状多孔体可以用作生物人造胰腺，细胞碎片或用于移植胰岛细胞的载体。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2010063372A Culture substrate for culturing undifferentiated mesenchymal stem cell 审中-公开
标题翻译：用于培养不同的MESENCHYMAL STEM细胞的培养基质
公开(公告)号：JP2010063372A
公开(公告)日：2010-03-25
申请号：JP2008230159
申请日：2008-09-08
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： YAMAMOTO SADAAKI , MORITA YUKA , ISHIRO KUNIHARU , SHIMOMURA MASATSUGU , TANAKA MASARU , YABU HIROSHI
IPC分类号： C12N5/07 , A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a culture substrate for proliferating undifferentiated mesenchymal stem cells. SOLUTION: There is provided the culture substrate for proliferating the undifferentiated mesenchymal stem cells, comprising a honeycomb-like porous material which comprises a water-insoluble polymer having a glass transition temperature of -50 to 200°C and a Young's modulus of 0.5 to 9 giga pascal and has pores having an average pore size of 1 μm. The culture substrate is excellent in that it enables to culture the mesenchymal stem cells which is especially useful in regenerative medicine, in an undifferentiated state. The culture substrate has a characteristic that bio-risks can be avoided at a point not needing the addition of a growth factor or the like to a culture medium. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于增殖未分化间充质干细胞的培养基质。提供了用于增殖未分化间充质干细胞的培养基质，其包含蜂窝状多孔材料，其包含玻璃化转变温度为-50至200℃的水不溶性聚合物和杨氏模量 0.5至9千兆帕斯卡，具有平均孔径为1μm的孔。培养基质是优异的，其能够培养在未分化状态下在再生医学中特别有用的间充质干细胞。培养基质具有在不需要向培养基中添加生长因子等的地方避免生物危害的特征。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009165403A Long-term culture method of fat cell by using honeycomb-shaped porous body 审中-公开
标题翻译：通过使用蜂窝状多孔体的脂肪细胞的长期培养方法
公开(公告)号：JP2009165403A
公开(公告)日：2009-07-30
申请号：JP2008006906
申请日：2008-01-16
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： YAMAMOTO SADAAKI , TANAKA MASARU , SHIMOMURA MASATSUGU , INOKUCHI JINICHI , SATO TAKASHIGE
IPC分类号： C12N5/07 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide a method for stably culturing fat cells over a long period.
SOLUTION: The method for culturing the fat cells includes a step for seeding the fat cells in a honeycomb-shaped porous body comprising a water-insoluble polymer, and a step for allowing the fat cells to be proliferated on the honeycomb-shaped porous body. By the method, the fat cells can be cultured stably for a long period, and matured fat cells can be differentiated and induced from the precursor fat cells. Further, by utilizing the method, a substance inhibiting the fat accumulation in the fat cell, or the differentiation and induction to the matured fat cell can be screened.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供长期稳定培养脂肪细胞的方法。解决方案：培养脂肪细胞的方法包括将脂肪细胞接种在包含水不溶性聚合物的蜂窝状多孔体中的步骤，以及使蜂窝状的脂肪细胞增殖的步骤多孔体。通过该方法，可以长时间稳定地培养脂肪细胞，并且可以从成熟的脂肪细胞分化并诱导前体脂肪细胞。此外，通过利用该方法，可以筛选抑制脂肪细胞中脂肪蓄积的物质，或成熟脂肪细胞的分化和诱导。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2008054621A Method for preparing non-spheroidized stem cell 有权
标题翻译：制备非细胞干细胞的方法
公开(公告)号：JP2008054621A
公开(公告)日：2008-03-13
申请号：JP2006237680
申请日：2006-09-01
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： TANAKA MASARU , TSURUMA AKINORI , YAMAMOTO SADAAKI , SHIMOMURA MASATSUGU
IPC分类号： C12N5/07 , C12N5/074 , C12N5/0775
摘要： PROBLEM TO BE SOLVED: To provide a new method for preparing non-spheroidized stem cells, by which the non-spheroidized undifferentiated stem cells can be prepared and/or preserved. SOLUTION: This method for preparing the non-spheroidized stem cells comprises a process (a) immobilizing the stem cells in a honeycomb porous material and an incubation process (b) for incubating the immobilized stem cells in a serum-free culture medium. By the method of the present invention, the non-spheroidized undifferentiated stem cells can be provided and preserved. The undifferentiated stem cells are very useful in various medical fields such as gene therapy, organ transplantation, bone marrow transplantation, cancer therapy and regenerative medicine. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种制备非球化干细胞的新方法，通过该方法可以制备和/或保存非球化的未分化干细胞。解决方案：用于制备非球形干细胞的方法包括将干细胞固定在蜂窝状多孔材料中的方法（a）和培养方法（b），用于将固定化的干细胞在无血清培养基。通过本发明的方法，可以提供和保存非球化的未分化干细胞。未分化的干细胞在诸如基因治疗，器官移植，骨髓移植，癌症治疗和再生医学等各种医学领域中非常有用。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2007308439A Material suitable for cultivation of floating cell 审中-公开
标题翻译：适用于浮选细胞培养的材料
公开(公告)号：JP2007308439A
公开(公告)日：2007-11-29
申请号：JP2006141093
申请日：2006-05-22
申请人： Hokkaido Univ , Rabo:Kk , 国立大学法人北海道大学 , 株式会社ラボ
发明人： TANAKA MASARU , YAMAMOTO SADAAKI , SHIMOMURA MASATSUGU , SAKAKI AKIO
IPC分类号： C07K17/02 , C12M3/02 , C12N5/02
CPC分类号： C12M25/16
摘要： PROBLEM TO BE SOLVED: To provide a material of a cultivation vessel capable of accelerating the growth of floating cells like a white blood cell etc. , and a vessel to cultivate floating cells without fear of contamination using the material.
SOLUTION: This material is a honeycomb porous body carrying a growth acceleration agent for floating cells on its surface. This vessel is a tightly sealable vessel for cultivating floating cells having a honeycomb porous structure carrying a growth acceleration agent on its surface for floating cells as its inner wall. This vessel enables easy cultivation of floating cells such as a lymph cell etc., in a closed pack, and can, as a result, decrease the burden of patients by holding down the expense of the mass preparation of floating cells to the minimum and keep the safety of the prepared floating cells at a high level.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够加速漂浮细胞如白细胞等的生长的培养容器的材料和培养浮动细胞的容器，而不用使用该材料的污染。
解决方案：该材料是一种蜂窝状多孔体，其携带用于其表面上的浮动细胞的生长促进剂。该容器是用于培养具有在其表面上具有生长促进剂的蜂窝状多孔结构的浮动细胞作为其内壁的浮动细胞的可密封容器。该容器能够容易地在封闭的包装中培养诸如淋巴细胞等的浮游细胞，并且因此可以通过将浮游细胞的大量制备的费用抑制到最小来降低患者的负担并保持准备好的浮动细胞在高水平上的安全性。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2008296481A Method for manufacturing resin film having three-dimensional structure formed therein 有权
标题翻译：制造具有三维结构的树脂膜的方法
公开(公告)号：JP2008296481A
公开(公告)日：2008-12-11
申请号：JP2007145890
申请日：2007-05-31
申请人： Hokkaido Univ , Mitsui Chemicals Inc , 三井化学株式会社 , 国立大学法人北海道大学
发明人： NISHINO FUMIAKI , TAKAGI TOSHIHIKO , KUWABARA MASAHIRO , SHIMOMURA MASATSUGU , ISHIRO KUNIHARU , YAMAMOTO SADAAKI , MATSUO YASUTAKA , YABU HIROSHI
IPC分类号： B29C69/02 , B29C41/12 , B29K105/04 , B29L7/00 , B29L31/60 , B32B37/00 , C08J9/28 , C12M3/00 , G02B5/02
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive and simple method for manufacturing a resin film in which a three-dimensional minute structure is formed, and a raw material for the resin film can be selected out of various resins, and to provide a method for producing a resin film which can be used in wide applications from the above film.
SOLUTION: A multilayer film comprising a honeycombed, porous resin film and a film contracted by being exposed to heat, light, infrared rays, or microwaves is exposed to heat, light, infrared rays, or microwaves. A material wherein the multilayer film is contracted and the honeycombed porous material is converted into a three-dimensional structure is formed.
COPYRIGHT: (C)2009,JPO&INPIT

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