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1. 发明专利

JP2009058427A Method and device for identifying surface molecule 审中-公开
标题翻译：用于鉴定表面分子的方法和装置
公开(公告)号：JP2009058427A
公开(公告)日：2009-03-19
申请号：JP2007226805
申请日：2007-08-31
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： OKAJIMA KOJI , NIIKURA KENICHI
IPC分类号： G01N33/53 , G01N37/00 , G01Q30/20 , G01Q60/18 , G01Q60/24 , G01Q80/00
摘要： PROBLEM TO BE SOLVED: To provide a method capable of selectively identifying molecules (object molecules) existing on a matter surface and can identify a plurality of kinds of object molecules and its positional information with high resolution.
SOLUTION: This method of identifying the object molecules existing on the sample surface comprises (A) a step of preparing two or more kinds of particulate groups of different physical characteristics where each particulate is decorated by a molecule specifically binding to different molecule; (B) a step of bringing the particulate into contact with the sample surface, binding the particulate of the particulate group to the object molecule, and fixing it to the sample surface; and (C) a step of scanning the sample surface to which the particulate is fixed using a scanning probe microscope and acquiring information capable of identifying each object molecule.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够选择性地识别物质表面上存在的分子（物体分子）的方法，并且可以以高分辨率识别多种物体分子及其位置信息。鉴定存在于样品表面上的物体分子的方法包括（A）制备两种或更多种不同物理特性的颗粒的步骤，其中每个颗粒被特异性结合不同分子的分子装饰; （B）使颗粒与样品表面接触的步骤，将颗粒基团的颗粒与物体分子结合，并将其固定在样品表面上; 和（C）使用扫描探针显微镜扫描待固定颗粒的样品表面并获取能够识别每个对象分子的信息的步骤。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2013044695A Measuring method and measuring device of mechanical properties of single cell 审中-公开
标题翻译：单细胞力学性能的测量方法和测量装置
公开(公告)号：JP2013044695A
公开(公告)日：2013-03-04
申请号：JP2011184403
申请日：2011-08-26
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： OKAJIMA KOJI , CAI PING-GEN , MIZUTANI YUSUKE , TSUCHIYA MASAHIRO
IPC分类号： G01Q80/00 , G01Q60/24
摘要： PROBLEM TO BE SOLVED: To provide a measuring method and a measuring device of mechanical properties of a single cell.SOLUTION: A method for measuring a large number of cells using an atomic force microscope includes the steps of: A) arraying individual cells on a microfabricated substrate and automatically positioning the individual cells; B) measuring a frequency characteristic of a complex elastic modulus of each of the arrayed cells; C) changing an intracellular position for measuring or an intracellular structure, and once more measuring the frequency characteristic of the complex elastic modulus of each of the large number of the cells; and D) quantitatively analyzing cell number distribution of cellular mechanical properties. There is also provided a measuring device.
摘要翻译：要解决的问题：提供单个电池的机械性能的测量方法和测量装置。解决方案：使用原子力显微镜测量大量细胞的方法包括以下步骤：A）将单个细胞排列在微制造的基底上并自动定位各个细胞; B）测量每个排列单元的复数弹性模量的频率特性; C）改变用于测量或细胞内结构的细胞内位置，并且再一次测量大量细胞中的每一个的复弹性模量的频率特性; 和D）定量分析细胞机械性质的细胞数分布。还提供了一种测量装置。版权所有（C）2013，JPO＆INPIT

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