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1. 发明专利

JP2012143196A Neural activity measurement system and method for the same 有权
标题翻译：神经活动测量系统及其相关方法
公开(公告)号：JP2012143196A
公开(公告)日：2012-08-02
申请号：JP2011004460
申请日：2011-01-13
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： YAMAMOTO TAKESHI , KOIZUMI HIDEAKI , HASHIZUME TOMIHIRO , HEIKE SEIJI
IPC分类号： C12M1/00 , C12Q1/02 , G01Q60/30 , G01Q80/00
CPC分类号： A61B5/04001 , A61B5/0478 , A61B5/4076 , A61B5/4848 , A61B5/7275 , B82Y35/00 , C12N13/00 , G01Q60/30 , G01Q60/44 , G01Q60/60
摘要： PROBLEM TO BE SOLVED: To provide a system for measuring the response of the neuron itself (electrical response), instead of the response of the general cell or cell membrane itself, and to achieve electrical measurement of the neural activity itself, allowing prediction and diagnosis of neuron disorders.SOLUTION: In the light of the fact that a voltage is generated in neural transmission, the invention provides a stimulator 14 for applying an electrical stimulus to a neuron 1, and a Kelving probe including a cantilever 4 for detecting the electrical signal propagated through the neuron.
摘要翻译：要解决的问题：提供用于测量神经元本身（电响应）的响应的系统，而不是一般细胞或细胞膜本身的反应，并且实现神经活动本身的电测量，允许神经元疾病的预测和诊断。解决方案：鉴于在神经传播中产生电压的事实，本发明提供了一种用于向神经元1施加电刺激的刺激器14，以及包括用于检测传播的电信号的悬臂4的凯氏探针通过神经元。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2008165813A Biological identification device 有权
标题翻译：生物识别装置
公开(公告)号：JP2008165813A
公开(公告)日：2008-07-17
申请号：JP2008009987
申请日：2008-01-21
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMASHITA YUICHI , KOIZUMI HIDEAKI
IPC分类号： G06T7/00 , A61B5/117 , G06T1/00
摘要： PROBLEM TO BE SOLVED: To provide a simple personal identification device that does not have the possibility of diversion of another person. SOLUTION: Image information on an individual biological structure is registered in a database by being associated with personal information (such as a name, a personal identification number and a magnetic card), and image information comprising a blood vessel pattern and a biological external shape measured by using the light, is collated with image information of the database. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种简单的个人识别装置，其不具有转移另一人的可能性。个人生物结构的图像信息通过与个人信息（例如姓名，个人识别号和磁卡）相关联而登记在数据库中，以及包括血管图案和生物体的图像信息通过使用光测量的外部形状，与数据库的图像信息进行核对。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2006042955A In vivo material optometric device 审中-公开
标题翻译：体内材料OPTOMETRIC设备
公开(公告)号：JP2006042955A
公开(公告)日：2006-02-16
申请号：JP2004225166
申请日：2004-08-02
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KIGUCHI MASAFUMI , TOMARU TATSUYA , KOIZUMI HIDEAKI , MAKI ATSUSHI , KAWAGUCHI HIDEO
IPC分类号： A61B5/145 , G01N21/21
CPC分类号： A61B5/14532 , A61B5/14558
摘要： PROBLEM TO BE SOLVED: To provide a compact device capable of easily being operated and adjusted for measuring glucose concentration without observing blood.
SOLUTION: A magnetic field applying direction is arranged so as to cross an optical axis in the device for observing a polarization angle changing synchronizing with a modulating wave.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够容易地操作和调整以测量葡萄糖浓度而不观察血液的紧凑的装置。解决方案：磁场施加方向布置成在用于观察与调制波同步变化的偏振角的装置中与光轴交叉。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005111283A Optical measuring apparatus 审中-公开
标题翻译：光学测量装置
公开(公告)号：JP2005111283A
公开(公告)日：2005-04-28
申请号：JP2004364263
申请日：2004-12-16
申请人： Hitachi Ltd , Hitachi Medical Corp , 株式会社日立メディコ , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMAMOTO TAKESHI , KOIZUMI HIDEAKI , YAMASHITA YUICHI
IPC分类号： G01N21/17 , A61B5/145 , A61B5/1455 , A61B10/00
摘要： PROBLEM TO BE SOLVED: To provide an optical measuring method and apparatus suitable for optically measuring a subject and easily processing and displaying images of predetermined items based on information obtained by the measurement. SOLUTION: Fig.94 shows an analytic flow in the case of performing data analysis (arithmetic processing) after measurement processing using the optical measuring apparatus shown in Fig.1. A screen displayed in a step 942 is a screen shown in Fig.33 (unillustrated) mentioned later, where a data analysis mode is selected. A screen displayed in a step 943 is a screen shown in Fig.34 (unillustrated), where registered data files can be read. A screen displayed in a step 944 is a screen shown in Fig.43, 48, 49, and the like (unillustrated), where a data processing method (a settlement processing method) is set. A screen displayed in a step 945 is a screen shown in Fig.53 (unillustrated), where an image is formed and registered as a file through an image shown in Fig.63 (unillustrated) displayed in a step 946. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种适于光学测量对象的光学测量方法和装置，并且基于通过测量获得的信息容易地处理和显示预定项目的图像。解决方案：图94示出了在使用图1所示的光学测量装置的测量处理之后进行数据分析（算术处理）的情况下的分析流程。在步骤942中显示的屏幕是后面提到的图33所示的屏幕（未示出），其中选择了数据分析模式。在步骤943中显示的屏幕是图34所示的屏幕（未示出），其中可以读取注册的数据文件。在步骤944中显示的屏幕是设置了数据处理方法（结算处理方法）的图43,48,49等所示的画面（未示出）。在步骤945中显示的屏幕是图53所示的屏幕（未示出），其中通过在步骤946中显示的图63所示的图像（未示出）形成图像并将其登记为文件。
版权（C）2005，JPO＆NCIPI

5. 发明专利

JP2004041815A Organismic light measuring device 有权
公开(公告)号：JP2004041815A
公开(公告)日：2004-02-12
申请号：JP2003393265
申请日：2003-11-25
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMASHITA YUICHI , KOIZUMI HIDEAKI
IPC分类号： G01N21/17 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/27 , G01N21/35 , G01N21/359
摘要： PROBLEM TO BE SOLVED: To provide an organismic light measuring device having high detecting sensitivity in an organism deep part. SOLUTION: The light from light sources 1-1 and 1-3 (a wave length λ1) and light sources 1-2 and 1-4 (a wave length λ2) are irradiated to a subject 7 via irradiating optical fibers 5-1 and 5-2, and are condensed by condensing optical fibers 8-1 and 8-2, and are photoelectrically converted and amplified by detectors 9-1 and 9-2. Output signals from the detectors 9-1 and 9-2 are distributed into two, and are then inputted to phase detectors 10-1, 10-2, 10-3 and 10-4. Intensity of the transmitted light with respective wave lengths from the condensing optical fibers 8-1 and 8-2 of a position opposed to the irradiating optical fibers 5-1 and 5-2 is separated, and is multiplied by multipliers 11-1 and 11-2 with respective wave lengths. After arithmetic operation processing, an arithmetic operation result is displayed on a display device 15. COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2003075331A Biological light measuring unit and image formation method therein 有权
标题翻译：生物光度测量单元及其图像形成方法
公开(公告)号：JP2003075331A
公开(公告)日：2003-03-12
申请号：JP2002189452
申请日：2002-06-28
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMASHITA YUICHI , ITO YOSHITOSHI , KOIZUMI HIDEAKI
IPC分类号： G01N21/17 , A61B10/00 , G01N21/35 , G01N21/359
摘要： PROBLEM TO BE SOLVED: To image a biological function by using a simple detector and by executing rapid measurement. SOLUTION: Light rays 2a-2d of plural wavelengths intensity-modulated by different frequencies 1a-1d are irradiated from plural radiating positions on the surface of a living body 6, and temporal change of organism passing- through light intensity for each of the respective wavelengths and the respective radiating positions is measured from different positions on the surface of the organism (7, 8 and 9). After finishing the measurement or during the measurement, absorbing body concentration change in the organism is obtained from the organism passing-through light intensity of plural wavelengths measured at the respective detection points (11), and an image 13 is formed by setting a measuring point on a vertical line passing the middle points of the respective incident points and the respective detection points.
摘要翻译：要解决的问题：通过使用简单的检测器和执行快速测量来对生物学功能进行成像。解决方案：通过不同频率1a-1d强度调制的多个波长的光线2a-2d从生物体6的表面上的多个辐射位置照射，并且各波长中的每个波长的生物穿过光强度的时间变化并且从生物体（7,8和9）的表面上的不同位置测量各个辐射位置。在完成测量或测量之后，从在各个检测点（11）测量的多个波长的生物穿过光强度获得生物体吸收体浓度变化，并且通过将测量点在通过各个入射点和各个检测点的中点的垂直线上。

7. 发明专利

JPH11271277A Mass spectrometry and mass spectrograph for humor 失效
标题翻译：大众质谱仪和人体质谱仪
公开(公告)号：JPH11271277A
公开(公告)日：1999-10-05
申请号：JP7760498
申请日：1998-03-25
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HIRABAYASHI YUKIKO , HIRABAYASHI TSUDOI , KOIZUMI HIDEAKI
IPC分类号： A61B5/00 , G01N1/10 , G01N1/28 , G01N27/62 , G01N30/72 , H01J49/04
CPC分类号： H01J49/0431 , A61B5/145 , A61B5/14528 , A61B5/14557 , A61B5/1459 , A61B5/4064 , A61B2010/0077
摘要： PROBLEM TO BE SOLVED: To effectively carry out ionization, and to conduct mass spectrometric analysis for a test sample liquid within a short time, in a humor of the test sample liquid of which a contained substance changes with the lapse of time and which has high electric conductivitity.
SOLUTION: A test sample liquid of a saline mixture solution containing a bio-substance from an organism 5 is introduced into a capillary 9 without generating seraration, an ionization source is provided to spray the test sample liquid to be ionized in the tip of the capillary 9 by passing gas with sonic velocity or near sonic velocity in an orifice 10 arranged coaxially with the capillary 9 to pass the tip of the capillary 9, and mass spectrometric analysis for the test sample liquid is carried out at once by a storage type mass spectrometer (3DQM) 12 for analyzing mass of an ion from the ionization source. Mass spectrimetric analysis for a bio-substance impossible of measurement and analysis in the prior art, in particular for a live condition of a neurotransfer sustance, can be carried out by this manner, so as to allow analysis in response to change of the organism while collecting a cerebrum liquid directly from a brain.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：为了有效地进行离子化，并且在短时间内对测试样品液体进行质谱分析，其中所含物质随着时间的流逝而变化的测试样品液体的幽默性并且具有高的电导率。解决方案：将含有来自生物体5的生物物质的盐水混合溶液的测试样品液体引入毛细管9中而不产生血清，提供电离源以将待离子化的待测样品液体喷射到毛细管尖端 9通过在与毛细管9同轴布置的孔口10中以声速或接近声速通过气体以通过毛细管9的尖端，并且通过存储型质谱仪一次进行测试样品液体的质谱分析（3DQM）12，用于分析来自电离源的离子的质量。可以通过这种方式进行现有技术中不可能测量和分析的生物物质，特别是对于神经转移维持的活条件的质谱分析，以便允许响应生物体的变化进行分析，从大脑直接收集大脑液体。

8. 发明专利

JPH11271273A Capillary tube electrophoretic device 失效
标题翻译：毛细管电泳装置
公开(公告)号：JPH11271273A
公开(公告)日：1999-10-05
申请号：JP7883398
申请日：1998-03-26
申请人： Hitachi Ltd , Japan Science & Technology Corp , 株式会社日立製作所 , 科学技術振興事業団
发明人： OKUMURA AKIHIKO , HIRABAYASHI TSUDOI , KOIZUMI HIDEAKI
IPC分类号： G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To improve the resolution by crossing a sample introducing groove to an electrophoretic groove, and regulating the charge quantity of the crossing part inner wall by the potential of an external electrode.
SOLUTION: A plate member 1 is formed by connecting a first base 11 to a second base 12. The first base 11 has an electrophoretic passage 2 and a sample injecting passage 3 crossing it which are formed on the connecting surface side of the first base 11, and the second base 12 has through-holes 4 for liquid basin which are formed in the position opposed to both ends of each of the electrophoretic passage 2 and the sample injecting passage 3, respectively. A first electrode 21 and a second electrode 22 are formed in the positions opposed to the crossing part of the passages 2, 3 on the first base 11 and the second base 12. A migration liquid is put in the liquid basins on both ends of the passage 2 and one end of the passage 3, and a sample solution is put in the liquid basin on the other end of the passage 3. The electrophoresis is performed in the state where a voltage is applied to the first electrode 21 and the second electrode 22, and a high voltage is applied to both ends of the passage 2 in this state. The components in the sample are separated in the migration passage and detected by an optical method or the like.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：通过将样品引入槽交叉到电泳槽来提高分辨率，并且通过外部电极的电位来调节交叉部分内壁的电荷量。解决方案：通过将第一基座11连接到第二基座12来形成板构件1.第一基座11具有电泳通道2和与其相交的样品注入通道3，其形成在第一基座11的连接表面侧上并且第二基座12具有分别形成在与电泳通道2和样本注入通道3的两端相对的位置的液槽用贯通孔4。第一电极21和第二电极22形成在与第一基底11和第二基底12上的通道2,3的交叉部分相对的位置。将迁移液体放置在第二电极21的两端的液体槽中通道2和通道3的一端，并且将样品溶液放入通道3另一端的液体槽中。在向第一电极21和第二电极施加电压的状态下进行电泳在这种状态下，在通道2的两端施加高电压。样品中的组分在迁移通道中分离并通过光学方法等进行检测。

9. 发明专利

JP2007012081A Biometric apparatus 有权
标题翻译：生物仪器
公开(公告)号：JP2007012081A
公开(公告)日：2007-01-18
申请号：JP2006205555
申请日：2006-07-28
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMASHITA YUICHI , KOIZUMI HIDEAKI
IPC分类号： G06T7/00 , A61B5/117 , G06F21/20 , H04L9/32
摘要： PROBLEM TO BE SOLVED: To provide a simple personal identification apparatus without any possibility of misappropriation by others. SOLUTION: An image information of bodily structure for each individual is registered to a database matched with personal information (name, PIN, magnetic card, etc.). An image information composed of a blood vessel pattern measured by light and exterior shape of a body is verified with the image information in the database. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2005118594A Light measuring device 有权
标题翻译：光测量装置
公开(公告)号：JP2005118594A
公开(公告)日：2005-05-12
申请号：JP2004364264
申请日：2004-12-16
申请人： Hitachi Ltd , Hitachi Medical Corp , 株式会社日立メディコ , 株式会社日立製作所
发明人： MAKI ATSUSHI , YAMAMOTO TAKESHI , KOIZUMI HIDEAKI , YAMASHITA YUICHI
IPC分类号： G01N21/17 , A61B5/145 , A61B5/1455 , A61B10/00
摘要： PROBLEM TO BE SOLVED: To provide a light measuring method and a device capable of easily processing and displaying an image of a predetermined item based on information provided by its measurement by measuring a subject by the light measuring device. SOLUTION: In this light measuring device, a data analysis (arithmetic processing) after measurement processing is performed on the basis of a flow of an analytical flow indicated in the figure. An image screen displayed in a step 942 is an image screen indicated in the figure 33 (unillustrated), and a data analytical mode is selected here. An image screen displayed in a step 943 is an image screen indicated in the figure 34 (unillustrated), and here, a registered data file can be read in. An image screen displayed in a step 944 is an image screen indicated in the figures 43, 48 and 49 (unillustrated), and here, a data processing method (an arithmetic processing method) is set. An image screen displayed in a step 945 is an image screen displayed in the figure 53 (unillustrated), and here, an image is made, and is registered as a file via an image indicated in the displaying figure 63 (unillustrated) in a step 946. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种光测量方法和能够根据由其测量提供的信息容易地处理和显示预定项目的图像的装置，该装置通过光测量装置测量被摄体。解决方案：在该光测量装置中，基于图中所示的分析流程的流程，进行测量处理之后的数据分析（运算处理）。在步骤942中显示的图像屏幕是图33（未示出）所示的图像屏幕，并且在此选择数据解析模式。在步骤943中显示的图像屏幕是图34（未示出）所示的图像屏幕，并且这里可以读取登记的数据文件。在步骤944中显示的图像屏幕是图43中所示的图像屏幕，48和49（未示出），并且这里设置数据处理方法（算术处理方法）。在步骤945中显示的图像屏幕是图53（未示出）中显示的图像屏幕，并且在这里，进行图像，并且通过在显示图63（未示出）中指示的图像在步骤中登记为文件版权所有（C）2005，JPO＆NCIPI

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