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1. 发明专利

JPS6056130B2 失效
公开(公告)号：JPS6056130B2
公开(公告)日：1985-12-09
申请号：JP3188378
申请日：1978-03-20
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU , TSUJI MASAYOSHI , AMANO HIDETOSHI , IDE HIROYUKI
IPC分类号： A61K31/60 , A61P25/04 , A61P29/00 , A61P37/08 , C07C235/38 , C07C235/56

3. 发明专利

JPS5920674B2 失效
公开(公告)号：JPS5920674B2
公开(公告)日：1984-05-15
申请号：JP15232675
申请日：1975-12-18
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU , HIRANO MUNEHIKO , YATANI TERUMI , IDE HIROYUKI
IPC分类号： C07D471/04

5. 发明专利

JPS5850229B2 JPS5850229B2 - 失效
公开(公告)号：JPS5850229B2
公开(公告)日：1983-11-09
申请号：JP7526275
申请日：1975-06-18
申请人： Hisamitsu Pharmaceutical Co
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU , IDE HIROYUKI
IPC分类号： C07D471/04 , A61K31/505 , A61P25/00 , A61P25/04 , A61P29/00 , C07D221/00 , C07D239/00

6. 发明专利

JPS5841865A NOVEL PREPARATION OF PHTHALIMIDINE DERIVATIVE 失效
公开(公告)号：JPS5841865A
公开(公告)日：1983-03-11
申请号：JP14201681
申请日：1981-09-07
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU
IPC分类号： C07D209/46
摘要： PURPOSE:To obtain the titled compound useful as an intermediate for synthesizing drugs, etc. by simple operations in high yield, by using a specific benzylidene derivative as a raw material, reacting it in the presence of a reducing agent so that it is subjected to ring formation. CONSTITUTION:An o-phtahlaldehyde-acid shown by the formulaI(R is H or lower alkyl) or its ester derivative is reacted with an aniline derivative shown by the formula II (X is H, CF3, or halogen), to give quantitatively a benzylidene shown by the formula III, which is not isolated, reacted in the presence of 1-3 times the molar quantity of a reducing agent such as NaBH4, KBH4, etc. in a solvent such as methanol, ethanol, diglyme(preferably methanol) at room temperature or under heating, so that it is subjected to ring formation, to give the desired compound shown by the formula IV. The use of CH3OH as a solvent can make the recovery easily and prepare the desired compound inexpensively. USE:An intermediate for preparing a phthalimide derivative shown by the formula V having medicinal effects such as antiphlogistic action, analgesic action, antipyretic action, etc.

7. 发明专利

JPS584033B2 失效
公开(公告)号：JPS584033B2
公开(公告)日：1983-01-24
申请号：JP6572181
申请日：1981-04-28
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU , YAMAGATA KENJI , YAMAZAKI SHUNZO , IDE HIROYUKI
IPC分类号： C07D471/04 , A61K31/505 , A61P25/00 , A61P25/04 , A61P29/00

9. 发明专利

JPS58429B2 失效
公开(公告)号：JPS58429B2
公开(公告)日：1983-01-06
申请号：JP9120274
申请日：1974-08-07
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , MOTOMURA TOSHIHARU , MYATA SATORU , IDE HIROYUKI
IPC分类号： C07D471/04 , A61K31/505 , A61P25/04 , A61P29/00 , C07D221/00 , C07D239/00

10. 发明专利

JPS5761755B2 失效
公开(公告)号：JPS5761755B2
公开(公告)日：1982-12-25
申请号：JP196874
申请日：1973-12-27
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , YAMAZAKI SHUNZO , MYATA SATORU , YAMAGATA KENJI , MOTOMURA TOSHIHARU , NAKAJIMA YOICHI , IDE HIROYUKI
IPC分类号： C07D471/04 , A61K31/505 , A61P25/04 , A61P29/00

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