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1. 发明专利

JP2007289469A Evaluation method for active state of cranial nerve cell 审中-公开
标题翻译： CRANIAL神经细胞活性状态的评估方法
公开(公告)号：JP2007289469A
公开(公告)日：2007-11-08
申请号：JP2006121632
申请日：2006-04-26
申请人： Hamano Life Science Research Foundation , Kao Corp , 花王株式会社 , 財団法人濱野生命科学研究財団
发明人： KAMINAMI MASAYUKI , ITO YUKIO , YADA YUKIHIRO , NAGASHIMA YOSHINAO , MITOBE HIROYUKI
IPC分类号： A61B5/055 , G01R33/28
摘要： PROBLEM TO BE SOLVED: To enable a brain functional activated area related to a task to be specified in such a manner that the task is applied to a subject while effectively suppressing physiological function change alone accompanying stresses, and measurement data of the brain function related to the task is accurately acquired by a simple and inexpensive constitution without applying a large burden on the subject. SOLUTION: This specifying method for the brain functional activated area enables delivery of a bio-active substance to the subject with a sensing stimulation or a brain function activating subject applied in a non-invasive brain functional examination method by a bio-functional measuring method. Then, the brain function activated area related to the sensing stimulation or the execution of the brain function activating subject, which makes an indicia of the change of an intracerebral blood flow, is specified. As the bio-active substance, cedrol is preferably used, and the cedrol is preferably inhaled at a concentration of 0.01 to 50 μg/L. Also, the cedrol is preferably volatilized from a volatilization device 15 being formed by using a non-magnetic material. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：使得能够以如下方式指定与任务相关的脑功能激活区域：使任务应用于受试者，同时有效地抑制伴随应力的生理功能变化，以及大脑的测量数据与该任务有关的功能通过简单廉价的结构被准确地获得，而不对该对象施加大的负担。解决方案：用于脑功能激活区域的这种指定方法使得能够通过生物功能的非侵入性脑功能检查方法中的感测刺激或脑功能激活受试者将生物活性物质递送给受试者测量方法。然后，规定与感觉刺激相关的大脑功能激活区域或大脑功能激活对象的执行，这是脑内血流量变化的标记。作为生物活性物质，优选使用雪松汁，优选以0.01〜50μg/ L的浓度吸入雪松汁。此外，雪松膏优选通过使用非磁性材料形成的挥发装置15挥发。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2004041670A Discriminating extraction method of biological function intelligence and its apparatus 审中-公开
标题翻译：鉴别生物功能智能提取方法及其设备
公开(公告)号：JP2004041670A
公开(公告)日：2004-02-12
申请号：JP2002265051
申请日：2002-09-11
申请人： Hamano Life Science Research Foundation , 財団法人濱野生命科学研究財団
发明人： KAMINAMI MASAYUKI
IPC分类号： G01R33/54 , A61B5/00 , A61B5/01 , A61B5/055 , G01R33/28
摘要： PROBLEM TO BE SOLVED: To provide intelligence by constituents by classifying a signal with sufficient precision into constituents of diverging physiological origins even when physiological fluctuation having other origins is intermingled with signal variation accompanied with partial nerve activity. SOLUTION: Biological function data are measured (1) and selection of an analysis area (2), pretreatment (3) , and preparation (4) of an input signal are conducted as needed, and a mathematical model for describing an input-output relation for each pixel or channel for biological function measurement data is built (5). Biological function intelligence of the constituents of diverging physiological origins included in the signal of the biological function measurement data is discriminated and extracted by this. The extraction result is displayed on, for example, a displaying device. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：即使当具有其他来源的生理波动与伴随部分神经活动的信号变化混合时，通过将具有足够精度的信号分类为分散生理来源的成分来提供智力。
解决方案：测量生物功能数据（1），根据需要进行输入信号的分析区域（2），预处理（3）和准备（4）的选择，以及用于描述输入的数学模型构建了用于生物学功能测量数据的每个像素或通道的输出关系（5）。生物功能测量数据信号中包含的生理分化成分的生物功能智能被鉴别和提取。提取结果显示在例如显示装置上。版权所有（C）2004，JPO

3. 发明专利

JP2005074188A Biological information measuring method and biological information measuring apparatus 审中-公开
标题翻译：生物信息测量方法和生物信息测量装置
公开(公告)号：JP2005074188A
公开(公告)日：2005-03-24
申请号：JP2003312263
申请日：2003-09-04
申请人： Hamano Life Science Research Foundation , 財団法人濱野生命科学研究財団
发明人： KAMINAMI MASAYUKI , ITO YUKIO
IPC分类号： A61B5/06 , A61B5/145 , A61B5/1459
摘要： PROBLEM TO BE SOLVED: To provide a biological information measuring apparatus by which a measurement over a wide range in a living body is possible, specification of a measurement part can be exactly performed, and a high measurement accuracy can be obtained.
SOLUTION: The apparatus is mounted in a moving member 5 in the body, and is equipped with a light emitting part 3 movably arranged in the living body 1 for emitting a prescribed light, a light receiving part 8 movably arranged on the outer surface of the living body, and a biological information measuring part 11 for measuring the biological information based on the detection result on the light received by the light receiving part 8. A light regulating means 10 for regulating the prescribed light emitted from the light emitting part 3 to the light in a specified direction is provided in the light receiving part 8. Among the prescribed light, only the light in the specified direction regulated by the light regulating means 10 is received by the light receiving part 8.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供一种生物信息测量装置，通过该生物信息测量装置可以精确地执行测量部分的指定，并且可以获得高的测量精度。解决方案：该装置安装在主体中的移动构件5中，并且配备有可移动地布置在生物体1中用于发射规定光的发光部3，可移动地布置在外部的光接收部8 生物信息测定部11，用于根据由受光部8接受的光的检测结果来测定生物体信息。一种调光装置10，用于调节从发光部发出的规定光光指定方向上的光3设置在光接收部分8中。在规定的光中，仅由光调节装置10调节的指定方向上的光被光接收部分8接收。（C）2005，JPO＆NCIPI

4. 发明专利

JP2005034387A Visualizing method for current distribution in vivo 审中-公开
标题翻译： VIVO中电流分布的可视化方法
公开(公告)号：JP2005034387A
公开(公告)日：2005-02-10
申请号：JP2003274503
申请日：2003-07-15
申请人： Hamano Life Science Research Foundation , 財団法人濱野生命科学研究財団
发明人： KAMEI HIROTAKE , OGAWA SEIJI , KAMINAMI MASAYUKI , SEI RETSUKAN
IPC分类号： G01R33/28 , A61B5/055
摘要： PROBLEM TO BE SOLVED: To provide a visualizing method for a current distribution in vivo by which the measurement is easy, and for which a magnetic resonance imaging method is used.
SOLUTION: Data of an image at the time of rest of a subject are collected (a step 22), and the image at the time of rest is obtained (a step 23). In the meantime, e.g., the irradiation of the subject with light is performed by a stimulating device (a step 24), and e.g., a 90° pulse is generated relating to the irradiation, and nerve activity information due to the occurrence of an optic nerve current is encoded into a lateral magnitization (a step 25). Then, an image at the time of activities is acquired (a step 27) by collecting data of an image at the time of activities (a step 26). In the image at the time of activities, an effect of the current in vivo due to the stimulation is reflected. A difference portion between the image at the time of activities and the image at the time of rest is acquired (a step 28), and a nerve current image is acquired based on this (a step 29).
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供容易测量的体内电流分布的可视化方法，并且使用磁共振成像方法。收集对象的休息时的图像的数据（步骤22），得到休息时的图像（步骤23）。同时，例如，通过刺激装置（步骤24）进行用光照射被检体，例如产生与照射有关的90°脉冲，以及由于发生光学的神经活动信息将神经电流编码为横向放大（步骤25）。然后，通过在活动时收集图像的数据来获取活动时的图像（步骤27）（步骤26）。在活动时的图像中，体现了由于刺激引起的体内电流的影响。获取活动时的图像与休息时的图像之间的差异部分（步骤28），并且基于此获取神经电流图像（步骤29）。版权所有（C）2005，JPO＆NCIPI

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