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1. 发明专利

JP2006068006A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006068006A
公开(公告)日：2006-03-16
申请号：JP2005235120
申请日：2005-08-15
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/04 , A61P3/10 , A61P9/04 , A61P13/12 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a new polypeptide derived from a human tissue and to provide a nucleic acid molecule encoding the polypeptide. SOLUTION: The polypeptide having a specific amino acid sequence and a polynucleotide having a specified nucleic acid sequence encoding the polypeptide are provided. Furthermore, a vector and a host cell comprising the nucleic acid sequence, a chimera polypeptide molecule comprising a polypeptide fused to a heterogenous polypeptide sequence and an antibody binding to the polypeptide are provided. Furthermore, a method for producing the polypeptide is provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供衍生自人体组织的新多肽并提供编码该多肽的核酸分子。提供了具有特定氨基酸序列的多肽和具有编码该多肽的特定核酸序列的多核苷酸。此外，提供了包含核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合体多肽分子和与多肽结合的抗体。此外，提供了生产多肽的方法。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006051031A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006051031A
公开(公告)日：2006-02-23
申请号：JP2005238217
申请日：2005-08-19
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a new secreted and transmembrane polypeptide and a nucleic acid molecule encoding the polypeptide. SOLUTION: The invention provides a new secreted and transmembrane polypeptide and a nucleic acid molecule encoding the polypeptide. It further provides a vector and a host cell containing the nucleic acid molecule sequence, a chimeric polypeptide molecule containing the polypeptide fused to a heterologous polypeptide sequence, an antibody binding to the polypeptide and a method for producing the polypeptide. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供新的分泌和跨膜多肽和编码该多肽的核酸分子。解决方案：本发明提供了新的分泌和跨膜多肽和编码该多肽的核酸分子。它进一步提供了含有核酸分子序列的载体和宿主细胞，含有与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体和产生多肽的方法。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2007302681A Medicine containing polypeptide 有权
标题翻译：含多糖的药物
公开(公告)号：JP2007302681A
公开(公告)日：2007-11-22
申请号：JP2007172879
申请日：2007-06-29
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI J CHRISTOPHER , GURNEY AUSTIN L , KLJAVIN IVAR J , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： A61K39/395 , G01N33/53 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/17 , A61K48/00 , A61P1/04 , A61P3/10 , A61P9/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K14/05 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566
CPC分类号： A61K38/17 , C07K14/005 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2710/16222
摘要： PROBLEM TO BE SOLVED: To provide a technique to inhibit the growth of the capillary endothelial cells of the adrenal cortex. SOLUTION: The medicine is a growth inhibitor for the growth of the capillary endothelial cells of the adrenal cortex containing an antibody which specifically bonds to a polypeptide and inhibits the ability of the polypeptide to stimulate the growth of the capillary endothelial cells of the adrenal cortex. The peptide has an amino acid sequence shown in figure 266 (sequence no.: 371) with or without a signal peptide and an amino acid sequence encoded by a nucleic acid molecule deposited under ATCC accession No. 203091 with or without a signal peptide. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供抑制肾上腺皮质毛细血管内皮细胞生长的技术。解决方案：该药物是含有特异性结合多肽的抗体的肾上腺皮质毛细血管内皮细胞生长的生长抑制剂，并且抑制多肽刺激毛细血管内皮细胞生长的能力肾上腺皮质。该肽具有图266所示的氨基酸序列（序列号：371），其具有或不具有信号肽和由具有或不具有信号肽的ATCC保藏号203091下保藏的核酸分子编码的氨基酸序列。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006061156A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006061156A
公开(公告)日：2006-03-09
申请号：JP2005238244
申请日：2005-08-19
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/04 , A61P3/10 , A61P7/00 , A61P9/00 , A61P13/12 , A61P17/02 , A61P19/02 , A61P27/02 , A61P35/00 , A61P37/02 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a new polypeptide and a nucleic acid molecule encoding the polypeptide. SOLUTION: This invention provides the new polypeptide, the nucleic acid molecule encoding the polypeptide, a vector and a host cell containing the sequence of the nucleic acid molecule, a chimera polypeptide molecule containing the polypeptide fused to a heterologous polypeptide sequence, an antibody bonding to the polypeptide, and a method for producing the polypeptide. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供编码该多肽的新的多肽和核酸分子。解决方案：本发明提供新的多肽，编码多肽的核酸分子，含有核酸分子序列的载体和宿主细胞，含有与异源多肽序列融合的多肽的嵌合体多肽分子，与多肽结合的抗体，以及产生该多肽的方法。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2006025795A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006025795A
公开(公告)日：2006-02-02
申请号：JP2005238266
申请日：2005-08-19
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/485 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide identification and isolation of new DNA, and to provide new polypeptides. SOLUTION: The new polypeptides and nucleic acid molecules encoding the polypeptides are provided. Vectors and host cells comprising the nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides and the methods for producing the polypeptides are also provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供新DNA的鉴定和分离，并提供新的多肽。提供了编码多肽的新的多肽和核酸分子。还提供了包含核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体和产生多肽的方法。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2004203742A Medicine comprising polypeptide 有权
标题翻译：包含多肽的药物
公开(公告)号：JP2004203742A
公开(公告)日：2004-07-22
申请号：JP2002341509
申请日：2002-09-25
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI J CHRISTOPHER , GURNEY AUSTIN L , KLJAVIN IVAR J , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P17/02 , A61P35/00 , C07K14/05 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566
CPC分类号： A61K38/17 , C07K14/005 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2710/16222
摘要： PROBLEM TO BE SOLVED: To provide a medicine comprising a new polypeptide utilizable for healing neovascularization, wounds, or the like. SOLUTION: This medicine is obtained by containing an isolated polypeptide having at least 80% sequence identity to an amino acid sequence represented by sequence number 371 or an isolated polypeptide having at least 80% sequence identitity to an amino acid sequence encoded with a nucleic acid molecule deposited as ATCC accession number 203091. A vector containing the nucleic acid molecule encoding the polypeptide, an antibody or an antibody fragment specifically binding to the polypeptide and inhibiting the ability to promote endothelial cell growth can be used. Furthermore, a method for identifying an agonist or an antagonist to the polypeptide is provided. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：提供包含可用于治愈新生血管形成，伤口等的新的多肽的药物。解决方案：该药物通过含有与由序列号371表示的氨基酸序列具有至少80％序列同一性的分离多肽而获得，或者与编码有氨基酸序列的氨基酸序列具有至少80％的序列同一性的分离多肽核苷酸分子保藏为ATCC登录号203091.可以使用含有编码多肽的核酸分子的载体，抗体或与多肽特异性结合并抑制促进内皮细胞生长能力的抗体片段。此外，提供了鉴定多肽的激动剂或拮抗剂的方法。版权所有（C）2004，JPO＆NCIPI

7. 发明专利

JP2006089489A Medicine for retinal disease 审中-公开
标题翻译：用于治疗疾病的药物
公开(公告)号：JP2006089489A
公开(公告)日：2006-04-06
申请号：JP2005290896
申请日：2005-10-04
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： KLJAVIN IVAR J , FLEUR MONIQUE LA
IPC分类号： A61K38/00 , A61K38/22 , A61K38/18 , A61P25/00 , A61P27/02 , A61P43/00 , C07K14/50 , C12N15/09
CPC分类号： A61K38/1825
摘要： PROBLEM TO BE SOLVED: To provide a medicine which prevents the death of light receptor cells without exhibiting a significant dividing effect on the light receptor cells and is used for retinal diseases. SOLUTION: This medicine for retarding or preventing the damages to or death of retinal cells or saving the retinal cells from the damages or death contains a therapeutically effective amount of an active FGF(fibroblast growth factor)-5 polypeptide. The active FGF-5 polypeptide has at least 90% of homology based on natural sequence FGF-5 molecule. The active FGF-5 polypeptide is selected from the group consisting of sequence number: 2, sequence number: 3 and sequence number: 5. The active FGF-5 polypeptide is encoded in a nucleotide sequence which is hybridized with the nucleic acid residues 26 to 769 of the sequence number: 1 under a stringent condition. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种药物，其可防止光受体细胞的死亡，而不对光受体细胞表现出显着的分裂作用，并用于视网膜疾病。解决方案：用于延缓或预防视网膜细胞损伤或死亡或节省视网膜细胞免于损伤或死亡的药物含有治疗有效量的活性FGF（成纤维细胞生长因子）-5多肽。基于天然序列FGF-5分子，活性FGF-5多肽具有至少90％的同源性。活性FGF-5多肽选自序列号：2，序列号3和序列号：5。活性FGF-5多肽编码在与核酸残基26杂交的核苷酸序列中序号为769，严格条件下为1。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2006051032A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006051032A
公开(公告)日：2006-02-23
申请号：JP2005238274
申请日：2005-08-19
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To clarify the structure of a new secreted/transmembrane polypeptide and a nucleic acid molecule encoding the polypeptide (an amino acid sequence and a base sequence, its intermolecular homology, etc., including a signal sequence, an extracellular domain, etc.), and provide basic information for the development of medicines/diagnostic methods. SOLUTION: The invention provides a vector and a host cell containing the base sequence of a nucleic acid encoding a number of polypeptides including new peptides such as chemokine and EGF family, a chimera molecule fused to a heterologous polypeptide, a binding antibody and a method for producing these substances. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了阐明新的分泌/跨膜多肽和编码多肽的核酸分子的结构（氨基酸序列和碱基序列，其分子间同源性等，包括信号序列，细胞外结构域等），为药物/诊断方法的开发提供基础信息。解决方案：本发明提供了载体和宿主细胞，其含有编码多种多肽的核酸的碱基序列，所述多肽包括新的肽，例如趋化因子和EGF家族，与异源多肽融合的嵌合体分子，结合抗体和这些物质的制造方法。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2005304500A Medicine comprising polypeptide 审中-公开
标题翻译：包含多肽的药物
公开(公告)号：JP2005304500A
公开(公告)日：2005-11-04
申请号：JP2005117472
申请日：2005-03-14
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI J CHRISTOPHER , GURNEY AUSTIN L , KLJAVIN IVAR J , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K51/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a medicine comprising a new polypeptide available to angiogenesis, wound healing and so on. SOLUTION: Disclosed is a medicine comprising an isolated polypeptide having at least 80% sequence identity to disclosed amino acid sequences or to amino acid sequences encoded by a nucleic acid molecule deposited by ATCC Accession No. 203091. A vector containing a nucleic acid encoding the polypeptide and an antibody or antibody fragment inhibiting an ability promoting the growth of endothelial cells through binding to the polypeptide are also available. Furthermore a method for identifying an agonist or antagonist of the polypeptide is provided. COPYRIGHT: (C)2006,JPO&NCIPI

10. 发明专利

JP2011236224A Medicine containing polypeptide 审中-公开
标题翻译：含多糖的药物
公开(公告)号：JP2011236224A
公开(公告)日：2011-11-24
申请号：JP2011138276
申请日：2011-06-22
申请人： Genentech Inc , ジェネンテック, インコーポレイテッド
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI J CHRISTOPHER , GURNEY AUSTIN L , KLJAVIN IVAR J , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： A61K39/395 , G01N33/53 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/17 , A61K48/00 , A61P9/00 , A61P17/02 , A61P35/00 , A61P43/00 , C07K14/05 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566
CPC分类号： A61K38/17 , C07K14/005 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2710/16222
摘要： PROBLEM TO BE SOLVED: To provide a technique to inhibit the growth of the capillary endothelial cells of the adrenal cortex.SOLUTION: A growth inhibitor for the growth of the capillary endothelial cells of the adrenal cortex contains an antibody which specifically bonds to a polypeptide and inhibits the ability of the polypeptide to stimulate the growth of the capillary endothelial cells of the adrenal cortex. The polypeptide has an amino acid sequence shown in Fig.266 (sequence no.371) and an amino acid sequence encoded by a nucleic acid molecule with or without a signal peptide deposited under ATCC accession No.203091, and further, the growth inhibitor for the growth of the capillary endothelial cells of the adrenal cortex either with or without the signal peptide is provided.
摘要翻译：要解决的问题：提供抑制肾上腺皮质毛细血管内皮细胞生长的技术。解决方案：用于肾上腺皮质毛细血管内皮细胞生长的生长抑制剂含有特异性结合多肽并抑制多肽刺激肾上腺皮质毛细血管内皮细胞生长的能力的抗体。该多肽具有图266（序列号371）所示的氨基酸序列和由具有或不具有保藏于ATCC登录号203091处的信号肽的核酸分子编码的氨基酸序列，此外，提供了有或没有信号肽的肾上腺皮质的毛细血管内皮细胞的生长。版权所有（C）2012，JPO＆INPIT

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