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1. 发明专利

JPH01190635A ANTIBODY AND ANTICARIOUS AGENT CONTAINING SAID ANTIBODY AS ACTIVE COMPONENT 失效
公开(公告)号：JPH01190635A
公开(公告)日：1989-07-31
申请号：JP1085388
申请日：1988-01-22
申请人： KANEBO LTD , GEN CORP KK
发明人： HORIKOSHI TOSHIO , HIRAOKA JUNICHIRO , FUJITA ISAMU , TOKORO TORU , KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI
IPC分类号： A61K6/00 , A61K8/00 , A61K8/64 , A61K8/66 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/40 , A61P1/02 , A61P31/04 , A61Q11/00 , C07K16/12 , C07K16/14 , C12N9/10
摘要： PURPOSE:To provide an anticarious agent effective in completely inhibiting the adhesion of Streptococcus mutans to the tooth surface and containing an antibody prepared from an egg laid by a hen immunized with a glucosyl transferase bonded with a bacterial cell of a specific Streptococcus mutans. CONSTITUTION:A S. mutans having serum type of c, e or f is cultured in a medium at least containing glucose (e.g., TTY medium), the bacterial cells are collected, as necessary washed, and extracted with a urea solution, a guanidine hydrochloride solution, etc., to obtain a bacterial cell-bonding glucosyl transferase having the following properties. Activity and substrate specificity, acting to sucrose to synthesize a water-insoluble glucan; optimum pH, 6.7-7.0; working temperature, 15-50 deg.C; inactivation condition, lose its activity at 80 deg.C for 5min; molecular weight, 150-165KD; immunogenicity, acting as immunogen in animal to produce a specific antigen. An antibody having immunological activity against S. mutans is obtained from an egg laid by a hen immunized with said enzyme.

2. 发明专利

JPH02121910A COSMETIC FOR PIMPLE 失效
公开(公告)号：JPH02121910A
公开(公告)日：1990-05-09
申请号：JP27431488
申请日：1988-10-28
申请人： KANEBO LTD , GEN CORP KK
发明人： MIYAMOTO TATSU , UCHIDA RYOICHI , TOUHO ASAMI , OGAWA TADATAKE , TOKORO TORU , KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/64 , A61K39/40 , A61Q19/00
摘要： PURPOSE:To obtain a cosmetic for pimple containing an egg yolk antibody prepared from an egg produced by a hen having immunized ingredient of cell wall of Propionibacterium acnes which is a bacterium always existing in skin, free from stimulation to skin and effective on prevention and remedy for pimple. CONSTITUTION:The aimed cosmetic for pimple containing an egg yolk antibody prepared by subjecting bacterium cell of Propionibacterium acness (P-acnes) which is a bacterium always existing in skin to supersonic crushing and then centrifugation to remove uncrushed bacterium cell and treating the supernatant thereof to provide ingredient of cell wall and using an egg produced by a hen immunized by the resultant ingredient of cell wall. The egg yolk antibody which is an active ingredient is specifically bonded to the surface of P-acnes to suppress activity and proliferation of bacterium. P-acnes is produced outside the bacterium cell and inhibits or lowers excision ability of inflammation in skin and exhibits excellent effect for treating pimple.

3. 发明专利

JPH0267227A VACCINE FOR INFECTIOUS SWINE OR BOVINE GASTROENTERITIS 失效
公开(公告)号：JPH0267227A
公开(公告)日：1990-03-07
申请号：JP21984588
申请日：1988-09-02
申请人： GEN CORP KK
发明人： KODAMA YOSHIKATSU
IPC分类号： A61K39/15 , A61K39/215 , A61P31/12
摘要： PURPOSE:To provide the subject vaccine produced by treating an inactivated or attenuated virus strain with a surfactant and capable of accomplishing effective milk immunization of newly born pigling or calf by inoculating to a pregnant animal before delivery. CONSTITUTION:Inactivated or attenuated virus of infectious swine or bovine gastroenteritis is treated with a surfactant, preferably a nonionic surfactant (e.g. polyoxyethylene sorbitan fatty acid ester surfactant) and the treated virus is used as the objective vaccine as it is or preferably as a mixture with an adjuvant. The concentration of the surfactant in the liquid in the above treatment is preferably >=0.01%, especially 0.5-5%. A neutral antibody against the virus is induced in the milk of the mother swine after delivery by the immunization of the pregnant swine with the vaccine before delivery. The lowering of the neutral antibody titer in the transfer from the colostrum to the normal milk is slow and the mild antibody value is maintained at a level comparable or superior to the level attained by the inoculation of strongly toxic strain. Effective milk immunization can be established by this process.

4. 发明专利

JPH01242534A ANTIBODY AND ANTICARIOUS AGENT CONTAINING SAID ANTIBODY AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH01242534A
公开(公告)日：1989-09-27
申请号：JP7033188
申请日：1988-03-23
申请人： KANEBO LTD , GEN CORP KK
发明人： HORIKOSHI TOSHIO , HIRAOKA JUNICHIRO , FUJITA ISAMU , TOKORO TORU , KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI
IPC分类号： A61K8/00 , A61K8/64 , A61K8/66 , A61K8/99 , A61K39/395 , A61P31/04 , A61Q11/00
摘要： PURPOSE:To obtain an antibody, consisting of immunoglobulin prepared from eggs produced by a hen immunized with a water-insoluble glucan synthetase produced by Stretococcus.mutans, capable of inhibiting sticking of the Streptococcus.mutans to tooth surfaces and useful as an active ingredient of an anticarious agent. CONSTITUTION:An antibody prepared by culturing Streptococcus.mutans having a serotype of a, d or g as a cariogenic pathogenic germ in a culture medium containing at least glucose to provide a water-insoluble glucan synthetase (TGF-1) from the culture supernatant thereof, immunizing a hen (preferably egg breed, such as White Leghorn) using the above-mentioned enzyme as an antigen, collecting eggs from the hen after the passage of >=1 months from the immunization and preparing the antibody having inhibitory activity against the TGF-1 therefrom. An IgG fraction can be specifically separated and purified by simple operation, such as migration of only the IgG fraction in immunoglobulin into egg yolk and preparation of the antibody from the egg yolk and a high antibody value can be normally obtained for about 3 months.

5. 发明专利

JPH01233229A ANTIBODY AND TOOTH DECAY PREVENTIVE CONTAINING THE SAME 失效
公开(公告)号：JPH01233229A
公开(公告)日：1989-09-19
申请号：JP5889088
申请日：1988-03-12
申请人： KANEBO LTD , GEN CORP KK
发明人： HORIKOSHI TOSHIO , HIRAOKA JUNICHIRO , FUJITA ISAMU , TOKORO TORU , KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI
IPC分类号： A61K8/00 , A61K8/64 , A61K8/66 , A61K8/99 , A61K39/395 , A61P1/02 , A61Q11/00
摘要： PURPOSE:To obtain an antibody which can be used as an active ingredient for preventing tooth decay, because it has satisfactory action to inhibit S. mutans from adhering to tooth surfaces, by preparing from eggs produced by hens immunized with a water-soluble glucan synthetase produced by S. mutans. CONSTITUTION:Streptococcus mutans of c, e or f serum type is cultured, as a pathogenic bacterium, in a medium containing at least glucose to obtain a water-soluble glucan synthetase (GFT-S) from the cell bodies. Hens are immunized using the enzyme as an antigen, eggs are collected from hens 1 or more months after immunization to prepare antiGFT-S antibody. High antibody values are kept for about 3 months. Since only IgG is transferred into the yolk, only IgG fraction can be specifically isolated through simple operation, namely yolk separation.

6. 发明专利

JP2006325447A ANTI-HELICOBACTER PYLORI FOOD AND DRINK 审中-公开
公开(公告)号：JP2006325447A
公开(公告)日：2006-12-07
申请号：JP2005151424
申请日：2005-05-24
申请人： NISSHIN PHARMA INC , GEN CORP KK
发明人： KAWACHI KOJI , HIRAMOTO SHIGERU , KIMURA NOBUTAKE , KODAMA YOSHIKATSU
IPC分类号： A23L1/30 , A61K31/7004 , A61K31/7016 , A61K31/717 , A61K31/729 , A61K31/732 , A61K31/734 , A61K31/736 , A61K38/16 , A61K38/17 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To provide anti-Helicobacter pylori food and drink which is improved in anti-Helicobacter pylori function of browning reaction products comprising sugar and protein, and effectively eliminating Helicobacter pylori. SOLUTION: The anti-Helicobacter pylori food and drink contains the browning reaction products from sugar and protein, and viscous polysaccharide. COPYRIGHT: (C)2007,JPO&INPIT

7. 发明专利

JP2002029999A PROPHYLACTIC AND THERAPEUTIC AGENT FOR DIGESTIVE ULCER 失效
公开(公告)号：JP2002029999A
公开(公告)日：2002-01-29
申请号：JP2000214835
申请日：2000-07-14
申请人： GEN CORP KK , NISSHIN PHARMA INC
发明人： KODAMA YOSHIKATSU , KIMURA NOBUTAKE
IPC分类号： A61K45/06 , A61K31/426 , A61K39/395 , A61K39/40 , A61P1/04 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To provide a prophylactic and therapeutic agent for digestive ulcer caused by infection with Helicobactor pylori. SOLUTION: The objective Helicobacter pyroli fixation inhibitor comprises (1) a specific chicken egg antibody obtained by immunizing chicken with the Helicobactor pyroli urease as an antigen and (2) a gastrin inhibitor. This Helicobactor pylori fixation inhibitor can perfectly remove the cell bodies of Helicobactor pyroli from the stomach and is useful as a prophylactic and a therapeutic for digestive ulcer.

8. 发明专利

JPH03151853A ANTIBODY AND INTESTINAL FUNCTION CONTROLLING FOOD CONTAINING THE ANTIBODY AS ACTIVE COMPONENT 失效
公开(公告)号：JPH03151853A
公开(公告)日：1991-06-28
申请号：JP29191889
申请日：1989-11-09
申请人： KANEBO LTD , GEN CORP KK
发明人： ONISHI SHIGEKI , MORITA KAZUYOSHI , TOKORO TORU , KODAMA YOSHIKATSU
IPC分类号： A23C9/13 , A23L1/30 , A61K39/40 , A61P1/12
摘要： PURPOSE:To obtain an antibody having immunological activity against Clostridium perfringens (a harmful intestinal bacteria) and useful as an active component of a food for controlling intestinal function by immunizing a chicken egg with a cell cortex antigen of Clostridium perfringens having a serum type of A and using an immunoglobulin prepared from the immunized egg as the antibody. CONSTITUTION:Clostridium perfringens having a serum type of A (e.g. NCTC 10578 strain) is cultured and a cell cortex antigen is collected from the bacterial cell. A chicken is immunized with the cell cortex antigen and eggs laid by the immunized chicken are collected and subjected to centrifugal separation, extraction with dextran sulfate, separation with various chromatographic means, etc., to separate an immunoglobulin from the egg in purified state. The obtained immunoglobulin acts as an antibody having immunological activity against Clostridium perfringens which is a harmful intestinal bacteria. Accordingly, a food having excellent effect to control intestinal function can be prepared by using the antibody as an active component.

9. 发明专利

JPH10298105A PREVENTING AND CURING AGENT FOR INFECTIOUS DISEASE CAUSED BY ENTEROHEMORRHAGIC ESCHERICHIA COLI 失效
公开(公告)号：JPH10298105A
公开(公告)日：1998-11-10
申请号：JP10648997
申请日：1997-04-23
申请人： GEN CORP KK
发明人： KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI , KOGA YASUHIRO , TANAKA KAZUO , AIBA TAKESHI
IPC分类号： A61K39/395 , A23L1/00 , A61K38/00 , A61K39/40 , A61P1/00 , A61P25/00 , A61P31/04 , A61P39/02 , C07K16/02 , C07K16/12
摘要： PROBLEM TO BE SOLVED: To obtain a safe and effective pharmaceutical agent capable of preventing and curing infectious diseases caused by enterohemorrhagic Escherichia coli (E. coli), O-157. SOLUTION: The preventing and curing agent and preventive food for infectiosus diseases caused by enterohemorrhagic E. coli, O-157, contain and antibody obtained from eggs laid by immunized hens which are immunized with cells of hemorrhagic E. coli, O-157, or toxoid-verotoxin as an antigen and specific to the antigen as an effective component and, further, the specific egg antibody and lactic acid bacteria and/or Lactobacillus bifidus as effective components. The egg antibody has a high neutralization activity against verotoxin produced by the E. coli.

10. 发明专利

JPH02121909A COSMETIC FOR PIMPLE 失效
公开(公告)号：JPH02121909A
公开(公告)日：1990-05-09
申请号：JP27431388
申请日：1988-10-28
申请人： KANEBO LTD , GEN CORP KK
发明人： UCHIDA RYOICHI , MIYAMOTO TATSU , TOUHO ASAMI , OGAWA TADATAKE , TOKORO TORU , KODAMA YOSHIKATSU , YOKOYAMA HIDEAKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/64 , A61K39/40 , A61Q19/00
摘要： PURPOSE:To obtain a cosmetic for pimple containing an egg yolk antibody prepared from an egg produced by a hen immunizing an acidic polysaccharide produced outside bacterium cell by Propionibacterium which is a bacterium always existing in a skin, free from stimulation and exhibiting action effective remedy for pimple. CONSTITUTION:A domestic fowl (preferably a hen of white leghorn, etc.) is subjected to immune operation using an acidic polysaccharide produced outside bacterium cell by Propionibacterium acness which is a bacterium always existing in skin to immunize the domestic fowl and an egg yolk antibody is obtained from an egg produced by the domestic fowl. The egg yolk antibody is blended at an amount of nearly 0.0001-0.5wt.% based on total amount of the composition to provide the cosmetic for pimple. The obtained cosmetic is free from stimulation to skin, has action effective to prevention and remedy for pimple and is stable even in the case of long-term storage and the commercial value is extremely high.

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