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1. 发明专利

JP2008127331A Protein-immobilized particle 审中-公开
标题翻译：蛋白质固定颗粒
公开(公告)号：JP2008127331A
公开(公告)日：2008-06-05
申请号：JP2006313954
申请日：2006-11-21
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KASAGI NORIYUKI , KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： A61K38/00 , A61K9/14 , A61K47/42 , A61K47/48 , A61K49/00 , A61P35/00 , B82B3/00 , C01G49/00 , C07K17/14
摘要： PROBLEM TO BE SOLVED: To provide a particle having a protein, an antibody, etc., immobilized on a particle such as a magnetic nano-particle while keeping its activity without using a reduction treatment, and to provide a method for producing the particle.
SOLUTION: The protein-immobilized particle is produced by contacting a particle having an aldehyde group with a protein having an aminoxy group, a carboxyhydrazine group or a hydrazine group and forming an oxime bond or a hydrazone bond.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：为了提供固定在诸如磁性纳米颗粒的颗粒上的蛋白质，抗体等的颗粒，同时保持其活性而不使用还原处理，并且提供一种生产颗粒。解决方案：蛋白质固定的颗粒通过使具有醛基的颗粒与具有氨氧基，羧基肼或肼基的蛋白质接触并形成肟键或腙键来制备。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2008069093A Water-dispersible magnetic particle utilizing electrostatic interaction 审中-公开
标题翻译：使用静电相互作用的水分散磁性颗粒
公开(公告)号：JP2008069093A
公开(公告)日：2008-03-27
申请号：JP2006247643
申请日：2006-09-13
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KASAGI NORIYUKI , KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： A61K49/00 , A61K47/02 , A61K47/24 , A61K47/34 , B01F17/14 , B01F17/42 , C01G49/08 , C08K3/00 , C08L71/02 , H01F1/36
摘要： PROBLEM TO BE SOLVED: To provide a simply handleable water-dispersible magnetic particle reducing nonspecific adsorption of a biological substance such as a protein and stably dispersible by utilizing stronger interaction of the particle with a dispersing agent. SOLUTION: The water-dispersible magnetic particles comprises magnetic particles coated with the dispersing agent having a structure capable of providing electrostatic interaction with the magnetic particle. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供简单可操作的水分散磁性颗粒，通过利用颗粒与分散剂的更强的相互作用减少生物物质如蛋白质的非特异性吸附并稳定地分散。水分散性磁性颗粒包括用分散剂涂覆的磁性颗粒，其具有能够提供与磁性颗粒的静电相互作用的结构。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007216134A Water-dispersible magnetic nanoparticle 审中-公开
标题翻译：水分散磁性纳米粒子
公开(公告)号：JP2007216134A
公开(公告)日：2007-08-30
申请号：JP2006039111
申请日：2006-02-16
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： B01J19/00 , A61B5/055 , A61K9/10 , A61K9/18 , A61K41/00 , A61K47/02 , A61K47/18 , A61K47/20 , A61K49/00 , A61P7/02 , A61P17/18 , A61P29/00 , A61P35/00 , A61P37/08 , B01J19/10 , B01J20/22 , B01J20/26 , G01N33/543 , G01R33/28
摘要： PROBLEM TO BE SOLVED: To provide a water-monodispersible nanoparticle having a physiologically active substance on its surface and a convenient manufacturing method of the nanoparticle with high flexibility.
SOLUTION: The magnetic nanoparticle, dispersed in water and having an average particle size of 1-50 nm, keeps an amino acid fixed to its surface.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供其表面上具有生理活性物质的水 - 单分散纳米颗粒和具有高柔性的方便的纳米颗粒的制造方法。解决方案：分散在水中并具有1-50nm平均粒径的磁性纳米颗粒保持氨基酸固定在其表面上。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007112679A Nanoparticle and method for producing the same 审中-公开
标题翻译：纳米材料及其制造方法
公开(公告)号：JP2007112679A
公开(公告)日：2007-05-10
申请号：JP2005307695
申请日：2005-10-21
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： TAKANO KANAME , KOJIMA MASAYOSHI , NISHIGAKI JUNJI
IPC分类号： C01G9/02 , A61K9/16 , A61K47/02 , A61K47/08 , A61K47/16 , A61K47/20 , A61K47/24 , A61K47/34 , A61K47/48 , A61K49/00 , A61K49/04 , B01J13/04 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide nanoparticles having enhanced dispersibility and reactivity in an aqueous medium. SOLUTION: The nanoparticles are each constituted of a core part and an organic surface layer covering the surface of the core part. Each nanoparticle has surface reactive groups expressed by formulas: R 1 O-L 1 -group and Y-L 2 -group (wherein, L 1 and L 2 are each a divalent linking group and the length of the group L 2 is longer than that of the group L 1 ; R 1 is a 1-3C alkyl group or hydrogen atom; and Y is a group having reactivity with a substance to be labeled) in the organic surface layer. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供在水性介质中具有增强的分散性和反应性的纳米颗粒。解决方案：纳米颗粒各自由芯部分和覆盖芯部表面的有机表面层构成。每个纳米颗粒具有由下式表示的表面反应性基团：其中，L 1组和YL 2 和L 2 分别是二价连接基团，并且组L 2 的长度比组L 1 ;有机表面层中的R 1 是1-3C烷基或氢原子; Y是与待标记的物质具有反应性的基团）。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2007040978A Method for separating objective element using magnetic nanoparticles 审中-公开
标题翻译：使用磁性纳米粒子分离目标元件的方法
公开(公告)号：JP2007040978A
公开(公告)日：2007-02-15
申请号：JP2006149257
申请日：2006-05-30
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KOJIMA MASAYOSHI , HIRAI HIROYUKI , KAGEYAMA SHIGEKI , ABE YOSHIHIKO
IPC分类号： G01N33/92 , G01N33/52
CPC分类号： G01N33/5434 , G01N33/92 , G01N2446/80
摘要： PROBLEM TO BE SOLVED: To provide a method for using autoanalyzer to determine the quantity of an element contained in a specific fraction of lipoprotein within a biological sample, without requiring centrifuge-based fraction collection process.
SOLUTION: This method for separating objective element in the biological sample includes a process (1) of forming aggregates of the independently-dispersed magnetic nanoparticles of 50 nm or smaller, provided with anionic functional group on surface, and the biological sample which can interact with the above magnetic nanoparticles, by bringing the magnetic nanoparticles into contact with the biological sample; and a process (2) of collecting those aggregates through external magnetic field.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用自动分析仪来确定生物样品中脂蛋白特定部分中所含元素的量的方法，而不需要基于离心机的级分收集过程。解决方案：用于分离生物样品中的目标元素的方法包括形成50nm以下的独立分散磁性纳米粒子的聚集体的方法（1），其表面具有阴离子官能团，生物样品可以通过使磁性纳米粒子与生物样品接触而与上述磁性纳米粒子相互作用; 以及通过外部磁场收集这些聚集体的方法（2）。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2008120699A Novel pyridinium derivative and medicine 审中-公开
标题翻译：新型吡啶衍生物和药物
公开(公告)号：JP2008120699A
公开(公告)日：2008-05-29
申请号：JP2006303313
申请日：2006-11-08
申请人： Fujifilm Corp , Pharma Ip , 富士フイルム株式会社 , 有限責任中間法人ファルマIp
发明人： ASAI AKIYOSHI , SAWADA JUNICHI , MATSUNO KENJI , OGO NAOHISA , NISHIGAKI JUNJI , KOJIMA MASAYOSHI
IPC分类号： C07D213/04 , A61K31/4425 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a novel pyridinium derivative and a novel medicine that have excellent anti-tumor activity.
SOLUTION: The novel medicine comprises a pyridinium derivative represented by formula (I). The novel pyridinium derivative is comprised of a pyridinium ring binding to the 2-position of a naphthalene ring. In the formula, Q represents an aryl or an aromatic heterocycle group; R
A and R
B each represents a hydrogen atom, an alkyl, an aryl or the like; m represents 0 to 4; n represents 0 to 7; and X
- represents a pharmacologically acceptable anion.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供具有优异抗肿瘤活性的新型吡啶衍生物和新药。解决方案：新型药物包含由式（I）表示的吡啶衍生物。该新颖的吡啶鎓衍生物由结合萘环的2位的吡啶鎓环组成。在该式中，Q表示芳基或芳香族杂环基; R A 和R B 各自表示氢原子，烷基，芳基等; m表示0〜4; n表示0〜7; X - 表示药理学上可接受的阴离子。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2007217331A Water-dispersible magnetic nano-particle 审中-公开
标题翻译：水分散磁性纳米颗粒
公开(公告)号：JP2007217331A
公开(公告)日：2007-08-30
申请号：JP2006039109
申请日：2006-02-16
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： A61K33/26 , A61F7/00 , A61K9/14 , A61K41/00 , A61K49/00 , A61N2/08 , B82B1/00 , C07K14/00 , C07K14/475 , C07K14/78 , C07K16/00 , C07K17/14 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a water-monodispersible magnetic nano-particle having a physiologically active substance on the surface and to provide a simple method for producing the magnetic nano-particle with high general-purpose properties thereof. SOLUTION: The magnetic nano-particle is a magnetic nano-particle having 1-50 nm average particle diameter, dispersed in water and comprising a protein or a peptide immobilized on the surface. The magnetic nano-particle dispersed in water has the surface modified with a compound represented by general formula R 1 -(OCH 2 CH 2 ) n -O-L-X (wherein, R 1 represents a 1-24C alkyl group; n represents an integer of ≥1 to ≤20; L represents a single bond or a 1-10C alkylene group; and X represents a carboxylate group, a phosphate group, a sulfonate group or a borate group). The magnetic nano-particle can be used in the fields of life science, medical diagnosis, etc. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供在表面具有生理活性物质的水分散性磁性纳米颗粒，并提供一种具有高通用性质的磁性纳米颗粒的制备方法。解决方案：磁性纳米颗粒是具有1-50nm平均粒径的磁性纳米颗粒，分散在水中并且包含固定在表面上的蛋白质或肽。分散在水中的磁性纳米粒子用通式R 1表示的化合物进行表面改性，（OCH 2 SB 2 CH 2） SB> n -OLX（其中，R 1 表示1-24C烷基; n表示≥1〜≤20的整数; L表示单键或1-10C 亚烷基; X表示羧酸酯基，磷酸酯基，磺酸酯基或硼酸酯基）。磁性纳米颗粒可用于生命科学，医学诊断等领域。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2009179589A Antiviral agent 审中-公开
标题翻译：抗病毒剂
公开(公告)号：JP2009179589A
公开(公告)日：2009-08-13
申请号：JP2008019558
申请日：2008-01-30
申请人： Fujifilm Corp , Pharma Ip , 一般社団法人ファルマIp , 富士フイルム株式会社
发明人： ASAI AKIYOSHI , SUZUKI TAKASHI , OGO NAOHISA , SUZUKI YASUO , SHIMIZU MOTOHIRO , NISHIGAKI JUNJI , KOJIMA MASAYOSHI
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4196 , A61K31/519 , A61P31/12 , A61P31/16 , C07D207/36 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/88 , C07D487/04
摘要： PROBLEM TO BE SOLVED: To provide an antiviral agent effective for influenza or the like. SOLUTION: The antiviral agent contains a pyrrole derivative represented by formula (I) (wherein, R A , R B , R C and R D are the same or different and each a hydrogen atom, an alkyl group, an aryl group or the like; X is a hydrogen atom, a substituted alkyl group or the like; or each of X and R A , R A and R B , and R C and R D may form a ring by bonding to each other). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供对流感等有效的抗病毒剂。解决方案：抗病毒剂含有由式（I）表示的吡咯衍生物（其中R 1，R 2，R 2，和R“SP”相同或不同，各自为氢原子，烷基，芳基等; X为氢原子，取代烷基等，或X为和R A ，R A 和R B 和R C 和R D 可以通过彼此结合而形成环）。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2007269632A Inorganic nanoparticle onto which drug is fixed 审中-公开
标题翻译：无机氮化合物固定在其上
公开(公告)号：JP2007269632A
公开(公告)日：2007-10-18
申请号：JP2006093451
申请日：2006-03-30
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： A61K9/14 , A61B5/055 , A61K47/02 , A61K47/18 , A61K49/00 , G01R33/28
CPC分类号： A61K9/5094 , A61K9/0009 , A61K9/5115 , A61K41/0052 , A61K47/6923 , A61K49/1833 , A61K49/1836 , A61K49/1866 , A61K49/1869 , B82Y5/00 , G01N33/54346
摘要： PROBLEM TO BE SOLVED: To provide a composite of a medicinal compound (i. e. an active substance) and an inorganic nanoparticle, and a versatile, simple manufacturing method of the inorganic nanoparticle composite.
SOLUTION: The inorganic nanoparticle composite has the active substance fixed through physical adsorption onto the surface of the inorganic particle with an average particle size of 1-500 nm. The inorganic nanoparticle composite is manufactured by mixing a solution of the medicinal compound with a dispersion of the inorganic nanoparticle and exposing the mixture to an ultrasonic irradiation. The inorganic nanoparticle composite is used in the field of life science or medical diagnosis.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供药物化合物（即活性物质）和无机纳米颗粒的复合物，以及无机纳米粒子复合材料的通用简单的制造方法。解决方案：无机纳米颗粒复合材料通过物理吸附将活性物质固定在无机颗粒表面上，平均粒度为1-500nm。通过将药物化合物的溶液与无机纳米颗粒的分散体混合并将混合物暴露于超声波照射来制造无机纳米颗粒复合物。无机纳米颗粒复合材料用于生命科学或医学诊断领域。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2007220867A Water-dispersible magnetic nanoparticle 审中-公开
标题翻译：水分散磁性纳米粒子
公开(公告)号：JP2007220867A
公开(公告)日：2007-08-30
申请号：JP2006039110
申请日：2006-02-16
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： KOJIMA MASAYOSHI , HIRAI HIROYUKI
IPC分类号： H01F1/36 , A61B5/055 , A61K49/00 , C01G49/08 , C09C1/24 , C09C3/10 , G01N33/543 , G01R33/28
摘要： PROBLEM TO BE SOLVED: To provide water-dispersible magnetic nanoparticles which have physiologically active material on their surfaces, and to provide a method of manufacturing the above magnetic nanoparticles which is simple and high in general-purpose properties.
SOLUTION: The magnetic nanoparticles are dispersed in water with 1 to 50 nm average grain diameter, and acid polysaccharide is fixed on their surfaces.
COPYRIGHT: (C)2007,JPO&INPIT

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