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1. 发明专利

JPH0349891B2 失效
公开(公告)号：JPH0349891B2
公开(公告)日：1991-07-31
申请号：JP14549089
申请日：1989-06-09
申请人： EISAI CO LTD
发明人： YAMAMOTO MASAKAZU , ARAKI SEIICHI , YAMAMOTO HIROSHI , YAMATSU ISAO , SUZUKI TAKESHI , KAJIWARA SHOJI , SUZUKI YOSHIKAZU , ARAI MASAE
IPC分类号： A61K31/045 , A61K31/08 , A61K31/215 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , C07C33/02 , C07C43/15 , C07C69/007

2. 发明专利

JPH026326B2 失效
公开(公告)号：JPH026326B2
公开(公告)日：1990-02-08
申请号：JP8980682
申请日：1982-05-28
申请人： EISAI CO LTD
发明人： YAMAMOTO MASAKAZU , ARAKI SEIICHI , YAMAMOTO HIROSHI , YAMATSU ISAO , SUZUKI TAKESHI , KAJIWARA SHOJI , SUZUKI YOSHIKAZU , ARAI MASAE
IPC分类号： A61K31/045 , A61P31/04 , A61P37/04 , C07C29/147 , C07C33/02 , C07C43/15 , C07C49/04 , C07C49/203 , C07C51/08 , C07C51/38 , C07C57/03

3. 发明专利

JPS6332058B2 失效
公开(公告)号：JPS6332058B2
公开(公告)日：1988-06-28
申请号：JP4455880
申请日：1980-04-07
申请人： EISAI CO LTD
发明人： YAMATSU TAKUMI , INAI JUICHI , ABE SHINYA , SUZUKI TAKESHI , SUZUKI YOSHIKAZU , TAGAYA OSAMU , SUZUKI KOICHI , ABE KOICHI , YAMADA KOJI
IPC分类号： A61K8/36 , A61K31/19 , A61K31/20 , A61P35/00 , A61Q19/00 , C07C27/00 , C07C27/02 , C07C51/00 , C07C51/347 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44

4. 发明专利

JPH0228109A PREVENTIVE AND TREATING AGENT FOR DISEASE CAUSED BY IMMUNOLOGICAL DYSFUNCTION 失效
公开(公告)号：JPH0228109A
公开(公告)日：1990-01-30
申请号：JP14887989
申请日：1989-06-12
申请人： EISAI CO LTD
发明人： YAMAMOTO MASAKAZU , ARAKI SEIICHI , YAMAMOTO HIROSHI , YAMATSU ISAO , SUZUKI TAKESHI , KAJIWARA SHOJI , SUZUKI YOSHIKAZU , ARAI MASAE
IPC分类号： A61K31/045 , A61K39/39 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , C07C31/125
摘要： PURPOSE:To obtain the subject preventive and treating agent, containing docosanol and having action of normalizing human and animal immunological function and enhancing infection resistance. CONSTITUTION:A preventive and treating agent containing docosanol as an active ingredient. The above-mentioned composition is effective against rheumarithritis, autoimmune diseases, cancer asthma and various infectious diseases for humans and porcine diarrhea, pneumonia and TGE, avian pneumonia and Marek's disease, bovine diarrhea, pneumonia and mammitis, etc., for animals. In administration to humans and animal infectious diseases, treating effects thereof are remarkably enhanced by use with an antibiotic substance. The dose for humans is within the range of 10-4000mg, preferably 50-500mg per day for an adult.

5. 发明专利

JPS6334855B2 失效
公开(公告)号：JPS6334855B2
公开(公告)日：1988-07-12
申请号：JP18211580
申请日：1980-12-24
申请人： EISAI CO LTD
发明人： YAMATSU ISAO , INAI JUICHI , ABE SHINYA , SUZUKI TAKESHI , SUZUKI YOSHIKAZU , TAGAYA OSAMU , SUZUKI KOICHI , ABE KOICHI , YAMADA KOJI
IPC分类号： C07C69/587 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/22 , A61K31/23 , A61P35/00 , C07C51/00 , C07C57/03 , C07C67/00 , C07C231/00 , C07C233/09

6. 发明专利

JPS5731615A Remedy for skin disease with keratinization 失效
标题翻译：用于治疗皮肤疾病的补救措施
公开(公告)号：JPS5731615A
公开(公告)日：1982-02-20
申请号：JP10442080
申请日：1980-07-31
申请人： Eisai Co Ltd
发明人： YAMATSU TAKUMI , INAI HIROICHI , ABE SHINYA , SUZUKI TAKESHI , SUZUKI YOSHIKAZU , TAGAYA OSAMU , KOYANAGI NOZOMI
IPC分类号： A61K31/20 , A61K8/36 , A61K31/19 , A61P17/00 , A61Q19/00 , C07C51/00 , C07C51/087 , C07C57/02 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44
CPC分类号： A61Q19/00 , A61K8/361 , A61K9/1652 , A61K31/202 , C07C57/03 , C07C69/587 , C07C317/44 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： NEW MATERIAL:3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenic acid shown by the formula and its salt.
USE: A remedy for skin disease with keratinization. Having no side effects and high safety.
PROCESS: Triethylphosphonoacetate is reacted with 6,10,14-trimethylpentadeca-3,5, 9,13-tetraene-2-one in the presence of a sodium halide in a solvent, e.g., n-hexane, etc. and extracted with hexane, to give 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenic acid ethyl ester. This compound is heated in the presence of KOH in a solvent, isopropyl alcohol, etc., cooled, acidified with HCl, and extracted with ethyl ether, to give a compound shown by the formula.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：由式及其盐表示的3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸。用途：用于角质化皮肤病的补救措施。无副作用，安全性高。方法：在卤化钠存在下，在溶剂例如正己烷等中，使三乙基膦酰基乙酸酯与6,10,14-三甲基十五烷基-3,5,9,13-四烯-2-酮反应，并用己烷得到3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸乙酯。该化合物在KOH存在下在溶剂，异丙醇等中加热，冷却，用HCl酸化，用乙醚萃取，得到式中所示的化合物。

7. 发明专利

JPH026327B2 失效
公开(公告)号：JPH026327B2
公开(公告)日：1990-02-08
申请号：JP18364282
申请日：1982-10-21
申请人： EISAI CO LTD
发明人： YAMAMOTO MASAKAZU , ARAKI SEIICHI , YAMAMOTO HIROSHI , YAMATSU ISAO , SUZUKI TAKESHI , KAJIWARA SHOJI , SUZUKI YOSHIKAZU , ARAI MASAE
IPC分类号： A61K31/045 , A61P37/04 , C07C33/02

8. 发明专利

JPH0131484B2 失效
公开(公告)号：JPH0131484B2
公开(公告)日：1989-06-26
申请号：JP10442080
申请日：1980-07-31
申请人： EISAI CO LTD
发明人： YAMATSU TAKUMI , INAI JUICHI , ABE SHINYA , SUZUKI TAKESHI , SUZUKI YOSHIKAZU , TAGAYA OSAMU , KOYANAGI NOZOMI
IPC分类号： A61K31/20 , A61K8/36 , A61K31/19 , A61P17/00 , A61Q19/00 , C07C51/00 , C07C51/087 , C07C57/02 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44

9. 发明专利

JPS6160612A Carcinostatic intensifier 失效
标题翻译：致癌细胞
公开(公告)号：JPS6160612A
公开(公告)日：1986-03-28
申请号：JP18238484
申请日：1984-08-31
申请人： Eisai Co Ltd
发明人： SETO TOSHIO , SUZUKI YOSHIKAZU
IPC分类号： A61K31/20 , A61K31/19 , A61P35/00 , C07C57/03
CPC分类号： A61K31/19
摘要： PURPOSE: A safe carcinostatic intensifier that contains, as an active ingredient, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid or its salt, thus intensifying carcinostatic effect by synergism in combination with another carcinostatic agent.
CONSTITUTION: 3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid of the formula and its salt are used as a carcinostatic intensifier. The compound of the formula is known as an anticancer and remedy for dermatopathy, but the inventors have found that it strongly intensifies its carcinostatic effect, when combined with another known carcinostatic agent. Especially, this effect is markedly developed in combination with 5-Fu, MMC, REP, Further, the compound of the formula is structurally completely novel and shows high safety, therefore its clinical value is high.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：一种安全的致癌增强剂，含有作为活性成分的3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸或其盐，从而通过与另一种组合的协同作用增强制癌的作用制癌剂。构成：将下式的3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸及其盐用作制癌增强剂。该化合物被称为皮肤病的抗癌和补救剂，但是发明人已经发现，当与另一种已知的制癌剂组合时，其强烈地增强其制癌作用。特别是与5-Fu，MMC，REP组合显着发挥作用。此外，式中化合物结构完全新颖，安全性高，临床价值高。

10. 发明专利

JPS58206517A Preventive and remedy for disease caused by immunoinsufficiency 失效
标题翻译：免疫力引起的疾病预防和补救措施
公开(公告)号：JPS58206517A
公开(公告)日：1983-12-01
申请号：JP8980682
申请日：1982-05-28
申请人： Eisai Co Ltd
发明人： YAMAMOTO MASAKAZU , ARAKI SEIICHI , YAMAMOTO HIROSHI , YAMATSU ISAO , SUZUKI TAKESHI , KAJIWARA SHIYOUJI , SUZUKI YOSHIKAZU , ARAI MASAE
IPC分类号： A61K31/045 , A61P31/04 , A61P37/04 , C07C29/147 , C07C33/02 , C07C43/15 , C07C49/04 , C07C49/203 , C07C51/08 , C07C51/38 , C07C57/03
CPC分类号： C07C255/00 , C07C29/147 , C07C33/02 , C07C43/15 , C07C49/04 , C07C49/203 , C07C51/08 , C07C51/38 , C07C57/03 , C07C69/145 , C07C69/78 , C07C57/13
摘要： PURPOSE: To provide a preventive and remedy for the diseases caused by the immunoinsufficiency of man and animal, especially effective to increase the resistance to the infectious diseases of man and animal, and having low toxicity and high stability, by using a polyprenyl alcohol compound as an active component.
CONSTITUTION: The polyprenyl alcohol compound of formula I (a and b are H or together form a bond; n is integer of 1W10) is used as an active component. A concrete example of the compound of formula is 3,7,11,15,19,23,27,31-octamethyl- 2,6,10,14,18,22,26,30-dotriacontaoctaen-1-ol. It can be prepared via several steps using the compound of formula II and a cyanoacetic acid lower alkyl ester as starting raw materials. It can be administered in the form of e.g. granules, powder, etc., and can be prepared by a conventional process using a conventional carrier.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：通过使用聚丙烯醇化合物作为人体和动物的免疫缺陷引起的疾病的预防和补救措施，特别是有效增加人畜传染病的抗性，毒性低，稳定性低活性成分。构成：式I的聚乙烯醇化合物（a和b为H或一起形成键; n为1-10的整数）用作活性组分。式的化合物的具体实例是3,7,11,15,19,23,27,31-八甲基-2,6,10,14,18,22,26,30-三七八烯-1-醇。其可以通过使用式II化合物和氰基乙酸低级烷基酯作为起始原料的几个步骤制备。它可以以例如，颗粒，粉末等，并且可以通过使用常规载体的常规方法制备。

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