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1. 发明专利

JPH10251223A PRODUCTION OF YNOL THIOETHER 失效
公开(公告)号：JPH10251223A
公开(公告)日：1998-09-22
申请号：JP5598497
申请日：1997-03-11
申请人： DAISO CO LTD
发明人： NAKAMURA KAORU , TAKENAKA KEIJI , OONO JIYUNKICHI , FURUKAWA YOSHIRO
IPC分类号： C07C319/14 , C07C323/14 , C07F7/08 , C07F7/18
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as an available intermediate, by reacting a 1-butyn-3-ol with a specific sulfenyl halide in the presence of a base and then reducing the reaction product or deprotecting and reducing. SOLUTION: 1-Butyn-3-ol (e.g. optically active substance) is reacted with a sulfenyl halide of the formula R SX (R is a lower alkyl, an aryl, etc.; X is a halogen) (e.g. phenylsulfenyl chloride) in the presence of a base (an alkyllithium or an alkylmagnesium halide such as n-butyllithium) to form an ynol thioether of formula I, which is reduced or deprotected and reduced to give the objective compound of formula II (R is H or an OH-protecting group or an alkyl-containing silyl such as trimethylsilyl or t-butylmethylsilyl).

2. 发明专利

JPH09227437A PRODUCTION OF CATECHOL DERIVATIVE 失效
公开(公告)号：JPH09227437A
公开(公告)日：1997-09-02
申请号：JP33678496
申请日：1996-12-17
申请人： DAISO CO LTD
发明人： FURUKAWA YOSHIRO , TAKENAKA KEIJI
IPC分类号： B01J27/135 , C07B61/00 , C07C37/56 , C07C39/08 , C07C41/26 , C07C43/23 , C07C45/45 , C07C45/64 , C07C47/565 , C07C47/575
摘要： PROBLEM TO BE SOLVED: To obtain the subject high-purity derivative useful for synthesizing medicines, hardly preparing a by-product, in high yield, slight in admixture of position isomer, by reacting a phenol (derivative) as a raw material under a specific condition at two stages. SOLUTION: In production of this compound of formula I (R is H, an alkyl, a cycloalkyl, an aralkyl, an alkoxyl, a halogen, allyl or an aryl; R is an OH- protecting group), a phenol or a phenol derivative of formula II is reacted with a base and paraformaldehyde in an organic solvent in the presence of stannous chloride and/or stannic chloride at 60-85 deg.C until the reaction rate reaches 30-80%. Then the reaction is completed at 95-105 deg.C and a prepared salicylaldehyde of formula III is treated with an alkylating agent in water and/or an organic solvent in the presence of a base. A prepared formyl ether of formula IV is oxidized with an oxidizing agent in water and/or an organic solvent and then hydrolyzed with an acid or a base.

3. 发明专利

JP2010143867A Method for producing refined lactide of high-purity 审中-公开
标题翻译：生产高纯度精制乳液的方法
公开(公告)号：JP2010143867A
公开(公告)日：2010-07-01
申请号：JP2008323708
申请日：2008-12-19
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： TAKENAKA KEIJI , FUJIMOTO RYOSUKE , EBATA HIDEAKI
IPC分类号： C07D319/12 , C08G63/08 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining lactide of high purity in a high yield.
SOLUTION: The method for producing refined lactide of high-purity comprises a step of bringing (a) a mixture of L-lactide and/or D-lactide and meso-lactide into contact with (b) a mixed solvent of an aromatic compound solvent and an aliphatic hydrocarbon compound solvent and/or an alicyclic hydrocarbon compound solvent, and a step of solid-liquid separation to recover solid contents.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供以高产率获得高纯度的丙交酯的方法。解决方案：制备高纯度精制丙交酯的方法包括使（a）将L-丙交酯和/或D-丙交酯和内消旋丙交酯的混合物与（b）混合溶剂接触的步骤芳族化合物溶剂和脂族烃化合物溶剂和/或脂环烃化合物溶剂，以及固液分离步骤，以回收固体含量。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009215246A Catalyst for producing chlorohydrin 有权
标题翻译：催化剂生产氯罗丹明
公开(公告)号：JP2009215246A
公开(公告)日：2009-09-24
申请号：JP2008061837
申请日：2008-03-11
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： KIKUZONO YASUO , TAKENAKA KEIJI , OTAKA SEIJI
IPC分类号： C07C29/62 , C07B61/00 , C07C31/36 , C07C31/42
摘要： PROBLEM TO BE SOLVED: To provide a method for more efficiently producing a chlorohydrin by reacting a polyhydroxy group-substituted aliphatic hydrocarbon such as glycerol etc., and/or a polyhydroxy group-substituted aliphatic hydrocarbon ester with a chlorinating agent.
SOLUTION: In the method for producing a chlorohydrin, a polyhydroxy group-substituted aliphatic hydrocarbon and/or a polyhydroxy group-substituted aliphatic hydrocarbon ester is reacted with a chlorinating agent in the presence of at least one or more kinds of compounds selected from the group consisting of a carboxylic acid and a carboxylic acid derivative and a solid catalyst to greatly increase formation of a chlorohydrin.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过使多羟基取代的脂族烃如甘油等与/或多羟基取代的脂族烃酯与氯化剂反应来更有效地制备氯代醇的方法。解决方案：在制备氯代醇的方法中，将多羟基取代的脂族烃和/或多羟基取代的脂族烃酯与氯化剂在至少一种或多种选择的化合物的存在下反应由羧酸和羧酸衍生物组成的组和固体催化剂，以大大增加氯代醇的形成。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2000228994A PRODUCTION OF OPTICALLY ACTIVE COMPOUND 失效
公开(公告)号：JP2000228994A
公开(公告)日：2000-08-22
申请号：JP3371699
申请日：1999-02-12
申请人： DAISO CO LTD
发明人： OONO JIYUNKICHI , NAKAMURA KAORU , TAKENAKA KEIJI , FURUKAWA YOSHIRO
IPC分类号： C12P41/00 , C07C323/14 , C07C323/18
摘要： PROBLEM TO BE SOLVED: To obtain an optical active compound that is useful as a synthetic intermediate for medicines, agrochemicals and the like in high yield by allowing (R, S) sulfur-containing propargyl alcohol to react with an esterifying agent in the presence of a stereospecifically catalyzing lipase. SOLUTION: (R, S) sulfur-containing propargyl alcohol represented by formula I [R1 and R2 are each a (substituted) alkyl, a (substituted) aralkyl, a (substituted) aryl] is reacted with an esterifying agent in an organic solvent in the presence of a lipase that can esterify either the R isomer or the S isomer of the propargyl alcohol to form the ester of one optically active sulfur-containing propargyl alcohol, while the other optically active sulfur-containing propargyl alcohol represented by formula III is allowed to remain. Thus, the objective optically active sulfur-containing propargyl alcohol of high optical purity, useful as a synthetic intermediate for medicines, agrochemicals, physiologically active substances and the like can be inexpensively obtained in high yield.

6. 发明专利

JP2009292812A Method for recovering catalyst 审中-公开
标题翻译：回收催化剂的方法
公开(公告)号：JP2009292812A
公开(公告)日：2009-12-17
申请号：JP2009111695
申请日：2009-05-01
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： KITAMURA TORU , TAKENAKA KEIJI , OTAKA SEIJI , ISHIHARA TOSHIYUKI , KAGAWA NAOTO , MIKI YASUSHI
IPC分类号： C07C67/58 , B01J31/04 , B01J31/40 , B01J38/00 , C07B61/00 , C07C29/62 , C07C29/86 , C07C31/34 , C07C31/42 , C07C69/63
CPC分类号： Y02P20/584
摘要： PROBLEM TO BE SOLVED: To provide a method for recovering a catalyst in a simple process with low energy in producing chlorohydrins by a chlorinating reaction of a multihydroxy group-substituted aliphatic hydrocarbon and/or an ester of the multihydroxy group-substituted hydrocarbon using a carboxylic acid-based compound as the catalyst. SOLUTION: It is found that the catalyst present as an ester of the chlorohydrins can be recovered by extracting oligomers of the multihydroxy group-substituted aliphatic hydrocarbon, produced as a by-product in a chlorinating step, in an extraction step, and carrying out separation thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过多羟基取代的脂族烃和/或多羟基取代烃的酯的氯化反应以简单的方法回收催化剂的方法，其中低能量生产氯氢化物使用羧酸类化合物作为催化剂。解决方案：发现作为氯氢化物的酯存在的催化剂可以通过提取在提取步骤中作为副产物在氯化步骤中产生的多羟基取代的脂族烃的低聚物来回收，以及进行分离。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009249309A Method for producing dichlorohydrin 有权
标题翻译：生产二氯乙醇的方法
公开(公告)号：JP2009249309A
公开(公告)日：2009-10-29
申请号：JP2008097123
申请日：2008-04-03
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： ISHIHARA TOSHIYUKI , KITAMURA TORU , MIKI YASUSHI , TAKENAKA KEIJI , OTAKA SEIJI , KAGAWA NAOTO
IPC分类号： C07C29/64 , C07B61/00 , C07C31/36 , C07D303/08
摘要： PROBLEM TO BE SOLVED: To reduce the amount of an alkali required in a subsequent dehydrochlorination process and the amount of water and a salt formed in the dehydrochlorination process by efficiently recovering hydrogen chloride from the resulting reaction mixture in the process of producing dichlorohydrin by way of chlorinating glycerin.
SOLUTION: It has been discovered that the above problem can be solved by separating and recovering hydrogen chloride gas by way of heating at least a part of the reaction mixture comprising dichlorohydrin, hydrogen chloride and water obtained by chlorinating glycerin.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了减少随后的脱氯化氢过程中所需的碱的量以及在脱氯化氢过程中形成的盐的量，在生产二氯丙醇的过程中从所得反应混合物中有效地回收氯化氢通过氯化甘油。解决方案：已经发现，通过加热至少一部分包含二氯丙醇，氯化氢和通过氯化甘油获得的水的反应混合物，可以分离和回收氯化氢气体来解决上述问题。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009096797A Method for purifying crude chlorohydrin 审中-公开
标题翻译：净化氯罗坦的方法
公开(公告)号：JP2009096797A
公开(公告)日：2009-05-07
申请号：JP2008207720
申请日：2008-08-12
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： KITAMURA TORU , KAGAWA NAOTO , TAKENAKA KEIJI , OTAKA SEIJI , MIKI YASUSHI
IPC分类号： C07C29/88 , C07C29/62 , C07C29/78 , C07C31/36
CPC分类号： C07C29/62 , C07C29/76 , C07C31/42 , C07C31/36
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently purifying crude chlorohydrin, that is a reaction product obtained by reacting a polyhydroxylated aliphatic hydrocarbon, such as glycerol, and/or an ester of the polyhydroxylated aliphatic hydrocarbon with a chlorinating agent. SOLUTION: The method for purifying crude chlorohydrin is to bring crude chlorohydrin, obtained by reacting a polyhydroxylated aliphatic hydrocarbon and/or an ester of the polyhydroxylated aliphatic hydrocarbon with a chlorinating agent, into countercurrent contact with a diffuser gas and draw out at least a portion of chlorohydrin from crude chlorohydrin entrained by the diffuser gas. The diffuser gas preferably contains hydrogen chloride gas. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种高效纯化氯代醇的方法，即通过使多羟基化脂族烃如甘油与/或多羟基化脂族烃的酯与氯化剂反应获得的反应产物。解决方案：纯化氯代醇的方法是将通过使多羟基化脂族烃和/或多羟基化脂族烃的酯与氯化剂反应获得的粗氯代醇与扩散气体逆流接触，并在由通过扩散气体夹带的来自粗氯醇的至少一部分氯代醇。扩散气优选含有氯化氢气体。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2009046437A Method for producing chlorhydrins in presence of aldehyde and/or ketone 审中-公开
标题翻译：生产氯仿和/或酮的氯仿的方法
公开(公告)号：JP2009046437A
公开(公告)日：2009-03-05
申请号：JP2007214768
申请日：2007-08-21
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： TAKENAKA KEIJI , KIKUZONO YASUO
IPC分类号： C07C29/62 , C07B61/00 , C07C31/36 , C07C31/42 , C07D301/26 , C07D303/08 , C07D303/14
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a chlorohydrin by using a catalyst except a carboxylic acid, a carboxylic acid derivative and a compound having a carboxylic acid structure, namely a new catalyst except a carboxylic acid-based catalyst in a method for producing the chlorohydrin by reacting a polyhydroxy-substituted aliphatic hydrocarbon such as glycerin etc., with a chlorinating agent.
SOLUTION: It is found that an aldehyde and/or a ketone is used as a catalyst in the method for producing a chlorohydrin. More concretely, a chlorohydrin is produced, for example, by using glycerin as a polyhydroxy-substituted aliphatic hydrocarbon. Epichlorohydrin and glycidol are suitably produced by using a chlorohydrin produced by the method.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过使用除了羧酸，羧酸衍生物和具有羧酸结构的化合物以外的催化剂，即除了羧酸系催化剂以外的新型催化剂，生成氯代醇的方法通过使多羟基取代的脂族烃如甘油等与氯化剂反应来制备氯代醇的方法。解决方案：发现在制备氯代醇的方法中使用醛和/或酮作为催化剂。更具体地，例如通过使用甘油作为多羟基取代的脂族烃来制备氯代醇。表氯醇和缩水甘油通过使用通过该方法制备的氯代醇适当地制备。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2002003463A METHOD FOR PRODUCING N-PROTECTING N-ALKYLATED AMINO ACID 失效
公开(公告)号：JP2002003463A
公开(公告)日：2002-01-09
申请号：JP2000182933
申请日：2000-06-19
申请人： DAISO CO LTD
发明人： TAKENAKA KEIJI , KAMEYAMA NAOTAKA , FURUKAWA YOSHIRO
IPC分类号： B01J31/12 , C07B61/00 , C07C269/06 , C07C271/22
摘要： PROBLEM TO BE SOLVED: To obtain an N-protecting N-alkylated amino acid simply and in a high yield. SOLUTION: This method for producing an N-protecting N-alkylated amino acid represented by formula (2) (R1 is a group selected from an alkyl group, an aryl group and an aralkyl group; R2 is hydrogen or a group selected from an alkyl group, an aryl group and an aralkyl group; R3 is hydrogen, a group selected from an alkyl group, an aryl group and an aralkyl group, a protein amino acid side chain or its derivative; and (n) is 0 or 1) comprises reacting an N-protecting amino acid represented by formula (1) (R1, R2, R3 and (n) are each the same as that shown above; and R4 is an alkyl group) with a dialky sulfate in an ether-based solvent in the presence of an alkali metal or an alkaline earth metal hydride.

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