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1. 发明专利

JPS5927830A Antitumor glycoproteinic substance 失效
标题翻译：抗肿瘤药物
公开(公告)号：JPS5927830A
公开(公告)日：1984-02-14
申请号：JP13720982
申请日：1982-08-09
申请人： Cosmo Co Ltd
发明人： SASAKI TAKUMA , NAKAMICHI KAZUYA , TACHIBANA YAKUDOU , MINAMI SEIJI
IPC分类号： A61K35/56 , A23J1/04 , A61P35/00 , C07K14/435
CPC分类号： A23J1/04 , Y10S530/857
摘要： NEW MATERIAL:An antitumor glycoproteinic substance having the following properties: White solid powder. Readily soluble in water and insoluble in organic solvents, e.g. methanol. Ampholytic electrolyte having an isoelectric point at 5.2pH. Positive to the biuret reaction, etc. and negative to the cysteine-sulfuric acid reaction. Average molecular weight: About 5000 (measured by the gel electrophoretic method).
USE: An antitumor agent.
PROCESS: A broth of a scallop (including a concentrate solution obtained in boiling or steaming the scallop) or a concentrate or a dried powder thereof is first dissolved in an aqueous solvent, and the undissolved substances are removed by the centrifugation or filtration, etc. The resultant aqueous solution is then desalted by the gel filtration or dialysis, and then subjected to the ion exchange chromatography with a basic ion exchanger. A component having an isoelectric point of 5.2pH is obtained from the resultant fraction, and then subjected to the fractionation treatment of molecular weight, e.g. vertical slab gel electrophoresis or gel filtration, etc. to afford the aimed antitumor glycoproteinic substance having 5000mol.wt.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：具有以下性质的抗肿瘤糖蛋白物质：白色固体粉末。易溶于水，不溶于有机溶剂，例如甲醇。两电解质的等电点为5.2pH。对于缩二脲反应等是阳性的，对半胱氨酸 - 硫酸反应是负的。平均分子量：约5000（通过凝胶电泳法测定）。用途：抗肿瘤剂。方法：将扇贝肉汤（包括煮沸或蒸煮扇贝中的浓缩液）或浓缩物或其干燥粉末溶解在水性溶剂中，通过离心或过滤等除去未溶解的物质。然后将所得水溶液通过凝胶过滤或透析脱盐，然后用碱性离子交换剂进行离子交换层析。从所得部分得到等电点为5.2pH的成分，然后进行分子量的分级处理，例如垂直板状凝胶电泳或凝胶过滤等，得到目标抗肿瘤糖蛋白物质，具有5000mol.wt。

2. 发明专利

JPS5927831A Antitumor substance 失效
标题翻译：抗菌剂
公开(公告)号：JPS5927831A
公开(公告)日：1984-02-14
申请号：JP13721082
申请日：1982-08-09
申请人： Cosmo Co Ltd
发明人： SASAKI TAKUMA , NAKAMICHI KAZUYA , TACHIBANA YAKUDOU , MINAMI SEIJI
IPC分类号： A61K35/56 , A23J1/04 , A61K35/60 , A61P35/00 , C07K14/435
CPC分类号： A61K35/60 , A23J1/04 , Y10S530/857
摘要： NEW MATERIAL:An antitumor glycoproteinic substance having the following properties: White solid powder. Readily soluble in water and insoluble in organic solvents, e.g. methanol. An ampholytic electrolyte having an isoelectric point at 5.2pH. Positive to the color reactions such as the biuret reaction and cysteine-sulfuric acid reaction, etc. Average molecular weight: About 470000.
USE: An antitumor agent.
PROCESS: A concentrate of a broth of a scallop (including a broth or liquid obtained in obtaining an edible shellfish flesh by boiling or steaming or hot processing an edible part of a scallop with hot steam or hot liquid of an aqueous solvent, e.g. water or a saline solution, or a dried powder thereof is first dissolved in an aqueous solvent, and the undissolved substances are removed by the centrifugation, etc. The resultant aqueous solution is then desalted by the gel filtration or dialysis, etc. and then subjected to the anion exchange chromatography with a basic ion exchanger. The resultant fraction is further subjected to the fractionation treatment of molecular weight, e.g. vertical slab gel electrophoresis, to give the aimed antitumor glycoproteinic substance having about 470000mol.wt.
EFFECT: A wide antitumor spectrum without the cytotoxicity and a remarkable tumor diminution effects by administration from different sites.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：具有以下性质的抗肿瘤糖蛋白物质：白色固体粉末。易溶于水，不溶于有机溶剂，例如甲醇。具有等电点为5.2pH的两性电解质。平衡分子量：约470000.用途：抗肿瘤药物。方法：将扇贝的肉汤（包括通过煮沸或蒸煮或热加工扇贝的可食用部分获得可食用的贝类肉类的肉汤或液体的浓缩物，其中包含热水蒸气或水溶剂的热液体，例如水或首先将盐水溶液或其干燥粉末溶解在水性溶剂中，通过离心等除去未溶解物质。然后通过凝胶过滤或透析等将所得水溶液脱盐，然后进行用碱性离子交换剂进行阴离子交换层析，所得馏分进一步进行分子量分级处理，例如垂直平板凝胶电泳，得到目标抗肿瘤糖蛋白物质，具有约470000mol.wt。效应：广谱抗肿瘤谱无细胞毒性和通过不同部位的给药显着的肿瘤减少作用。

3. 发明专利

JPS5927829A Antitumor agent and preparation thereof 失效
标题翻译：抗菌剂及其制剂
公开(公告)号：JPS5927829A
公开(公告)日：1984-02-14
申请号：JP13720882
申请日：1982-08-09
申请人： Cosmo Co Ltd
发明人： SASAKI TAKUMA , NAKAMICHI KAZUYA
IPC分类号： A61K35/56 , A61P35/00 , C07K14/435
摘要： PURPOSE: An antitumor agent consisting of a water-soluble glycoprotein obtained from a broth powder of a shellfish or concentrate thereof.
CONSTITUTION: An antitumor agent obtained by subjecting a dried powder or a concentrate of a broth obtained in boiling or steaming and processing an edible part of a shellfish, e.g. a wide range of mollusks such as an ear shell or mud shell including marine and limnetic shellfish, with hot aqueous medium as a raw material to the ion exchange chromatography with a basic anion exchanger or filtration chromatography with a gel filtration gel to collect an antitumor substance consisting of a water-soluble glycoprotein having 10,000W300,000 molecular weight (a slightly brownish whiteWwhite solid; readily soluble in water and insoluble in organic solvents, e.g. methanol; an ampholytic electrolyte; positive to the biuret reaction, positive to the anthrone-sulfuric acid reaction and quasi- positive to cysteine-sulfuric acid reaction), and incorporating the resultant antitumor substance therein. The above-mentioned boiling or steaming and heat- treating are carried out preferably in divided two stages. The amount of the hot aqueous medium is small, and the extraction effect of the antitumor substance is good. The concentrating of the aimed broth is easily carried out with a high heating efficiency by using a simple apparatus.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：一种由贝类或其浓缩物的肉汤粉末获得的水溶性糖蛋白组成的抗肿瘤剂。构成：通过在沸腾或蒸汽中获得的干燥粉末或肉汤浓缩物处理贝类的可食用部分，例如，各种软体动物如耳壳或泥壳，包括海洋和有限的贝类，用热水性介质作为原料，用碱性阴离子交换剂进行离子交换色谱，或用凝胶过滤凝胶进行过滤色谱以收集抗肿瘤物质由分子量为10,000-300,000的水溶性糖蛋白组成（浅棕色白色白色固体;易溶于水，不溶于有机溶剂，例如甲醇;两性电解质;对于缩二脲反应呈阳性，对于蒽酮 - 硫酸反应和准半胱氨酸 - 硫酸反应准），并将所得抗肿瘤物质并入其中。上述沸腾或蒸汽和热处理优选分两个阶段进行。热水介质的量少，抗肿瘤物质的提取效果好。通过使用简单的装置，可以容易地以高加热效率进行目标肉汤的浓缩。

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