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1. 发明专利

JP2009029805A Production method of clopidogrel 审中-公开
标题翻译：石蜡生产方法
公开(公告)号：JP2009029805A
公开(公告)日：2009-02-12
申请号：JP2008179540
申请日：2008-07-09
申请人： Cadila Healthcare Ltd , カディラヘルスケアリミティド
发明人： PANDEY BIPIN , LOHRAY VIDYA BHUSHAN , LOHRAY BRAJ BHUSHAN
IPC分类号： C07D495/04 , C07B57/00
CPC分类号： C07D495/04
摘要： PROBLEM TO BE SOLVED: To provide a novel production method of thieno[3,2-c]pyridine derivative and its salt. SOLUTION: The production method comprises the following steps: (i) a compound of formula (V) or its salt is reacted with a cyanide of formula (VII) and a compound of formula (VI) is added, thus producing a racemic compound of formula (IV); (ii) the compound of formula (IV) in a (±) form or in an optically active (+) or (-) form is reacted with an acidic or basic reactant to obtain a compound of formula (II) or a salt holding its shape; (iii) the compound of formula (II) in a (±) form or in an optically active (+) or (-) form is reacted with an acidic reactant in the presence of methanol to obtain a compound of formula (I) or a salt holding its shape; (iv) and finally the (±) compound of formula (I) or its salt is divided into an optical isomer. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供噻吩并[3,2-c]吡啶衍生物及其盐的新型制备方法。解决方案：制备方法包括以下步骤：（i）将式（Ⅴ）化合物或其盐与式（Ⅶ）的氰化物反应，加入式（Ⅵ）化合物，从而产生式（IV）的外消旋化合物; （ii）以（±）形式或光学活性（+）或（ - ）形式的式（IV）化合物与酸性或碱性反应物反应，得到式（II）化合物或其盐其形状; （iii）以（±）形式或光学活性（+）或（ - ）形式的式（II）化合物与甲酸存在下的酸性反应物反应，得到式（I）或保持其形状的盐; （iv），最后将式（I）的（±）化合物或其盐分成旋光异构体。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2009102423A New pyrrole having activity to reduce lipid and cholesterol, method of preparing the pyrrole, medicinal composition containing the pyrrole, and method of utilizing the pyrrole in medical treatment 审中-公开
标题翻译：具有活性以减少脂质和胆固醇的新型红细胞，制备微粒的方法，含有微量元素的药物组合物，以及在医疗治疗中使用吡喃酮的方法
公开(公告)号：JP2009102423A
公开(公告)日：2009-05-14
申请号：JP2009024338
申请日：2009-02-04
申请人： Cadila Healthcare Ltd , カディラヘルスケアリミティド
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , BAROT VIJAY KUMAR , RAVAL SAURIN KHIMSHANKAR , RAVAL PREETI SAURIN , BASU SUJAY
IPC分类号： C07D207/325 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/10 , A61K31/216 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/4709 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/32 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D207/46 , C07D207/48 , C07D401/04 , C07D405/04 , C07D409/04 , G06F3/14 , G09G5/36
CPC分类号： C07D207/325 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/36 , C07D207/48 , C07D401/04 , C07D405/04 , C07D409/04 , G06F3/14 , G06F3/1438 , G09G5/363 , G09G2360/122
摘要： PROBLEM TO BE SOLVED: To provide a new compound useful for medically treating obesity, hyperlipemia, hypercholesterolemia, X syndrome and diabetes. SOLUTION: The invention specially relates to a new substituted pyrrole compound expressed by general formula (I), its analogs, its derivatives, its polymorphs, its tautomers, its pharmaceutically allowable salts, and a medicinal composition containing the compound. The invention also relates to compounds like this, compositions containing the compound like this, and a method of using the compounds and compositions like this in medical treatment. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种可用于医疗治疗肥胖症，高脂血症，高胆固醇血症，X综合征和糖尿病的新化合物。解决方案：本发明特别涉及由通式（I）表示的新的取代吡咯化合物，其类似物，其衍生物，其多晶型物，其互变异构体，其药学上可允许的盐以及含有该化合物的药物组合物。本发明还涉及这样的化合物，含有这样的化合物的组合物，以及在医疗中使用这些化合物和组合物的方法。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2008308504A New compound having hypolipidemia and hypocholesterolemia activity, their manufacturing method, and formulation composition containing them 有权
标题翻译：具有高磷酸酯和高磷脂酰胆碱活性的新化合物及其制备方法和含有它们的制剂组合物
公开(公告)号：JP2008308504A
公开(公告)日：2008-12-25
申请号：JP2008200104
申请日：2008-08-01
申请人： Cadila Healthcare Ltd , カディラヘルスケアリミティド
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , BAROT VIJAY KUMAR GAJUBHAI
IPC分类号： C07D207/325 , A61K31/40 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/00 , A61P17/04 , A61P19/10 , A61P21/04 , A61P25/18 , A61P29/00 , A61P35/00 , C07D207/32 , C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/34
CPC分类号： C07D207/325 , C07D207/327 , C07D207/33 , C07D207/333 , C07D207/34
摘要： PROBLEM TO BE SOLVED: To provide a new substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their steric isomers, their polymorphs, their pharmaceutically permissible salts, their pharmaceutically permissible solvates, and pharmaceutically permissible compositions containing them. SOLUTION: This invention relates to a new substituted pyrrole compound having general formula (I), their analogs, their derivatives, their polymorphs, their tautomeric forms, their pharmaceutically permissible salts, their pharmaceutically permissible solvates, and formation compositions containing them. This invention relates to the manufacturing method of those compounds, compositions containing those compounds, and use of those compounds and compositions in medical care. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供新的取代吡咯化合物，其衍生物，其类似物，其互变异构形式，其空间异构体，其多晶型物，其药学上可允许的盐，其药学上可允许的溶剂化物和含有它们的药学上允许的组合物。解决方案：本发明涉及具有通式（I）的新的取代吡咯化合物，其类似物，其衍生物，其多晶型物，其互变异构形式，其药学上可允许的盐，其药学上可用的溶剂化物和含有它们的地层组合物。本发明涉及这些化合物的制造方法，含有那些化合物的组合物，以及这些化合物和组合物在医疗护理中的用途。版权所有（C）2009，JPO＆INPIT

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