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1. 发明专利

JPH03262472A MILK SERUM-CONTAINING ALCOHOLIC BEVERAGE AND PRODUCTION THEREOF 失效
公开(公告)号：JPH03262472A
公开(公告)日：1991-11-22
申请号：JP6091690
申请日：1990-03-14
申请人： CALPIS FOOD IND CO LTD
发明人： KITAMURA SHUJI , TAKANO TOSHIAKI
IPC分类号： A23C21/02 , C12G3/02
摘要： PURPOSE:To obtain the title new beverage with mellow smell and excellent fanciness by mixing milk serum and honey, etc., followed by alcoholic fermentation. CONSTITUTION:A mixture of (A) milk serum treated by lactic fermentation and/or with a proteinase, (B) a mixed component comprising hops, fruit juice and honey etc., and/or (C) a saccharide component, is incorporated, pref. at 5-30 deg.C, with 0.1-10wt.%, based on 100 pts.wt. of the raw material components, of yeast followed by alcoholic fermentation, thus obtaining the objective beverage.

2. 发明专利

JPH07123977A LACTIC BACTERIA AND FERMENTED DAIRY PRODUCT 失效
公开(公告)号：JPH07123977A
公开(公告)日：1995-05-16
申请号：JP27579193
申请日：1993-11-04
申请人： CALPIS FOOD IND CO LTD
发明人： YAMAMOTO NAOYUKI , MASUJIMA YOSHIKO , TAKANO TOSHIAKI
IPC分类号： A23C9/123 , A61K35/20 , A61K35/66 , A61K35/74 , A61K35/747 , A61P9/12 , A61P43/00 , C12N1/20 , C12R1/225
摘要： PURPOSE:To provide new lactic bacteria low in the increments of lactic acid acidity during its preservation, low in cell membrane-binding adenosine triphosphatase activity, presenting tolerance to neomycin, useful for producing fermented dairy products having hypotensive activity. CONSTITUTION:Lactic bacteria, Lactobacillus helveticus JCM-1003 as parent strain is inoculated into a medium and cultured at 37 deg.C for 20hr and then further cultured in a fresh medium at 37 deg.C for 6hr, thus gathering the resultant bacteria being in logarithmic proliferation period. The bacteria gathered is irradiated with ultraviolet light and inoculated on an agar medium to conduct a culture at 37 deg.C for 2 days followed by selecting from the cultured product a strain capable of forming a relatively large colony, which is then inoculated on skimmed milk to conduct a culture at 37 deg.C for 3 days, and one strain higher in the final pH value compared to the parent strain is selected, thus obtaining the objective new Lactobacillus lactic bacteria >=0.5% in the increments of lactic acid acidity after preserved at 10 deg.C for two weeks,

3. 发明专利

JPH06197786A PRODUCTION OF PEPTIDE INHIBITING ANGIOTENSIN CONVERTING ENZYME 失效
公开(公告)号：JPH06197786A
公开(公告)日：1994-07-19
申请号：JP27579093
申请日：1993-11-04
申请人： CALPIS FOOD IND CO LTD
发明人： YAMAMOTO NAOYUKI , NAKAMURA YASUNORI , TAKANO TOSHIAKI
IPC分类号： C07K14/195 , C07K1/14 , C07K1/20 , C07K14/37 , C07K14/41 , C07K14/81 , C12P21/00 , C12P21/02 , C12P39/00 , C12R1/225 , C12R1/865 , C07K3/12
摘要： PURPOSE:To easily obtain a peptide inhibiting an angiotensin converting enzyme useful as pharmaceuticals and functional foods by culturing lactic bacteria (and yeast) in a medium containing a specific peptide and/or protein and purifying the product. CONSTITUTION:A lactobacillus (or yeast) strain is cultured in a medium containing a peptide and/or protein containing Ile-Pro-Pro and/or Val-Pro-Pro as constituent component and the culture product is purified to obtain the subject peptide containing Ile-Pro-Pro and/or Val-Pro-Pro and exhibiting excellent ACEinhibiting activity with an extremely small amount.

4. 发明专利

JPH0641191A PEPTIDE AND PHYSIOLOGICAL ACTIVATOR CONTAINING THE SAME 失效
公开(公告)号：JPH0641191A
公开(公告)日：1994-02-15
申请号：JP4304793
申请日：1993-03-03
申请人： CALPIS FOOD IND CO LTD
发明人： YAMAMOTO NAOYUKI , AKINO ATSUKO , TAKANO TOSHIAKI
IPC分类号： A23J3/10 , A23J3/34 , A23L1/305 , A61K38/00 , A61K38/17 , A61P3/00 , A61P3/14 , A61P9/12 , C07K1/20 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C12P21/06 , A61K37/16 , A61K37/18 , C07K7/10
摘要： PURPOSE:To provide a new peptide useful as a physiological activator, etc., having vasodepressor activity, calcium absorption promoting activity and antioxidation activity, comprising a specific amino acid sequence by hydrolyzing animal milk, etc., with lactic acid bacteria-producing proteinase. CONSTITUTION:Lactic acid bacteria (e.g. Lactobacillus helveticus JCM-1,003, etc.) are cultured in skimmed milk at pH 6.0, centrifuged, collected, extracted with 50 mM tris-hydrochloric acid buffer solution (pH 8.0). The extracted solution is passed through an anion exchange column, the adsorbed material is eluted with a buffer solution containing 1.0 M NaCl to give lactic acid bacteria- producing proteinase. Then, the proteinase is blended with a solution of animal milk casein in a phosphoric acid buffer solution, reacted at 40 deg.C for 5 hours and the reaction solution is purified by ultrafiltration to give the peptide useful as a physiological activator, etc., showing at least one of vasodepressor activity, calcium absorption promoting activity and antioxidation activity.

5. 发明专利

JPS63209542A PREPARATION OF FERMENTED MILK CONTAINING BIFIDUS BACTERIUM 失效
公开(公告)号：JPS63209542A
公开(公告)日：1988-08-31
申请号：JP4009887
申请日：1987-02-25
申请人： CALPIS FOOD IND CO LTD
发明人： TAKANO TOSHIAKI , SAITO YOSHIO , FUTAMI AKIRA , HAYAKAWA KUNIHIKO
IPC分类号： A23C9/12 , A23C9/123 , C12N1/20 , C12R1/01
摘要： PURPOSE:To produce the titled fermented milk having a high survival rate of Bifidobacterium longum during its storage, by culturing a mixture of a specific lactic acid bacterium and the Bifidobacterium longum, etc. CONSTITUTION:The objective fermented milk is produced by culturing a mixture of a lactic acid bacterium selected from a group of Lactobacillus casei C-2203, Lactobacillus casei C-2204, Lactobacillus casei C-2205 and Lactobacillus casei C-2254 and Bifidobacterium longum or separately culturing the strains and mixing the cultured products or treated products thereof.

6. 发明专利

JPH0640944A INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME AND ITS PRODUCTION 失效
公开(公告)号：JPH0640944A
公开(公告)日：1994-02-15
申请号：JP19723992
申请日：1992-07-23
申请人： CALPIS FOOD IND CO LTD
发明人： NAKAMURA YASUNORI , TAKANO TOSHIAKI
IPC分类号： A61K38/55 , A23C9/123 , A61K38/00 , A61P9/12 , A61P43/00 , C07K5/083 , C07K5/103 , C07K5/117 , C07K7/06 , C12N9/99 , C12P21/02 , C12R1/225 , A61K37/64
摘要： PURPOSE:To obtain an industrially extremely effective angiotensin converting enzyme inhibitor capable of exhibiting excellent activity inhibiting the angiotensin converting enzyme by a very small amount of oral administration, inexpensively and readily producing. CONSTITUTION:The angiotensin converting enzyme inhibitor contains a peptide containing Val-Pro-Pro and having 3-10 amino acid residue number as an active ingredient. This inhibitor is produced by subjecting a food raw material containing a peptide composed of Val-Pro-Pro to fermentation treatment with lactic acid bacteria.

7. 发明专利

JPH059124A COMPOSITION FOR REGULATING INTERLEUKIN PRODUCTIVITY 失效
公开(公告)号：JPH059124A
公开(公告)日：1993-01-19
申请号：JP18329991
申请日：1991-06-28
申请人： CALPIS FOOD IND CO LTD
发明人： FUTAMI AKIRA , TAKANO TOSHIAKI
IPC分类号： A23L1/30 , A61K35/20
摘要： PURPOSE:To obtain a composition, containing a fermented milk or its treated substance as an active ingredient and capable of regulating interleukin productivity of human or animal cells without any toxicity and side effects. CONSTITUTION:A composition containing a fermented milk prepared by fermenting a milk ingredient such as whole milk of, e.g. animal milk or soybean milk, skim milk or whey with a lactic acid bacterium such as lactic acid- producing bacterium, e.g. Streptococcus thermophilus or Lactobacillus bulgaricus or the lactic acid bacterium and a yeast or its treated substance as an active ingredient. The aforementioned composition is capable of regulating interleukin productivity of human or animal cells, especially enhancing the interleukin-2 productivity or interleukin-3 productivity of the human or animal cells and/or suppressing interleukin-6 productivity. The fermented milk or its treated substance herein used has advantages in that living bodies are not adversely affected even by ingesting a large amount thereof. The composition may directly be used or added to a food to provide a functional food or health food.

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