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1. 发明专利

JP2010013651A Zwitterionic polymer 审中-公开
标题翻译： ZWITTERICIC聚合物
公开(公告)号：JP2010013651A
公开(公告)日：2010-01-21
申请号：JP2009192153
申请日：2009-08-21
申请人： Biocompatibles Uk Ltd , バイオコンパティブルズユーケーリミテッド
发明人： LEWIS ANDREW LENNARD , WILLIS SEAN LEO , ARMES STEVEN PETER , LOBB EMMA JANICE , MA YINGHUA
IPC分类号： A61K9/10 , C08F20/28 , A61K47/32 , C08F4/40 , C08F20/22 , C08F20/58 , C08F246/00 , C08F293/00 , C08F297/06
CPC分类号： C08F4/40 , C08F246/00 , C08F293/005 , C08F2438/01
摘要： PROBLEM TO BE SOLVED: To provide a zwitterionic polymer having a controlled chain length and/or a block chain length in a block copolymer, and to provide a polymerization process for the same. SOLUTION: The polymers are made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerizations such as group or atom transfer radical polymerization. For instance polymers are formed by using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2'-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供在嵌段共聚物中具有受控链长度和/或嵌段链长度的两性离子聚合物，并提供其聚合方法。解决方案：使用活性聚合如基团或原子转移自由基聚合，聚合物由具有受控结构和分子量的两性离子单体制成。例如，通过使用氯化铜催化剂，水溶性配体和水溶性叔烷基卤引发剂来形成聚合物，以形成控制多分散度小于1.5的均聚物和与其它亲水或疏水单体的嵌段共聚物。一种合适的两性离子单体是2-甲基丙烯酰氧基-2'-三甲基铵乙基磷酸内酯盐。嵌段共聚物可以自发形成胶束，据信其具有两性离子，例如磷酸胆碱，外表面的基团，其可用作具有改善的生物相容性的药物递送系统。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2008239997A Zwitterionic polymer 有权
标题翻译： ZWITTERICIC聚合物
公开(公告)号：JP2008239997A
公开(公告)日：2008-10-09
申请号：JP2008132527
申请日：2008-05-20
申请人： Biocompatibles Uk Ltd , バイオコンパティブルズユーケーリミテッド
发明人： LEWIS ANDREW LENNARD , WILLIS SEAN LEO , ARMES STEVEN PETER , LOBB EMMA JANICE , MA YINGHUA
IPC分类号： A61K9/10 , C08F20/22 , A61K47/32 , C08F4/40 , C08F246/00 , C08F293/00 , C08F297/00
CPC分类号： C08F4/40 , C08F246/00 , C08F293/005 , C08F2438/01
摘要： PROBLEM TO BE SOLVED: To provide a polymer useful as a drug delivery system with improved biocompatibility. SOLUTION: The polymer may be made from a zwitterionic monomer having controlled structure and molecular weight, using living polymerization such as group or atom transfer radical polymerization. For instance, the polymer may be formed by atom transfer radical polymerization using a copper chloride catalyst, a ligand which is water soluble, and a water-soluble tertiary alkyl halide initiator to form a homopolymer having a controlled polydispersity of less than 1.5 and a block copolymer with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2'-trimethylammoniumethyl phosphate inner salt. The block copolymer may spontaneously form micelles, and have zwitterionic, for instance phosphorylcholine, groups at the external surface. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可用作具有改善的生物相容性的药物递送系统的聚合物。解决方案：聚合物可以由具有受控结构和分子量的两性离子单体制备，使用活性聚合如基团或原子转移自由基聚合。例如，聚合物可以通过使用氯化铜催化剂，水溶性配体和水溶性叔烷基卤引发剂的原子转移自由基聚合形成，以形成受控的多分散性小于1.5的均聚物和嵌段与其他亲水或疏水单体的共聚物。一种合适的两性离子单体是2-甲基丙烯酰氧基-2'-三甲基铵乙基磷酸内酯盐。嵌段共聚物可以自发形成胶束，并且在外表面具有两性离子的，例如磷酸胆碱基团。版权所有（C）2009，JPO＆INPIT

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