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1. 发明专利

JP2010143876A Plant disease injury-controlling agent 有权
标题翻译：植物病害控制代理
公开(公告)号：JP2010143876A
公开(公告)日：2010-07-01
申请号：JP2008324219
申请日：2008-12-19
申请人： Arysta Lifescience Corp , Hokkai Sankyo Kk , Hokkaido Government , National Agriculture & Food Research Organization , アリスタライフサイエンス株式会社 , 北海三共株式会社 , 北海道 , 独立行政法人農業・食品産業技術総合研究機構
发明人： TAKENAKA SHIGEHITO , HANZAWA SUGURU , DESAKI RIEKO , NAKA SADAHIRO , YAMANAKA SATOSHI , MATSUDA AKIRA , TAKAI AKIRA , IKEDA SACHIKO
IPC分类号： A01N63/02 , A01N59/06 , A01P3/00
摘要： PROBLEM TO BE SOLVED: To provide a plant disease injury-controlling agent of high controlling effects using pythium oligandrum.
SOLUTION: The plant disease injury-controlling agent includes oospores of pythium oligandrum and a calcium salt as a controlling effect enhancer. A method for producing the agent is also provided. Besides, methods for controlling plant disease injuries using the agent are also provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供使用pythium oligandrum具有高控制作用的植物病害损伤控制剂。解决方案：植物病害损伤控制剂包括ium includes的卵孢子和钙盐作为控制作用增强剂。还提供了一种制备该试剂的方法。此外，还提供了使用该试剂控制植物病害的方法。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2014177404A Nucleic acid antibiotic derivative 审中-公开
标题翻译：核酸抗生素衍生物
公开(公告)号：JP2014177404A
公开(公告)日：2014-09-25
申请号：JP2011146098
申请日：2011-06-30
申请人： Hokkaido Univ , 国立大学法人北海道大学 , Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： ICHIKAWA SATOSHI , MATSUDA AKIRA , OKAMOTO KAZUYA , SAKAGAMI MASAHIRO
IPC分类号： C07K5/06 , A61K38/00 , A61P31/04
CPC分类号： A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid antibiotic derivative having antibacterial active effect.SOLUTION: This invention provides a compound exhibiting antibacterial activity, more preferably an antibacterial nucleoside compound that exhibits antibacterial activity by inhibiting the action of MraY, and particularly, a novel derivative of Pacidamycin that is MraY inhibitor. This invention provides a novel derivative of Pacidamycin or pharmacologically acceptable salt thereof. This invention provides total synthesis of natural product Pacidamycin D and a derivative thereof.
摘要翻译：要解决的问题：提供具有抗菌活性效果的核酸抗生素衍生物。解决方案：本发明提供具有抗菌活性的化合物，更优选通过抑制MraY的作用而具有抗菌活性的抗菌核苷化合物，特别是新颖的作为MraY抑制剂的Pacidamycin衍生物。本发明提供了Pacidamycin或其药理学上可接受的盐的新型衍生物。本发明提供天然产物Pacidamycin D及其衍生物的全合成。

3. 发明专利

JP2014101276A Muraymycin derivative 审中-公开
标题翻译： MURAYMYCIN DERIVATIVE
公开(公告)号：JP2014101276A
公开(公告)日：2014-06-05
申请号：JP2012252037
申请日：2012-11-16
申请人： Hokkaido Univ , 国立大学法人北海道大学 , Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： ICHIKAWA SATOSHI , MATSUDA AKIRA , YANO TETSUYA , TAKEOKA YUSUKE
IPC分类号： C07H19/06 , A61K31/7072 , A61P31/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a new compound having antibacterial active effect, specifically anti-pseudomonas aeruginosa active effect, which is a compound exhibiting antibacterial activity, more preferably an antibacterial nucleoside compound exhibiting antibacterial activity by inhibiting MraY action, in particular, a new derivative of Muraymycin as a MraY inhibitor.SOLUTION: The above problem is solved by providing a new derivative of Muraymycin according to the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译：要解决的问题：提供具有抗菌活性效果的新化合物，特别是抗铜绿假单胞菌的活性作用，其是表现出抗菌活性的化合物，更优选通过抑制MraY作用显示抗菌活性的抗菌核苷化合物，特别是新的 Muraymycin的衍生物作为MraY抑制剂。解决方案：通过提供根据本发明的Muraymycin的新衍生物或其药学上可接受的盐来解决上述问题。

4. 发明专利

JP2009118804A DNA CASSETTE FOR EXPRESSING shRNA 审中-公开
标题翻译：用于表达shRNA的DNA CASSETTE
公开(公告)号：JP2009118804A
公开(公告)日：2009-06-04
申请号：JP2007298097
申请日：2007-11-16
申请人： Geneticlab Co Ltd , Hokkaido Univ , 国立大学法人北海道大学 , 株式会社ジェネティックラボ
发明人： MATSUDA AKIRA , NAMIKAWA NORIAKI , SHIONOYA AKI , OGAWA NAOKI
IPC分类号： C12N15/09 , A61K31/712 , A61K48/00 , C07H21/04
摘要： PROBLEM TO BE SOLVED: To provide a new nucleic acid molecule stably supplying shRNA in a living body and a production method thereof. SOLUTION: Disclosed is a DNA cassette for expressing shRNA comprising a promoter sequence, a target nucleic acid sequence linked to the promoter sequence, and one or more 4'-thio-2'-deoxyribonucleotide. The DNA cassette has an advantage that the expression control of a target gene can be exhibited over a prolonged period of time. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供稳定地供体shRNA的新的核酸分子及其生产方法。解决方案：公开了用于表达shRNA的DNA盒，其包含启动子序列，与启动子序列连接的靶核酸序列和一种或多种4'-硫代-2'-脱氧核糖核苷酸。 DNA盒具有能够长时间显示靶基因的表达控制的优点。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008195648A 4'-selenonucleoside and 4'-selenonucleotide 审中-公开
标题翻译： 4'-SELENONUCLEOSIDE和4'-SELENONUCLEOTIDE
公开(公告)号：JP2008195648A
公开(公告)日：2008-08-28
申请号：JP2007032111
申请日：2007-02-13
申请人： Hokkaido Univ , 国立大学法人北海道大学
发明人： MATSUDA AKIRA , NAMIKAWA NORIAKI , INAGAKI YUTEN
IPC分类号： C07H19/052 , C07H19/067
CPC分类号： Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a 4'-selenonucleoside where a selenium atom is substituted for an oxygen atom in the nucleoside furanose ring, and to artificially synthesize an oligonucleotide made therefrom. SOLUTION: The 4'-selenonucleoside or 4'-selenonucleotide is represented by general formula (wherein, R 1 is H or a triphosphate group; R 2 is H, OH, an alkoxy or alkoxyalkoxy group; B is a purine base or pyrimidine base, wherein the hydroxy group may be protected with a protecting group). The oligonucleotide made therefrom is also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供在核苷呋喃糖环中硒原子取代氧原子的4'-硒核苷，并人造合成由其制备的寡核苷酸。解决方案：4'-硒核苷或4'-硒核苷酸由通式表示（其中，R SP 1是H或三磷酸基; R 2 = H ，OH，烷氧基或烷氧基烷氧基; B是嘌呤碱或嘧啶碱，其中羟基可以被保护基保护）。还提供了由其制备的寡核苷酸。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2012096997A Nucleoside-type antibiotic 审中-公开
标题翻译：核苷类抗生素
公开(公告)号：JP2012096997A
公开(公告)日：2012-05-24
申请号：JP2009043189
申请日：2009-02-25
申请人： Hokkaido Univ , Shionogi & Co Ltd , 国立大学法人北海道大学 , 塩野義製薬株式会社
发明人： MATSUDA AKIRA , ICHIKAWA SATOSHI
IPC分类号： C07H19/06 , A61K31/7072 , A61P31/04 , A61P43/00
CPC分类号： C07H19/067
摘要： PROBLEM TO BE SOLVED: To provide a compound having an antibacterial activity and a derivative thereof, more preferably an antibacterial nucleoside compound that can inhibit the activity of MraY to exert an antibacterial activity and a derivative of the nucleoside compound, particularly a novel derivative of Muraymycin that is an MraY inhibitor.SOLUTION: A novel derivative of Muraymycin or a pharmaceutically acceptable salt thereof is provided. The compound has good intracellular penetration properties and a potent antibacterial activity. The compound also has resistance against enzymes such as an esterase occurring in blood. A preferred embodiment of the compound has an inhibitory activity on MraY. The preferred embodiment of the compound is effective against resistant bacteria such as VRE and MRSA.
摘要翻译：待解决的问题：为了提供具有抗菌活性的化合物及其衍生物，更优选可以抑制MraY发挥抗菌活性的活性的抗菌核苷化合物和核苷化合物的衍生物，特别是新颖的作为MraY抑制剂的Muraymycin的衍生物。解决方案：提供了Muraymycin或其药学上可接受的盐的新型衍生物。该化合物具有良好的细胞内渗透性能和有效的抗菌活性。该化合物还具有对诸如血液中发生的酯酶等酶的抗性。化合物的优选实施方案对MraY具有抑制活性。该化合物的优选实施方案对抗抗性细菌如VRE和MRSA是有效的。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2012102019A Nucleoside-type antibiotic derivative 审中-公开
标题翻译：核苷类抗生素衍生物
公开(公告)号：JP2012102019A
公开(公告)日：2012-05-31
申请号：JP2009049963
申请日：2009-03-03
申请人： Hokkaido Univ , Shionogi & Co Ltd , 国立大学法人北海道大学 , 塩野義製薬株式会社
发明人： MATSUDA AKIRA , ICHIKAWA SATOSHI
IPC分类号： C07H19/067 , A61K31/7072 , A61P31/04 , A61P43/00
CPC分类号： C07H19/067
摘要： PROBLEM TO BE SOLVED: To provide a compound exhibiting antimicrobial activity, more preferably an antibacterial nucleoside compound exhibiting antibacterial activity by inhibiting MraY action, especially a new derivative of Muraymycin being an MraY inhibitor.SOLUTION: The new derivative of Muraymycin or its pharmaceutically acceptable salt solves the problem. The compound is easily supplied in terms of synthetic chemistry while maintaining activity at a level equivalent to or higher than those of nucleic acid-type antibiotics.

8. 发明专利

JP2009107939A New purine dimer compound or its salt, and its use 审中-公开
标题翻译：新型二酯化合物或其盐类及其用途
公开(公告)号：JP2009107939A
公开(公告)日：2009-05-21
申请号：JP2007279056
申请日：2007-10-26
申请人： Hokkaido Univ , Taiho Yakuhin Kogyo Kk , 国立大学法人北海道大学 , 大鵬薬品工業株式会社
发明人： MURANAKA KAZUHIRO , ICHIKAWA SATOSHI , MATSUDA AKIRA , SANO AKIKO
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a new purine compound that has an HSP90-inhibiting activity and exhibits an excellent anti-tumor effect.
SOLUTION: The purine dimer compound represented by general formula (1) or its salt is disclosed. The anti-tumor agent comprises the compound as an active ingredient.
COPYRIGHT: (C)2009,JPO&INPIT

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