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1. 发明专利

JP2017114784A オクタデセン酸化合物审中-公开
公开(公告)号：JP2017114784A
公开(公告)日：2017-06-29
申请号：JP2015249203
申请日：2015-12-22
申请人：株式会社くらこん , Kurakon Co Ltd , 国立大学法人宮崎大学 , Univ Of Miyazaki , 国立大学法人宮崎大学
发明人： DENPO HIROSHI , SHIROSUGI ICHIRO , SAKAKIBARA YOICHI , SUIKO MASAHITO
IPC分类号： C07C59/42 , A23L33/10 , A61K8/36 , A61K8/97 , A61K31/201 , A61K36/02 , A61P35/00 , A61P39/06 , A61Q19/00
摘要：【課題】ヒトなどの動物において、抗酸化作用などの有用な薬理活性を示すに至る因子として、水酸基を含有する不飽和脂肪酸を提供することを目的とする。【解決手段】【化1】(R,R´は、水素又は水酸基のいずれかであるが少なくとも一方が水酸基である)で示されたオクタデセン酸化合物、また、このうちR´が水素、Rが水酸基である11−ヒドロキシ−9(Z)−オクタデセン酸であることオクタデセン酸化合物などにより解決することができた。【選択図】図1

2. 发明专利

JP2008022762A Method, program and apparatus for evaluating high throughput function 审中-公开
标题翻译：用于评估高通量功能的方法，程序和设备
公开(公告)号：JP2008022762A
公开(公告)日：2008-02-07
申请号：JP2006198145
申请日：2006-07-20
申请人： Miyazakiken Sangyo Shien Zaidan , Univ Of Miyazaki , 国立大学法人宮崎大学 , 財団法人宮崎県産業支援財団
发明人： SUIKO MASAHITO , FUKUDA NOBUHIRO , SAKUNO MASANOBU , NISHIYAMA KAZUO , ETO NOZOMI , SAKAKIBARA YOICHI , KAWAHARA SATOSHI , YAMAZAKI MASAO , YOSHIHARA IKUO , YAMAMORI KAZUTO , NAGAHAMA KIYOKO
IPC分类号： C12Q1/02 , C12M1/34 , C40B30/02 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a high throughput function evaluation method for attaining the accuracy of evaluation in high reliability despite of the presence of fluctuation characteristic to biological evaluation system and the use of small number of data.
SOLUTION: A functionality-unknown material such as a food material component is mixed with human-originated culture cells to obtain a cell extract corresponding to the food material as a test sample. The test sample is subjected to an evaluation array equipped with a plurality of wells having different biological function-evaluation abilities. In the evaluation test, the expression quantities of biomarkers corresponding to antibodies are measured by immunoassays based on antigen-antibody reactions. The functionality level of the functionality-unknown specimen is estimated by comparing the obtained expression quantities of the biomarkers of the functionality-unknown material with an imaginary data set corresponding to a functionality value of a functionality-known material and expanding the obtained data set by boot strap method. The proper evaluation functionality-unknown material includes biological resources involving food materials and other chemical substances.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供高生产率功能评估方法，用于尽可能高的可靠性地获得评价的准确度，尽管存在生物学评估系统的波动特性和使用少量的数据。解决方案：将功能性未知的材料如食物材料组分与人源培养细胞混合以获得对应于作为测试样品的食物材料的细胞提取物。对测试样品进行装备有具有不同生物功能评价能力的多个孔的评价阵列。在评价试验中，通过基于抗原 - 抗体反应的免疫测定来测量与抗体相应的生物标志物的表达量。通过将获得的功能性未知材料的生物标志物的表达量与对应于功能性已知材料的功能值的虚数据集进行比较来估计功能性未知标本的功能水平，并通过引导扩展获得的数据集带子法。适当的评估功能 - 未知的材料包括涉及食品材料和其他化学物质的生物资源。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2013101567A Program for constructing expansion weight update type self-organization map, program for estimating characteristic value using constructed expansion weight update type self-organization map and characteristic value estimation apparatus employing expansion weight update type self-organization map 审中-公开
标题翻译：用于构建扩展重量的程序更新类型自组织映射，使用构造扩展权重估计特征值的程序更新类型自组织映射和特征值估计装置使用扩展权重更新类型自组织映射
公开(公告)号：JP2013101567A
公开(公告)日：2013-05-23
申请号：JP2011245872
申请日：2011-11-09
申请人： Univ Of Miyazaki , 国立大学法人宮崎大学 , Miyazakiken Sangyo Shien Zaidan , 財団法人宮崎県産業支援財団
发明人： YAMAMORI KAZUTO , YOSHIHARA IKUO , NISHIYAMA KAZUO , ETO NOZOMI , SAKAKIBARA YOICHI , NAGAHAMA KIYOKO
IPC分类号： G06N3/00 , C12M1/34
摘要： PROBLEM TO BE SOLVED: To provide a program for constructing an expansion weight update type self-organization map while using much data for learning.SOLUTION: When a feature amount obtained by measuring a substance is inputted, a program for constructing an expansion weight update type self-organization map for quantitatively calculating and outputting a characteristic value of which the character is different from the feature amount, allows a computer to execute the steps of accepting input of a plurality of measurements of the feature amount and a plurality of measurements of the characteristic value which are measured under different conditions (step S1), and calculating variance of the measurements and excludes the measurements of which the variance is equal to or more than a predetermined threshold value (step S3). Further, outlier values are excluded from among the measurements (step S4) and a learning sample is created by making the remaining measurements of the feature amount and the characteristic value through statistical analysis (step S5). In accordance with the created learning sample, the self-organization map is allowed to perform expansion weight update learning so as to be constructed as an expansion weight update type self-organization map having a competitive layer in which a relationship between feature amounts is mapped (step S6).
摘要翻译：要解决的问题：提供一种用于构建扩展权重更新型自组织图的程序，同时使用大量用于学习的数据。解决方案：当输入通过测量物质获得的特征量时，用于构建用于定量计算并输出字符与特征量不同的特征值的扩展权重更新型自组织图的程序允许执行接受特征量的多个测量的输入和在不同条件下测量的特征值的多个测量（步骤S1）的步骤的计算机，并且计算测量的方差并且排除其中的测量值方差等于或大于预定阈值（步骤S3）。此外，从测量中排除异常值（步骤S4），并且通过统计分析进行特征量和特征值的剩余测量来创建学习样本（步骤S5）。根据创建的学习样本，允许自组织图执行扩展权重更新学习，以便被构造为具有映射特征量之间的关系的竞争层的扩展权重更新类型自组织映射（步骤S6）。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2008025991A Differential gel electrophoretic method for protein expression analysis 审中-公开
标题翻译：蛋白质表达分析的差异性凝胶电泳方法
公开(公告)号：JP2008025991A
公开(公告)日：2008-02-07
申请号：JP2006195004
申请日：2006-07-18
申请人： Miyazakiken Sangyo Shien Zaidan , Univ Of Miyazaki , Unkai , 国立大学法人宮崎大学 , 財団法人宮崎県産業支援財団 , 雲海酒造株式会社
发明人： SAKAKIBARA YOICHI , MORINAGA HIROMICHI
IPC分类号： G01N27/447 , C09B23/00 , G01N33/58 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive and simple differential gel electrophoretic method for protein expression analysis having high detection sensitivity and repeatability, and having high labeling efficiency. SOLUTION: This differential gel two-dimensional electrophoretic method for protein expression analysis is widely used for comparing two or more kinds of proteins with each other. At least two kinds of protein specimens are heat-denatured by using guanidine hydrochloride before they are two-dimensionally electrophoresed. Desirably, denaturation temperature is within the range of 96-100°C, with 98°C being suitable. Likewise, it is desirable that denaturation time is of the order of 2-3 minutes in the case of 98°C. The other conditions are based on a differential gel two-dimensional electrophoretic method of common use. In this method, protein detection sensitivity is high since such heat-denaturation makes it easy for coloring matter to covalently bond to a desired part of protein. Since coloring matter bonding efficiency does not depend on a three-dimensional structure, labeling efficiency is stochastically equalized among respective protein specimens, making it possible to enhance reproducibility. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有高检测灵敏度和重复性并且具有高标记效率的蛋白质表达分析的廉价且简单的差分凝胶电泳方法。解决方案：用于蛋白质表达分析的差分凝胶二维电泳方法被广泛用于比较两种或更多种蛋白质。在二维电泳之前，使用盐酸胍将至少两种蛋白质标本进行热变性。理想的是，变性温度在96-100℃的范围内，98℃是合适的。同样，在98℃的情况下，变性时间优选2-3分钟。其他条件是基于常用的差示凝胶二维电泳法。在这种方法中，蛋白质检测灵敏度高，因为这种热变性使着色物质易于共价键合到蛋白质的所需部分。由于色素键合效率不依赖于三维结构，所以标记效率在各个蛋白质样品之间随机均衡，使得可以提高再现性。版权所有（C）2008，JPO＆INPIT

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