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    • 4. 发明专利
    • Modified low-density lipoprotein receptor
    • 改良低密度脂蛋白受体
    • JP2008263992A
    • 2008-11-06
    • JP2008139974
    • 2008-05-28
    • Nippon Chemiphar Co Ltd日本ケミファ株式会社
    • SAWAMURA TATSUYAMAZAKI TOMOO
    • C12N15/09G01N33/53A61K38/00C07H21/04C07K14/705C07K16/28C12N15/12C12P21/02C12R1/91G01N33/566
    • C07K14/705A61K38/00
    • PROBLEM TO BE SOLVED: To clarify structures of modified low-density lipoprotein receptor of vascular endothelial cell, and to provide a DNA sequence encoding the modified low-density lipoprotein receptor of vascular endothelial cell. SOLUTION: There is provided a DNA sequence substantially composed of a region encoding the receptor of the modified low-density lipoprotein of specific mammalian vascular endothelial cells. The DNA sequence may be a cDNA clone originating from an open reading frame of the modified low-density lipoprotein receptor gene of natural mammalian vascular endothelial cells. The DNA sequence may be a DNA sequence hybridizing with the cDNA clone, and encoding the modified low-density lipoprotein receptor of mammalian vascular endothelial cells having biological activity. The DNA sequence described above may be a DNA sequence encoding the modified low-density lipoprotein receptor as the result of a degeneration of the genetic code. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:阐明血管内皮细胞修饰的低密度脂蛋白受体的结构,并提供编码血管内皮细胞修饰的低密度脂蛋白受体的DNA序列。 提供了基本上由编码特定哺乳动物血管内皮细胞的修饰的低密度脂蛋白的受体的区域组成的DNA序列。 DNA序列可以是源自天然哺乳动物血管内皮细胞的修饰的低密度脂蛋白受体基因的开放阅读框的cDNA克隆。 DNA序列可以是与cDNA克隆杂交的DNA序列,并且编码具有生物活性的哺乳动物血管内皮细胞的修饰的低密度脂蛋白受体。 上述DNA序列可以是编码经修饰的低密度脂蛋白受体的DNA序列,作为遗传密码子退化的结果。 版权所有(C)2009,JPO&INPIT