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1. 发明专利

JP2006305345A Drug for relieving carbonyl stress state and peritoneal dialysate 审中-公开
标题翻译：用于缓解碳应力状态和皮质透析液的药物
公开(公告)号：JP2006305345A
公开(公告)日：2006-11-09
申请号：JP2006113192
申请日：2006-04-17
申请人： Kurokawa Kiyoshi , Toshio Miyata , Tokai Univ , 学校法人東海大学 , 敏男宮田 , 黒川清
发明人： MIYATA TOSHIO
IPC分类号： A61M1/14 , A61K31/15 , A61K31/155 , A61K31/198 , A61K31/4415 , A61K33/44 , A61K45/00 , A61M1/28 , A61P7/08 , B01J20/26 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a drug, a dialysate, and a method for relieving peritoneal disorders accompanying a peritoneal dialysis by inhibiting carbonyl compounds from modifying protein in the peritoneum during the peritoneal dialysis. SOLUTION: Carbonyl compounds formed and accumulated in a peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds formed during the sterilization and storage of the peritoneal dialysate can be eliminated by bringing the compounds into contact with the trapping agent in advance. Furthermore, it is made possible to eliminate carbonyl compounds originating in the blood of a patient which have flowed into the peritoneal cavity as the dialysis proceeds, by adding the trapping agent to the peritoneal dialysate or by circulating the fluid through a carbonyl compound-trapping cartridge. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供药物，透析液和通过腹膜透析期间通过抑制羰基化合物修饰腹膜中的蛋白质来缓解腹膜透析引起的腹膜疾病的方法。解决方案：在腹膜透析液中形成和积聚的羰基化合物可以被羰基化合物捕获剂如氨基胍灭活或消除。通过使化合物预先与捕获剂接触可以消除在腹膜透析液的灭菌和储存期间形成的羰基化合物。此外，通过将捕获剂添加到腹膜透析液中或通过使流体循环通过羰基化合物捕获盒，可以消除源自透析进入腹腔的患者的血液中的羰基化合物。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JPH11155608A ANTISLIPPING BELT AND SOLE FOR SNOW-COVERED ROAD 失效
公开(公告)号：JPH11155608A
公开(公告)日：1999-06-15
申请号：JP36968597
申请日：1997-11-27
申请人： KUROKAWA KIYOSHI
发明人： KUROKAWA KIYOSHI
IPC分类号： A43B13/22 , A43C15/12
摘要： PROBLEM TO BE SOLVED: To deter generation of water film between shoes and the surface of the road causing a slip on the rain-wet or snow-covered street by applying gum-processed light pile to shoes. SOLUTION: The front part of a shoe is rolled by a piece of belt-shaped light pile that has mounted a pair of a hook-and-loop faster which realize easy fit to a shoe at the both ends. The light pile can be attached to a part of sole 1, a sole part of heel or the whole, and in the cases, a small piece of light pile is attached as a constituent of the sole 1 in manufacturing process for sole 1, the heel or the whole body. Then, as antislippers, they deter generation of water film that occurs between a shoe and the surface of the road. They can prevent users, especially eldery people and children, from tumbling or having a traffic accident.

3. 发明专利

JP2011173904A Carbonyl stress-ameliorating agent 审中-公开
标题翻译：碳纤维应变剂
公开(公告)号：JP2011173904A
公开(公告)日：2011-09-08
申请号：JP2011094578
申请日：2011-04-21
申请人： Kurokawa Kiyoshi , Toshio Miyata , Tokai Univ , 学校法人東海大学 , 敏男宮田 , 黒川清
发明人： MIYATA TOSHIO
IPC分类号： A61K38/00 , A61K38/43 , A61K38/51 , A61K47/48 , A61M1/28 , A61M1/36 , A61P7/08 , A61P43/00
CPC分类号： A61M1/287 , A61K38/51 , A61M1/3687 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a carbonyl stress-ameliorating agent which can quickly eliminate carbonyl compounds accumulated in the peritoneal dialyzing fluid during peritoneal dialysis of a patient suffered from renal failure.
SOLUTION: This agent is a 3-deoxyglucosone eliminator containing an enzyme having glyoxalase I activity and a carbonyl compound-reducing agent as the active ingredients. By ameliorating carbonyl stress conditions of the peritoneal dialyzing fluid, it results in suppression of reduction in peritoneal functions (dehydration function) caused by carbonyl modification of protein in the abdominal cavity, also in suppression of development of peritoneal sclerosis.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种羰基应激改善剂，其可以在患有肾衰竭的患者的腹膜透析期间快速消除积累在腹膜透析液中的羰基化合物。解决方案：该试剂是含有乙二醛酶I活性的酶和羰基化合物还原剂作为活性成分的3-脱氧葡萄糖酮消除剂。通过改善腹膜透析液的羰基应激条件，可以抑制由腹部蛋白质的羰基修饰引起的腹膜功能降低（脱水功能），也抑制腹膜硬化的发展。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2006075170A Megsin protein 审中-公开
标题翻译： MEGSIN蛋白
公开(公告)号：JP2006075170A
公开(公告)日：2006-03-23
申请号：JP2005292475
申请日：2005-10-05
申请人： Kurokawa Kiyoshi , Toshio Miyata , Tokai Univ , 学校法人東海大学 , 敏男宮田 , 黒川清
发明人： MIYATA TOSHIO
IPC分类号： C12N15/09 , A01K67/027 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a gene expressed specifically in mesangial cells. SOLUTION: The DNA expressed specifically in mesangial cells, the protein encoded by the DNA, the antibody binding to the protein, etc., are provided. These substances are indigenous to the mesangial cells and, therefore, useful in identifying the mesangial cells and detecting abnormalities in the mesangial cells. Moreover, the protein would be helpful for clarification of the functions of the mesangial cells and, in its turn, for clarification of the causes of diseases relating to the mesangial cells. The protein is expectedly applicable to the treatment and diagnosis of diseases relating to mesangial cells. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供特异性在肾小球系膜细胞中表达的基因。解决方案：提供在肾小球系膜细胞中特异性表达的DNA，由DNA编码的蛋白质，与蛋白质结合的抗体等。这些物质对于肾小球膜细胞是土着的，因此可用于鉴定肾小球系膜细胞和检测肾小球系膜细胞中的异常。此外，该蛋白质将有助于澄清肾小球系膜细胞的功能，反过来，用于澄清与肾小球系膜细胞有关的疾病的原因。蛋白质预期适用于与肾小球系膜细胞有关的疾病的治疗和诊断。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JPH11116941A NONSKID MIXED AGENT FOR ICE AND SNOW 失效
公开(公告)号：JPH11116941A
公开(公告)日：1999-04-27
申请号：JP32940997
申请日：1997-10-09
申请人： KUROKAWA KIYOSHI
发明人： KUROKAWA KIYOSHI
IPC分类号： B60B39/04 , B60C11/02 , B60C11/14 , C09K3/14
摘要： PROBLEM TO BE SOLVED: To obtain a nonskid mixed agent for ice and snow capable of increasing the frictional force of the surface of a bicycle tire for snowfall districts against ice and snow or increasing the frictional force of the removable belt for the sole of a shoe against ice and snow and stabilizing the frictional force. SOLUTION: A mixed agent (a) is prepared by mixing a chloroprene rubber adhesive effective for rubber with particles such as emery, iron powder and sand. (b) A mixed agent is prepared by mixing a polyurethane adhesive effective for leather with particles such as emery, iron powder and sand. In winter, the mixed agent (a) of the chloroprene rubber based adhesive is bonded to the surface of a bicycle tire for snowfall districts which is brought into contact with ice and sow. Also, a removable belt for the sole of a shoe is prepared with the mixed agent (b) of the polyurethane based adhesive and attached to the sole of a shoe.

6. 发明专利

JP2007176950A Megsin protein 有权
标题翻译： MEGSIN蛋白
公开(公告)号：JP2007176950A
公开(公告)日：2007-07-12
申请号：JP2007043827
申请日：2007-02-23
申请人： Kurokawa Kiyoshi , Toshio Miyata , Tokai Univ , 学校法人東海大学 , 敏男宮田 , 黒川清
发明人： MIYATA TOSHIO
IPC分类号： C07K14/47 , A01K67/027 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To isolate a gene expressed specifically in mesangial cells. SOLUTION: A DNA expressed specifically in mesangial cells; a protein encoded by this DNA; an antibody binding to this protein, etc. These substances are indigenous to mesangial cells and, therefore, useful in, for example, identifying mesangial cells and detecting abnormalities in mesangial cells. Moreover, the above protein would be helpful for clarification of the functions of mesangial cells and, in its turn, for clarification of the causes of diseases relating to mesangial cells. This protein is expectedly applicable to the treatment and diagnosis of diseases relating to mesangial cells. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：分离在肾小球系膜细胞中特异性表达的基因。解决方案：特异性在肾小球系膜细胞中表达的DNA; 由该DNA编码的蛋白质; 与该蛋白质结合的抗体等。这些物质属于肾小球系膜细胞，因此可用于例如鉴定肾小球膜细胞和检测肾小球系膜细胞异常。此外，上述蛋白质将有助于澄清肾小球系膜细胞的功能，反过来，用于澄清与肾小球系膜细胞有关的疾病的原因。该蛋白质预期适用于与肾小球膜细胞有关的疾病的治疗和诊断。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2002291879A DOMICILIARY TREATMENT MANAGEMENT SYSTEM 失效
公开(公告)号：JP2002291879A
公开(公告)日：2002-10-08
申请号：JP2001103918
申请日：2001-04-02
申请人： KUROKAWA KIYOSHI , MIYATA TOSHIO
发明人： MIYATA TOSHIO
IPC分类号： A61B5/00 , A61B5/145 , A61M1/28 , G06Q50/22 , G06F17/60
摘要： PROBLEM TO BE SOLVED: To provide a useful domiciliary treatment management system that keeps track of and manage conditions of patients in real time and presents appropriate guidelines so as to allow safe, convenient and long-term domiciliary disease treatment such as dialytic treatment. SOLUTION: The domiciliary treatment management system comprises treatment apparatuses, regional examination facilities, a central management facility, and an information communication network connecting them, and has medication means, detection means to detect symptoms, primary storage means, transmission and reception means, setting change means, evaluation parameter computation means, treatment monitoring means, and further has treatment apparatuses that can be installed at homes, relay transmission and reception means, secondary storage means, medical instruments, regional examination facilities with input and output terminals, transmission and reception means, evaluation parameter computation means, personal information databases, disease information databases, condition judgment expert subsystems, treatment program preparation subsystems, and treatment program approval means.

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