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1. 发明专利

JP2008100951A Method for preparing 2-cyclopentadecenone 审中-公开
标题翻译：制备2-环戊二烯酮的方法
公开(公告)号：JP2008100951A
公开(公告)日：2008-05-01
申请号：JP2006285550
申请日：2006-10-19
申请人： Kawaguchi Yakuhin Kk , National Univ Corp Shizuoka Univ , 国立大学法人静岡大学 , 川口薬品株式会社
发明人： TAKABE KUNIHIKO , MASE NOBUYUKI , SHIMIZU YASUHIRO , OKUI NOBUYUKI
IPC分类号： C07C45/65 , C07B61/00 , C07C45/69 , C07C49/385 , C07C49/587
摘要： PROBLEM TO BE SOLVED: To provide a technique for preparing 2-cyclopentadecenone at a high yield using fewer reaction steps and under a mild preparation condition, and a method for preparing muscone from 2-cyclopentadecenone prepared by the above method.
SOLUTION: The method for preparing 2-cyclopentadecenone comprises a step of causing a 2-substituted cyclopentadecanone represented by formula 1 (wherein R represents -SO
2 R
1 , R
1 represents a methyl group or a tolyl group) to undergo an elimination reaction in the presence of an acid. A 2-4C organic acid that may contain a fluorine atom, a 1-3C alkanesulfonic acid that may contain a fluorine atom, or an arylsufonic acid is preferred as an organic acid to be used in the above reaction. A mineral acid such as sulfuric acid, hydrochloric acid and nitric acid is preferred as an inorganic acid to be used in the above reaction.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种使用较少的反应步骤和在轻度制备条件下以高产率制备2-环戊烯酮的技术，以及通过上述方法制备的2-环戊烯酮的制备方法。解决方案：制备2-环戊烯酮的方法包括使由式1表示的2-取代的环十五烷酮（其中R表示-SO 2 S S 1 < R 1 表示甲基或甲苯基）在酸的存在下进行消除反应。作为上述反应中使用的有机酸，优选可含有氟原子的2-4C有机酸，可含有氟原子的1-3C烷烃磺酸或芳基磺酸作为有机酸。作为上述反应中使用的无机酸，优选无机酸如硫酸，盐酸和硝酸。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2004300070A Acetal adduct of muscone, method for preparing the adduct, and method for optical resolution of (±)-muscone 有权
公开(公告)号：JP2004300070A
公开(公告)日：2004-10-28
申请号：JP2003095454
申请日：2003-03-31
申请人： Kawaguchi Yakuhin Kk , Kunihiko Takabe , 川口薬品株式会社 , 圀彦高部
发明人： TAKABE KUNIHIKO , SUGIURA MASATAKA , MASE NOBUYUKI
IPC分类号： C07D317/72 , C07B53/00 , C07B57/00 , C07C45/42 , C07C45/78 , C07C49/385 , C11B9/00
摘要： PROBLEM TO BE SOLVED: To provide a diastereomer of a racemic form (±)-muscone with large solubility difference between the isomers, to provide a method for preparing the diastereomer, and to provide a method for the optical resolution of the (±)-muscone into (R)-(-) form muscone or (S)-(+) form muscone. SOLUTION: The diastereomer of (±)-muscone is obtained by reaction between the racemic form (±)-muscone composed of (R)-(-) form and (S)-(+) form and dibenzyl L-tartrate or dibenzyl D-tartrate under specified conditions to form an acetal linkage. The method for preparing the diastereomer comprises carrying out the reaction between the racemic form (±)-muscone composed of (R)-(-) form and (S)-(+) form and dibenzyl L-tartrate in an inert solvent in the presence of an acid catalyst and under a dehydrating condition to form an acetal linkage. The method for the optical resolution of the (±)-muscone involves using the diastereomer. COPYRIGHT: (C)2005,JPO&NCIPI

3. 发明专利

JP2005008555A Acetal adduct of muscone, method for preparing the same and optical resolution method of (±)-muscone 有权
标题翻译：麦芽糖的乙酰辅酶，其制备方法和（±） - 麦克风的光分辨方法
公开(公告)号：JP2005008555A
公开(公告)日：2005-01-13
申请号：JP2003174469
申请日：2003-06-19
申请人： Kawaguchi Yakuhin Kk , Kunihiko Takabe , 川口薬品株式会社 , 圀彦高部
发明人： TAKABE KUNIHIKO , SUGIURA MASATAKA , MASE NOBUYUKI
IPC分类号： C07D317/72 , C07B57/00 , C07B61/00 , C07C45/59 , C07C45/85 , C07C49/385
摘要： PROBLEM TO BE SOLVED: To obtain a diastereomer of racemic (±)-muscone having large difference in solubility between isomers, to provide a diastereomerization method and a method for optically resolving (±)-muscone into (R)-(-) muscone or (S)-(+) muscone. SOLUTION: The diastereomer of (±)-muscone is obtained by reacting racemic (±) muscone composed of (R)-(-) isomer and (S)-(+) isomer with N,N'-dibenzyl-L-tartaric acid diamide or N,N'-dibenzyl-D-tartaric acid diamide under a fixed condition to form an acetal bond. The method for preparing the diastereomer is provided. The method for optically resolving muscone using the diastereomer is provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得异构体之间的溶解度差异大的外消旋（±） - 肌醇酮的非对映异构体，提供非对映异构化方法和将（±） - 木质素光学拆分成（R） - （ - ）肌肉或（S） - （+）肌肉。（±） - 肌醇酮的非对映异构体是通过将由（R） - （ - ） - 异构体和（S） - （+）异构体组成的外消旋（±）肌肉与N，N'-二苄基-L - 酒石酸二酰胺或N，N'-二苄基-D-酒石酸二酰胺，以形成缩醛键。提供了制备非对映异构体的方法。提供了使用非对映体光学拆分肌肉的方法。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2877154B2 失效
公开(公告)号：JP2877154B2
公开(公告)日：1999-03-31
申请号：JP17460290
申请日：1990-07-03
申请人： KAWAGUCHI YAKUHIN KK
发明人： KITAMURA SOICHI , TOMIOKA MASARU , GOTO TAKAKUNI
IPC分类号： B01J31/02 , C07B61/00 , C07C45/64 , C07C45/68 , C07C45/70 , C07C49/84

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