专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2003329677A Method of detecting biochemical sample and detection chip 有权
标题翻译：检测生物化学样品和检测芯片的方法
公开(公告)号：JP2003329677A
公开(公告)日：2003-11-19
申请号：JP2001401649
申请日：2001-12-28
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YAMAGUCHI HIROSHI , YABUBAYASHI TADAAKI , MISAWA HIROAKI , TANAKA MASAZUMI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting a biochemical sample making it possible to simplify detection processes by use of a new label for detection, in a way assuring good reproducibility, while not requiring much skill on the part of a measurer, increasing the accuracy of detection, and consisting of simple processes; and a detection chip. SOLUTION: Probe DNAs are aligned on a thin film of gold formed on the surface of a glass substrate, in such a way that the probe DNAs together form a loop structure, with their open terminals located on the thin film so that, when there is a target gene, hybridization occurs, releasing the loop structure. Thus, only the hybridized DNA probes can be selectively modified with fine ceramic particles; a light scattering method is applied to these to detect the hybridization through the observation of the intensity of light scattered by the particles. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种检测生化样品的方法，使得可以通过使用用于检测的新标签来简化检测过程，以确保良好的再现性的方式，同时不需要很多技能测量，提高检测精度，并由简单的过程组成; 和检测芯片。解决方案：探针DNA在玻璃基底表面上形成的金薄膜上排列，使得探针DNA一起形成环结构，其开放末端位于薄膜上，当有靶基因时，发生杂交，释放环结构。因此，只有杂交的DNA探针可以用精细的陶瓷颗粒选择性地修饰; 应用光散射法，通过观察由颗粒散射的光的强度来检测杂交。版权所有（C）2004，JPO

2. 发明专利

JP2003329676A Method of detecting biochemical sample and detection chip 审中-公开
标题翻译：检测生物化学样品和检测芯片的方法
公开(公告)号：JP2003329676A
公开(公告)日：2003-11-19
申请号：JP2001401638
申请日：2001-12-28
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YAMAGUCHI HIROSHI , YABUBAYASHI TADAAKI , MISAWA HIROAKI , TANAKA MASAZUMI
IPC分类号： G01N21/64 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting a biochemical sample making it possible to simplify detection processes in a manner assuring good reproducibility for the method of detecting fluorescently-modified double-helix DNA, while not requiring much skill on the part of a measurer, increasing the accuracy of detection, and consisting of simple processes; and a detection chip for fluoroscopy.
SOLUTION: Probe DNAs are aligned on a thin film of gold formed on a glass substrate, in such a manner that the probe DNAs together form a loop structure with their open terminals located on the thin film so that, when there is a target gene, hybridization occurs, releasing the loop structure. Thus when fluorescent labels are provided, fluorescence is emitted only from the hybridized probe DNAs. Alternatively, when the DNAs are modified after the hybridization, it is possible to fluorescently label only the target DNA, resulting in reduced background noise and higher accuracy of detection.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种检测生物化学样品的方法，使得可以以确保荧光改性双螺旋DNA检测方法的良好再现性的方式简化检测过程，同时不需要太多的技术测量者的一部分，提高检测的准确性，并由简单的过程组成; 以及用于荧光透视的检测芯片。解决方案：探针DNA在玻璃基底上形成的金薄膜上排列，使得探针DNA一起形成环状结构，其开放末端位于薄膜上，使得当存在靶基因，发生杂交，释放环结构。因此，当提供荧光标记时，仅从杂交的探针DNA发射荧光。或者，当杂交后修饰DNA时，可以仅对目标DNA进行荧光标记，导致背景噪声降低和检测精度更高。版权所有（C）2004，JPO

3. 发明专利

JP2005017233A Detection method for biochemical reactant, and biochip 审中-公开
标题翻译：生物化学反应物和生物化学检测方法
公开(公告)号：JP2005017233A
公开(公告)日：2005-01-20
申请号：JP2003185853
申请日：2003-06-27
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YABUBAYASHI TADAAKI , MISAWA HIROAKI
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/68 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a detecting method of a biochemical reactant capable of simplifying a detection process with satisfactory reproducibility, without requiring excessive workmanship of a measuring person, capable of enhancing precisions of respective execution techniques and efficiencies in modification processes for hybridization and a label, and capable of enhancing finally detection precision of an objective specimen.
SOLUTION: A probe is fixed on a surface of a DNA (deoxyribonucleic acid) chip to be surface-treated thereafter with a hydrophobic surface treating agent, a substrate surface gets hydrophobic therein, the objective specimen gets thereby easy to react with the probe in the hybridization, modification probability of the label to the probe is also enhanced irrespectively before the hybridization and after the hybridization, and detection sensitivity is remarkably enhanced in any detection method.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够以令人满意的再现性简化检测过程的生物化学反应物的检测方法，而不需要测量人员过多的工艺，能够增强各种执行技术的精度和改进方法的效率杂交和标记，并且能够提高目标样品的最终检测精度。解决方案：探针固定在DNA（脱氧核糖核酸）芯片的表面上，然后用疏水性表面处理剂进行表面处理，底物表面在其中疏水，因此目标样品易于与在杂交中探针，杂交前和杂交后，标记对探针的修饰概率也增强，检测灵敏度在任何检测方法中显着增强。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004268309A Method and apparatus for dividing sapphire substrate 有权
公开(公告)号：JP2004268309A
公开(公告)日：2004-09-30
申请号：JP2003059317
申请日：2003-03-06
申请人： Hiroaki Misawa , Tecdia Kk , テクダイヤ株式会社 , 弘明三澤
发明人： MISAWA HIROAKI , KOYAMA ETSUO
IPC分类号： B28D5/00 , B23K26/00 , B23K26/40 , B23K101/40 , C03B33/09 , C30B29/20 , C30B33/00 , H01L21/301
CPC分类号： Y02P40/57
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently dividing a sapphire substrate in a high yield at a low cost, and an apparatus therefor. SOLUTION: The method for dividing the sapphire substrate includes a first step for forming scribed grooves 11 to the first surface 10a of the sapphire substrate 10 and a second step for irradiating the positions 11' corresponding to the formed scribed grooves 11 with a laser beam 32 from the first surface 10a side or second surface 10b side of the sapphire substrate. The laser beam 32 has a wavelength enabling the sapphire substrate 10 to yield multiphoton absorption including two-photon absorption and the irradiation energy of the laser beam 32 is the breakdown energy of the sapphire substrate 10. COPYRIGHT: (C)2004,JPO&NCIPI

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式