专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明专利

JP2673937B2 失效
公开(公告)号：JP2673937B2
公开(公告)日：1997-11-05
申请号：JP21521394
申请日：1994-08-18
IPC分类号： C07D401/04 , A61K31/47 , A61K31/4725 , A61P31/04 , C07D215/56
摘要： A 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative represented by the general formula: wherein R is a hydrogen atom or a lower alkyl group; R is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl group or a residue of carboxylic acid ester; R is a hydrogen atom or a lower alkyl group; R , R or R are each independently a hydrogen atom or a lower alkyl group; or two of R , R and R may be taken together to form a -(CH2) n - group wherein n is 1 or 2, a stereoisomer thereof, or a pharmacologically acceptable salt thereof, the process for preparing these compounds, a pharmaceutical composition comprising an effective amount of these compounds and methods for the treatment of infectious diseases through the administration to patients of an effective amount of these compounds, and intermediates of these compounds are disclosed. These compounds are effective as antibacterial agents.

82. 发明专利

JPH09509957A 失效
公开(公告)号：JPH09509957A
公开(公告)日：1997-10-07
申请号：JP52335195
申请日：1995-02-22
IPC分类号： A61K31/47 , A61K31/535 , A61P29/00 , A61P35/00 , A61P37/00 , C07D215/56 , C07D401/04 , C07D401/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D498/06

83. 发明专利

JP2631640B2 失效
公开(公告)号：JP2631640B2
公开(公告)日：1997-07-16
申请号：JP13593695
申请日：1995-05-09
申请人： KYORIN SEIYAKU KK
发明人： MASUZAWA KUNYASU , SUZUE SEIGO , HIRAI KEIJI , ISHIZAKI TAKAYOSHI
IPC分类号： A61K31/47 , A61K31/495 , A61P31/04 , C07C65/21 , C07D215/56 , C07D401/04

84. 发明专利

JPH09169735A QUINOLINE DERIVATIVE, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH09169735A
公开(公告)日：1997-06-30
申请号：JP27567396
申请日：1996-10-18
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： FURUYA SHUICHI , CHO NOBUO , SASAKI SATOSHI
IPC分类号： C07D215/56 , A61K31/47 , A61P5/00
摘要： PROBLEM TO BE SOLVED: To produce a new quinoline derivative useful as a preventing or a therapeutic agent for sex hormone-dependent cancer, prostatic hypertrophy, etc., due to excellent antagonistic actions on a gonadotropic hormone-releasing hormone possessed thereby, goodness in peroral absorbability and excellence in stability. SOLUTION: This compound of formula I [R is formula II (R is an aralkyl; R is an alkyl; X is an alkylene) or an alkyl which may be halogenated; R is an acylaminoaryl; R is a halogenoaralkyl; R is carboxyl which may be esterified or amidated] or its salt, e.g. ethyl 6-(N-benzyl-N- methylaminomethyl)-1,4-dihydro-1-(2,6-difluorobenzyl)-7-(4-propionylam inophenyl)-4- oxoquinoline-3carboxylate. The compound is obtained by reacting a compound of formula III (Y is a halogen) with an arylboric acid derivative of the formula R -B(OH)2 in the presence of a base such as sodium carbonate in a solvent such as ethyl ether.

85. 发明专利

JPH09504519A 失效
公开(公告)号：JPH09504519A
公开(公告)日：1997-05-06
申请号：JP51152195
申请日：1994-10-20
IPC分类号： A61K31/50 , A61K31/5025 , A61P3/08 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07D215/56 , C07D221/00 , C07D221/04 , C07D237/00 , C07D471/04 , C07D471/14 , C07D495/14
摘要： (4,5-b)quinoline-1,10-dione derivs. and tricyclic hetero-fused pyridazino-pyridine analogues of formula (I) and their salts and tautomers are new, including B-ring tautomers or reduced derivs. of formula (I'):Z = O, S or NH; Z1 = H, OH, SH or NH2; ring A = ortho-fused phenyl, pyridyl, furyl,etc.; R4 = halo, Q, NO2, CN, 1-3C perfluoroalkyl, OH,etc.;R1 = H or -(CH2)nL; L = M or W; M = e.g. (i) phenyl (or benzo deriv.), opt. substd. by 1-4 of OQ, 2-4C alkenyloxy, 2-4C alkynyloxy,-OCOQ'-phenyl,etc.;(ii) 5-7 membered heterocyclyl contg. 1-3 of O, N and S as heteroatoms,etc.;or (iii) heteroaryl (or benzy deriv.) including pyridyl, thienyl, furyl, gps. contg. 2 heteroatoms selected from N, O and S (e.g. pyrazole, imidazol etc.);W = OH, ORa, OCORa, S(O)mRa, S(O)mNRaRb,etc.;W may also be CORa, NRaCORb,etc., if n is other than zero; n = 0-6;R2 = H or (CH2)nL'; L' = M' or W; M' = e.g. (i) phenyl (or benzo deriv.), opt. substd. by 1-3 of 1-3 of OQ, OH, halo, NO2,etc.; R = H or Q; Ra,Rb = H, Q, 2-4C alkenyl, 2-4C alkynyl,etc.; m = 0-2; Q = 1-4C alkyl (or alkylene if appropriate); Q' = 1-6C alkyl (or alkylene if appropriate); provided that R1 and R2 are not both H.

86. 发明专利

JP2604124B2 失效
公开(公告)号：JP2604124B2
公开(公告)日：1997-04-30
申请号：JP27859594
申请日：1994-10-19
IPC分类号： C07D498/00 , A61K31/435 , A61K31/47 , A61P31/04 , C07C45/00 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D403/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/06 , C07D519/00

87. 发明专利

JPH09500640A 失效
公开(公告)号：JPH09500640A
公开(公告)日：1997-01-21
申请号：JP50508795
申请日：1994-06-10
IPC分类号： A61K31/47 , A61K31/4704 , A61P31/04 , A61P35/00 , C07D215/54 , C07D215/56

88. 发明专利

JPH0824536B2 失效
公开(公告)号：JPH0824536B2
公开(公告)日：1996-03-13
申请号：JP15107391
申请日：1991-05-27
IPC分类号： A23K1/16 , A23K20/195 , A61K31/47 , A61K31/495 , A61P31/04 , C07C69/716 , C07C69/738 , C07D215/56 , C07D401/00

89. 发明专利

JPH089597B2 失效
公开(公告)号：JPH089597B2
公开(公告)日：1996-01-31
申请号：JP22014986
申请日：1986-09-18
IPC分类号： A61K31/47 , A61K31/495 , A61P31/04 , C07D215/56 , C07D401/04

90. 发明专利

JPH07316109A FLUOROCYCLOPROPYLAMINOACRYLIC ACID ESTER DERIVATIVE 失效
公开(公告)号：JPH07316109A
公开(公告)日：1995-12-05
申请号：JP24851292
申请日：1992-08-05
申请人： DAIICHI SEIYAKU CO
发明人： HAYAKAWA ISAO , SHINKO SHOGO , YOKOHAMA SHUICHI , IMAMURA MASAZUMI
IPC分类号： C07C211/37 , A61K31/47 , A61K31/495 , A61P31/04 , C07C67/00 , C07C209/00 , C07C209/56 , C07C229/34 , C07C253/00 , C07C255/50 , C07D215/00 , C07D215/56 , C07D241/00 , C07D401/04 , C07D401/14
摘要： PURPOSE:To obtain a new fluorocyclopropylaminoacrylic acid ester derivative useful as an intermediate of a compound having a quinolinecarboxylic acid skeleton and useful as a medicine, especially an antimicrobial agent CONSTITUTION:A fluorocyclopropylaminoacrylic acid ester derivative represented by formula I (X is a halogen or H; X is a halogen or H; X is a halogen; X is a halogen; X is a halogen; R is H or a lower alkyl), e.g. 3-(cis-2- fluorocyclopropylamino)-2-(2,4,5-trifluorobenzoyl)-aerylic acid ethyl ester. A compound of formula I, especially an exemplified compaund of formula VIIa (R is C2H5) is synthesized by reacting 3-ethoxy-2-(2,4,5-trifluorobenzoy1)acrylic acid ethyl ester of formula VIa with a new cis-1-amino-2-fluorocyclopropane. In addition, if the compound of formula VIIa is reacted with equimolar sodium hydride in anhydrous dioxane solvent, a compound of formula IIa is obtain. From the compound of formula IIa, a compound of formula III as an antimierobial agent can be obtained.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式