基本信息:
- 专利标题: FLUOROCYCLOPROPYLAMINOACRYLIC ACID ESTER DERIVATIVE
- 申请号:JP24851292 申请日:1992-08-05
- 公开(公告)号:JPH07316109A 公开(公告)日:1995-12-05
- 发明人: HAYAKAWA ISAO , SHINKO SHOGO , YOKOHAMA SHUICHI , IMAMURA MASAZUMI
- 申请人: DAIICHI SEIYAKU CO
- 专利权人: DAIICHI SEIYAKU CO
- 当前专利权人: DAIICHI SEIYAKU CO
- 优先权: JP26422184 1984-12-14; JP3700885 1985-02-26
- 主分类号: C07C211/37
- IPC分类号: C07C211/37 ; A61K31/47 ; A61K31/495 ; A61P31/04 ; C07C67/00 ; C07C209/00 ; C07C209/56 ; C07C229/34 ; C07C253/00 ; C07C255/50 ; C07D215/00 ; C07D215/56 ; C07D241/00 ; C07D401/04 ; C07D401/14
摘要:
PURPOSE:To obtain a new fluorocyclopropylaminoacrylic acid ester derivative useful as an intermediate of a compound having a quinolinecarboxylic acid skeleton and useful as a medicine, especially an antimicrobial agent CONSTITUTION:A fluorocyclopropylaminoacrylic acid ester derivative represented by formula I (X is a halogen or H; X is a halogen or H; X is a halogen; X is a halogen; X is a halogen; R is H or a lower alkyl), e.g. 3-(cis-2- fluorocyclopropylamino)-2-(2,4,5-trifluorobenzoyl)-aerylic acid ethyl ester. A compound of formula I, especially an exemplified compaund of formula VIIa (R is C2H5) is synthesized by reacting 3-ethoxy-2-(2,4,5-trifluorobenzoy1)acrylic acid ethyl ester of formula VIa with a new cis-1-amino-2-fluorocyclopropane. In addition, if the compound of formula VIIa is reacted with equimolar sodium hydride in anhydrous dioxane solvent, a compound of formula IIa is obtain. From the compound of formula IIa, a compound of formula III as an antimierobial agent can be obtained.
公开/授权文献:
- JP2520549B2 公开/授权日:1996-07-31
信息查询:
EspacenetIPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C211/00 | 含有与碳架连接的氨基的化合物 |
--------C07C211/01 | .与非环碳原子连接的氨基 |
----------C07C211/34 | ..饱和碳架的 |
------------C07C211/37 | ...进一步被卤原子或硝基或亚硝基取代 |