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71. 发明专利

JPH0862200A ION SOURCE, AND MASS SPECTROSCOPE USING IT 失效
公开(公告)号：JPH0862200A
公开(公告)日：1996-03-08
申请号：JP20176794
申请日：1994-08-26
申请人： HITACHI LTD
发明人： HIRABAYASHI TSUDOI , SAKAIRI MINORU , TAKADA YASUAKI , KOIZUMI HIDEAKI , UMEMURA KAORU
IPC分类号： G01N27/62 , G01N30/72 , H01J27/26 , H01J37/05 , H01J37/08 , H01J49/04 , H01J49/10
摘要： PURPOSE: To provide an ion source whose ionization efficiency is high without applying voltage to a capillary and to provide a mass spectrometer using the ion source, whose ion intensity is 10 times or higher than that of an ionization method in conventional cases and which can be operated safely. CONSTITUTION: A sample solution is introduced into a capillary inside the ion source 2 from a sample-solution supply part 1. The flow rate of a gas which is supplied from a gas supply part 3 is adjusted by a flowmeter 4, the gas is made to flow along the outer circumferential part of the capillary, and the gas is introduced into a gas guide tube which is constituted so as to be spouted at the tip part of the capillary. The sample solution is ionized by the action effect of the spouted gas at the tip part of the capillary so as to be analyzed by a mass spectrometer 11.

72. 发明专利

JPH05223806A GLYCOPROTEIN ANALYZING DEVICE 失效
公开(公告)号：JPH05223806A
公开(公告)日：1993-09-03
申请号：JP2650292
申请日：1992-02-13
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , HIRABAYASHI TSUDOI , TAKADA YASUAKI , OKANO KAZUNOBU
IPC分类号： G01N30/88
摘要： PURPOSE:To conduct a primary structural analysis of a sugar chain in glycoprotein. CONSTITUTION:A glycoprotein analyzing device is constituted of a liquid chromatograph 2, mass spectrometer 5a, gas chromatograph 1, control part 8a, data processing part 8b and sample processing part 7. Among different purpose analyses, analyzing means are used in common; a bond position analysis of a sugar chain of glycoprotein is conducted by constitution of the liquid chromatograph and mass spectrometer, a bond position analysis of carbon among the sugar chains, by constitution of the gas chromatograph and mass spectrometer, an arrangement analysis of the sugar chains and anomer analysis, by constitution of the liquid chromatograph and mass spectrometer or liquid chromatograph. In the arrangement analysis of the sugar chains and anomer analysis wherein sample processing operation is complicated, a series of the sample processing operation and analyzing operation from a digestion reaction to concentration and recovery of a digestion reaction solution are automated. The glycoprotein analyzing device capable of labor saving can be provided at a low cost so as to efficiently conduct the glycoprotein analysis.

73. 发明专利

JP2001312996A MASS SPECTROMETER AND MASS SPECTROMETRY 失效
公开(公告)号：JP2001312996A
公开(公告)日：2001-11-09
申请号：JP2001086626
申请日：2001-03-26
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , SAKAIRI MINORU , NABESHIMA TAKAYUKI , HIRABAYASHI YUKIKO , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide an ion trap mass spectrometer for improving the detection sensitivity of highly polar substances. SOLUTION: A potential difference for reducing the velocity of ions is provided between an electrode 9 for opening the second slit and an end cap 12a for opening an ion acquisition, achieving a lower energy injected to the ion mass spectrometer. The lower ion injection energy irrespective of a drift voltage facilitates accumulation of ions in the mass spectrometer. As a high drift voltage can be used, a solvent can be effectively removed form the highly polar substances in a differentially pumped part, and the sensitivity of detecting the highly polar substances can be improved.

74. 发明专利

JP2000306545A MASS SPECTROMETER AND MASS SPECTROMETRY 失效
公开(公告)号：JP2000306545A
公开(公告)日：2000-11-02
申请号：JP11181699
申请日：1999-04-20
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , NABESHIMA TAKAYUKI , SAKAIRI MINORU
IPC分类号： H01J49/42 , B01D59/46 , G01N27/62
摘要： PROBLEM TO BE SOLVED: To enhance the generation efficiency of fragment ions by varying at least one parameters of a resonance signal applied between end cap electrodes with specified timing. SOLUTION: The kinetic energy of precursor ions is enhanced by a resonance phenomenon by using a signal 14 having an amplitude V0 and a frequency f0. Next, the phase of the signal 14 is reversed at a time t1. Before the kinetic energy of the precursor ions is enhanced by the resonance and the ions are exhausted from a mass spectrometer, the phase of the signal 14 is reversed again at a time t2. By reversing the phase of the resonance signal 14 applied between the cap electrodes at predetermined timing like this, the upper limit of the kinetic energy of the precursor ions can be set. This can prevent a phenomenon in which the kinetic energy of the precursor ions is lost from the inside of an ion trap mass spectrometer because it is excessively enhanced by the resonance, so that mass spectrometry can be executed with high sensitivity.

75. 发明专利

JP2000164169A MASS SPECTROMETER 失效
公开(公告)号：JP2000164169A
公开(公告)日：2000-06-16
申请号：JP33525698
申请日：1998-11-26
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , NABESHIMA TAKAYUKI , SAKAIRI MINORU
IPC分类号： H01J49/10 , G01N21/73 , G01N27/62 , H05H1/00
摘要： PROBLEM TO BE SOLVED: To enhance measuring accuracy by measuring a parameter of plasma, and performing mass spectrometry on an ion of a sample ionized by a plasma ion source. SOLUTION: An atomized sample solution is introduced to a sample introducing pipe 4, and then, to plasma 10 through an ion source 5 to be ionized. In the plasma 10, a parameter such as a temperature and density is measured by a measuring instrument 24. A signal obtained from the measuring instrument 24 is sent to either of an atomizing part 3, a plasma gas supply part 6, a microwave generating part 8, a power source 18 and a mass spectrometer control part 20 via a signal line 22' to control the ion source 5 and a mass spectrometer 19. For example, a plasma temperature is measured by the measuring instrument 24, and when the plasma temperature lowers, output of the microwave generating part 8 is enhanced to prevent reduction in ionizing efficiency to improve quantitatively determining accuracy of a sample. When plasma electric potential changes, an ion optical system 17 and the mass spectrometer 19 are controlled by the power source 18 and the mass spectrometer control part 20 on the basis of the signal of the measuring instrument 24.

76. 发明专利

JP2000088808A MASS SPECTROMETER, AND ION SOURCE THEREFOR 失效
公开(公告)号：JP2000088808A
公开(公告)日：2000-03-31
申请号：JP29046599
申请日：1999-10-13
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , SAKAIRI MINORU , HIRABAYASHI TSUDOI , NABESHIMA TAKAYUKI , KOIZUMI HIDEAKI
IPC分类号： H01J49/04 , G01N27/62 , G01N30/72 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To enhance separation capability for a mixed sample in a liquid chromatopgraph and a mass spectrometer, by allowing a mobile phase solvent containing a slightly volatile salt to be used. SOLUTION: After a sample separated by a liquid chromatograph 14 is atomized in an electrostatic atomizing part 15, it is heated to be vaporized in a vaporizing part 5, a resultant gaseous sample molecule is ionized by proton addition reaction or the like due to chemical reaction in an ionization part 6 provided with a corona discharge part, and it is introduced into a high vacuum part 12 from ion introducing pores 9a, 9b to be analyzed in a mass spectrometric analysis part 13. A salt contained in a solution is converted into a gaseous ion thereby, its path is bent by electric fields in the vicinity of the ion introducing pores 9a, 9b, and the pores 9a, 9b are prevented from being blocked by deposit of a slightly volatile salt.

77. 发明专利

JPH1173910A MASS SPECTROMETER 失效
公开(公告)号：JPH1173910A
公开(公告)日：1999-03-16
申请号：JP23576097
申请日：1997-09-01
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , MIMURA TADAO , ISHIZUKA TOSHIHIRO , TOMIOKA MASARU , TAKADA YASUAKI , NABESHIMA TAKAYUKI
IPC分类号： G01N27/62 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To prevent stray ions or minute droplets from reaching an ion detector, and to effectively suppress the increase in random noise by arranging a conductive shielding member for extinguishing the stray ions and minute droplets on at least one of the ion-emitting side vicinity and incident-side vicinity of a mass analyzer part. SOLUTION: A conductive shielding member 22a is arranged on the ion emitting-side vicinity of an ion-trap mass analyzer part within a chamber. Therefore, stray ions or charged minute droplets carried thereto is extinguished through a process of collision and neutralization with the shielding member 22a without reaching the conversion dynode of an ion detector 14, so that the increase in random noise and reduction in S/N ratio of a signal can be prevented effectively. As the shielding member 22a, a stainless steel-made mesh- like plate having an opening at the center is used. The mesh-like plate is manufactured by chemically etching a stainless steel plate.

78. 发明专利

JPH1164282A ADJUSTING METHOD OF MASS SPECTROGRAPH 失效
公开(公告)号：JPH1164282A
公开(公告)日：1999-03-05
申请号：JP22223097
申请日：1997-08-19
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , TOMIOKA MASARU , TAKADA YASUAKI
IPC分类号： G01N27/62 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To shorten the rise time of the whole by mainly adjusting parameters which can be adjusted in the state that the vacuum of the interior of the ion trap mass spectrograph has not completely risen separately from parameters which can be adjusted only in the stage that the vacuum has completely risen. SOLUTION: After the transferring in, assembling, and vacuum-drawing of a device, in the stage that the inside of an ion trap mass spectrograph part is not sufficiently evacuated, the adjustment of an ion source and an ion lens, which are parameters having no relation with the interior pressure, is started. A ground potential or a d.c. voltage is impressed on end cap electrodes 11a and 11b and a ring electrode 12. Ions generated at the ion source are transmitted through the end cap electrodes 11a and 11b and the ring electrode 12, and the total amount of a current is measured. The ion source and the ion lens are adjusted so that the value of the current becomes the maximum. When the interior pressure becomes sufficient during the adjustment, the adjustment of an acceleration voltage of ions and the ion trap mass spectrograph part is started.

79. 发明专利

JPH10255715A MASS SPECTROMETER AND ION SOURCE 失效
公开(公告)号：JPH10255715A
公开(公告)日：1998-09-25
申请号：JP5587997
申请日：1997-03-11
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , SAKAIRI MINORU
IPC分类号： G01N27/62 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To strongly and stably provide the strength of an ion contained in a sample molecule by minimizing the cross-sectional area of the tip of a capillary of a mass spectrometer at its terminal end. SOLUTION: An effluent from a liquid chromatograph 1 is fed to a capillary 11 through a pipeline 2. When the capillary 11 is heated by a heater 10, the effluent is heated and atomized to form jets 16 of a high speed. At this time, if the cross-sectional area of the capillary 11 is gradually diminished toward the tip, air flows 19 are generated at the tip of the capillary 11, thereby preventing any generation of a vacuum space. As a result, the jets 16 are hardly dispersed, and a sufficient quantity of ions can reach a pore 13a even if a distance 15 is long. Consequently, more ions can be taken through the pore 13a, so that the strength of the ion can be observed strongly by a mass spectrometer. Furthermore, since the jetting direction cannot be changed even if nonvolatile foreign matters are deposited, stable jetting can be performed for a long period. Therefore, it is possible to enhance stability and reproducibility of the liquid chromatograph mass spectrometer.

80. 发明专利

JPH1012182A ION SOURCE AND MASS SPECTROMETRY DEVICE 失效
公开(公告)号：JPH1012182A
公开(公告)日：1998-01-16
申请号：JP5879797
申请日：1997-03-13
申请人： HITACHI LTD
发明人： HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , TAKADA YASUAKI , SAKAIRI MINORU , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , H01J40/04 , H01J49/14
摘要： PROBLEM TO BE SOLVED: To optimize liquid drop density taken in a mass spectrometry device and reduce noise in a sonic spray ion source and the mass spectrometry device. SOLUTION: A solution sample in a sample solution introducing part 1 is introduced in a capillary 2. The capillary 2 is set in an ion source 6. Gas supplied from a gas supply part 4 is introduced into the ion source 6 through a gas pipe 5, flows along the outer circumference part of the capillary 2, and is discharge from an orifice 3 to the atmosphere. Gas flow strikes against a diffusion member 7 and the gas is diffused. Micro liquid drops or ions produced in the atmosphere are passed through a hole 8 of the diffusion member 7, and taken in a mass spectrometer 11 from a small hole 10, and mass spectrometry is conducted. Use of the flow rate of the sample solution higher than in the conventional sonic spray ion source and mass spectrometry device is made possible. The adjusting job by a user is lightened by auto-tuning.

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